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Protein

Homeobox protein CDX-1

Gene

cdx1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1. Binds to the PRKD1 promoter. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi150 – 209HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein CDX-1
Short name:
xCAD2
Gene namesi
Name:cdx1
Synonyms:cad2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-864834 cdx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002534631 – 263Homeobox protein CDX-1Add BLAST263

Structurei

3D structure databases

ProteinModelPortaliQ91622
SMRiQ91622
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni153 – 174Interaction with DNABy similarityAdd BLAST22
Regioni192 – 203Interaction with 5-mCpG DNABy similarityAdd BLAST12

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 120Pro-richAdd BLAST106
Compositional biasi138 – 143Poly-Thr6
Compositional biasi241 – 247Poly-Ser7

Sequence similaritiesi

Belongs to the Caudal homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG005302
KOiK09312

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR006820 Caudal_activation_dom
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF04731 Caudal_act, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q91622-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVGYLLDKD NNMYPNPVRH PGLNLNPQNY VPAPPQYSDF PSYHHVPGIN
60 70 80 90 100
SDPHHGQPGG TWSSYTPSRE DWHPYGPGPG ASSANPTQIA FSPSDYNPVQ
110 120 130 140 150
PPGSGLLPPS INSSVPPLSP SAQRADPYEW MRRTGVPTTT TTTNGKTRTK
160 170 180 190 200
DKYRVVYTDH QRLELEKEFH YSRYITIRRK AELAAALGLT ERQVKIWFQN
210 220 230 240 250
RRAKERKVNK KKMQQQSQQA STTTPTPPSV GTTAGMGGLC SSSSSNSNLV
260
SPSSMPIKEE YLS
Length:263
Mass (Da):29,201
Last modified:November 1, 1996 - v1
Checksum:iA950FF028BD1EFE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04302 mRNA Translation: AAA03642.1
PIRiA40856
RefSeqiNP_001081175.1, NM_001087706.1
UniGeneiXl.1358

Genome annotation databases

GeneIDi397695
KEGGixla:397695

Similar proteinsi

Entry informationi

Entry nameiCDX1_XENLA
AccessioniPrimary (citable) accession number: Q91622
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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