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Protein

Isotocin-neurophysin IT 2

Gene
N/A
Organism
Oncorhynchus keta (Chum salmon) (Salmo keta)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Isotocin causes contraction of smooth muscles.

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Isotocin-neurophysin IT 2
Cleaved into the following 2 chains:
OrganismiOncorhynchus keta (Chum salmon) (Salmo keta)
Taxonomic identifieri8018 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Peptidei20 – 289IsotocinPRO_0000020562
Chaini32 – 156125Neurophysin IT 2PRO_0000020563Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi20 ↔ 25By similarity
Modified residuei28 – 281Glycine amideBy similarity
Disulfide bondi41 ↔ 85By similarity
Disulfide bondi44 ↔ 58By similarity
Disulfide bondi52 ↔ 75By similarity
Disulfide bondi59 ↔ 65By similarity
Disulfide bondi92 ↔ 105By similarity
Disulfide bondi99 ↔ 117By similarity
Disulfide bondi106 ↔ 111By similarity

Post-translational modificationi

Seven disulfide bonds are present in neurophysin.By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ91167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004462.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00003. NH. 1 hit.
[Graphical view]
SUPFAMiSSF49606. SSF49606. 1 hit.
PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91167-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGAAVSVCL LYALSVCSAC YISNCPIGGK RSIMDAPQRK CMSCGPGEQG
60 70 80 90 100
RCFGPSICCG KDVGCWMGSP ETAHCMEENY LPTPCQVGGR PCGSDTVRCA
110 120 130 140 150
SPGVCCDSEG CSADQSCFAE EEGDNQIGQS EGSNSADVIL RLLHLADHTP

PHRVHQ
Length:156
Mass (Da):16,352
Last modified:November 1, 1996 - v1
Checksum:i23717F951CFB1914
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10941 mRNA. Translation: BAA01735.1.
PIRiJC1490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10941 mRNA. Translation: BAA01735.1.
PIRiJC1490.

3D structure databases

ProteinModelPortaliQ91167.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG004462.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00003. NH. 1 hit.
[Graphical view]
SUPFAMiSSF49606. SSF49606. 1 hit.
PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNEU2_ONCKE
AccessioniPrimary (citable) accession number: Q91167
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: January 20, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.