Reviewed,
UniProtKB/Swiss-Prot Q91571 (EPB1A_XENLA)
Last modified
February 9, 2010.
Version 91.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ephrin type-B receptor 1-A EC=2.7.10.1 Alternative name(s): Tyrosine-protein kinase receptor XEK | ||||
| Gene names |
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| Organism | Xenopus laevis (African clawed frog) | ||||
| Taxonomic identifier | 8355 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Protein attributes
| Sequence length | 985 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Receptor for members of the ephrin-B family. May play a role in the development or function of the central nervous system. |
| Catalytic activity | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Subcellular location | |
| Developmental stage | Maternally expressed, it decreases at mid blastula transition and reappears at late neurulation. Expressed at higher levels in the anterior and dorsal regions of embryonic stages 16, 24 and 37. In adult it appears to be ubiquitously expressed with higher expression in brain and ovary. Expression in the brain, brachial arches, trigeminal facial ganglion, and the retina of swimming tadpole stage of development. |
| Sequence similarities | Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain. Contains 1 SAM (sterile alpha motif) domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Repeat Signal Transmembrane |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Receptor Transferase Tyrosine-protein kinase |
| PTM | Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase signaling pathwayInferred from electronic annotation. Source: InterPro |
| Cellular component | integral to plasma membrane Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ephrin receptor activityInferred from electronic annotation. Source: InterPro protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 19 | 19 | Potential | ||||||
| Chain | 20 – 985 | 966 | Ephrin type-B receptor 1-A | PRO_0000016826 | |||||
Regions | |||||||||
| Topological domain | 20 – 542 | 523 | Extracellular Potential | ||||||
| Transmembrane | 543 – 563 | 21 | Potential | ||||||
| Topological domain | 564 – 985 | 422 | Cytoplasmic Potential | ||||||
| Domain | 325 – 426 | 102 | Fibronectin type-III 1 | ||||||
| Domain | 436 – 527 | 92 | Fibronectin type-III 2 | ||||||
| Domain | 620 – 883 | 264 | Protein kinase | ||||||
| Domain | 912 – 976 | 65 | SAM | ||||||
| Nucleotide binding | 626 – 634 | 9 | ATP By similarity | ||||||
| Motif | 983 – 985 | 3 | PDZ-binding Potential | ||||||
| Compositional bias | 185 – 321 | 137 | Cys-rich | ||||||
Sites | |||||||||
| Active site | 745 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 652 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 336 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 428 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 482 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| [1] | "Expression of an amphibian homolog of the Eph family of receptor tyrosine kinases is developmentally regulated." Jones T.L., Karavanova I., Maeno M., Ong R.C., Kung H.-F., Daar I.O. Oncogene 10:1111-1117(1995) [PubMed: 7700636] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U14164 mRNA. Translation: AAA74888.1. |
| PIR | I51672. |
| RefSeq | NP_001084070.1. |
| UniGene | Xl.1028 |
3D structure databases | |
| SMR | Q91571. Positions 20-199, 324-532, 593-890, 622-970, 901-985. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 399288. |
| KEGG | xla:399288. |
Organism-specific databases | |
| CTD | 399288. |
| Xenbase | XB-FEAT-488625. ephb1. |
Phylogenomic databases | |
| HOVERGEN | Q91571. |
Enzyme and pathway databases | |
| BRENDA | 2.7.10.1. 648. |
Family and domain databases | |
| InterPro | IPR001090. Ephrin_rcpt_lig-bd. IPR008957. Fibronectin_typ-III-like_fold. IPR003961. FN_III. IPR008979. Galactose-bd-like. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001660. SAM. IPR011510. SAM_2. IPR010993. SAM_homology. IPR013761. SAM_type. IPR020635. Tyr_Pkinase_cat_dom. IPR020685. Tyr_prot_kinase. IPR008266. Tyr_prot_kinase_AS. IPR016257. Tyr_prot_kinase_ephrin_rcpt. IPR001426. Tyr_prot_kinase_rcpt_V_CS. [Graphical view] |
| Gene3D | G3DSA:2.60.40.30. FN_III-like. 1 hit. G3DSA:1.10.150.50. SAM_type. 1 hit. |
| PANTHER | PTHR23256. Tyr_prot_kinase. 1 hit. |
| Pfam | PF01404. Ephrin_lbd. 1 hit. PF00041. fn3. 2 hits. PF07647. SAM_2. 1 hit. [Graphical view] |
| PIRSF | PIRSF000666. TyrPK_ephrin_receptor. 1 hit. |
| SMART | SM00615. EPH_lbd. 1 hit. SM00060. FN3. 2 hits. SM00454. SAM. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view] |
| PROSITE | PS01186. EGF_2. 1 hit. Uncertain. PS50853. FN3. 2 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00790. RECEPTOR_TYR_KIN_V_1. False negative. PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit. PS50105. SAM_DOMAIN. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | EPB1A_XENLA | ||||||||
| Accession | Primary (citable) accession number: Q91571 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Xenopus annotation project | ||||||||

Clusters with


