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Q91041

- TRYX_GADMO

UniProt

Q91041 - TRYX_GADMO

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Protein

Trypsin-10

Gene
N/A
Organism
Gadus morhua (Atlantic cod)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei59 – 591Charge relay systemBy similarity
Active sitei103 – 1031Charge relay systemBy similarity
Sitei189 – 1891Required for specificityBy similarity
Active sitei195 – 1951Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. digestion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Protein family/group databases

MEROPSiS01.125.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin-10 (EC:3.4.21.4)
Alternative name(s):
Trypsin X
OrganismiGadus morhua (Atlantic cod)
Taxonomic identifieri8049 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeGadus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1313Sequence AnalysisAdd
BLAST
Propeptidei14 – 196Activation peptidePRO_0000028311
Chaini20 – 241222Trypsin-10PRO_0000028312Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 155PROSITE-ProRule annotation
Disulfide bondi44 ↔ 60PROSITE-ProRule annotation
Disulfide bondi128 ↔ 228PROSITE-ProRule annotation
Disulfide bondi135 ↔ 201PROSITE-ProRule annotation
Disulfide bondi166 ↔ 180PROSITE-ProRule annotation
Disulfide bondi191 ↔ 215PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliQ91041.
SMRiQ91041. Positions 20-239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 239220Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG013304.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91041-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSLIFVLLL GAVFAEEDKI VGGYECTRHS QAHQVSLNSG YHFCGGSLVS
60 70 80 90 100
KDWVVSAAHC YKSVLRVRLG EHHIRVNEGT EQFISSSSVI RHPNYSSYNI
110 120 130 140 150
DNDIMLIKLT EPATLNQYVH AVALPTECAA DATMCTVSGW GNTMSSVDDG
160 170 180 190 200
DKLQCLNLPI LSHADCANSY PGMITQSMFC AGYLEGGKDS CQGDSGGPVV
210 220 230 240
CNGVLQGVVS WGYGCAERDN PGVYAKVCVL SGWVRDTMAS Y
Length:241
Mass (Da):25,976
Last modified:November 1, 1997 - v2
Checksum:i853D7C26BCAF9DD7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76887 mRNA. Translation: CAA54215.1.
PIRiS39048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76887 mRNA. Translation: CAA54215.1 .
PIRi S39048.

3D structure databases

ProteinModelPortali Q91041.
SMRi Q91041. Positions 20-239.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.125.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG013304.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of cDNAs from Atlantic cod encoding two different forms of trypsinogen."
    Gudmundsdottir A., Gudmundsdottir E., Oskarsson S., Bjarnason J.B., Eakin A.E., Craik C.S.
    Eur. J. Biochem. 217:1091-1097(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pyloric caecum.

Entry informationi

Entry nameiTRYX_GADMO
AccessioniPrimary (citable) accession number: Q91041
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3