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Protein

Interferon-induced GTP-binding protein Mx1

Gene

mx1

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Does not inhibit strain RB-1 of the fish pathogen, infectious hematopoietic necrosis virus (IHNV).1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi41 – 488GTPSequence analysis
Nucleotide bindingi142 – 1465GTPSequence analysis
Nucleotide bindingi211 – 2144GTPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced GTP-binding protein Mx1
Short name:
RBTMx1
Alternative name(s):
Interferon-inducible Mx protein 1
Gene namesi
Name:mx1
Synonyms:mx
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

  • Cytoplasm 1 Publication

  • Note: Exhibits cytoplasmic staining in a large globular pattern surrounding the nucleus.

GO - Cellular componenti

  • perinuclear region of cytoplasm Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 621621Interferon-induced GTP-binding protein Mx1PRO_0000206604Add
BLAST

Expressioni

Inductioni

By polyinosinic-polycytidylic acid (poly I:C) and viral haemorrhagic septicaemia virus (VHSV) strain 07.71 in muscle, head kidney, spleen and liver.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ91192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 304274Dynamin-type GAdd
BLAST
Domaini535 – 62187GEDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GED domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG008788.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91192-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNTLNQHYE EKVRPCIDLI DSLRSLGVEK DLALPAIAVI GDQSSGKSSV
60 70 80 90 100
LEALSGVALP RGSGIVTRCP LELKMKRKKE GEEWHGKISY QDHEEEIEDP
110 120 130 140 150
SDVEKKIREA QDEMAGVGVG ISDDLISLEI GSPDVPDLTL IDLPGIARVA
160 170 180 190 200
VKGQPENIGE QIKRLIRKFI MKQETISLVV VPCNVDIATT EALKMAQEVD
210 220 230 240 250
PEGERTLGIL TKPDLVDKGT EETVVDIVHN EVIHLTKGYM IVKCRGQKEI
260 270 280 290 300
MERVSLTEAT EREKAFFKEH AHLSTLYDEG HATIPKLAEK LTLELVHHIE
310 320 330 340 350
KSLPRLEEQI EAKLSETHAE LERYGTGPPE DSAERLYFLI DKVTAFTQDA
360 370 380 390 400
INLSTGEEMK SGVRLNVFST LRKEFGKWKL HLERSGEIFN QRIEGEVDDY
410 420 430 440 450
EKTYRGRELP GFINYKTFEV MVKDQIKQLE GPAVKKLKEI SDAVRKVFLL
460 470 480 490 500
LAQSSFTGFP NLLKSAKTKI EAIKQVNEST AESMLRTQFK MELIVYTQDS
510 520 530 540 550
TYSHSLCERK REEDEDQPLT EIRSTIFSTD NHATLQEMML HLKSYYWISS
560 570 580 590 600
QRLADQIPMV IRYLVLQEFA SQLQREMLQT LQEKDNIEQL LKEDIDIGSK
610 620
RAALQSKLKR LMKARSYLVE F
Length:621
Mass (Da):70,641
Last modified:November 1, 1996 - v1
Checksum:i3C7E2BB1AE348521
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30253 mRNA. Translation: AAA87839.1.
RefSeqiNP_001165372.1. NM_001171901.1.
UniGeneiOmy.11791.

Genome annotation databases

GeneIDi100335041.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30253 mRNA. Translation: AAA87839.1.
RefSeqiNP_001165372.1. NM_001171901.1.
UniGeneiOmy.11791.

3D structure databases

ProteinModelPortaliQ91192.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100335041.

Organism-specific databases

CTDi100335041.

Phylogenomic databases

HOVERGENiHBG008788.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Gonad.
  2. "Cloning of the rainbow trout (Oncorhynchus mykiss) Mx2 and Mx3 cDNAs and characterization of trout Mx protein expression in salmon cells."
    Trobridge G.D., Chiou P.P., Leong J.A.
    J. Virol. 71:5304-5311(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  3. "In vitro and in vivo differential expression of rainbow trout (Oncorhynchus mykiss) Mx isoforms in response to viral haemorrhagic septicaemia virus (VHSV) G gene, poly I:C and VHSV."
    Tafalla C., Chico V., Perez L., Coll J.M., Estepa A.
    Fish Shellfish Immunol. 23:210-221(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiMX1_ONCMY
AccessioniPrimary (citable) accession number: Q91192
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: December 9, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.