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Q91280

- UGT3_PLEPL

UniProt

Q91280 - UGT3_PLEPL

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Protein
UDP-glucuronosyltransferase
Gene
ugt3
Organism
Pleuronectes platessa (European plaice)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase (EC:2.4.1.17)
    Short name:
    UDPGT
    Gene namesi
    Name:ugt3
    OrganismiPleuronectes platessa (European plaice)
    Taxonomic identifieri8262 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataCarangimorphariaePleuronectiformesPleuronectoideiPleuronectidaePleuronectinaePleuronectes

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei436 – 45621Helical; Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 472›472UDP-glucuronosyltransferase
    PRO_0000074137Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi59 – 591N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi227 – 2271N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi377 – 3771N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ91280.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG004033.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q91280-1 [UniParc]FASTAAdd to Basket

    « Hide

    LVPESSLFMH QSEDYETEVY PVSFTTEEMD ATHKQLKDGL FLKQPDWTEY    50
    YVNIMRFVNF TSIHLRGCEN LLENQPLMSR MRGMGFDIVL TDPFFPCGAL 100
    VGNIFSIPVV NFLRGLPCGL DMKVNKCPSP PSYIPVPYSG NTNIMTFPQR 150
    VINMAMTVVE SYQCSLLYGH YDEMVSKYVG NNMDYRTLLS HGALWLIRNE 200
    FTLDWPRPLL PNMVLIGGIN CAEKKKNASL PADLEEFVQG SGDDGFIIFT 250
    LGSMLPDMPQ EKAQHFLDAF RQIPQRVVWR YAGDPPKGLP KNVRLMKWLP 300
    QKELLAHPKA KLFLTHGGSH SVYEGICNAV PMLMFPLFAE QGDNGLRMVT 350
    RGAAETLNIY DVTSDNLLAA LNKILKNKSY KEKITEMSQI HHDRPVAPLD 400
    LAIFWTEFVI RHKGASHLRV AAHELNWIQY HSLDVFGFIL LILLTVLWVT 450
    LKCCLFCTRR CCRRGTAKTK SE 472
    Length:472
    Mass (Da):53,781
    Last modified:November 1, 1997 - v1
    Checksum:iCCCC44363B54643B
    GO

    Non-terminal residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74116 mRNA. Translation: CAA52214.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74116 mRNA. Translation: CAA52214.1 .

    3D structure databases

    ProteinModelPortali Q91280.
    ModBasei Search...

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG004033.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the major 3-MC inducible phase I and phase II detoxification enzymes of plaice liver."
      Pirrit L., Healey R., Assheton H., Leaver M.J., George S.G.
      Mar. Environ. Res. 39:15-19(1995)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiUGT3_PLEPL
    AccessioniPrimary (citable) accession number: Q91280
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: June 11, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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