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Protein

Estrogen receptor

Gene

ESR1

Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi177 – 24266Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri177 – 19721NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri213 – 23725NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • muscle fiber development Source: AgBase
  • positive regulation of gene expression Source: AgBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Lipid-binding, Metal-binding, Steroid-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen receptor
Short name:
ER
Alternative name(s):
ER-alpha
Estradiol receptor
Nuclear receptor subfamily 3 group A member 1
Gene namesi
Name:ESR1
Synonyms:ESR, NR3A1
OrganismiTaeniopygia guttata (Zebra finch) (Poephila guttata)
Taxonomic identifieri59729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaEstrildidaeEstrildinaeTaeniopygia
Proteomesi
  • UP000007754 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587Estrogen receptorPRO_0000053636Add
BLAST

Interactioni

Subunit structurei

Binds DNA as a homodimer. Can form a heterodimer with ER-beta (By similarity).By similarity

Protein-protein interaction databases

STRINGi59729.ENSTGUP00000011604.

Structurei

3D structure databases

ProteinModelPortaliQ91250.
SMRiQ91250. Positions 172-245, 293-542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 176176Modulating (transactivation AF-1)Add
BLAST
Regioni243 – 30260HingeAdd
BLAST
Regioni303 – 587285Transactivation AF-2By similarityAdd
BLAST
Regioni303 – 543241Steroid-bindingAdd
BLAST

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The modulating domain, also known as A/B or AF-1 domain has a ligand-independent transactivation function. The C-terminus contains a ligand-dependent transactivation domain, also known as E/F or AF-2 domain which overlaps with the ligand binding domain. AF-1 and AF-2 activate transcription independently and synergistically and act in a promoter- and cell-specific manner (By similarity).By similarity

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri177 – 19721NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri213 – 23725NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000233468.
HOVERGENiHBG108344.
InParanoidiQ91250.
KOiK08550.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001292. Oestr_rcpt.
IPR024736. Oestrogen-typ_rcpt_final_C_dom.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF12743. ESR1_C. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF02159. Oest_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF500101. ER-a. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSiPR00543. OESTROGENR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 2 hits.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91250-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLHTKTSGV TLLHQIQGTE LETLSRPQLK IPLERSLSDM YVETNKTGVF
60 70 80 90 100
NYPEGATYDF GTTAPVYSST TLSYAPTSES FGSSSLAGFH SLNSVPPSPV
110 120 130 140 150
VFLQTAPHWS PFIHHHSQQV PYYLENDQGS FGMREAAPPA FYRPNSDNRR
160 170 180 190 200
HSIRERMSSA NEKGSLSMES TKETRYCAVC NDYASGYHYG VWSCEGCKAF
210 220 230 240 250
FKRSIQGHND YMCPATNQCT IDKNRRKSCQ ACRLRKCYEV GMMKGGIRKD
260 270 280 290 300
RRGGRVMKQK RQREEQDSRN GEASSTELRA PTLWASPLVV KHNKKNSPAL
310 320 330 340 350
SLTAEQMVSA LLEAEPPLVY SEYDPNRPFN EASMMTLLTN LADRELVHMI
360 370 380 390 400
NWAKRVPGFV DLTLHDQVHL LECAWLEILM IGLVWRSMEH PGKLLFAPNL
410 420 430 440 450
LLDRNQGKCV EGMVEIFDML LATAARFRMM NLQGEEFVCL KSIILLNSGV
460 470 480 490 500
YTFLSSTLKS LEEKDYIHRV LDKITDTLIH LMAKSGLSLQ QQHRRLAQLL
510 520 530 540 550
LILSHIRHMS NKGMEHLYNM KCKNVVPLYD LLLEMLDAHR LHAPAARSAA
560 570 580
PMEEENRSQL TTASASSHSL QSFYINSKEE ENMQNTL
Length:587
Mass (Da):66,553
Last modified:November 1, 1996 - v1
Checksum:i2B254168A7A910AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L79911 mRNA. Translation: AAB81108.1.
RefSeqiNP_001070169.1. NM_001076701.1.
UniGeneiTgu.6701.

Genome annotation databases

GeneIDi751998.
KEGGitgu:751998.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L79911 mRNA. Translation: AAB81108.1.
RefSeqiNP_001070169.1. NM_001076701.1.
UniGeneiTgu.6701.

3D structure databases

ProteinModelPortaliQ91250.
SMRiQ91250. Positions 172-245, 293-542.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi59729.ENSTGUP00000011604.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi751998.
KEGGitgu:751998.

Organism-specific databases

CTDi2099.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000233468.
HOVERGENiHBG108344.
InParanoidiQ91250.
KOiK08550.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001292. Oestr_rcpt.
IPR024736. Oestrogen-typ_rcpt_final_C_dom.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF12743. ESR1_C. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF02159. Oest_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF500101. ER-a. 1 hit.
PIRSF002527. ER-like_NR. 1 hit.
PRINTSiPR00543. OESTROGENR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 2 hits.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiESR1_TAEGU
AccessioniPrimary (citable) accession number: Q91250
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: January 20, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.