Q91119 (GLHA_MORSA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycoprotein hormones alpha chain

Alternative name(s):
GTH-alpha
Gonadotropin alpha chain

Gene names

Name:

cga

Organism

Morone saxatilis (Striped bass)

Taxonomic identifier

34816 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Euteleostei › Neognathi › Neoteleostei › Eurypterygii › Ctenosquamata › Acanthomorpha › Euacanthomorpha › Holacanthopterygii › Acanthopterygii › Euacanthopterygii › Percomorpha › Perciformes › Percoidei › Moronidae › Morone

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in gametogenesis and steroidogenesis.
Subunit structure	Heterodimer of an alpha and a beta chain.
Subcellular location	Secreted.
Sequence similarities	Belongs to the glycoprotein hormones subunit alpha family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	By similarity
	Chain	24 – 117	94	Glycoprotein hormones alpha chain		PRO_0000011668
Amino acid modifications
	Glycosylation	78	1	N-linked (GlcNAc...) Potential
	Glycosylation	103	1	N-linked (GlcNAc...) Potential
	Disulfide bond	34 ↔ 57		By similarity
	Disulfide bond	37 ↔ 86		By similarity
	Disulfide bond	54 ↔ 107		By similarity
	Disulfide bond	58 ↔ 109		By similarity
	Disulfide bond	85 ↔ 112		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q91119 [UniParc]. Last modified January 1, 1998. Version 2. Checksum: 62CCD867AE9A8C5D	FASTA	117	13,066
	10 20 30 40 50 60 MGSVKSAGLS LLLLSFILYV VDSYPSMDLS NMGCEECTLR KNSVFSRDRP VYQCMGCCFS 70 80 90 100 110 RAYPTPLKAM KTMTIPKNIT SEATCCVAKH SYETEVAGIK VRNHTDCHCS TCYFHKI

References

[1]	"Molecular cloning and sequence analysis of striped bass (Morone saxatilis) gonadotrophin-I and -II subunits." Hassin S., Elizur A., Zohar Y. J. Mol. Endocrinol. 15:23-35(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pituitary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L35071 mRNA. Translation: AAB66489.1.
PIR	I50992.
3D structure databases
ProteinModelPortal	Q91119.
SMR	Q91119. Positions 34-116.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG000452.
Family and domain databases
InterPro	IPR000476. Glyco_hormone. [Graphical view]
PANTHER	PTHR11509. PTHR11509. 1 hit.
Pfam	PF00236. Hormone_6. 1 hit. [Graphical view]
PRINTS	PR00274. GLYCOHORMONE.
SMART	SM00067. GHA. 1 hit. [Graphical view]
PROSITE	PS00779. GLYCO_HORMONE_ALPHA_1. 1 hit. PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit. PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLHA_MORSA

Accession

Primary (citable) accession number: Q91119

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	April 3, 2013
This is version 52 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program