Q91044 (NTRK3_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NT-3 growth factor receptor
EC=2.7.10.1

Alternative name(s):
Neurotrophic tyrosine kinase receptor type 3
TrkC tyrosine kinase
Short name=Trk-C

Gene names

Name:	NTRK3
Synonyms:	TRKC

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	827 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase and PLCG1. The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit structure	Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures.
Subcellular location	Membrane; Single-pass type I membrane protein.
Developmental stage	Expression occurs in the embryonal day 2 (E2) embryo with increasing levels later in development. In the E9 embryo highest levels are found in brain and spinal cord with intermediate levels in eye, heart, gut and muscle. Low levels are found in kidney, liver, skin and yolk sac.
Post-translational modification	Ligand-mediated auto-phosphorylation By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin domain Leucine-rich repeat Repeat Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Developmental protein Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mechanoreceptor differentiation Inferred from electronic annotation. Source: Compara neurotrophin signaling pathway Inferred from electronic annotation. Source: GOC positive regulation of axon extension involved in regeneration Inferred from electronic annotation. Source: Compara transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara integral to plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW neurotrophin receptor activity Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform Alpha-FL (identifier: Q91044-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Alpha-KT (identifier: Q91044-2)

The sequence of this isoform differs from the canonical sequence as follows:
     633-664: AHGPDAMILVDGQPRQAKGELGLSQMLHIASQ → LEDTPCCLSAGCLRRASCTGSSQRRVTSGASG
     665-827: Missing.

Isoform Alpha-KD (identifier: Q91044-3)

The sequence of this isoform differs from the canonical sequence as follows:
     581-619: LAARKDFQRE...GDGDPLIMVF → CFREIMLNPI...VYFSKGRHGF
     620-827: Missing.

Isoform Beta-KD (identifier: Q91044-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: Missing.
     581-619: LAARKDFQRE...GDGDPLIMVF → CFREIMLNPI...VYFSKGRHGF
     620-827: Missing.

Isoform TRKC-3 (identifier: Q91044-5)

The sequence of this isoform differs from the canonical sequence as follows:
     581-599: LAARKDFQREAELLTNLQH → CFREIMLNPISLPGHCQTS
     600-827: Missing.

Note: The kinase domain is of 19 aa instead of 39aa in the isoform alpha-KD due to a frameshift.

Isoform KI25 (identifier: Q91044-6)

The sequence of this isoform differs from the canonical sequence as follows:
     713-713: R → REGPRPKGQLSTAWQRHRLAPPAAAT

