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Q91169 (PIT1_ONCKE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pituitary-specific positive transcription factor 1

Short name=PIT-1
Alternative name(s):
Growth hormone factor 1
Short name=GHF-1
Gene names
Name:pou1f1
Synonyms:pit1
OrganismOncorhynchus keta (Chum salmon) (Salmo keta)
Taxonomic identifier8018 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the POU transcription factor family. Class-1 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionActivator
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 365365Pituitary-specific positive transcription factor 1
PRO_0000100705

Regions

Domain188 – 26275POU-specific
DNA binding278 – 33760Homeobox

Sequences

Sequence LengthMass (Da)Tools
Q91169 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: D75D74842E8FE54A

FASTA36540,333
        10         20         30         40         50         60 
MSCQAFSADS FTTLAGDSLP LLMHHASAAD CLPSSASTHT HNMVSAVPSG LSLLQSSKRS 

        70         80         90        100        110        120 
HMHLSTSTLG NGPPGLHYPV TPCHYSNQQT TYGMMAAQEM LSASISQTRI LQTCSVPHPN 

       130        140        150        160        170        180 
MVNGANTLQG SLAPCLYKFP EHGLGGGSCS LSHSFPPLPP AVLSEEPPLG GTKDLRLRSR 

       190        200        210        220        230        240 
PPDDPPDMDS PQIRELEKFA NNFKLRRIKL GYTQTNVGEA LAAVHGSEFS QTTICRFENL 

       250        260        270        280        290        300 
QLSFKNACTL KAILAKWLDE AEQAGALFNE KMGMNERKRK RRTTISLGAK EALERSFREK 

       310        320        330        340        350        360 
IKPSSQEIVR MAEGLHLEKE VVRVWFCNRR QREKRVKTSL HHSSYLTKDS PTYRYPYLSP 


NAIKP 

« Hide

References

[1]"Structures of cDNAs encoding chum salmon pituitary-specific transcription factor, Pit-1/GHF-1."
Ono M., Takayama Y.
Gene 116:275-279(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D10444 mRNA. Translation: BAA01234.1.
PIRJC1168.

3D structure databases

ProteinModelPortalQ91169.
SMRQ91169. Positions 193-337.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG053120.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR015586. Pit_1.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PANTHERPTHR11636:SF82. PTHR11636:SF82. 1 hit.
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePIT1_ONCKE
AccessionPrimary (citable) accession number: Q91169
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families