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Protein

Prothrombin

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.UniRule annotation

Catalytic activityi

Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei393Charge relay systemUniRule annotation1
Active sitei449Charge relay systemUniRule annotation1
Active sitei554Charge relay systemUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation
Biological processAcute phaseUniRule annotation, Blood coagulationUniRule annotation, Hemostasis
LigandCalciumSAAS annotation

Protein family/group databases

MEROPSiS01.217.

Names & Taxonomyi

Protein namesi
Recommended name:
ProthrombinUniRule annotation (EC:3.4.21.5UniRule annotation)
Alternative name(s):
Coagulation factor IIUniRule annotation
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500431919224 – 607ProthrombinSequence analysisAdd BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi61 ↔ 66UniRule annotation
Disulfide bondi91 ↔ 104UniRule annotation
Disulfide bondi109 ↔ 185UniRule annotation
Disulfide bondi130 ↔ 168UniRule annotation
Disulfide bondi156 ↔ 180UniRule annotation
Disulfide bondi207 ↔ 284UniRule annotation
Disulfide bondi228 ↔ 268UniRule annotation
Disulfide bondi256 ↔ 279UniRule annotation
Disulfide bondi323 ↔ 469Interchain (between light and heavy chains)UniRule annotation
Disulfide bondi378 ↔ 394UniRule annotation
Disulfide bondi522 ↔ 536UniRule annotation
Disulfide bondi550 ↔ 580UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Proteomic databases

PaxDbiQ91001.
PRIDEiQ91001.

Structurei

3D structure databases

ProteinModelPortaliQ91001.
SMRiQ91001.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 90GlaInterPro annotationAdd BLAST47
Domaini108 – 185KringleInterPro annotationAdd BLAST78
Domaini206 – 284KringleInterPro annotationAdd BLAST79
Domaini351 – 604Peptidase S1InterPro annotationAdd BLAST254

Sequence similaritiesi

Belongs to the peptidase S1 family.UniRule annotationSAAS annotation

Keywords - Domaini

KringlePROSITE-ProRule annotationSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IKPN. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000251824.
HOVERGENiHBG108381.
PhylomeDBiQ91001.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di4.10.140.10. 1 hit.
4.10.740.10. 1 hit.
InterProiView protein in InterPro
IPR017857. Coagulation_fac_subgr_Gla_dom.
IPR000294. GLA_domain.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR003966. Prothrombin/thrombin.
IPR018992. Thrombin_light_chain.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
PANTHERiPTHR24254:SF13. PTHR24254:SF13. 1 hit.
PfamiView protein in Pfam
PF00594. Gla. 1 hit.
PF00051. Kringle. 2 hits.
PF09396. Thrombin_light. 1 hit.
PF00089. Trypsin. 1 hit.
PIRSFiPIRSF001149. Thrombin. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
PR00001. GLABLOOD.
PR01505. PROTHROMBIN.
SMARTiView protein in SMART
SM00069. GLA. 1 hit.
SM00130. KR. 2 hits.
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 2 hits.
SSF57630. SSF57630. 1 hit.
PROSITEiView protein in PROSITE
PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
PS00021. KRINGLE_1. 2 hits.
PS50070. KRINGLE_2. 2 hits.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHSKTTMLQ GLLLFGLLHL TLSHDGVFLE KGQALSLLKR PRRANKGFLE
60 70 80 90 100
EMIKGNLERE CLEETCNYEE AFEALESTVD TDAFWAKYQV CQGTKMPRTT
110 120 130 140 150
LDACLEGNCA ANLGQNYRGT INYTKSGIEC QVWTSKYPHI PKFNASIYPD
160 170 180 190 200
LTENYCRNPD NNSEGPWCYT RDPTVEREEC PIPVCGQERT TVEFTPRVKP
210 220 230 240 250
STTGQPCESE KGMLYTGTLS VTVSGARCLP WASEKAKALL QDKTINPEVK
260 270 280 290 300
LLENYCRNPD ADDEGVWCVI DEPPYFEYCD LHYCDSSLED ENEQVEEIAG
310 320 330 340 350
RTIFQEFKTF FDEKTFGEGE ADCGTRPLFE KKQITDQSEK ELMDSYMGGR
360 370 380 390 400
VVHGNDAEVG SAPWQVMLYK KSPQELLCGA SLISNSWILT AAHCLLYPPW
410 420 430 440 450
DKNLTTNDIL VRMGLHFRAK YERNKEKIVL LDKVIIHPKY NWKENMDRDI
460 470 480 490 500
ALLHLKRPVI FSDYIHPVCL PTKELVQRLM LAGFKGRVTG WGNLKETWAT
510 520 530 540 550
TPENLPTVLQ QLNLPIVDQN TCKASTRVKV TDNMFCAGYS PEDSKRGDAC
560 570 580 590 600
EGDSGGPFVM KNPDDNRWYQ VGIVSWGEGC DRDGKYGFYT HVFRLKKWMR

KTIEKQG
Length:607
Mass (Da):69,110
Last modified:November 1, 1996 - v1
Checksum:i002F3606EA36270F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81391 mRNA. Translation: AAA21619.1.
PIRiD42696.
RefSeqiNP_989936.1. NM_204605.1.
UniGeneiGga.4117.

Genome annotation databases

GeneIDi395306.

Entry informationi

Entry nameiQ91001_CHICK
AccessioniPrimary (citable) accession number: Q91001
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation