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Protein
Submitted name:

Tumor suppressor

Gene

dcc

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor suppressorImported
Gene namesi
Name:dccImported
Synonyms:XDCCaImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5872596. dcc.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1080 – 110425HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MAZP562702EBI-1809954,EBI-1809742From a different organism.

Protein-protein interaction databases

IntActiQ91562. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ91562.
SMRiQ91562. Positions 420-524, 531-1029.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 133123Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini139 – 22991Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini239 – 32688Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini331 – 41686Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini431 – 52494Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini530 – 62091Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini625 – 71894Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini728 – 82194Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini828 – 92497Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini929 – 102698Fibronectin type-IIIInterPro annotationAdd
BLAST

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG005455.
KOiK06765.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR033012. DCC.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR010560. Neogenin_C.
[Graphical view]
PANTHERiPTHR10489:SF68. PTHR10489:SF68. 1 hit.
PfamiPF00041. fn3. 6 hits.
PF07679. I-set. 3 hits.
PF13895. Ig_2. 1 hit.
PF06583. Neogenin_C. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 6 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 6 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91562-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENCLGFYSL PKLVFLLYGF TLLNLNLTVS GSQVKSFTSL WFLSEPSDAV
60 70 80 90 100
TMRGGNVVLN CSAQSDRGAP IIKWKKDGVY LNLVIDERRQ QLPSGSFLIQ
110 120 130 140 150
NVVHSRHHRP DEGVYQCEAS LDSVGTIVSR TAKVLVAGPL RILSQTESVT
160 170 180 190 200
AFVGDTALLR CEITGEPMPT ISWQKNEEDL KVTPGDPRLL VLPSGTLQIS
210 220 230 240 250
RLQTADGGVY RCLAKNPGSA RVGNEAELRI LSESGLHRQQ VFLQRPSNVV
260 270 280 290 300
AIEGQDAVLE CAVSGYPTPT IVWMQGDEPV PIRTRKYSVL GGSNLLISNV
310 320 330 340 350
TDDDAGAYTC VATYKNENTS FSADLTVMVP PQFLNHPANL YAYESMDIEF
360 370 380 390 400
ECAVSGKPSP TVKWTKNGEV VIPSDYFQIV DGSNLRILGL VKSDEGYYQC
410 420 430 440 450
IAENEAGNIQ TYAQLIIPDP AVPSSSILPS APRDVVPVLV SSRFVRLSWR
460 470 480 490 500
PPVESKGNIQ TYTVYFSKQG VQRERAVNTS QPISLQITVG NLTPEETYNF
510 520 530 540 550
RVVAYNEWGP GESSQEVKVV TQPELQVPGP VENLQVVSTA PTSVLISWDP
560 570 580 590 600
PAYANGPVQG YRLFCAETFS GREQNIEVDG IVYRLEGLRK FTEYSIRVLA
610 620 630 640 650
YNRYGPGVSS EEHTVVTLSD VPSAMPQNVS LEVANSRSIK VSWLPPPPGT
660 670 680 690 700
QNGFITGYKI RHRKTTRRGE LETLEPNNLW YLFTGLEKGS QYSFQVAAMT
710 720 730 740 750
VNGTGPSSDW YTAETPENDL DESQVPDQPS SLHVRPLTTS IIMSWTPPLN
760 770 780 790 800
PNIVVRGYII GYGVGSPYAE TVRVDSKQRY YSIENLEPSS HYVISLKAFN
810 820 830 840 850
NAGEGVPLYE SATTRSQTVP DMSTPMLPPV GVQAVALTHD AVRVSWADNS
860 870 880 890 900
VLKNQKTTEV RFYTIRWRTS YSASSKYKSA DTTSLSHTVT GLKPNTMYEF
910 920 930 940 950
SVMVTKGRRS STWSMTAHAT TYETAPTSAP KDLTVITRER KPRAVIVSWQ
960 970 980 990 1000
PPIEANGKII DFILFYTLDK NLQLDDWIMV TITGDRLTHE ILDLNLDTAY
1010 1020 1030 1040 1050
YFRIQARNAK GLGPLSEPIT FRTPKVEHPD KMANDQGRHG DGGYWSVDTN
1060 1070 1080 1090 1100
LIDRSSLNEP PIGQMHPPHG SVTPQKNSNL LVIIVVTVGA ITILVVVIVA
1110 1120 1130 1140 1150
VICTRRSSAQ QRKKRATHSA GKRKGSQKDL RPPDLWIHHE EMEMKNIEKP
1160 1170 1180 1190 1200
SGSDTQGRDS PRQSCQDITP VSHSQSESQL GSKSTSHSGP DADEVGSNIS
1210 1220 1230 1240 1250
TLERTLAARR ATRAKLMIPM DSQPSSNPPV VSAIPVPTLE SAQYPGILPS
1260 1270 1280 1290 1300
PTCGYPHPQF TLRPVPFPTL TVDRGFGTSR VTEVPASQQS SVLSHPQPEH
1310 1320 1330 1340 1350
STSEDAPSRT IPTACVRPTH PLRSFANPLL PPPMTAMEPK VPYTTLLSQT
1360 1370 1380 1390 1400
GSGLSKAQVK TASLGLAGKA RSPLLPVSVP TAPEVSEESH KHTDDPSSVY
1410 1420
EQDDLSEQMA SLEGLMKQLN AITGSAF
Length:1,427
Mass (Da):156,534
Last modified:November 1, 1996 - v1
Checksum:i61FEA12C8A674972
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10986 mRNA. Translation: AAA70168.1.
PIRiI51669.
RefSeqiNP_001079254.1. NM_001085785.1.
UniGeneiXl.953.

Genome annotation databases

GeneIDi378529.
KEGGixla:378529.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10986 mRNA. Translation: AAA70168.1.
PIRiI51669.
RefSeqiNP_001079254.1. NM_001085785.1.
UniGeneiXl.953.

3D structure databases

ProteinModelPortaliQ91562.
SMRiQ91562. Positions 420-524, 531-1029.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91562. 1 interaction.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi378529.
KEGGixla:378529.

Organism-specific databases

CTDi1630.
XenbaseiXB-GENE-5872596. dcc.

Phylogenomic databases

HOVERGENiHBG005455.
KOiK06765.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR033012. DCC.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR010560. Neogenin_C.
[Graphical view]
PANTHERiPTHR10489:SF68. PTHR10489:SF68. 1 hit.
PfamiPF00041. fn3. 6 hits.
PF07679. I-set. 3 hits.
PF13895. Ig_2. 1 hit.
PF06583. Neogenin_C. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 6 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 6 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of a homologue of the deleted in colorectal cancer (DCC) gene in the nervous system of developing Xenopus embryos."
    Pierceall W.E., Reale M.A., Candia A.F., Wright C.V., Cho K.R., Fearon E.R.
    Dev. Biol. 166:654-665(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ91562_XENLA
AccessioniPrimary (citable) accession number: Q91562
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.