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Protein

Receptor-type tyrosine-protein phosphatase

Gene

ptpra

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei430SubstrateUniRule annotation1
Active sitei462Phosphocysteine intermediateUniRule annotation1
Binding sitei506SubstrateUniRule annotation1
Active sitei752Phosphocysteine intermediateUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:ptpraImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1012350. ptpra.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei172 – 195HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500431865220 – 822Receptor-type tyrosine-protein phosphataseSequence analysisAdd BLAST803

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei818PhosphotyrosineUniRule annotation1

Keywords - PTMi

PhosphoproteinUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ91556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini261 – 521Tyrosine-protein phosphataseInterPro annotationAdd BLAST261
Domaini441 – 512TYR_PHOSPHATASE_2InterPro annotationAdd BLAST72
Domaini553 – 811Tyrosine-protein phosphataseInterPro annotationAdd BLAST259
Domaini727 – 802TYR_PHOSPHATASE_2InterPro annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni462 – 468Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG053758.
KOiK18032.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR016336. Tyr_Pase_rcpt_a/e-type.
IPR027262. Tyr_Pase_rcpt_alpha.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFiPIRSF500808. PTPR_alpha. 1 hit.
PIRSF002006. PTPR_alpha_epsilon. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSWLVIALL ATVLPCSAAE NATAVGPTPA LNYTTRPAQQ DPPPELTNET
60 70 80 90 100
AASSGEPELK ATAPFTTTKP AVILAPNVTD IISPYPPAGN DSDANNQTEA
110 120 130 140 150
TNSTTAPTTV EVNGGTSTPI APNINVETTR GIINVISPTT GDLPTDVFFP
160 170 180 190 200
ADTTTGNPGN NGSEERRDET PIIAVMVALS SLLVIVFIII VLYMLRFKKY
210 220 230 240 250
KQAGSHSNSF RLSNGRVDDT EPQSMPLLAR SPSTNRKYPP LPVDKLEEEI
260 270 280 290 300
NRRMADDNKL FREESNALPA CPIQATCEAA SKEENMEKNR YVNILPYDHS
310 320 330 340 350
RVHLSPIEGV PDSDYINSSF INGYQEKNKF IAAQGPKEET VNDFWRMIWE
360 370 380 390 400
QNTATIVMVT NLKERKECKC AQYWPDQGCW TYGNIRVSVE DMTVLVDYTV
410 420 430 440 450
RKFCIQQVGD VTNKKPQRLI TQFHFTSWPD FGVPFTPIGM LKFLKKVKNC
460 470 480 490 500
NPQYAGAIVV HCSAGVGRTG TFMVIDAMLD MMNTEKKVDV YGFVTRIRAQ
510 520 530 540 550
RCQMVQTDMQ YVFIYQALLE HFLYGDTELE VTSLETHLQK LYSKFPGTNS
560 570 580 590 600
TGLEEEFKKL TSIKIQNDKM RTGNFPAYMK ENRVLQIIPY EFNRVIIPVK
610 620 630 640 650
RGEENTDYVN ASFIDGYRQK DSYIAGQGPL RHSLEDFWRM IWEWKSCSIV
660 670 680 690 700
MLTELEERGQ EKCAQYWPSE GTMSFGDITI ELKKEEESES YTVRDMFVTN
710 720 730 740 750
TRENKSRQIR QFHFHGWPEV GIPTDGKGMI NIIAAVQKQQ QQSGNHPITV
760 770 780 790 800
HCSAGAGRTG TFCALSTVLE RVKAEGILDV FQTVKSLRLQ RPHMVQTLEQ
810 820
YEFCYRVVQE YIDAFSDYAN FK
Length:822
Mass (Da):92,705
Last modified:November 1, 1996 - v1
Checksum:i81AD1ED960E07658
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09135 mRNA. Translation: AAA17990.1.
RefSeqiNP_001081056.1. NM_001087587.1.
UniGeneiXl.922.

Genome annotation databases

GeneIDi394358.
KEGGixla:394358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09135 mRNA. Translation: AAA17990.1.
RefSeqiNP_001081056.1. NM_001087587.1.
UniGeneiXl.922.

3D structure databases

ProteinModelPortaliQ91556.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi394358.
KEGGixla:394358.

Organism-specific databases

CTDi5786.
XenbaseiXB-GENE-1012350. ptpra.

Phylogenomic databases

HOVERGENiHBG053758.
KOiK18032.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR016336. Tyr_Pase_rcpt_a/e-type.
IPR027262. Tyr_Pase_rcpt_alpha.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFiPIRSF500808. PTPR_alpha. 1 hit.
PIRSF002006. PTPR_alpha_epsilon. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ91556_XENLA
AccessioniPrimary (citable) accession number: Q91556
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.