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Protein

Interferon-induced GTP-binding protein Mx2

Gene

mx2

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Does not inhibit strain RB-1 of the fish pathogen, infectious hematopoietic necrosis virus (IHNV).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi41 – 48GTPSequence analysis8
Nucleotide bindingi142 – 146GTPSequence analysis5
Nucleotide bindingi211 – 214GTPSequence analysis4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced GTP-binding protein Mx2
Short name:
RBTMx21 PublicationImported
Gene namesi
Name:mx21 Publication
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004303251 – 635Interferon-induced GTP-binding protein Mx2Add BLAST635

Expressioni

Inductioni

By polyinosinic-polycytidylic acid (poly I:C) and viral haemorrhagic septicaemia virus (VHSV) strain 07.71 in muscle, head kidney, spleen and liver.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ91196
SMRiQ91196
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 304Dynamin-type GPROSITE-ProRule annotationAdd BLAST274
Domaini549 – 635GEDPROSITE-ProRule annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 48G1 motifPROSITE-ProRule annotation8
Regioni66 – 68G2 motifPROSITE-ProRule annotation3
Regioni142 – 145G3 motifPROSITE-ProRule annotation4
Regioni211 – 214G4 motifPROSITE-ProRule annotation4
Regioni243 – 246G5 motifPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG008788

Family and domain databases

CDDicd08771 DLP_1, 1 hit
InterProiView protein in InterPro
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11566 PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit

Sequencei

Sequence statusi: Complete.

Q91196-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYTLNQHYE EKVRPSIDLI DSLRSLGVEK DLALPAIAVI GDQSSGKSSV
60 70 80 90 100
LEALSGVALP RGSGIVTRCP LELKMKRKKE GEEWHGKISY QDREEEIEDP
110 120 130 140 150
SDVENKIRKA QDEMAGVGVG ISDDLISLEI GSPDVPDLTL IDLPGIARVA
160 170 180 190 200
VKGQPENIGE QIKRLIRKFI TKQETINLVV VPCNVDIATT EALKMAQEVD
210 220 230 240 250
PDGERTLGIL TKPDLVDKGT EETVVDIVHN EVIQLTKGYM IVKCRGQKEI
260 270 280 290 300
MERVSLTEAT EREKAFFKEH AHLSTLYDEG HATIPKLAEK LTLELVQHIE
310 320 330 340 350
KSMPRLKEQI EEKLEETRTA LEKCGTGPPE DPKERLYFLI DKVTLFTQDA
360 370 380 390 400
INLSTGEELK SGDINVFSTL RTEFGKWKAY VDRSGKNFNK KIEKEVADYE
410 420 430 440 450
KRYRGRELPG FINYKTFEVI VKDQIKQLEE PAVKKLKELS DAARKAFILL
460 470 480 490 500
AQNSFTGFPI LLKTAKTKIE TIKQEKESTA ESTLRTQFKM ELIVYTQDST
510 520 530 540 550
YSSSLKKRKR EEEELEEGEL VKNNLGSWKG LPVVSVRSTV NGLDTHATLR
560 570 580 590 600
EMMLHLKSYY HIASQRLADQ IPMVIRYLVL QEFASQLQRE MLQTLQEKDN
610 620 630
IEQLLKEDID IGSKRAALQS KLKRLMKAHN YLVEF
Length:635
Mass (Da):72,113
Last modified:November 1, 1996 - v1
Checksum:i6868253BA6752D90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47945 mRNA Translation: AAC60214.1
RefSeqiNP_001118223.1, NM_001124751.1
UniGeneiOmy.11702

Genome annotation databases

GeneIDi100137062

Similar proteinsi

Entry informationi

Entry nameiMX2_ONCMY
AccessioniPrimary (citable) accession number: Q91196
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 2014
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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