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Protein

Glucagon-2

Gene

gcg2

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.By similarity

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-2
Alternative name(s):
Glucagon II
Cleaved into the following 4 chains:
Gene namesi
Name:gcg2
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PeptideiPRO_000001136422 – 49Glicentin-related polypeptide 2Add BLAST28
PeptideiPRO_000001136552 – 80Glucagon-2Add BLAST29
PropeptideiPRO_000001136683 – 875
PeptideiPRO_000001136790 – 120Glucagon-like peptide 1-2Add BLAST31
PropeptideiPRO_0000011368123 – 134Add BLAST12
PeptideiPRO_0000011369137 – 169Glucagon-like peptide 2Add BLAST33
PropeptideiPRO_0000011370171 – 1788

Keywords - PTMi

Cleavage on pair of basic residues

Expressioni

Inductioni

Produced in the A cells of the islets of Langerhans in response to a drop in blood sugar concentration.

Structurei

3D structure databases

ProteinModelPortaliQ91189.
SMRiQ91189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG003010.

Family and domain databases

InterProiIPR015550. Glucagon.
IPR000532. Glucagon_GIP_secretin_VIP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PANTHERiPTHR11418:SF0. PTHR11418:SF0. 1 hit.
PfamiPF00123. Hormone_2. 3 hits.
[Graphical view]
SMARTiSM00070. GLUCA. 3 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Intestinal (identifier: Q91189-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFGIHSLAGV LLLVIVQSQL ASPLQEAEDN SSLETADSLL EDLRGVPNMK
60 70 80 90 100
RQSEGTFSNY YSKYQEERMA RDFLHWLMNS KRSGAPSKRH ADGTYTSDVS
110 120 130 140 150
TYLQDQAAKD FVSWLKSGPA RRESAEESMN GPMSRRHVDG SFTSDVNKVL
160 170
DSLAAKEYLL WVMTSKTSGK SNKRQEDH
Length:178
Mass (Da):19,998
Last modified:November 1, 1996 - v1
Checksum:iE89D73866CD91C66
GO
Isoform Pancreatic (identifier: Q91189-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-178: Missing.

Show »
Length:123
Mass (Da):13,859
Checksum:i199B406D0B8A3CBE
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_050471124 – 178Missing in isoform Pancreatic. CuratedAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19914 mRNA. Translation: AAC59668.1.
U19916, U19915 Genomic DNA. Translation: AAC60210.1.
U19915 Genomic DNA. Translation: AAC60209.1.
PIRiI51057.
RefSeqiNP_001118172.1. NM_001124700.1. [Q91189-1]
UniGeneiOmy.11704.

Genome annotation databases

GeneIDi100136748.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19914 mRNA. Translation: AAC59668.1.
U19916, U19915 Genomic DNA. Translation: AAC60210.1.
U19915 Genomic DNA. Translation: AAC60209.1.
PIRiI51057.
RefSeqiNP_001118172.1. NM_001124700.1. [Q91189-1]
UniGeneiOmy.11704.

3D structure databases

ProteinModelPortaliQ91189.
SMRiQ91189.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100136748.

Organism-specific databases

CTDi100136748.

Phylogenomic databases

HOVERGENiHBG003010.

Family and domain databases

InterProiIPR015550. Glucagon.
IPR000532. Glucagon_GIP_secretin_VIP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PANTHERiPTHR11418:SF0. PTHR11418:SF0. 1 hit.
PfamiPF00123. Hormone_2. 3 hits.
[Graphical view]
SMARTiSM00070. GLUCA. 3 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLUC2_ONCMY
AccessioniPrimary (citable) accession number: Q91189
Secondary accession number(s): Q92168
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.