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Protein
Submitted name:

Tumor suppressor

Gene

dcc

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor suppressorImported
Gene namesi
Name:dccImported
Synonyms:XDCCaImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5872596. dcc.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1080 – 1104HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MAZP562702EBI-1809954,EBI-1809742From Homo sapiens.

Protein-protein interaction databases

IntActiQ91562. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ91562.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 133Ig-likeInterPro annotationAdd BLAST123
Domaini139 – 229Ig-likeInterPro annotationAdd BLAST91
Domaini239 – 326Ig-likeInterPro annotationAdd BLAST88
Domaini331 – 416Ig-likeInterPro annotationAdd BLAST86
Domaini431 – 524Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini530 – 620Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini625 – 718Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini728 – 821Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini828 – 924Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini929 – 1026Fibronectin type-IIIInterPro annotationAdd BLAST98

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG005455.
KOiK06765.

Family and domain databases

CDDicd00063. FN3. 6 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiView protein in InterPro
IPR033012. DCC.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR010560. Neogenin_C.
PANTHERiPTHR10489:SF898. PTHR10489:SF898. 1 hit.
PfamiView protein in Pfam
PF00041. fn3. 6 hits.
PF07679. I-set. 3 hits.
PF13895. Ig_2. 1 hit.
PF06583. Neogenin_C. 1 hit.
SMARTiView protein in SMART
SM00060. FN3. 6 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 4 hits.
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF49265. SSF49265. 4 hits.
PROSITEiView protein in PROSITE
PS50853. FN3. 6 hits.
PS50835. IG_LIKE. 4 hits.

Sequencei

Sequence statusi: Complete.

Q91562-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENCLGFYSL PKLVFLLYGF TLLNLNLTVS GSQVKSFTSL WFLSEPSDAV
60 70 80 90 100
TMRGGNVVLN CSAQSDRGAP IIKWKKDGVY LNLVIDERRQ QLPSGSFLIQ
110 120 130 140 150
NVVHSRHHRP DEGVYQCEAS LDSVGTIVSR TAKVLVAGPL RILSQTESVT
160 170 180 190 200
AFVGDTALLR CEITGEPMPT ISWQKNEEDL KVTPGDPRLL VLPSGTLQIS
210 220 230 240 250
RLQTADGGVY RCLAKNPGSA RVGNEAELRI LSESGLHRQQ VFLQRPSNVV
260 270 280 290 300
AIEGQDAVLE CAVSGYPTPT IVWMQGDEPV PIRTRKYSVL GGSNLLISNV
310 320 330 340 350
TDDDAGAYTC VATYKNENTS FSADLTVMVP PQFLNHPANL YAYESMDIEF
360 370 380 390 400
ECAVSGKPSP TVKWTKNGEV VIPSDYFQIV DGSNLRILGL VKSDEGYYQC
410 420 430 440 450
IAENEAGNIQ TYAQLIIPDP AVPSSSILPS APRDVVPVLV SSRFVRLSWR
460 470 480 490 500
PPVESKGNIQ TYTVYFSKQG VQRERAVNTS QPISLQITVG NLTPEETYNF
510 520 530 540 550
RVVAYNEWGP GESSQEVKVV TQPELQVPGP VENLQVVSTA PTSVLISWDP
560 570 580 590 600
PAYANGPVQG YRLFCAETFS GREQNIEVDG IVYRLEGLRK FTEYSIRVLA
610 620 630 640 650
YNRYGPGVSS EEHTVVTLSD VPSAMPQNVS LEVANSRSIK VSWLPPPPGT
660 670 680 690 700
QNGFITGYKI RHRKTTRRGE LETLEPNNLW YLFTGLEKGS QYSFQVAAMT
710 720 730 740 750
VNGTGPSSDW YTAETPENDL DESQVPDQPS SLHVRPLTTS IIMSWTPPLN
760 770 780 790 800
PNIVVRGYII GYGVGSPYAE TVRVDSKQRY YSIENLEPSS HYVISLKAFN
810 820 830 840 850
NAGEGVPLYE SATTRSQTVP DMSTPMLPPV GVQAVALTHD AVRVSWADNS
860 870 880 890 900
VLKNQKTTEV RFYTIRWRTS YSASSKYKSA DTTSLSHTVT GLKPNTMYEF
910 920 930 940 950
SVMVTKGRRS STWSMTAHAT TYETAPTSAP KDLTVITRER KPRAVIVSWQ
960 970 980 990 1000
PPIEANGKII DFILFYTLDK NLQLDDWIMV TITGDRLTHE ILDLNLDTAY
1010 1020 1030 1040 1050
YFRIQARNAK GLGPLSEPIT FRTPKVEHPD KMANDQGRHG DGGYWSVDTN
1060 1070 1080 1090 1100
LIDRSSLNEP PIGQMHPPHG SVTPQKNSNL LVIIVVTVGA ITILVVVIVA
1110 1120 1130 1140 1150
VICTRRSSAQ QRKKRATHSA GKRKGSQKDL RPPDLWIHHE EMEMKNIEKP
1160 1170 1180 1190 1200
SGSDTQGRDS PRQSCQDITP VSHSQSESQL GSKSTSHSGP DADEVGSNIS
1210 1220 1230 1240 1250
TLERTLAARR ATRAKLMIPM DSQPSSNPPV VSAIPVPTLE SAQYPGILPS
1260 1270 1280 1290 1300
PTCGYPHPQF TLRPVPFPTL TVDRGFGTSR VTEVPASQQS SVLSHPQPEH
1310 1320 1330 1340 1350
STSEDAPSRT IPTACVRPTH PLRSFANPLL PPPMTAMEPK VPYTTLLSQT
1360 1370 1380 1390 1400
GSGLSKAQVK TASLGLAGKA RSPLLPVSVP TAPEVSEESH KHTDDPSSVY
1410 1420
EQDDLSEQMA SLEGLMKQLN AITGSAF
Length:1,427
Mass (Da):156,534
Last modified:November 1, 1996 - v1
Checksum:i61FEA12C8A674972
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10986 mRNA. Translation: AAA70168.1.
PIRiI51669.
RefSeqiNP_001079254.1. NM_001085785.1.
UniGeneiXl.953.

Genome annotation databases

GeneIDi378529.
KEGGixla:378529.

Similar proteinsi

Entry informationi

Entry nameiQ91562_XENLA
AccessioniPrimary (citable) accession number: Q91562
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)