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Protein

Interferon-induced GTP-binding protein Mx1

Gene

mx1

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Does not inhibit strain RB-1 of the fish pathogen, infectious hematopoietic necrosis virus (IHNV).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi41 – 48GTPSequence analysis8
Nucleotide bindingi142 – 146GTPSequence analysis5
Nucleotide bindingi211 – 214GTPSequence analysis4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced GTP-binding protein Mx1
Short name:
RBTMx1
Alternative name(s):
Interferon-inducible Mx protein 1
Gene namesi
Name:mx1
Synonyms:mx
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002066041 – 621Interferon-induced GTP-binding protein Mx1Add BLAST621

Proteomic databases

PRIDEiQ91192

Expressioni

Inductioni

By polyinosinic-polycytidylic acid (poly I:C) and viral haemorrhagic septicaemia virus (VHSV) strain 07.71 in muscle, head kidney, spleen and liver.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ91192
SMRiQ91192
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 304Dynamin-type GPROSITE-ProRule annotationAdd BLAST274
Domaini535 – 621GEDPROSITE-ProRule annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 48G1 motifPROSITE-ProRule annotation8
Regioni66 – 68G2 motifPROSITE-ProRule annotation3
Regioni142 – 145G3 motifPROSITE-ProRule annotation4
Regioni211 – 214G4 motifPROSITE-ProRule annotation4
Regioni243 – 246G5 motifPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG008788

Family and domain databases

CDDicd08771 DLP_1, 1 hit
InterProiView protein in InterPro
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11566 PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit

Sequencei

Sequence statusi: Complete.

Q91192-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNTLNQHYE EKVRPCIDLI DSLRSLGVEK DLALPAIAVI GDQSSGKSSV
60 70 80 90 100
LEALSGVALP RGSGIVTRCP LELKMKRKKE GEEWHGKISY QDHEEEIEDP
110 120 130 140 150
SDVEKKIREA QDEMAGVGVG ISDDLISLEI GSPDVPDLTL IDLPGIARVA
160 170 180 190 200
VKGQPENIGE QIKRLIRKFI MKQETISLVV VPCNVDIATT EALKMAQEVD
210 220 230 240 250
PEGERTLGIL TKPDLVDKGT EETVVDIVHN EVIHLTKGYM IVKCRGQKEI
260 270 280 290 300
MERVSLTEAT EREKAFFKEH AHLSTLYDEG HATIPKLAEK LTLELVHHIE
310 320 330 340 350
KSLPRLEEQI EAKLSETHAE LERYGTGPPE DSAERLYFLI DKVTAFTQDA
360 370 380 390 400
INLSTGEEMK SGVRLNVFST LRKEFGKWKL HLERSGEIFN QRIEGEVDDY
410 420 430 440 450
EKTYRGRELP GFINYKTFEV MVKDQIKQLE GPAVKKLKEI SDAVRKVFLL
460 470 480 490 500
LAQSSFTGFP NLLKSAKTKI EAIKQVNEST AESMLRTQFK MELIVYTQDS
510 520 530 540 550
TYSHSLCERK REEDEDQPLT EIRSTIFSTD NHATLQEMML HLKSYYWISS
560 570 580 590 600
QRLADQIPMV IRYLVLQEFA SQLQREMLQT LQEKDNIEQL LKEDIDIGSK
610 620
RAALQSKLKR LMKARSYLVE F
Length:621
Mass (Da):70,641
Last modified:November 1, 1996 - v1
Checksum:i3C7E2BB1AE348521
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30253 mRNA Translation: AAA87839.1
RefSeqiNP_001165372.1, NM_001171901.1
UniGeneiOmy.11791

Genome annotation databases

GeneIDi100335041

Similar proteinsi

Entry informationi

Entry nameiMX1_ONCMY
AccessioniPrimary (citable) accession number: Q91192
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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