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Protein

Arginase, non-hepatic 3

Gene

arg2-c

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

As well as its role in the urea cycle, may be involved in tissue remodeling.

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.By similarity

Cofactori

Mn2+PROSITE-ProRule annotationNote: Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

Pathwayi: urea cycle

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine and urea from L-arginine.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Arginase (arg1), Arginase (arg2), Arginase (XELAEV_18026971mg), Arginase-1 (arg1), Arginase, non-hepatic 1 (arg2-a), Arginase, non-hepatic 2 (arg2-b), Arginase (XELAEV_18012182mg), Arginase (XELAEV_18014996mg), Arginase, non-hepatic 3 (arg2-c)
This subpathway is part of the pathway urea cycle, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine and urea from L-arginine, the pathway urea cycle and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi122Manganese 1PROSITE-ProRule annotation1
Metal bindingi145Manganese 1PROSITE-ProRule annotation1
Metal bindingi145Manganese 2PROSITE-ProRule annotation1
Metal bindingi147Manganese 2PROSITE-ProRule annotation1
Metal bindingi149Manganese 1PROSITE-ProRule annotation1
Binding sitei204SubstrateBy similarity1
Metal bindingi253Manganese 1PROSITE-ProRule annotation1
Metal bindingi253Manganese 2PROSITE-ProRule annotation1
Metal bindingi255Manganese 2PROSITE-ProRule annotation1
Binding sitei267SubstrateBy similarity1
Binding sitei298SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processArginine metabolism, Urea cycle
LigandManganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00158; UER00270

Names & Taxonomyi

Protein namesi
Recommended name:
Arginase, non-hepatic 3 (EC:3.5.3.1By similarity)
Gene namesi
Name:arg2-c
Synonyms:arg3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001737011 – 360Arginase, non-hepatic 3Add BLAST360

Expressioni

Tissue specificityi

Expressed at differing tadpole stages in tail, intestine, hindlimb and trunk region. Strongest in tadpole tail.

Developmental stagei

First detected in early tailbud (stage 23/24). Highest levels in whole tadpole found around stage 47/48. In the intestine, increased levels are found during metamorphosis (stages 58-64) and in the hindlimb, expressed at low levels during metamorphosis until stage 66 when levels dramatically increase. In the tail, a constant high level of expression is found throughout metamorphosis.

Inductioni

By thyroid hormone (T3).

Interactioni

Subunit structurei

Homotrimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ91555
SMRiQ91555
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni147 – 151Substrate bindingBy similarity5
Regioni158 – 160Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG003030

Family and domain databases

InterProiView protein in InterPro
IPR014033 Arginase
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
IPR020855 Ureohydrolase_Mn_BS
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PIRSFiPIRSF036979 Arginase, 1 hit
PRINTSiPR00116 ARGINASE
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01229 rocF_arginase, 1 hit
PROSITEiView protein in PROSITE
PS01053 ARGINASE_1, 1 hit
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q91555-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIRSNFVRL LKKQVNIIKL QKKCSHSVAV IGAPFSKGQK RRGVEHGPAA
60 70 80 90 100
IRSAGLIDRL SNLGCNVCDF GDLHFSQVPN DEQYNSIVKH PRTVGLACKV
110 120 130 140 150
LAKEVGKAVG AGHTCVTLGG DHSLAFGSIT GHAQQCPDLC VIWVDAHADI
160 170 180 190 200
NTPLTTPSGN LHGQPVSFLL RELQDKIPPI PGFSWAKPCL SKSDIVYIGL
210 220 230 240 250
RDLDPAEQFI LKNYNISYYS MRHIDCMGIR KVMEKTFDQL LGRRDRPIHL
260 270 280 290 300
SFDIDAFDPA LAPATGTPVI GGLTYREGVY ITEEIHNTGM LSALDLVEVN
310 320 330 340 350
PVLATTSEEV KATANLAVDV IASCFGQTRE GAHTRADTII DVLPTPSTSY
360
ESDNEEQVRI
Length:360
Mass (Da):39,238
Last modified:November 1, 1997 - v1
Checksum:iF1515DED32514662
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08408 mRNA Translation: AAA56893.1
BC094076 mRNA Translation: AAH94076.1
PIRiI51665
UniGeneiXl.893

Similar proteinsi

Entry informationi

Entry nameiARGN3_XENLA
AccessioniPrimary (citable) accession number: Q91555
Secondary accession number(s): Q52L42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health