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Protein

Phosphoinositide phospholipase C

Gene
N/A
Organism
Meleagris gallopavo (Common turkey)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei327 – 3271UniRule annotation
Active sitei374 – 3741UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation, TransducerSAAS annotation

Keywords - Biological processi

Lipid degradationUniRule annotation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
OrganismiMeleagris gallopavo (Common turkey)
Taxonomic identifieri9103 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaeMeleagridinaeMeleagris

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: AgBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ91086.

Interactioni

Protein-protein interaction databases

STRINGi9103.ENSMGAP00000003311.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JADX-ray2.40A/B878-1158[»]
ProteinModelPortaliQ91086.
SMRiQ91086. Positions 11-801, 880-1154.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ91086.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini312 – 463152PI-PLC X-boxInterPro annotationAdd
BLAST
Domaini544 – 660117PI-PLC Y-boxInterPro annotationAdd
BLAST
Domaini667 – 76599C2InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili901 – 92828Sequence analysisAdd
BLAST
Coiled coili1029 – 105628Sequence analysisAdd
BLAST
Coiled coili1090 – 112536Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PI-PLC X-box domain.UniRule annotation
Contains 1 PI-PLC Y-box domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IUKD. Eukaryota.
ENOG4111F5W. LUCA.
HOVERGENiHBG053609.
KOiK05858.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_dom-like.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028403. PLC-beta2.
IPR014815. PLC-beta_C.
IPR009535. PLC-beta_CS.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF10. PTHR10336:SF10. 1 hit.
PfamiPF00168. C2. 1 hit.
PF06631. DUF1154. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91086-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMLTPVLQP PEVKEYLSRG ERFIKWDDET ASASPVILRV DPKGFYLYWT
60 70 80 90 100
YQNKEMEILD ITSIRDTRVG RFAKIPKCQK LREVFNLDYP HSTFLLKTLT
110 120 130 140 150
IVSGPDMVDL TFHNFVSYKE NVGKSWAEDI MAIVQNPLTY NASRYTFLEK
160 170 180 190 200
ILVKLKMQLN AEGKIPVRNI FQMFPADRKR VEAALNACHL PKGKNDAINP
210 220 230 240 250
EDFPETVYKT FLMNLCPRPE IDEIFTSHHF KAKPYMTKEH LAKFINKKQR
260 270 280 290 300
DSRLNDILFP PAKPEQVQSL IEKYEPSVIN IQRGQLSPEG MVWFLCGPEN
310 320 330 340 350
NVIALDKLVL YQDMTQPLSH YFINSSHNTY LTAGQFSGIS SPEMYRQTLL
360 370 380 390 400
AGCRCVELDC WKGRPPDEEP IITHGFTMTT EILFKDAIEA IAESAFKTSL
410 420 430 440 450
YPVILSFENH VDSPKQQAKM AEYCRTIFGD MLLTEPLEKY PLKPGVPLPS
460 470 480 490 500
PKDLLGKILI KNKKKQFVSE KRQSSMKKGK NVEPEIIEQP AFTDAEDTVW
510 520 530 540 550
AGDVAEEEPE EEDDQLGNLD EEEIKKMQSD EGTAGLEVTA YEEMSSLVNY
560 570 580 590 600
IQPIKFDSFE VSAQKNRSYV ISSFTELKAY DLLTKFPMQF VEYNKRQMSR
610 620 630 640 650
IYPKGTRMDS SNYMPQMFWN VGCQMVALNF QTMDVPMQQN MALFEFNGQC
660 670 680 690 700
GYLLKHEFMR RPDKQFDPFS VDRIDVVVAS TVSVTILSGQ FLSDRSVKTY
710 720 730 740 750
VEVELFGLPR DTKRKYRTKL TSTANSINPV WKEEPFVFEK IVMPELASLK
760 770 780 790 800
IVAFEEGGKF IGHRVIPIIA VHSGYHHVCL RSESNMPLTM PSLFVYLEVK
810 820 830 840 850
DYVPDAWADL TIALSNPIKF FNLQEKRSVN LKDGSEVERP DMQRNFSFPE
860 870 880 890 900
NNGIPESTRI FSTPFANGPA GAAALVKDGN MKEVTQLPEP QTASLAELQQ
910 920 930 940 950
MKLFLKLLKK QEKELKELER KGSKRREELL QKYSVLFLEP VYPRGKKRSM
960 970 980 990 1000
HSRKTQKKRS LTTGDVGTCM QPVEMAEKLD SQVVELKERL EMELIHLGEE
1010 1020 1030 1040 1050
YHDGIRRRKE QHATEQTAKI TELAREKQIA ELKALKESSE SNIKDIKKKL
1060 1070 1080 1090 1100
EAKRLDRIQV MMRSTSDKAA QERLKKEINN SHIQEVVQTI KLLTEKTARY
1110 1120 1130 1140 1150
QQKLEEKQAE NLRAIQEKEG QLQQEAVAEY EEKLKTLTVE VQEMVKNYMK
1160 1170 1180 1190 1200
EVFPDGPEIQ KEAVLSIPVE EQGSTKQLEE KIPGAEVPRL TAATTEPPGA
1210
ETDINIEESI L
Length:1,211
Mass (Da):139,062
Last modified:November 1, 1996 - v1
Checksum:i4E96A10C6AFD6B5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49431 mRNA. Translation: AAC60011.1.
PIRiS68251.
RefSeqiNP_001290130.1. NM_001303201.1.
XP_010709152.1. XM_010710850.1.
UniGeneiMga.4447.

Genome annotation databases

GeneIDi664713.
KEGGimgp:664713.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49431 mRNA. Translation: AAC60011.1.
PIRiS68251.
RefSeqiNP_001290130.1. NM_001303201.1.
XP_010709152.1. XM_010710850.1.
UniGeneiMga.4447.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JADX-ray2.40A/B878-1158[»]
ProteinModelPortaliQ91086.
SMRiQ91086. Positions 11-801, 880-1154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9103.ENSMGAP00000003311.

Proteomic databases

PRIDEiQ91086.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi664713.
KEGGimgp:664713.

Organism-specific databases

CTDi5330.

Phylogenomic databases

eggNOGiENOG410IUKD. Eukaryota.
ENOG4111F5W. LUCA.
HOVERGENiHBG053609.
KOiK05858.

Miscellaneous databases

EvolutionaryTraceiQ91086.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_dom-like.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028403. PLC-beta2.
IPR014815. PLC-beta_C.
IPR009535. PLC-beta_CS.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF10. PTHR10336:SF10. 1 hit.
PfamiPF00168. C2. 1 hit.
PF06631. DUF1154. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning, expression and regulatory activity of G alpha 11- and beta gamma-subunit-stimulated phospholipase C-beta from avian erythrocytes."
    Waldo G.L., Paterson A., Boyer J.L., Nicholas R.A., Harden T.K.
    Biochem. J. 316:559-568(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q."
    Singer A.U., Waldo G.L., Harden T.K., Sondek J.
    Nat. Struct. Biol. 9:32-36(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 878-1158.

Entry informationi

Entry nameiQ91086_MELGA
AccessioniPrimary (citable) accession number: Q91086
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 13, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.