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Protein

Interferon-induced GTP-binding protein Mx2

Gene

mx2

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Does not inhibit strain RB-1 of the fish pathogen, infectious hematopoietic necrosis virus (IHNV).1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi41 – 488GTPSequence analysis
Nucleotide bindingi142 – 1465GTPSequence analysis
Nucleotide bindingi211 – 2144GTPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced GTP-binding protein Mx2
Short name:
RBTMx21 PublicationImported
Gene namesi
Name:mx21 Publication
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication

  • Note: Displays highly punctate staining of the nucleus. In some cells, punctate staining is observed in both nucleus and cytoplasm.1 Publication

GO - Cellular componenti

  • cytosol Source: AgBase
  • nucleus Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Interferon-induced GTP-binding protein Mx2PRO_0000430325Add
BLAST

Expressioni

Inductioni

By polyinosinic-polycytidylic acid (poly I:C) and viral haemorrhagic septicaemia virus (VHSV) strain 07.71 in muscle, head kidney, spleen and liver.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ91196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 304274Dynamin-type GSequence analysisAdd
BLAST
Domaini549 – 63587GEDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GED domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG008788.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91196-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYTLNQHYE EKVRPSIDLI DSLRSLGVEK DLALPAIAVI GDQSSGKSSV
60 70 80 90 100
LEALSGVALP RGSGIVTRCP LELKMKRKKE GEEWHGKISY QDREEEIEDP
110 120 130 140 150
SDVENKIRKA QDEMAGVGVG ISDDLISLEI GSPDVPDLTL IDLPGIARVA
160 170 180 190 200
VKGQPENIGE QIKRLIRKFI TKQETINLVV VPCNVDIATT EALKMAQEVD
210 220 230 240 250
PDGERTLGIL TKPDLVDKGT EETVVDIVHN EVIQLTKGYM IVKCRGQKEI
260 270 280 290 300
MERVSLTEAT EREKAFFKEH AHLSTLYDEG HATIPKLAEK LTLELVQHIE
310 320 330 340 350
KSMPRLKEQI EEKLEETRTA LEKCGTGPPE DPKERLYFLI DKVTLFTQDA
360 370 380 390 400
INLSTGEELK SGDINVFSTL RTEFGKWKAY VDRSGKNFNK KIEKEVADYE
410 420 430 440 450
KRYRGRELPG FINYKTFEVI VKDQIKQLEE PAVKKLKELS DAARKAFILL
460 470 480 490 500
AQNSFTGFPI LLKTAKTKIE TIKQEKESTA ESTLRTQFKM ELIVYTQDST
510 520 530 540 550
YSSSLKKRKR EEEELEEGEL VKNNLGSWKG LPVVSVRSTV NGLDTHATLR
560 570 580 590 600
EMMLHLKSYY HIASQRLADQ IPMVIRYLVL QEFASQLQRE MLQTLQEKDN
610 620 630
IEQLLKEDID IGSKRAALQS KLKRLMKAHN YLVEF
Length:635
Mass (Da):72,113
Last modified:November 1, 1996 - v1
Checksum:i6868253BA6752D90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47945 mRNA. Translation: AAC60214.1.
RefSeqiNP_001118223.1. NM_001124751.1.
UniGeneiOmy.11702.

Genome annotation databases

GeneIDi100137062.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47945 mRNA. Translation: AAC60214.1.
RefSeqiNP_001118223.1. NM_001124751.1.
UniGeneiOmy.11702.

3D structure databases

ProteinModelPortaliQ91196.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100137062.

Organism-specific databases

CTDi4600.

Phylogenomic databases

HOVERGENiHBG008788.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of the rainbow trout (Oncorhynchus mykiss) Mx2 and Mx3 cDNAs and characterization of trout Mx protein expression in salmon cells."
    Trobridge G.D., Chiou P.P., Leong J.A.
    J. Virol. 71:5304-5311(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
  2. "In vitro and in vivo differential expression of rainbow trout (Oncorhynchus mykiss) Mx isoforms in response to viral haemorrhagic septicaemia virus (VHSV) G gene, poly I:C and VHSV."
    Tafalla C., Chico V., Perez L., Coll J.M., Estepa A.
    Fish Shellfish Immunol. 23:210-221(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiMX2_ONCMY
AccessioniPrimary (citable) accession number: Q91196
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 2014
Last sequence update: November 1, 1996
Last modified: December 9, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.