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Protein
Submitted name:

Furin, paired basic amino acid cleaving enzyme

Gene

FURIN

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Enzyme and pathway databases

BRENDAi3.4.21.75 1306
ReactomeiR-GGA-1442490 Collagen degradation
R-GGA-1566948 Elastic fibre formation
R-GGA-1592389 Activation of Matrix Metalloproteinases
R-GGA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-GGA-167060 NGF processing
R-GGA-186797 Signaling by PDGF
R-GGA-1912420 Pre-NOTCH Processing in Golgi
R-GGA-2173789 TGF-beta receptor signaling activates SMADs

Protein family/group databases

MEROPSiS08.071

Names & Taxonomyi

Protein namesi
Submitted name:
Furin, paired basic amino acid cleaving enzymeImported
Submitted name:
Trans Golgi network protease furinImported
Gene namesi
Name:FURINImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei707 – 729HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_501431242828 – 789Sequence analysisAdd BLAST762

Expressioni

Gene expression databases

BgeeiENSGALG00000008341

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013566

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini445 – 577P/Homo BInterPro annotationAdd BLAST133

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3525 Eukaryota
COG1404 LUCA
COG4935 LUCA
GeneTreeiENSGT00750000117358
HOGENOMiHOG000192536
HOVERGENiHBG008705
KOiK01349
OMAiPRPHDYS
OrthoDBiEOG091G05HI
TreeFamiTF314277

Family and domain databases

CDDicd04059 Peptidases_S8_Protein_converta, 1 hit
Gene3Di2.60.120.260, 1 hit
3.30.70.850, 1 hit
3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR006212 Furin_repeat
IPR008979 Galactose-bd-like_sf
IPR009030 Growth_fac_rcpt_cys_sf
IPR034182 Kexin/furin
IPR002884 P_dom
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023827 Peptidase_S8_Asp-AS
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR032815 S8_pro-domain
IPR038466 S8_pro-domain_sf
PfamiView protein in Pfam
PF01483 P_proprotein, 1 hit
PF00082 Peptidase_S8, 1 hit
PF16470 S8_pro-domain, 1 hit
PRINTSiPR00723 SUBTILISIN
SMARTiView protein in SMART
SM00261 FU, 2 hits
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52743 SSF52743, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS51829 P_HOMO_B, 1 hit
PS00136 SUBTILASE_ASP, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q91000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLRPCSLLL LWTLVVALAL LAREVLAQRI YTNTWAVLVP AGPLEANRLA
60 70 80 90 100
RKHGFLNLGP IFGDYYHFQH RGVVKRSLSP HQPWHSRLAR EPQVHWLEQQ
110 120 130 140 150
VAKRRTKRDI FMEPTDPKFP QQWYLYNTNQ RDLNVRQAWE QGYTGKGIVV
160 170 180 190 200
SILDDGIEKN HPDLEANYDP GASFDVNDQD PDPQPRYTQM NDNRHGTRCA
210 220 230 240 250
GEVAAVANNG ICGVGVAYNA RIGGVRMLDG EVTDAVEAHS LGLNPNHIHI
260 270 280 290 300
YSASWGPEDD GKTVDGPARL AEEAFFRGVS QGRGGLGSIF VWASGNGGRE
310 320 330 340 350
HDSCNCDGYT NSIYTLSISS TTQYGNVPWY SEACSSTLAT TYSSGNQNEK
360 370 380 390 400
QIVTTDLRQK CTESHTGTSA SAPLAAGIIA LALEANKNLT WRDMQHLVVQ
410 420 430 440 450
TSKPAHLNAN DWVTNGVGRK VSHSYGYGLL DAGAMVSLAR NWITVGPQRK
460 470 480 490 500
CVIDVLTEPK DIGKRLEVRR KVDACLGKAN YISRLEHAQA RLTLSYNRRG
510 520 530 540 550
DLAIHLVSPM GTRSTLLAAR PHDYSADGFN DWAFMTTHSW DEDPSGEWLL
560 570 580 590 600
EIENTSDANN YGTLTKFTLV LYGTATDPPG LSNQLESSGC KTLTPSQTCV
610 620 630 640 650
VCEEGYYLHQ KSCLKRCPPG FAPGVQNTHY NLENSMEPIA PQLCLPCHPS
660 670 680 690 700
CATCTGPGPN QCLTCPAHSH FSSLDLSCSH QTQSSRASPA LVEGEGQSEA
710 720 730 740 750
PPPANPLVLI ASLSCVLIVV IFITVFLVLQ VRSGFSLRGV KVYALDSGII
760 770 780
SYKGLPSDIW QEEGPSESDI EECEVHNERT AFIRDQSAL
Length:789
Mass (Da):86,631
Last modified:November 1, 1996 - v1
Checksum:i4CD8B3E960FA04BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000131 Genomic DNA No translation available.
Z68093 mRNA Translation: CAA92109.1
RefSeqiNP_990046.1, NM_204715.1
UniGeneiGga.1751

Genome annotation databases

EnsembliENSGALT00000013581; ENSGALP00000013566; ENSGALG00000008341
ENSGALT00000074085; ENSGALP00000051587; ENSGALG00000008341
GeneIDi395457
KEGGigga:395457

Similar proteinsi

Entry informationi

Entry nameiQ91000_CHICK
AccessioniPrimary (citable) accession number: Q91000
Secondary accession number(s): F1NXT1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health