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	By similarity
	Chain	32 – 827	796	NT-3 growth factor receptor		PRO_0000016736
Regions
	Topological domain	32 – 430	399	Extracellular Potential
	Transmembrane	431 – 455	25	Helical; Potential
	Topological domain	456 – 827	372	Cytoplasmic Potential
	Repeat	104 – 125	22	LRR 1
	Repeat	128 – 149	22	LRR 2
	Domain	160 – 209	50	LRRCT
	Domain	210 – 300	91	Ig-like C2-type 1
	Domain	319 – 382	64	Ig-like C2-type 2
	Domain	540 – 812	273	Protein kinase
	Nucleotide binding	546 – 554	9	ATP By similarity
Sites
	Active site	681	1	Proton acceptor By similarity
	Binding site	574	1	ATP By similarity
	Site	518	1	Interaction with SHC1 By similarity
	Site	822	1	Interaction with PLC-gamma-1 By similarity
Amino acid modifications
	Modified residue	518	1	Phosphotyrosine; by autocatalysis By similarity
	Modified residue	707	1	Phosphotyrosine; by autocatalysis By similarity
	Modified residue	711	1	Phosphotyrosine; by autocatalysis By similarity
	Modified residue	712	1	Phosphotyrosine; by autocatalysis By similarity
	Modified residue	822	1	Phosphotyrosine; by autocatalysis By similarity
	Glycosylation	68	1	N-linked (GlcNAc...) Potential
	Glycosylation	72	1	N-linked (GlcNAc...) Potential
	Glycosylation	79	1	N-linked (GlcNAc...) Potential
	Glycosylation	163	1	N-linked (GlcNAc...) Potential
	Glycosylation	203	1	N-linked (GlcNAc...) Potential
	Glycosylation	218	1	N-linked (GlcNAc...) Potential
	Glycosylation	232	1	N-linked (GlcNAc...) Potential
	Glycosylation	259	1	N-linked (GlcNAc...) Potential
	Glycosylation	267	1	N-linked (GlcNAc...) Potential
	Glycosylation	272	1	N-linked (GlcNAc...) Potential
	Glycosylation	294	1	N-linked (GlcNAc...) Potential
	Glycosylation	375	1	N-linked (GlcNAc...) Potential
	Glycosylation	388	1	N-linked (GlcNAc...) Potential
	Disulfide bond	320 ↔ 362		By similarity
Natural variations
	Alternative sequence	1 – 98	98	Missing in isoform Beta-KD.		VSP_002938
	Alternative sequence	581 – 619	39	LAARK…LIMVF → CFREIMLNPISLPGHSKPLN QGIYVEDVSVYFSKGRHGF in isoform Alpha-KD and isoform Beta-KD.		VSP_002939
	Alternative sequence	581 – 599	19	LAARK…TNLQH → CFREIMLNPISLPGHCQTS in isoform TRKC-3.		VSP_002941
	Alternative sequence	600 – 827	228	Missing in isoform TRKC-3.		VSP_002942
	Alternative sequence	620 – 827	208	Missing in isoform Alpha-KD and isoform Beta-KD.		VSP_002940
	Alternative sequence	633 – 664	32	AHGPD…HIASQ → LEDTPCCLSAGCLRRASCTG SSQRRVTSGASG in isoform Alpha-KT.		VSP_002943
	Alternative sequence	665 – 827	163	Missing in isoform Alpha-KT.		VSP_002944
	Alternative sequence	713	1	R → REGPRPKGQLSTAWQRHRLA PPAAAT in isoform KI25.		VSP_002945
Experimental info
	Sequence conflict	1 – 39	39	MDVSL…NCLCS → MHFICWRIFASDRLKVLF Ref.2
	Sequence conflict	124	1	A → G in CAA42202. Ref.2
	Sequence conflict	378	1	I → F in CAA82907. Ref.3
	Sequence conflict	481 – 496	16	SPLHH…TPSSL → ATHTSTTDTRFVT in CAA42202. Ref.2
	Sequence conflict	795	1	W → C in CAA42202. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform Alpha-FL [UniParc]. Last modified July 15, 1999. Version 2. Checksum: AB97373113DCB28A	FASTA	827	93,181
	10 20 30 40 50 60 MDVSLCPTKC TFWRVFLLWS IWGDYLLSVL ACPANCLCSK TDINCKKPDD GNLFPLLEGQ 70 80 90 100 110 120 DSGSSNGNTS INITDISRNI TSIHIENWKN LQTLNAVDME LYTGLQRLTI RNSGLRNIQP 130 140 150 160 170 180 RAFAKNPHLR YIDLSGNRLT TLSWQLFQTL RLFDLRLERN PFNCSCDIRW IQLWQEKGEA 190 200 210 220 230 240 NLQSQQLHCM NLDTAVILLR NMNITQCDLP EISVSHVNLT VREGENAVIT CNGSGSPLPD 250 260 270 280 290 300 VDWTVADLHS INTHQTNLNW TNVHAINLTL VNVTSEDNGF LLTCIAENVV GMSNASVLLT 310 320 330 340 350 360 VYYPPRILTL EEPVLHLEHC IAFAVHGNPA PTLHWLHNGQ VLRETEIIHM EFYQQGEVSE 370 380 390 400 410 420 GCLLFNKPTH YNNGNYTIVA TNQLGSANQT IKGHFLEKPF PESTDNFVSI GDYEVSPTPP 430 440 450 460 470 480 ITVTHKPEED TFGVSIAVGL AAFACVLLVV LFIMINKYGR RSKFGMKGPV AVISGEEDSA 490 500 510 520 530 540 SPLHHINHGI TTPSSLDAGP DTVVIGMTRI PVIENPQYFR QGHNCHKPDT YVQHIKRRDI 550 560 570 580 590 600 VLKRELGEGA FGKVFLAECY NLSPTNDKML VAVKALKDPT LAARKDFQRE AELLTNLQHE 610 620 630 640 650 660 HIVKFYGVCG DGDPLIMVFE YMKHGDLNKF LRAHGPDAMI LVDGQPRQAK GELGLSQMLH 670 680 690 700 710 720 IASQIASGMV YLASQHFVHR DLATRNCLVG ANLLVKIGDF GMSRDVYSTD YYRVGGHTML 730 740 750 760 770 780 PIRWMPPESI MYRKFTTESD VWSFGVILWE IFTYGKQPWF QLSNTEVIEC ITQGRVLERP 790 800 810 820 RVCPKEVYDI MLGCWQREPQ QRLNIKEIYK ILHALGKATP IYLDILG
	Isoform Alpha-KT [UniParc]. Checksum: 11028413AB7DC850	FASTA	664	74,109
	10 20 30 40 50 60 MDVSLCPTKC TFWRVFLLWS IWGDYLLSVL ACPANCLCSK TDINCKKPDD GNLFPLLEGQ 70 80 90 100 110 120 DSGSSNGNTS INITDISRNI TSIHIENWKN LQTLNAVDME LYTGLQRLTI RNSGLRNIQP 130 140 150 160 170 180 RAFAKNPHLR YIDLSGNRLT TLSWQLFQTL RLFDLRLERN PFNCSCDIRW IQLWQEKGEA 190 200 210 220 230 240 NLQSQQLHCM NLDTAVILLR NMNITQCDLP EISVSHVNLT VREGENAVIT CNGSGSPLPD 250 260 270 280 290 300 VDWTVADLHS INTHQTNLNW TNVHAINLTL VNVTSEDNGF LLTCIAENVV GMSNASVLLT 310 320 330 340 350 360 VYYPPRILTL EEPVLHLEHC IAFAVHGNPA PTLHWLHNGQ VLRETEIIHM EFYQQGEVSE 370 380 390 400 410 420 GCLLFNKPTH YNNGNYTIVA TNQLGSANQT IKGHFLEKPF PESTDNFVSI GDYEVSPTPP 430 440 450 460 470 480 ITVTHKPEED TFGVSIAVGL AAFACVLLVV LFIMINKYGR RSKFGMKGPV AVISGEEDSA 490 500 510 520 530 540 SPLHHINHGI TTPSSLDAGP DTVVIGMTRI PVIENPQYFR QGHNCHKPDT YVQHIKRRDI 550 560 570 580 590 600 VLKRELGEGA FGKVFLAECY NLSPTNDKML VAVKALKDPT LAARKDFQRE AELLTNLQHE 610 620 630 640 650 660 HIVKFYGVCG DGDPLIMVFE YMKHGDLNKF LRLEDTPCCL SAGCLRRASC TGSSQRRVTS GASG
	Isoform Alpha-KD [UniParc]. Checksum: 13E6054D108EC9E8	FASTA	619	69,225
	10 20 30 40 50 60 MDVSLCPTKC TFWRVFLLWS IWGDYLLSVL ACPANCLCSK TDINCKKPDD GNLFPLLEGQ 70 80 90 100 110 120 DSGSSNGNTS INITDISRNI TSIHIENWKN LQTLNAVDME LYTGLQRLTI RNSGLRNIQP 130 140 150 160 170 180 RAFAKNPHLR YIDLSGNRLT TLSWQLFQTL RLFDLRLERN PFNCSCDIRW IQLWQEKGEA 190 200 210 220 230 240 NLQSQQLHCM NLDTAVILLR NMNITQCDLP EISVSHVNLT VREGENAVIT CNGSGSPLPD 250 260 270 280 290 300 VDWTVADLHS INTHQTNLNW TNVHAINLTL VNVTSEDNGF LLTCIAENVV GMSNASVLLT 310 320 330 340 350 360 VYYPPRILTL EEPVLHLEHC IAFAVHGNPA PTLHWLHNGQ VLRETEIIHM EFYQQGEVSE 370 380 390 400 410 420 GCLLFNKPTH YNNGNYTIVA TNQLGSANQT IKGHFLEKPF PESTDNFVSI GDYEVSPTPP 430 440 450 460 470 480 ITVTHKPEED TFGVSIAVGL AAFACVLLVV LFIMINKYGR RSKFGMKGPV AVISGEEDSA 490 500 510 520 530 540 SPLHHINHGI TTPSSLDAGP DTVVIGMTRI PVIENPQYFR QGHNCHKPDT YVQHIKRRDI 550 560 570 580 590 600 VLKRELGEGA FGKVFLAECY NLSPTNDKML VAVKALKDPT CFREIMLNPI SLPGHSKPLN 610 QGIYVEDVSV YFSKGRHGF
