Q91428 (GATA3_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor GATA-3

Alternative name(s):
GATA-binding factor 3

Gene names

Name:	gata3
Synonyms:	gta3

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus.
Developmental stage	Expressed during gastrulation in the ventral region of the embryo which includes tissue fated to form the non-neural ectoderm.
Sequence similarities	Contains 2 GATA-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW ventral spinal cord interneuron differentiation Inferred from mutant phenotype. Source: ZFIN
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 438	438	Transcription factor GATA-3		PRO_0000083411
Regions
	Zinc finger	256 – 280	25	GATA-type 1
	Zinc finger	310 – 334	25	GATA-type 2
	Compositional bias	69 – 72	4	Poly-Pro
	Compositional bias	130 – 135	6	Poly-Ser
	Compositional bias	235 – 238	4	Poly-Ser
	Compositional bias	315 – 319	5	Poly-Thr

Sequences

	Sequence		Length	Mass (Da)
	Q91428 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 528CE29C9775653C	FASTA	438	47,590
	10 20 30 40 50 60 MEVSPEQHRW VTHHTVGQHP ETHHPGLGHS YMDPSQYQLA EDVDVLFNID GQSNHPYYGN 70 80 90 100 110 120 PVRAVQRYPP PPHSSQMCRP SLLHGSLPWL DGGKSIGPHH STSPWNLGPF PKTSLHHSSP 130 140 150 160 170 180 GPLSVYPPAS SSSLSAGHSS PHLFTFPPTP PKDVSPDPAI STSGSGSSVR QEDKECIKYQ 190 200 210 220 230 240 VSLAESMKLD SAHSRSMASI GAGASSAHHP IATYPSYVPD YGPGLFPPSS LIGGSSSSYG 250 260 270 280 290 300 SKTRPKTRSS SEGRECVNCG ATSTPLWRRD GTGHYLCNAC GLYHKMNGQN RPLIKPKRRL 310 320 330 340 350 360 SAARRAGTSC ANCQTTTTTL WRRNANGDPV CNACGLYYKL HNINRPLTMK KEGIQTRNRK 370 380 390 400 410 420 MSSKSKKSKK SHDSMEDFSK SLMEKNSSFS PAALSRHMTS FPPFSHSGHM LTTPTPMHPS 430 SSLPFASHHP SSMVTAMG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of zebrafish GATA 3 (gta3) during gastrulation and neurulation suggests a role in the specification of cell fate." Neave B., Rodaway A., Wilson S.W., Patient R., Holder N. Mech. Dev. 51:169-182(1995) [PubMed: 7547465] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	The Danio rerio sequencing project at the Sanger Institute Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S80425 mRNA. Translation: AAA93491.1. BX901908 Genomic DNA. Translation: CAH69073.1.
IPI	IPI00499138.
RefSeq	NP_571286.1. NM_131211.1.
UniGene	Dr.77524.
3D structure databases
ProteinModelPortal	Q91428.
SMR	Q91428. Positions 251-295, 301-358.
ModBase	Search...
Protein-protein interaction databases
STRING	Q91428.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000025153; ENSDARP00000017572; ENSDARG00000016526.
GeneID	30458.
KEGG	dre:30458.
Organism-specific databases
CTD	2625.
ZFIN	ZDB-GENE-990415-82. gata3.
Phylogenomic databases
eggNOG	fiNOG13437.
GeneTree	ENSGT00550000074470.
HOGENOM	HBG716943.
HOVERGEN	HBG051705.
InParanoid	Q91428.
OMA	HGSQVCR.
OrthoDB	EOG49P9ZM.
Gene expression databases
ArrayExpress	Q91428.
Bgee	Q91428.
Family and domain databases
InterPro	IPR016374. TF_GATA-1/2/3. IPR000679. Znf_GATA. IPR013088. Znf_NHR/GATA. [Graphical view]
Gene3D	G3DSA:3.30.50.10. Znf_NHR/GATA. 2 hits.
KO	K09182.
Pfam	PF00320. GATA. 2 hits. [Graphical view]
PIRSF	PIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTS	PR00619. GATAZNFINGER.
SMART	SM00401. ZnF_GATA. 2 hits. [Graphical view]
PROSITE	PS00344. GATA_ZN_FINGER_1. 2 hits. PS50114. GATA_ZN_FINGER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GATA3_DANRE

Accession

Primary (citable) accession number: Q91428

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program