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Protein

Prothrombin

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Catalytic activityi

Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei393Charge relay systemUniRule annotation1
Active sitei449Charge relay systemUniRule annotation1
Active sitei554Charge relay systemUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation
Biological processAcute phaseUniRule annotation, Blood coagulationUniRule annotation, Hemostasis

Protein family/group databases

MEROPSiS01.217

Names & Taxonomyi

Protein namesi
Recommended name:
ProthrombinUniRule annotation (EC:3.4.21.5UniRule annotation)
Alternative name(s):
Coagulation factor IIUniRule annotation
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500431919224 – 607ProthrombinSequence analysisAdd BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi61 ↔ 66UniRule annotation
Disulfide bondi91 ↔ 104UniRule annotation
Disulfide bondi109 ↔ 185UniRule annotation
Disulfide bondi130 ↔ 168UniRule annotation
Disulfide bondi156 ↔ 180UniRule annotation
Disulfide bondi207 ↔ 284UniRule annotation
Disulfide bondi228 ↔ 268UniRule annotation
Disulfide bondi256 ↔ 279UniRule annotation
Disulfide bondi323 ↔ 469Interchain (between light and heavy chains)UniRule annotation
Disulfide bondi378 ↔ 394UniRule annotation
Disulfide bondi522 ↔ 536UniRule annotation
Disulfide bondi550 ↔ 580UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Proteomic databases

PRIDEiQ91001

Structurei

3D structure databases

ProteinModelPortaliQ91001
SMRiQ91001
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 90GlaInterPro annotationAdd BLAST47
Domaini108 – 185KringleInterPro annotationAdd BLAST78
Domaini206 – 284KringleInterPro annotationAdd BLAST79
Domaini351 – 604Peptidase S1InterPro annotationAdd BLAST254

Sequence similaritiesi

Belongs to the peptidase S1 family.UniRule annotationSAAS annotation

Keywords - Domaini

KringlePROSITE-ProRule annotationSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IKPN Eukaryota
COG5640 LUCA
HOGENOMiHOG000251824
HOVERGENiHBG108381
KOiK01313
PhylomeDBiQ91001

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
Gene3Di2.40.20.10, 2 hits
4.10.140.10, 1 hit
4.10.740.10, 1 hit
InterProiView protein in InterPro
IPR017857 Coagulation_fac-like_Gla_dom
IPR035972 GLA-like_dom_SF
IPR000294 GLA_domain
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR003966 Prothrombin/thrombin
IPR018992 Thrombin_light_chain
IPR037111 Thrombin_light_chain_sf
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PANTHERiPTHR24254:SF10 PTHR24254:SF10, 1 hit
PfamiView protein in Pfam
PF00594 Gla, 1 hit
PF00051 Kringle, 2 hits
PF09396 Thrombin_light, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF001149 Thrombin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
PR00001 GLABLOOD
PR01505 PROTHROMBIN
SMARTiView protein in SMART
SM00069 GLA, 1 hit
SM00130 KR, 2 hits
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF57440 SSF57440, 2 hits
SSF57630 SSF57630, 1 hit
PROSITEiView protein in PROSITE
PS00011 GLA_1, 1 hit
PS50998 GLA_2, 1 hit
PS00021 KRINGLE_1, 2 hits
PS50070 KRINGLE_2, 2 hits
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q91001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHSKTTMLQ GLLLFGLLHL TLSHDGVFLE KGQALSLLKR PRRANKGFLE
60 70 80 90 100
EMIKGNLERE CLEETCNYEE AFEALESTVD TDAFWAKYQV CQGTKMPRTT
110 120 130 140 150
LDACLEGNCA ANLGQNYRGT INYTKSGIEC QVWTSKYPHI PKFNASIYPD
160 170 180 190 200
LTENYCRNPD NNSEGPWCYT RDPTVEREEC PIPVCGQERT TVEFTPRVKP
210 220 230 240 250
STTGQPCESE KGMLYTGTLS VTVSGARCLP WASEKAKALL QDKTINPEVK
260 270 280 290 300
LLENYCRNPD ADDEGVWCVI DEPPYFEYCD LHYCDSSLED ENEQVEEIAG
310 320 330 340 350
RTIFQEFKTF FDEKTFGEGE ADCGTRPLFE KKQITDQSEK ELMDSYMGGR
360 370 380 390 400
VVHGNDAEVG SAPWQVMLYK KSPQELLCGA SLISNSWILT AAHCLLYPPW
410 420 430 440 450
DKNLTTNDIL VRMGLHFRAK YERNKEKIVL LDKVIIHPKY NWKENMDRDI
460 470 480 490 500
ALLHLKRPVI FSDYIHPVCL PTKELVQRLM LAGFKGRVTG WGNLKETWAT
510 520 530 540 550
TPENLPTVLQ QLNLPIVDQN TCKASTRVKV TDNMFCAGYS PEDSKRGDAC
560 570 580 590 600
EGDSGGPFVM KNPDDNRWYQ VGIVSWGEGC DRDGKYGFYT HVFRLKKWMR

KTIEKQG
Length:607
Mass (Da):69,110
Last modified:November 1, 1996 - v1
Checksum:i002F3606EA36270F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81391 mRNA Translation: AAA21619.1
PIRiD42696
RefSeqiNP_989936.1, NM_204605.1
UniGeneiGga.4117

Genome annotation databases

GeneIDi395306
KEGGigga:395306

Similar proteinsi

Entry informationi

Entry nameiQ91001_CHICK
AccessioniPrimary (citable) accession number: Q91001
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health