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Protein

Nuclear factor 7, ovary

Gene
N/A
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that determines dorsal-ventral body axis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri146 – 18641RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri220 – 26142B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear factor 7, ovary
Short name:
xNF7-O
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6256071. xnf7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 610610Nuclear factor 7, ovaryPRO_0000055978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei104 – 1041Phosphothreonine; by CDK1By similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Abundant in oocytes. At the neurula stage, low expression in dorsal embryo region including neural folds and somites.1 Publication

Developmental stagei

Expressed both maternally and zygotically.1 Publication

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiQ91431. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ91431.
SMRiQ91431. Positions 223-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini415 – 610196B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili295 – 37480Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri146 – 18641RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri220 – 26142B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

HOVERGENiHBG001357.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003649. Bbox_C.
IPR003879. Butyrophylin.
IPR000953. Chromo/shadow_dom.
IPR016197. Chromodomain-like.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR025995. Tudor-knot.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF11717. Tudor-knot. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00502. BBC. 1 hit.
SM00336. BBOX. 1 hit.
SM00298. CHROMO. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q91431-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEDEGADDG EQEEEEVLLV NVGSTYPCKR SDGSQHDADI VKTRYNKQAG
60 70 80 90 100
REEYYVHYVG LNRRQNEWVD KSRLVLTKPP KEVETNGTDQ EEMTEPTEQP
110 120 130 140 150
DSKTPQKRKL EEPEPEPKKA KVEDKDASKT AASLGAAGDF AEELTCPLCV
160 170 180 190 200
ELFKDPVMVA CGHNFCRSCI DKVWEGQSSF ACPECKESIT DRKYTINRVL
210 220 230 240 250
ANLAKKAACT PVTPVEKKTR PLEKCSEHDE RLKLYCKDDG TLGCVICRDS
260 270 280 290 300
LKHASHNFLP ILDAIGVYRE ELSAIVAPLE ASLKVTEQLS GEQSDKIEQH
310 320 330 340 350
NKNVSQYKEH VTSEFEKLHK FLKEREEKLL EQLKEQGDNL LTEMENNLVK
360 370 380 390 400
MQENQDAIKK TISLAKERME ETDSISFLTD IKTFIDKCQE QQRAVISTGN
410 420 430 440 450
TLLSKELCQG TFKGPIQYIM WKELKSVITP SLTPMLLDPN SAHPNLHLSD
460 470 480 490 500
GLTSVRYGEN KLSLPDNPKR FSQCILVLGS QGFDSGRHYW EVEVGDKTAW
510 520 530 540 550
DVGMASESSN RKGKIKLNPK NGYWAIWLRN GNRYKALESP SKALSLTSHP
560 570 580 590 600
RKIGVYVDYE GGQISFYNAD NMTIIYTFSA TFTEKLYPYL SPFLHDSGKN
610
VDALRFVHNQ
Length:610
Mass (Da):69,115
Last modified:November 1, 1996 - v1
Checksum:iD828F60060572EC1
GO
Isoform 2Curated (identifier: Q91431-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-118: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:553
Mass (Da):62,404
Checksum:i8F3E0CEA0BBAB686
GO

Sequence cautioni

The sequence AAH47956.1 differs from that shown. Reason: Frameshift at position 62. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti265 – 2651I → V in AAH47956 (Ref. 2) Curated
Sequence conflicti533 – 5331R → A in AAH47956 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei62 – 11857Missing in isoform 2. 1 PublicationVSP_051606Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80988 mRNA. Translation: AAB35876.1.
BC047956 mRNA. Translation: AAH47956.1. Frameshift.
RefSeqiNP_001079694.2. NM_001086225.2. [Q91431-1]
UniGeneiXl.2747.

Genome annotation databases

GeneIDi379381.
KEGGixla:379381.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80988 mRNA. Translation: AAB35876.1.
BC047956 mRNA. Translation: AAH47956.1. Frameshift.
RefSeqiNP_001079694.2. NM_001086225.2. [Q91431-1]
UniGeneiXl.2747.

3D structure databases

ProteinModelPortaliQ91431.
SMRiQ91431. Positions 223-261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91431. 1 interaction.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi379381.
KEGGixla:379381.

Organism-specific databases

CTDi379381.
XenbaseiXB-GENE-6256071. xnf7.

Phylogenomic databases

HOVERGENiHBG001357.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003649. Bbox_C.
IPR003879. Butyrophylin.
IPR000953. Chromo/shadow_dom.
IPR016197. Chromodomain-like.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR025995. Tudor-knot.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF11717. Tudor-knot. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00502. BBC. 1 hit.
SM00336. BBOX. 1 hit.
SM00298. CHROMO. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two forms of Xenopus nuclear factor 7 have overlapping spatial but different temporal patterns of expression during development."
    Gong S.-G., Reddy B.A., Etkin L.D.
    Mech. Dev. 52:305-318(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Ovary1 Publication.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: EmbryoImported.

Entry informationi

Entry nameiNF7O_XENLA
AccessioniPrimary (citable) accession number: Q91431
Secondary accession number(s): Q801R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.