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Protein

Phosphoinositide phospholipase C

Gene
N/A
Organism
Meleagris gallopavo (Common turkey)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei327UniRule annotation1
Active sitei374UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation, TransducerSAAS annotation
Biological processLipid degradationUniRule annotation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
OrganismiMeleagris gallopavo (Common turkey)
Taxonomic identifieri9103 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaeMeleagridinaeMeleagris

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: AgBase

Interactioni

Protein-protein interaction databases

STRINGi9103.ENSMGAP00000003311.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JADX-ray2.40A/B878-1158[»]
ProteinModelPortaliQ91086.
SMRiQ91086.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ91086.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini312 – 463PI-PLC X-boxInterPro annotationAdd BLAST152
Domaini544 – 660PI-PLC Y-boxInterPro annotationAdd BLAST117
Domaini667 – 765C2InterPro annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili901 – 928Sequence analysisAdd BLAST28
Coiled coili1029 – 1056Sequence analysisAdd BLAST28
Coiled coili1090 – 1125Sequence analysisAdd BLAST36

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IUKD. Eukaryota.
ENOG4111F5W. LUCA.
HOVERGENiHBG053609.
KOiK05858.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiView protein in InterPro
IPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_dom-like.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028403. PLC-beta2.
IPR014815. PLC-beta_C.
IPR009535. PLC-beta_CS.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF122. PTHR10336:SF122. 1 hit.
PfamiView protein in Pfam
PF00168. C2. 1 hit.
PF06631. DUF1154. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiView protein in SMART
SM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiView protein in PROSITE
PS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91086-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMLTPVLQP PEVKEYLSRG ERFIKWDDET ASASPVILRV DPKGFYLYWT
60 70 80 90 100
YQNKEMEILD ITSIRDTRVG RFAKIPKCQK LREVFNLDYP HSTFLLKTLT
110 120 130 140 150
IVSGPDMVDL TFHNFVSYKE NVGKSWAEDI MAIVQNPLTY NASRYTFLEK
160 170 180 190 200
ILVKLKMQLN AEGKIPVRNI FQMFPADRKR VEAALNACHL PKGKNDAINP
210 220 230 240 250
EDFPETVYKT FLMNLCPRPE IDEIFTSHHF KAKPYMTKEH LAKFINKKQR
260 270 280 290 300
DSRLNDILFP PAKPEQVQSL IEKYEPSVIN IQRGQLSPEG MVWFLCGPEN
310 320 330 340 350
NVIALDKLVL YQDMTQPLSH YFINSSHNTY LTAGQFSGIS SPEMYRQTLL
360 370 380 390 400
AGCRCVELDC WKGRPPDEEP IITHGFTMTT EILFKDAIEA IAESAFKTSL
410 420 430 440 450
YPVILSFENH VDSPKQQAKM AEYCRTIFGD MLLTEPLEKY PLKPGVPLPS
460 470 480 490 500
PKDLLGKILI KNKKKQFVSE KRQSSMKKGK NVEPEIIEQP AFTDAEDTVW
510 520 530 540 550
AGDVAEEEPE EEDDQLGNLD EEEIKKMQSD EGTAGLEVTA YEEMSSLVNY
560 570 580 590 600
IQPIKFDSFE VSAQKNRSYV ISSFTELKAY DLLTKFPMQF VEYNKRQMSR
610 620 630 640 650
IYPKGTRMDS SNYMPQMFWN VGCQMVALNF QTMDVPMQQN MALFEFNGQC
660 670 680 690 700
GYLLKHEFMR RPDKQFDPFS VDRIDVVVAS TVSVTILSGQ FLSDRSVKTY
710 720 730 740 750
VEVELFGLPR DTKRKYRTKL TSTANSINPV WKEEPFVFEK IVMPELASLK
760 770 780 790 800
IVAFEEGGKF IGHRVIPIIA VHSGYHHVCL RSESNMPLTM PSLFVYLEVK
810 820 830 840 850
DYVPDAWADL TIALSNPIKF FNLQEKRSVN LKDGSEVERP DMQRNFSFPE
860 870 880 890 900
NNGIPESTRI FSTPFANGPA GAAALVKDGN MKEVTQLPEP QTASLAELQQ
910 920 930 940 950
MKLFLKLLKK QEKELKELER KGSKRREELL QKYSVLFLEP VYPRGKKRSM
960 970 980 990 1000
HSRKTQKKRS LTTGDVGTCM QPVEMAEKLD SQVVELKERL EMELIHLGEE
1010 1020 1030 1040 1050
YHDGIRRRKE QHATEQTAKI TELAREKQIA ELKALKESSE SNIKDIKKKL
1060 1070 1080 1090 1100
EAKRLDRIQV MMRSTSDKAA QERLKKEINN SHIQEVVQTI KLLTEKTARY
1110 1120 1130 1140 1150
QQKLEEKQAE NLRAIQEKEG QLQQEAVAEY EEKLKTLTVE VQEMVKNYMK
1160 1170 1180 1190 1200
EVFPDGPEIQ KEAVLSIPVE EQGSTKQLEE KIPGAEVPRL TAATTEPPGA
1210
ETDINIEESI L
Length:1,211
Mass (Da):139,062
Last modified:November 1, 1996 - v1
Checksum:i4E96A10C6AFD6B5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49431 mRNA. Translation: AAC60011.1.
PIRiS68251.
RefSeqiNP_001290130.1. NM_001303201.1.
XP_010709152.1. XM_010710850.1.
UniGeneiMga.4447.

Genome annotation databases

GeneIDi664713.
KEGGimgp:664713.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49431 mRNA. Translation: AAC60011.1.
PIRiS68251.
RefSeqiNP_001290130.1. NM_001303201.1.
XP_010709152.1. XM_010710850.1.
UniGeneiMga.4447.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JADX-ray2.40A/B878-1158[»]
ProteinModelPortaliQ91086.
SMRiQ91086.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9103.ENSMGAP00000003311.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi664713.
KEGGimgp:664713.

Organism-specific databases

CTDi5330.

Phylogenomic databases

eggNOGiENOG410IUKD. Eukaryota.
ENOG4111F5W. LUCA.
HOVERGENiHBG053609.
KOiK05858.

Miscellaneous databases

EvolutionaryTraceiQ91086.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiView protein in InterPro
IPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_dom-like.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028403. PLC-beta2.
IPR014815. PLC-beta_C.
IPR009535. PLC-beta_CS.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF122. PTHR10336:SF122. 1 hit.
PfamiView protein in Pfam
PF00168. C2. 1 hit.
PF06631. DUF1154. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiView protein in SMART
SM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiView protein in PROSITE
PS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ91086_MELGA
AccessioniPrimary (citable) accession number: Q91086
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: February 15, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.