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Q91090 (PON2_MELGA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serum paraoxonase/arylesterase 2
Short name=PON 2
EC=3.1.1.2
EC=3.1.8.1
Alternative name(s):
Aromatic esterase 2
Short name=A-esterase 2
Serum aryldialkylphosphatase 2
Gene names
Name:PON2
OrganismMeleagris gallopavo (Common turkey) [Reference proteome]
Taxonomic identifier9103 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Meleagridinae › Meleagris

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The absence of paraoxonase activity in turkey and chicken blood and in turkey liver indicates that PON2, if expressed, does not hydrolyze paraoxon.

Catalytic activity

A phenyl acetate + H2O = a phenol + acetate.

An aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol.

Cofactor

Binds 2 calcium ions per subunit By similarity.

Subcellular location

Membrane; Peripheral membrane protein By similarity.

Post-translational modification

Glycosylated By similarity.

The signal sequence is not cleaved By similarity.

Sequence similarities

Belongs to the paraoxonase family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
   LigandCalcium
Metal-binding
   Molecular functionHydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: InterPro

membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaryldialkylphosphatase activity

Inferred from electronic annotation. Source: EC

arylesterase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Serum paraoxonase/arylesterase 2
PRO_0000223295
Signal peptide1 – ?Not cleaved Potential

Sites

Active site1141Proton acceptor By similarity
Metal binding531Calcium 1; catalytic By similarity
Metal binding541Calcium 2 By similarity
Metal binding1161Calcium 2; via carbonyl oxygen By similarity
Metal binding1671Calcium 1; catalytic By similarity
Metal binding1681Calcium 2 By similarity
Metal binding2231Calcium 1; catalytic By similarity
Metal binding2681Calcium 1; catalytic By similarity
Metal binding2691Calcium 1; catalytic By similarity

Amino acid modifications

Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation2541N-linked (GlcNAc...) Potential
Glycosylation2691N-linked (GlcNAc...) Potential
Glycosylation3231N-linked (GlcNAc...) Potential
Disulfide bond42 ↔ 352 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91090 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 3C76DB161DFCDB05

FASTA35439,541
        10         20         30         40         50         60 
MGKVLAAALI GIAAALAAER LLAFRNRLNA TREVDPVALP NCRLIKGIEA GSEDIDILPN 

        70         80         90        100        110        120 
GLAFISSGLK YPGLKSLAPD KPGEIFLMDL NEKKPKASEL RISRGFDLGS FNPHGISTYI 

       130        140        150        160        170        180 
DKDDTVYLFV VNHPHQKSTV ELFKFMEEDN SLLHLKTIRH DLLTSVNDVV AVGPDSFYAT 

       190        200        210        220        230        240 
NDHYFYDFIL MFLEMYLGLT WSNVVYYSPK EVKEVAAGFY SANGINISPD KKYIYIADIF 

       250        260        270        280        290        300 
DHNVHVMEKH ADWNLTHVKT LQLDTLADNL SVDPDTGDIW TGCHPNGMKL FYNDPDNPPA 

       310        320        330        340        350 
SEVLRIQNIL AEQPTVTRVY AENGSVLQGT SVATVYNRKL LIGTVYHRAL YCEL

« Hide

References

[1]"The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family."
Primo-Parmo S.L., Sorenson R.C., Teiber J., La Du B.N.
Genomics 33:498-507(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L47572 mRNA. Translation: AAC42235.1.
UniGeneMga.4448.

3D structure databases

ProteinModelPortalQ91090.
SMRQ91090. Positions 23-354.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG003604.

Family and domain databases

Gene3D2.120.10.30. 1 hit.
InterProIPR011042. 6-blade_b-propeller_TolB-like.
IPR002640. Arylesterase.
IPR008364. Paraoxonase2.
[Graphical view]
PfamPF01731. Arylesterase. 1 hit.
[Graphical view]
PRINTSPR01785. PARAOXONASE.
PR01787. PARAOXONASE2.
ProtoNetSearch...

Entry information

Entry namePON2_MELGA
AccessionPrimary (citable) accession number: Q91090
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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