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Protein

Transcription factor GATA-3

Gene

gata3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri256 – 28025GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33425GATA-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cardiac muscle tissue regeneration Source: ZFIN
  • cell fate commitment Source: GO_Central
  • digestive tract development Source: GO_Central
  • ectodermal placode development Source: ZFIN
  • ectodermal placode formation Source: ZFIN
  • embryonic neurocranium morphogenesis Source: ZFIN
  • fibroblast growth factor receptor signaling pathway Source: UniProtKB
  • fin regeneration Source: UniProtKB
  • heart development Source: GO_Central
  • otic placode formation Source: ZFIN
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of neurogenesis Source: UniProtKB
  • positive regulation of neuron migration Source: UniProtKB
  • positive regulation of T cell differentiation Source: InterPro
  • tissue regeneration Source: ZFIN
  • ventral spinal cord interneuron differentiation Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DRE-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor GATA-3
Alternative name(s):
GATA-binding factor 3
Gene namesi
Name:gata3
Synonyms:gta3
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 4

Organism-specific databases

ZFINiZDB-GENE-990415-82. gata3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Transcription factor GATA-3PRO_0000083411Add
BLAST

Proteomic databases

PaxDbiQ91428.

Expressioni

Developmental stagei

Expressed during gastrulation in the ventral region of the embryo which includes tissue fated to form the non-neural ectoderm.

Gene expression databases

BgeeiENSDARG00000016526.
ExpressionAtlasiQ91428. differential.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000017572.

Structurei

3D structure databases

ProteinModelPortaliQ91428.
SMRiQ91428. Positions 251-295, 301-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi69 – 724Poly-Pro
Compositional biasi130 – 1356Poly-Ser
Compositional biasi235 – 2384Poly-Ser
Compositional biasi315 – 3195Poly-Thr

Sequence similaritiesi

Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri256 – 28025GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33425GATA-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047701.
HOVERGENiHBG051705.
InParanoidiQ91428.
KOiK17895.
OMAiQRYPPTH.
OrthoDBiEOG091G0AUR.
PhylomeDBiQ91428.
TreeFamiTF315391.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR029521. GATA-3.
IPR016374. TF_GATA-2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF106. PTHR10071:SF106. 1 hit.
PfamiPF00320. GATA. 2 hits.
[Graphical view]
PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91428-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVSPEQHRW VTHHTVGQHP ETHHPGLGHS YMDPSQYQLA EDVDVLFNID
60 70 80 90 100
GQSNHPYYGN PVRAVQRYPP PPHSSQMCRP SLLHGSLPWL DGGKSIGPHH
110 120 130 140 150
STSPWNLGPF PKTSLHHSSP GPLSVYPPAS SSSLSAGHSS PHLFTFPPTP
160 170 180 190 200
PKDVSPDPAI STSGSGSSVR QEDKECIKYQ VSLAESMKLD SAHSRSMASI
210 220 230 240 250
GAGASSAHHP IATYPSYVPD YGPGLFPPSS LIGGSSSSYG SKTRPKTRSS
260 270 280 290 300
SEGRECVNCG ATSTPLWRRD GTGHYLCNAC GLYHKMNGQN RPLIKPKRRL
310 320 330 340 350
SAARRAGTSC ANCQTTTTTL WRRNANGDPV CNACGLYYKL HNINRPLTMK
360 370 380 390 400
KEGIQTRNRK MSSKSKKSKK SHDSMEDFSK SLMEKNSSFS PAALSRHMTS
410 420 430
FPPFSHSGHM LTTPTPMHPS SSLPFASHHP SSMVTAMG
Length:438
Mass (Da):47,590
Last modified:November 1, 1996 - v1
Checksum:i528CE29C9775653C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80425 mRNA. Translation: AAA93491.1.
BX901908 Genomic DNA. Translation: CAH69073.1.
RefSeqiNP_571286.1. NM_131211.1.
XP_005164862.1. XM_005164805.2.
UniGeneiDr.77524.

Genome annotation databases

EnsembliENSDART00000025153; ENSDARP00000017572; ENSDARG00000016526.
GeneIDi30458.
KEGGidre:30458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80425 mRNA. Translation: AAA93491.1.
BX901908 Genomic DNA. Translation: CAH69073.1.
RefSeqiNP_571286.1. NM_131211.1.
XP_005164862.1. XM_005164805.2.
UniGeneiDr.77524.

3D structure databases

ProteinModelPortaliQ91428.
SMRiQ91428. Positions 251-295, 301-358.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000017572.

Proteomic databases

PaxDbiQ91428.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000025153; ENSDARP00000017572; ENSDARG00000016526.
GeneIDi30458.
KEGGidre:30458.

Organism-specific databases

CTDi2625.
ZFINiZDB-GENE-990415-82. gata3.

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047701.
HOVERGENiHBG051705.
InParanoidiQ91428.
KOiK17895.
OMAiQRYPPTH.
OrthoDBiEOG091G0AUR.
PhylomeDBiQ91428.
TreeFamiTF315391.

Enzyme and pathway databases

ReactomeiR-DRE-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

PROiQ91428.

Gene expression databases

BgeeiENSDARG00000016526.
ExpressionAtlasiQ91428. differential.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR029521. GATA-3.
IPR016374. TF_GATA-2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF106. PTHR10071:SF106. 1 hit.
PfamiPF00320. GATA. 2 hits.
[Graphical view]
PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGATA3_DANRE
AccessioniPrimary (citable) accession number: Q91428
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.