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Protein

Transcription factor GATA-3

Gene

gata3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri256 – 280GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri310 – 334GATA-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • cardiac muscle tissue regeneration Source: ZFIN
  • ectodermal placode development Source: ZFIN
  • ectodermal placode formation Source: ZFIN
  • embryonic neurocranium morphogenesis Source: ZFIN
  • fibroblast growth factor receptor signaling pathway Source: UniProtKB
  • fin regeneration Source: UniProtKB
  • otic placode formation Source: ZFIN
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of neurogenesis Source: UniProtKB
  • positive regulation of neuron migration Source: UniProtKB
  • positive regulation of T cell differentiation Source: InterPro
  • tissue regeneration Source: ZFIN
  • ventral spinal cord interneuron differentiation Source: ZFIN

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DRE-5689880. Ub-specific processing proteases.
R-DRE-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor GATA-3
Alternative name(s):
GATA-binding factor 3
Gene namesi
Name:gata3
Synonyms:gta3
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 4

Organism-specific databases

ZFINiZDB-GENE-990415-82. gata3.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000834111 – 438Transcription factor GATA-3Add BLAST438

Proteomic databases

PaxDbiQ91428.

Expressioni

Developmental stagei

Expressed during gastrulation in the ventral region of the embryo which includes tissue fated to form the non-neural ectoderm.

Gene expression databases

BgeeiENSDARG00000016526.
ExpressionAtlasiQ91428. baseline and differential.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000017572.

Structurei

3D structure databases

ProteinModelPortaliQ91428.
SMRiQ91428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi69 – 72Poly-Pro4
Compositional biasi130 – 135Poly-Ser6
Compositional biasi235 – 238Poly-Ser4
Compositional biasi315 – 319Poly-Thr5

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri256 – 280GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri310 – 334GATA-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047701.
HOVERGENiHBG051705.
InParanoidiQ91428.
KOiK17895.
OMAiQRYPPTH.
OrthoDBiEOG091G0AUR.
PhylomeDBiQ91428.
TreeFamiTF315391.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiView protein in InterPro
IPR029521. GATA-3.
IPR016374. TF_GATA-2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
PANTHERiPTHR10071:SF229. PTHR10071:SF229. 1 hit.
PfamiView protein in Pfam
PF00320. GATA. 2 hits.
PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiView protein in SMART
SM00401. ZnF_GATA. 2 hits.
PROSITEiView protein in PROSITE
PS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q91428-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVSPEQHRW VTHHTVGQHP ETHHPGLGHS YMDPSQYQLA EDVDVLFNID
60 70 80 90 100
GQSNHPYYGN PVRAVQRYPP PPHSSQMCRP SLLHGSLPWL DGGKSIGPHH
110 120 130 140 150
STSPWNLGPF PKTSLHHSSP GPLSVYPPAS SSSLSAGHSS PHLFTFPPTP
160 170 180 190 200
PKDVSPDPAI STSGSGSSVR QEDKECIKYQ VSLAESMKLD SAHSRSMASI
210 220 230 240 250
GAGASSAHHP IATYPSYVPD YGPGLFPPSS LIGGSSSSYG SKTRPKTRSS
260 270 280 290 300
SEGRECVNCG ATSTPLWRRD GTGHYLCNAC GLYHKMNGQN RPLIKPKRRL
310 320 330 340 350
SAARRAGTSC ANCQTTTTTL WRRNANGDPV CNACGLYYKL HNINRPLTMK
360 370 380 390 400
KEGIQTRNRK MSSKSKKSKK SHDSMEDFSK SLMEKNSSFS PAALSRHMTS
410 420 430
FPPFSHSGHM LTTPTPMHPS SSLPFASHHP SSMVTAMG
Length:438
Mass (Da):47,590
Last modified:November 1, 1996 - v1
Checksum:i528CE29C9775653C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80425 mRNA. Translation: AAA93491.1.
BX901908 Genomic DNA. Translation: CAH69073.1.
RefSeqiNP_571286.1. NM_131211.1.
XP_005164862.1. XM_005164805.3.
UniGeneiDr.77524.

Genome annotation databases

EnsembliENSDART00000025153; ENSDARP00000017572; ENSDARG00000016526.
GeneIDi30458.
KEGGidre:30458.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGATA3_DANRE
AccessioniPrimary (citable) accession number: Q91428
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 12, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome