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Q91041

- TRYX_GADMO

UniProt

Q91041 - TRYX_GADMO

Protein

Trypsin-10

Gene
N/A
Organism
Gadus morhua (Atlantic cod)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei59 – 591Charge relay systemBy similarity
    Active sitei103 – 1031Charge relay systemBy similarity
    Sitei189 – 1891Required for specificityBy similarity
    Active sitei195 – 1951Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. digestion Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Digestion

    Protein family/group databases

    MEROPSiS01.125.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trypsin-10 (EC:3.4.21.4)
    Alternative name(s):
    Trypsin X
    OrganismiGadus morhua (Atlantic cod)
    Taxonomic identifieri8049 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeGadus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1313Sequence AnalysisAdd
    BLAST
    Propeptidei14 – 196Activation peptidePRO_0000028311
    Chaini20 – 241222Trypsin-10PRO_0000028312Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi26 ↔ 155PROSITE-ProRule annotation
    Disulfide bondi44 ↔ 60PROSITE-ProRule annotation
    Disulfide bondi128 ↔ 228PROSITE-ProRule annotation
    Disulfide bondi135 ↔ 201PROSITE-ProRule annotation
    Disulfide bondi166 ↔ 180PROSITE-ProRule annotation
    Disulfide bondi191 ↔ 215PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Structurei

    3D structure databases

    ProteinModelPortaliQ91041.
    SMRiQ91041. Positions 20-239.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 239220Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG013304.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q91041-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSLIFVLLL GAVFAEEDKI VGGYECTRHS QAHQVSLNSG YHFCGGSLVS    50
    KDWVVSAAHC YKSVLRVRLG EHHIRVNEGT EQFISSSSVI RHPNYSSYNI 100
    DNDIMLIKLT EPATLNQYVH AVALPTECAA DATMCTVSGW GNTMSSVDDG 150
    DKLQCLNLPI LSHADCANSY PGMITQSMFC AGYLEGGKDS CQGDSGGPVV 200
    CNGVLQGVVS WGYGCAERDN PGVYAKVCVL SGWVRDTMAS Y 241
    Length:241
    Mass (Da):25,976
    Last modified:November 1, 1997 - v2
    Checksum:i853D7C26BCAF9DD7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76887 mRNA. Translation: CAA54215.1.
    PIRiS39048.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76887 mRNA. Translation: CAA54215.1 .
    PIRi S39048.

    3D structure databases

    ProteinModelPortali Q91041.
    SMRi Q91041. Positions 20-239.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.125.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG013304.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of cDNAs from Atlantic cod encoding two different forms of trypsinogen."
      Gudmundsdottir A., Gudmundsdottir E., Oskarsson S., Bjarnason J.B., Eakin A.E., Craik C.S.
      Eur. J. Biochem. 217:1091-1097(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pyloric caecum.

    Entry informationi

    Entry nameiTRYX_GADMO
    AccessioniPrimary (citable) accession number: Q91041
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 70 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3