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Protein

ELAV-like protein 3

Gene

elavl3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to AU-rich sequences (AREs) of target mRNAs. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Ribonucleoprotein

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ELAV-like protein 3
Alternative name(s):
Protein ElrCImported
Gene namesi
Name:elavl3
Synonyms:elrCImported
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-866009. elavl3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348ELAV-like protein 3PRO_0000391373Add
BLAST

Expressioni

Tissue specificityi

Expression is neural-specific in both embryos and adults. Expressed from neurula stage onwards in primary motor-, inter- and sensory-neurons. Expressed in the closing neural tube and motor neurons of stage 18 embryos, and primarily in the ventricular zone and dorsal region of the tailbud and adult brain. Expressed from stage 26 onwards in the differentiating ganglion cell layer of the retina, extending to the inner nuclear layer at later stages.4 Publications

Developmental stagei

Expressed by late gastrula stage (stage 11).2 Publications

Inductioni

By bHLH transcription factors atoh7/ath5 and neurod1/neuroD.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ91584.
SMRiQ91584. Positions 31-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 11279RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini120 – 20081RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini265 – 34379RRM 3PROSITE-ProRule annotationAdd
BLAST

Domaini

RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences (By similarity).By similarity

Sequence similaritiesi

Belongs to the RRM elav family.Sequence analysis
Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG002295.
KOiK13208.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR006548. ELAD_HUD_SF.
IPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 3 hits.
SM00361. RRM_1. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
TIGRFAMsiTIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q91584-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVTIISTMET QANNGPGCVG ILNGTNGEAD DSKTNLIVNY LPQNMTQEEF
60 70 80 90 100
KSLFGSIGEI ESCKLVRDKI TGQSLGYGFV NYVDPNDADK AINTLNGLKL
110 120 130 140 150
QTKTIKVSYA RPSSASIRDA NLYVSSLPKT MNQKEMEQLF SQYGRIITSR
160 170 180 190 200
ILVDQVTGVS RGVGFIRFDK RIEAEEAIKG LNGQKPLGAS EPITVKFANN
210 220 230 240 250
PSQKTGQALL THLYQTTARR YTGPLHHQTQ RFSPLSILPR FSPITIDSVT
260 270 280 290 300
NLAGVSLTGP TTAGWCIFVY NLSPEADESV LWQLFGPFGA VTNVKVIRDF
310 320 330 340
TTNKCKGFGF VTMTNYDEAA MAIASLNGYR LGDRVLQVSF KTSKQHKA
Length:348
Mass (Da):38,143
Last modified:November 1, 1996 - v1
Checksum:i9C0FF1595AD631D5
GO
Isoform 2 (identifier: Q91584-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-239: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:341
Mass (Da):37,436
Checksum:iA1B1D9F4F71EC019
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei233 – 2397Missing in isoform 2. 1 PublicationVSP_038719

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17598 mRNA. Translation: AAA96944.1.
BC169769 mRNA. Translation: AAI69769.1.
PIRiI51677.
RefSeqiNP_001084080.1. NM_001090611.1. [Q91584-1]
UniGeneiXl.1035.

Genome annotation databases

GeneIDi399293.
KEGGixla:399293.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17598 mRNA. Translation: AAA96944.1.
BC169769 mRNA. Translation: AAI69769.1.
PIRiI51677.
RefSeqiNP_001084080.1. NM_001090611.1. [Q91584-1]
UniGeneiXl.1035.

3D structure databases

ProteinModelPortaliQ91584.
SMRiQ91584. Positions 31-203.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399293.
KEGGixla:399293.

Organism-specific databases

CTDi1995.
XenbaseiXB-GENE-866009. elavl3.

Phylogenomic databases

HOVERGENiHBG002295.
KOiK13208.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR006548. ELAD_HUD_SF.
IPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 3 hits.
SM00361. RRM_1. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
TIGRFAMsiTIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A conserved family of elav-like genes in vertebrates."
    Good P.J.
    Proc. Natl. Acad. Sci. U.S.A. 92:4557-4561(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Embryonic headImported.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: GastrulaImported.
  3. "Xenopus elav-like genes are differentially expressed during neurogenesis."
    Perron M., Furrer M.P., Wegnez M., Theodore L.
    Mech. Dev. 84:139-142(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  4. "Identification of shared transcriptional targets for the proneural bHLH factors Xath5 and XNeuroD."
    Logan M.A., Steele M.R., Van Raay T.J., Vetter M.L.
    Dev. Biol. 285:570-583(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.
  5. "Comparison of the expression patterns of five neural RNA binding proteins in the Xenopus retina."
    Amato M.A., Boy S., Arnault E., Girard M., Della Puppa A., Sharif A., Perron M.
    J. Comp. Neurol. 481:331-339(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiELAV3_XENLA
AccessioniPrimary (citable) accession number: Q91584
Secondary accession number(s): B7ZQD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.