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Protein

Beta-fibrinogenase mucrofibrase-3

Gene
N/A
Organism
Protobothrops mucrosquamatus (Taiwan habu) (Trimeresurus mucrosquamatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Snake venom serine protease with fibrinogenolytic activities. Cleaves beta-chain of fibrinogen (FGB) efficiently and shows relatively lower activity on alpha-chain.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei64Charge relay systemBy similarity1
Active sitei109Charge relay systemBy similarity1
Active sitei203Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Fibrinogenolytic toxin, Hemostasis impairing toxin, Hydrolase, Protease, Serine protease, Toxin

Protein family/group databases

MEROPSiS01.343.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-fibrinogenase mucrofibrase-3 (EC:3.4.21.-)
Alternative name(s):
Snake venom serine protease
Short name:
SVSP
OrganismiProtobothrops mucrosquamatus (Taiwan habu) (Trimeresurus mucrosquamatus)
Taxonomic identifieri103944 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeProtobothrops

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
PropeptideiPRO_000002841119 – 24By similarity6
ChainiPRO_000002841225 – 257Beta-fibrinogenase mucrofibrase-3Add BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 162PROSITE-ProRule annotation
Disulfide bondi49 ↔ 65PROSITE-ProRule annotation
Disulfide bondi97 ↔ 255PROSITE-ProRule annotation
Disulfide bondi141 ↔ 209PROSITE-ProRule annotation
Disulfide bondi173 ↔ 188PROSITE-ProRule annotation
Disulfide bondi199 ↔ 224PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ91509.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 248Peptidase S1PROSITE-ProRule annotationAdd BLAST224

Sequence similaritiesi

Belongs to the peptidase S1 family. Snake venom subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG013304.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91509-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLIRVLANL LILQLSYAQK SSELVIGGDE CNINEHPFLV LVYYDDYQCG
60 70 80 90 100
GTLLNEEWVL TAAHCNGKDM EIYLGVHSKK VPNKDVQRRV PKEKFFCDSS
110 120 130 140 150
KTYTKWNKDI MLIRLDRPVR KSAHIAPLSL PSSPPSVGSV CRVMGWGTIT
160 170 180 190 200
SPQETYPDVP HCANINLLDY EVCRAAYAGL PATSRTLCAG ILEGGKDSCV
210 220 230 240 250
GDSGGPLICN GQFQGIVSWG GDPCAQPREP GVYTNVFDHL DWIKGIIAGN

TDVTCPL
Length:257
Mass (Da):28,159
Last modified:November 1, 1996 - v1
Checksum:i781E8531FB641416
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83223 mRNA. Translation: CAA58223.1.
RefSeqiNP_001310175.1. NM_001323246.1.
XP_015671559.1. XM_015816073.1.

Genome annotation databases

GeneIDi107287552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83223 mRNA. Translation: CAA58223.1.
RefSeqiNP_001310175.1. NM_001323246.1.
XP_015671559.1. XM_015816073.1.

3D structure databases

ProteinModelPortaliQ91509.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS01.343.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi107287552.

Phylogenomic databases

HOVERGENiHBG013304.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVSP3_PROMU
AccessioniPrimary (citable) accession number: Q91509
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Does not have activity on gamma-chains of fibrinogen (FGG).1 Publication

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.