Reviewed, UniProtKB/Swiss-Prot Q91280 (UGT3_PLEPL)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase
      Short name=UDPGT
    EC=2.4.1.17

Gene names

Name:

ugt3

Organism

Pleuronectes platessa (Plaice)

Taxonomic identifier

8262 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Pleuronectiformes › Pleuronectoidei › Pleuronectidae › Pleuronectinae › Pleuronectes

Protein attributes

Sequence length	472 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome membrane; Single-pass membrane protein By similarity. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 472	›472	UDP-glucuronosyltransferase		PRO_0000074137
Regions
	Transmembrane	436 – 456	21	Potential
Amino acid modifications
	Glycosylation	59	1	N-linked (GlcNAc...) Potential
	Glycosylation	227	1	N-linked (GlcNAc...) Potential
	Glycosylation	377	1	N-linked (GlcNAc...) Potential
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q91280-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: CCCC44363B54643B	FASTA	472	53,781
	10 20 30 40 50 60 LVPESSLFMH QSEDYETEVY PVSFTTEEMD ATHKQLKDGL FLKQPDWTEY YVNIMRFVNF 70 80 90 100 110 120 TSIHLRGCEN LLENQPLMSR MRGMGFDIVL TDPFFPCGAL VGNIFSIPVV NFLRGLPCGL 130 140 150 160 170 180 DMKVNKCPSP PSYIPVPYSG NTNIMTFPQR VINMAMTVVE SYQCSLLYGH YDEMVSKYVG 190 200 210 220 230 240 NNMDYRTLLS HGALWLIRNE FTLDWPRPLL PNMVLIGGIN CAEKKKNASL PADLEEFVQG 250 260 270 280 290 300 SGDDGFIIFT LGSMLPDMPQ EKAQHFLDAF RQIPQRVVWR YAGDPPKGLP KNVRLMKWLP 310 320 330 340 350 360 QKELLAHPKA KLFLTHGGSH SVYEGICNAV PMLMFPLFAE QGDNGLRMVT RGAAETLNIY 370 380 390 400 410 420 DVTSDNLLAA LNKILKNKSY KEKITEMSQI HHDRPVAPLD LAIFWTEFVI RHKGASHLRV 430 440 450 460 470 AAHELNWIQY HSLDVFGFIL LILLTVLWVT LKCCLFCTRR CCRRGTAKTK SE

References

[1]	"Cloning of the major 3-MC inducible phase I and phase II detoxification enzymes of plaice liver." Pirrit L., Healey R., Assheton H., Leaver M.J., George S.G. Mar. Environ. Res. 39:15-19(1995) Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X74116 mRNA. Translation: CAA52214.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Phylogenomic databases
HOVERGEN	Q91280.
Enzyme and pathway databases
BRENDA	2.4.1.17. 74156.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UGT3_PLEPL

Accession

Primary (citable) accession number: Q91280

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)