	Isoform Beta-KD [UniParc]. Checksum: E62888AE1B708EA1	FASTA	521	58,334
	10 20 30 40 50 60 MELYTGLQRL TIRNSGLRNI QPRAFAKNPH LRYIDLSGNR LTTLSWQLFQ TLRLFDLRLE 70 80 90 100 110 120 RNPFNCSCDI RWIQLWQEKG EANLQSQQLH CMNLDTAVIL LRNMNITQCD LPEISVSHVN 130 140 150 160 170 180 LTVREGENAV ITCNGSGSPL PDVDWTVADL HSINTHQTNL NWTNVHAINL TLVNVTSEDN 190 200 210 220 230 240 GFLLTCIAEN VVGMSNASVL LTVYYPPRIL TLEEPVLHLE HCIAFAVHGN PAPTLHWLHN 250 260 270 280 290 300 GQVLRETEII HMEFYQQGEV SEGCLLFNKP THYNNGNYTI VATNQLGSAN QTIKGHFLEK 310 320 330 340 350 360 PFPESTDNFV SIGDYEVSPT PPITVTHKPE EDTFGVSIAV GLAAFACVLL VVLFIMINKY 370 380 390 400 410 420 GRRSKFGMKG PVAVISGEED SASPLHHINH GITTPSSLDA GPDTVVIGMT RIPVIENPQY 430 440 450 460 470 480 FRQGHNCHKP DTYVQHIKRR DIVLKRELGE GAFGKVFLAE CYNLSPTNDK MLVAVKALKD 490 500 510 520 PTCFREIMLN PISLPGHSKP LNQGIYVEDV SVYFSKGRHG F
	Isoform TRKC-3 [UniParc]. Checksum: ED8F7FED76FA0EA8	FASTA	599	66,934
	10 20 30 40 50 60 MDVSLCPTKC TFWRVFLLWS IWGDYLLSVL ACPANCLCSK TDINCKKPDD GNLFPLLEGQ 70 80 90 100 110 120 DSGSSNGNTS INITDISRNI TSIHIENWKN LQTLNAVDME LYTGLQRLTI RNSGLRNIQP 130 140 150 160 170 180 RAFAKNPHLR YIDLSGNRLT TLSWQLFQTL RLFDLRLERN PFNCSCDIRW IQLWQEKGEA 190 200 210 220 230 240 NLQSQQLHCM NLDTAVILLR NMNITQCDLP EISVSHVNLT VREGENAVIT CNGSGSPLPD 250 260 270 280 290 300 VDWTVADLHS INTHQTNLNW TNVHAINLTL VNVTSEDNGF LLTCIAENVV GMSNASVLLT 310 320 330 340 350 360 VYYPPRILTL EEPVLHLEHC IAFAVHGNPA PTLHWLHNGQ VLRETEIIHM EFYQQGEVSE 370 380 390 400 410 420 GCLLFNKPTH YNNGNYTIVA TNQLGSANQT IKGHFLEKPF PESTDNFVSI GDYEVSPTPP 430 440 450 460 470 480 ITVTHKPEED TFGVSIAVGL AAFACVLLVV LFIMINKYGR RSKFGMKGPV AVISGEEDSA 490 500 510 520 530 540 SPLHHINHGI TTPSSLDAGP DTVVIGMTRI PVIENPQYFR QGHNCHKPDT YVQHIKRRDI 550 560 570 580 590 VLKRELGEGA FGKVFLAECY NLSPTNDKML VAVKALKDPT CFREIMLNPI SLPGHCQTS
	Isoform KI25 [UniParc]. Checksum: 30DEB2057E27A274	FASTA	852	95,860
	10 20 30 40 50 60 MDVSLCPTKC TFWRVFLLWS IWGDYLLSVL ACPANCLCSK TDINCKKPDD GNLFPLLEGQ 70 80 90 100 110 120 DSGSSNGNTS INITDISRNI TSIHIENWKN LQTLNAVDME LYTGLQRLTI RNSGLRNIQP 130 140 150 160 170 180 RAFAKNPHLR YIDLSGNRLT TLSWQLFQTL RLFDLRLERN PFNCSCDIRW IQLWQEKGEA 190 200 210 220 230 240 NLQSQQLHCM NLDTAVILLR NMNITQCDLP EISVSHVNLT VREGENAVIT CNGSGSPLPD 250 260 270 280 290 300 VDWTVADLHS INTHQTNLNW TNVHAINLTL VNVTSEDNGF LLTCIAENVV GMSNASVLLT 310 320 330 340 350 360 VYYPPRILTL EEPVLHLEHC IAFAVHGNPA PTLHWLHNGQ VLRETEIIHM EFYQQGEVSE 370 380 390 400 410 420 GCLLFNKPTH YNNGNYTIVA TNQLGSANQT IKGHFLEKPF PESTDNFVSI GDYEVSPTPP 430 440 450 460 470 480 ITVTHKPEED TFGVSIAVGL AAFACVLLVV LFIMINKYGR RSKFGMKGPV AVISGEEDSA 490 500 510 520 530 540 SPLHHINHGI TTPSSLDAGP DTVVIGMTRI PVIENPQYFR QGHNCHKPDT YVQHIKRRDI 550 560 570 580 590 600 VLKRELGEGA FGKVFLAECY NLSPTNDKML VAVKALKDPT LAARKDFQRE AELLTNLQHE 610 620 630 640 650 660 HIVKFYGVCG DGDPLIMVFE YMKHGDLNKF LRAHGPDAMI LVDGQPRQAK GELGLSQMLH 670 680 690 700 710 720 IASQIASGMV YLASQHFVHR DLATRNCLVG ANLLVKIGDF GMSRDVYSTD YYREGPRPKG 730 740 750 760 770 780 QLSTAWQRHR LAPPAAATVG GHTMLPIRWM PPESIMYRKF TTESDVWSFG VILWEIFTYG 790 800 810 820 830 840 KQPWFQLSNT EVIECITQGR VLERPRVCPK EVYDIMLGCW QREPQQRLNI KEIYKILHAL 850 GKATPIYLDI LG

