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Protein
Submitted name:

Glutamate receptor subunit 2Ac

Gene

fGluR2Ac

Organism
Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamate receptor subunit 2AcImported
Gene namesi
Name:fGluR2AcImported
OrganismiOreochromis niloticus (Nile tilapia) (Tilapia nilotica)Imported
Taxonomic identifieri8128 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei548 – 568HelicalSequence analysisAdd BLAST21
Transmembranei629 – 651HelicalSequence analysisAdd BLAST23
Transmembranei819 – 841HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500431881729 – 895Sequence analysisAdd BLAST867

Structurei

3D structure databases

ProteinModelPortaliQ91227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini419 – 794PBPeInterPro annotationAdd BLAST376
Domaini429 – 494Lig_chan-Glu_bdInterPro annotationAdd BLAST66

Sequence similaritiesi

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1054. Eukaryota.
ENOG410XPSH. LUCA.
HOVERGENiHBG051839.

Family and domain databases

InterProiView protein in InterPro
IPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
PfamiView protein in Pfam
PF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
PRINTSiPR00177. NMDARECEPTOR.
SMARTiView protein in SMART
SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91227-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWCCARILN TTMKLLFLVA LLWRGALCGS PSVQIGGLFP RGADQEYSAF
60 70 80 90 100
RVGMVQFGMA DFRLTPHIDN LEVANSFAVT NCFCSQFSRG VYAIFGFYDK
110 120 130 140 150
KSVNTITSFC ETLHVSFITP SFPAEGMNQF VLQMRPDIKG ALVSLVEYYK
160 170 180 190 200
WEKFAYLYDS DRGLSTLQVI LDTAAEKKWV VTAINVGNLK DERKDEAYRS
210 220 230 240 250
LFQDLEIRKE RRIILDCEQD KVKDIMEQVI TIGRHVKGYH YIIANLGFVD
260 270 280 290 300
GDLSKIQYGG ANVSGFQIVD FDDPVVAKFD QRWEALEEKE YPGADTRIRY
310 320 330 340 350
PSALTYNAVH VMTEAFRFLH KQRTDISRRG NSGDCLANPA VPWATGVEIE
360 370 380 390 400
RALKQVHVDG LTGNIQFDQY GKRINYSVTI MELKNNGPVK IGYWNEVDKM
410 420 430 440 450
VLTKSDLYPN DTMGMENKTV IVTTILEAPY VMLKKNAELF QDNDRYEGYC
460 470 480 490 500
VDLAAEIAKH CGIRYQLRIV GDGKYGARDA ETKIWNGMVG ELVYGKADIA
510 520 530 540 550
IAPLTITLVR EEVIDFSKPF MSLGISIMIK KPQKSKPGVF SFLDPQAYEI
560 570 580 590 600
WMCIVFAYIG VSVVLFLVSR FSPYEWTLEE PEDGALPLTT ESTNEFGIFN
610 620 630 640 650
SLWFSLGAFM RQGCDISPRS LSGRIVGGVW WFFTLIIISS YTANLAAFLT
660 670 680 690 700
VERMVSPIES AEDLAKQTEI AYGTLDSGST KEFFRRSKIA LFDKMWQYMK
710 720 730 740 750
NAEPSVFVKK TSEGVQRVRK CKGKYAYLLE STMNEYIEQR KPCDTMKVGG
760 770 780 790 800
NLDSKGYGIA TPKGSPLGVP VNLAVLKLNE QGTLDKMKNK WWYDKGECGF
810 820 830 840 850
KDSTNKEKTS ALSLSNVAGV FYILVGGLGL AMMVALVEFC YKSRAEAKKM
860 870 880 890
KMKFTDAMRS KARLSITGST SENGRVPVAY LRPGLPMSLS MSDLS
Length:895
Mass (Da):100,700
Last modified:November 1, 1996 - v1
Checksum:iAE2359AB5819ECA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L46366 mRNA. Translation: AAA74200.1.
RefSeqiNP_001266479.1. NM_001279550.1.
UniGeneiOni.44249.

Genome annotation databases

GeneIDi100534587.

Similar proteinsi

Entry informationi

Entry nameiQ91227_ORENI
AccessioniPrimary (citable) accession number: Q91227
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)