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Protein

Inactive tyrosine-protein kinase 7

Gene

PTK7

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Inactive tyrosine kinase involved in Wnt signaling. pathway (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive tyrosine-protein kinase 7
Alternative name(s):
Kinase-like protein
Protein-tyrosine kinase 7
Pseudo tyrosine kinase receptor 7
Tyrosine-protein kinase-like 7
Gene namesi
Name:PTK7
Synonyms:KLG
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 685663ExtracellularSequence analysisAdd
BLAST
Transmembranei686 – 70621HelicalSequence analysisAdd
BLAST
Topological domaini707 – 1051345CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 10511029Inactive tyrosine-protein kinase 7PRO_0000016749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 88PROSITE-ProRule annotation
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence analysis
Disulfide bondi137 ↔ 187PROSITE-ProRule annotation
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence analysis
Disulfide bondi234 ↔ 282PROSITE-ProRule annotation
Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence analysis
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence analysis
Disulfide bondi326 ↔ 372PROSITE-ProRule annotation
Disulfide bondi414 ↔ 462PROSITE-ProRule annotation
Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence analysis
Disulfide bondi505 ↔ 551PROSITE-ProRule annotation
Glycosylationi548 – 5481N-linked (GlcNAc...)Sequence analysis
Disulfide bondi594 ↔ 645PROSITE-ProRule annotation
Glycosylationi627 – 6271N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ91048.

Expressioni

Tissue specificityi

Expressed in bone marrow, spleen, bursa, thymus and brain. Weakly expressed in fibroblasts. Also expressed in embryonic liver.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014004.

Structurei

3D structure databases

ProteinModelPortaliQ91048.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 10583Ig-like C2-type 1Add
BLAST
Domaini115 – 20490Ig-like C2-type 2Add
BLAST
Domaini213 – 29886Ig-like C2-type 3Add
BLAST
Domaini308 – 38881Ig-like C2-type 4Add
BLAST
Domaini393 – 47280Ig-like C2-type 5Add
BLAST
Domaini487 – 56680Ig-like C2-type 6Add
BLAST
Domaini573 – 66189Ig-like C2-type 7Add
BLAST
Domaini777 – 1048272Protein kinase; inactivePROSITE-ProRule annotationAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1026. Eukaryota.
KOG4475. Eukaryota.
ENOG410Y8QG. LUCA.
HOGENOMiHOG000115767.
HOVERGENiHBG008320.
InParanoidiQ91048.
KOiK05127.
PhylomeDBiQ91048.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07679. I-set. 4 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00409. IG. 7 hits.
SM00408. IGc2. 7 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 7 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 7 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91048-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALRALLLL LAVGAQAAIR FAKEPYSQDA LHGRSAILRC EVEEPAHVEF
60 70 80 90 100
EWLQNGLPIQ DTEQRFKEGS NLQFAAVDRH RDAGSFQCVA RNVQTGEEAR
110 120 130 140 150
TANASFNIKW METGSVVLKQ PASAAEIQPS STVVLRCHID GHPRPTWQWF
160 170 180 190 200
RDGAPLPDGR GTYSVSSKER TLTLRGAGPD DNGLYYCSAR PRAVGSVCSQ
210 220 230 240 250
DNFTLNIIDE SFPQAVVVPE DLIVTKNEEA MFDCQFAAVP PPTQEWLFED
260 270 280 290 300
SPITNRSKTT VFANGSLLIT QVKARSTGVY KCIGHGQKGK ALVLKATLRL
310 320 330 340 350
AEIEEMAPFS PKVLTANQGH RVSCACPRGV PTPQVWWERN QERVPTAGRV
360 370 380 390 400
YQEAEQLVFT SITEADAGIY TCHAANKAGE KKQELSITVA TVPKWVEMPK
410 420 430 440 450
DSQLEESKPG YLHCLSKASL KPTVTWYRNG VSISEDSRFE ISENGTLRIN
460 470 480 490 500
NVEVYDGTMY KCVSSTPAGS IEGYARVHVL EKLKFTPPPQ PLQCMEFNKE
510 520 530 540 550
VTVSCSATGR EKPTIQWTKT DGSSLPSHVS HRAGILSFHK VSRSDSGNYT
560 570 580 590 600
CIASNSPQGE IRATVQLVVA VYVTFKLEPE PTTVYQGHTA MFQCQAEGDP
610 620 630 640 650
VPHIQWKGKD KILDPSKLLP RIQIMPNGSL VIYDVTTEDS GKYTCIAGNS
660 670 680 690 700
CNIKHREAFL YVVDKPAAEE DEGPSSHTPY KMIQTIGLSV GAAVAYIIIV
710 720 730 740 750
LGLMFYCKKR RKAKRLKKHP EGEEPEMECL NGGTLLQNGQ TTAEIQEEVA
760 770 780 790 800
LTNLGSSSGA SKRHSARDKM HFPRSNLQTI TTLGRGEFGE VFLAKAKGAE
810 820 830 840 850
DAEGEALVLV KSLQTRDEQL QLDFRREAEM FGKLNHVNVV RLLGLCREAE
860 870 880 890 900
PHYMVLEYVD LGDLKQFLRI SKSKDESLKP QPLSTKHKVS LCTQVALGME
910 920 930 940 950
HLSNGRFVHR DLAARNCLVS AQRQVKVSAL SLSKDVYNSE YYHFRQAWIP
960 970 980 990 1000
LRWMPPEAVL EDEFSTKSDV WSFGVLMWEV FTQGEMPYAP LADDEVLAGL
1010 1020 1030 1040 1050
KSGKTKLPQP EGCPSRLTKL MQRCWAPSPK DRPSFSELAA ALGDSPADSK

A
Length:1,051
Mass (Da):116,366
Last modified:November 1, 1996 - v1
Checksum:i1752442AEA4CB702
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63437 mRNA. Translation: AAA48933.1.
PIRiA39712.
RefSeqiNP_001026206.1. NM_001031035.1.
UniGeneiGga.43472.

Genome annotation databases

GeneIDi421257.
KEGGigga:421257.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63437 mRNA. Translation: AAA48933.1.
PIRiA39712.
RefSeqiNP_001026206.1. NM_001031035.1.
UniGeneiGga.43472.

3D structure databases

ProteinModelPortaliQ91048.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014004.

Proteomic databases

PaxDbiQ91048.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi421257.
KEGGigga:421257.

Organism-specific databases

CTDi5754.

Phylogenomic databases

eggNOGiKOG1026. Eukaryota.
KOG4475. Eukaryota.
ENOG410Y8QG. LUCA.
HOGENOMiHOG000115767.
HOVERGENiHBG008320.
InParanoidiQ91048.
KOiK05127.
PhylomeDBiQ91048.

Miscellaneous databases

NextBioi20824049.
PROiQ91048.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07679. I-set. 4 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00409. IG. 7 hits.
SM00408. IGc2. 7 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 7 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 7 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of a member of the immunoglobulin gene superfamily that possibly represents an additional class of growth factor receptor."
    Chou Y.-H., Hayman M.J.
    Proc. Natl. Acad. Sci. U.S.A. 88:4897-4901(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Embryonic brain.

Entry informationi

Entry nameiPTK7_CHICK
AccessioniPrimary (citable) accession number: Q91048
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.