References

[1]	"Isoforms of the avian TrkC receptor: a novel kinase insertion dissociates transformation and process outgrowth from survival." Garner A.S., Large T.H. Neuron 13:457-472(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA-FL; ALPHA-KT; ALPHA-KD; BETA-KD AND KI25). Tissue: Embryonic brain.
[2]	"Molecular cloning and expression of a novel truncated form of chicken trkC." Okazawa H., Kamei M., Kanazawa I. FEBS Lett. 329:171-177(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA-FL AND TRKC-3).
[3]	"Molecular cloning and cellular localization of trkC in the chicken embryo." Williams R., Backstrom A., Ebendal T., Hallboeoek F. Brain Res. Dev. Brain Res. 75:235-252(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 378-513. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S74248 mRNA. Translation: AAB31699.1. X59669 mRNA. Translation: CAA42202.1. Z30091 mRNA. Translation: CAA82907.1.
IPI	IPI00576712. IPI00585755. IPI00589776. IPI00594003. IPI00596996. IPI00597592.
PIR	I51222. I51259. S35695.
RefSeq	NP_990500.1. NM_205169.1.
UniGene	Gga.509.
3D structure databases
ProteinModelPortal	Q91044.
SMR	Q91044. Positions 300-401.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-127882.
STRING	9031.ENSGALP00000010970.
Protein family/group databases
MEROPS	I43.001.
Proteomic databases
PaxDb	Q91044.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	396081.
KEGG	gga:396081.
Organism-specific databases
CTD	4916.
Phylogenomic databases
eggNOG	COG0515.
HOVERGEN	HBG056735.
KO	K05101.
Enzyme and pathway databases
BRENDA	2.7.10.1. 1306.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR011009. Kinase-like_dom. IPR001611. Leu-rich_rpt. IPR000372. LRR-contain_N. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR020446. Tyr_kin_neurotrophic_rcpt_3. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR020777. Tyr_kinase_NGF_rcpt. IPR002011. Tyr_kinase_rcpt_2_CS. [Graphical view]
Pfam	PF07679. I-set. 2 hits. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR01939. NTKRECEPTOR. PR01942. NTKRECEPTOR3. PR00109. TYRKINASE.
SMART	SM00409. IG. 1 hit. SM00082. LRRCT. 1 hit. SM00013. LRRNT. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS51450. LRR. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00239. RECEPTOR_TYR_KIN_II. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20816139.

Entry information

Entry name

NTRK3_CHICK

Accession

Primary (citable) accession number: Q91044
Secondary accession number(s): Q91011, Q92022

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1999
Last modified:	May 29, 2013
This is version 120 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program