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Protein

Prothrombin

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.UniRule annotation

Catalytic activityi

Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Keywords - Biological processi

Acute phaseUniRule annotation, Blood coagulationUniRule annotation, Hemostasis

Keywords - Ligandi

CalciumSAAS annotation

Protein family/group databases

MEROPSiS01.217.

Names & Taxonomyi

Protein namesi
Recommended name:
ProthrombinUniRule annotation (EC:3.4.21.5UniRule annotation)
Alternative name(s):
Coagulation factor IIUniRule annotation
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 607584ProthrombinSequence analysisPRO_5004319192Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ91001.
PRIDEiQ91001.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013544.

Structurei

3D structure databases

ProteinModelPortaliQ91001.
SMRiQ91001. Positions 204-607.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 9047Gla (gamma-carboxy-glutamate)InterPro annotationAdd
BLAST
Domaini108 – 18578KringleInterPro annotationAdd
BLAST
Domaini206 – 28479KringleInterPro annotationAdd
BLAST
Domaini351 – 604254Peptidase S1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.UniRule annotationSAAS annotation
Contains 1 peptidase S1 domain.UniRule annotation
Contains Gla (gamma-carboxy-glutamate) domain.SAAS annotation

Keywords - Domaini

KringleSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IKPN. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000251824.
HOVERGENiHBG108381.
KOiK01313.
PhylomeDBiQ91001.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di4.10.140.10. 1 hit.
4.10.740.10. 1 hit.
InterProiIPR017857. Coagulation_fac_subgr_Gla_dom.
IPR000294. GLA_domain.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR003966. Prothrombin/thrombin.
IPR018992. Thrombin_light_chain.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PANTHERiPTHR24254:SF10. PTHR24254:SF10. 1 hit.
PfamiPF00594. Gla. 1 hit.
PF00051. Kringle. 2 hits.
PF09396. Thrombin_light. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001149. Thrombin. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
PR00001. GLABLOOD.
PR01505. PROTHROMBIN.
SMARTiSM00069. GLA. 1 hit.
SM00130. KR. 2 hits.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 2 hits.
SSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
PS00021. KRINGLE_1. 2 hits.
PS50070. KRINGLE_2. 2 hits.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHSKTTMLQ GLLLFGLLHL TLSHDGVFLE KGQALSLLKR PRRANKGFLE
60 70 80 90 100
EMIKGNLERE CLEETCNYEE AFEALESTVD TDAFWAKYQV CQGTKMPRTT
110 120 130 140 150
LDACLEGNCA ANLGQNYRGT INYTKSGIEC QVWTSKYPHI PKFNASIYPD
160 170 180 190 200
LTENYCRNPD NNSEGPWCYT RDPTVEREEC PIPVCGQERT TVEFTPRVKP
210 220 230 240 250
STTGQPCESE KGMLYTGTLS VTVSGARCLP WASEKAKALL QDKTINPEVK
260 270 280 290 300
LLENYCRNPD ADDEGVWCVI DEPPYFEYCD LHYCDSSLED ENEQVEEIAG
310 320 330 340 350
RTIFQEFKTF FDEKTFGEGE ADCGTRPLFE KKQITDQSEK ELMDSYMGGR
360 370 380 390 400
VVHGNDAEVG SAPWQVMLYK KSPQELLCGA SLISNSWILT AAHCLLYPPW
410 420 430 440 450
DKNLTTNDIL VRMGLHFRAK YERNKEKIVL LDKVIIHPKY NWKENMDRDI
460 470 480 490 500
ALLHLKRPVI FSDYIHPVCL PTKELVQRLM LAGFKGRVTG WGNLKETWAT
510 520 530 540 550
TPENLPTVLQ QLNLPIVDQN TCKASTRVKV TDNMFCAGYS PEDSKRGDAC
560 570 580 590 600
EGDSGGPFVM KNPDDNRWYQ VGIVSWGEGC DRDGKYGFYT HVFRLKKWMR

KTIEKQG
Length:607
Mass (Da):69,110
Last modified:November 1, 1996 - v1
Checksum:i002F3606EA36270F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81391 mRNA. Translation: AAA21619.1.
PIRiD42696.
RefSeqiNP_989936.1. NM_204605.1.
UniGeneiGga.4117.

Genome annotation databases

GeneIDi395306.
KEGGigga:395306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81391 mRNA. Translation: AAA21619.1.
PIRiD42696.
RefSeqiNP_989936.1. NM_204605.1.
UniGeneiGga.4117.

3D structure databases

ProteinModelPortaliQ91001.
SMRiQ91001. Positions 204-607.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013544.

Protein family/group databases

MEROPSiS01.217.

Proteomic databases

PaxDbiQ91001.
PRIDEiQ91001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395306.
KEGGigga:395306.

Organism-specific databases

CTDi2147.

Phylogenomic databases

eggNOGiENOG410IKPN. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000251824.
HOVERGENiHBG108381.
KOiK01313.
PhylomeDBiQ91001.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di4.10.140.10. 1 hit.
4.10.740.10. 1 hit.
InterProiIPR017857. Coagulation_fac_subgr_Gla_dom.
IPR000294. GLA_domain.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR003966. Prothrombin/thrombin.
IPR018992. Thrombin_light_chain.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PANTHERiPTHR24254:SF10. PTHR24254:SF10. 1 hit.
PfamiPF00594. Gla. 1 hit.
PF00051. Kringle. 2 hits.
PF09396. Thrombin_light. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001149. Thrombin. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
PR00001. GLABLOOD.
PR01505. PROTHROMBIN.
SMARTiSM00069. GLA. 1 hit.
SM00130. KR. 2 hits.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 2 hits.
SSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
PS00021. KRINGLE_1. 2 hits.
PS50070. KRINGLE_2. 2 hits.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ91001_CHICK
AccessioniPrimary (citable) accession number: Q91001
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.