Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Trans Golgi network protease furin

Gene

FURIN

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Enzyme and pathway databases

BRENDAi3.4.21.75. 1306.
ReactomeiR-GGA-1442490. Collagen degradation.
R-GGA-1566948. Elastic fibre formation.
R-GGA-1592389. Activation of Matrix Metalloproteinases.
R-GGA-159782. Removal of aminoterminal propeptides from gamma-carboxylated proteins.
R-GGA-167060. NGF processing.
R-GGA-186797. Signaling by PDGF.
R-GGA-1912420. Pre-NOTCH Processing in Golgi.

Protein family/group databases

MEROPSiS08.071.

Names & Taxonomyi

Protein namesi
Submitted name:
Trans Golgi network protease furinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:FURINImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 10

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei707 – 72923HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 789762Sequence analysisPRO_5007215418Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013566.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 10875S8_pro-domainInterPro annotationAdd
BLAST
Domaini145 – 428284Peptidase S8InterPro annotationAdd
BLAST
Domaini485 – 57086P_proproteinInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotationSAAS annotation
Contains peptidase S8 domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
GeneTreeiENSGT00750000117358.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
KOiK01349.
OMAiIDILMEP.
OrthoDBiEOG7BW0JD.
TreeFamiTF314277.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.30.70.850. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR006212. Furin_repeat.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 3 hits.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF16470. S8_pro-domain. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SMARTiSM00261. FU. 2 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLRPCSLLL LWTLVVALAL LAREVLAQRI YTNTWAVLVP AGPLEANRLA
60 70 80 90 100
RKHGFLNLGP IFGDYYHFQH RGVVKRSLSP HQPWHSRLAR EPQVHWLEQQ
110 120 130 140 150
VAKRRTKRDI FMEPTDPKFP QQWYLYNTNQ RDLNVRQAWE QGYTGKGIVV
160 170 180 190 200
SILDDGIEKN HPDLEANYDP GASFDVNDQD PDPQPRYTQM NDNRHGTRCA
210 220 230 240 250
GEVAAVANNG ICGVGVAYNA RIGGVRMLDG EVTDAVEAHS LGLNPNHIHI
260 270 280 290 300
YSASWGPEDD GKTVDGPARL AEEAFFRGVS QGRGGLGSIF VWASGNGGRE
310 320 330 340 350
HDSCNCDGYT NSIYTLSISS TTQYGNVPWY SEACSSTLAT TYSSGNQNEK
360 370 380 390 400
QIVTTDLRQK CTESHTGTSA SAPLAAGIIA LALEANKNLT WRDMQHLVVQ
410 420 430 440 450
TSKPAHLNAN DWVTNGVGRK VSHSYGYGLL DAGAMVSLAR NWITVGPQRK
460 470 480 490 500
CVIDVLTEPK DIGKRLEVRR KVDACLGKAN YISRLEHAQA RLTLSYNRRG
510 520 530 540 550
DLAIHLVSPM GTRSTLLAAR PHDYSADGFN DWAFMTTHSW DEDPSGEWLL
560 570 580 590 600
EIENTSDANN YGTLTKFTLV LYGTATDPPG LSNQLESSGC KTLTPSQTCV
610 620 630 640 650
VCEEGYYLHQ KSCLKRCPPG FAPGVQNTHY NLENSMEPIA PQLCLPCHPS
660 670 680 690 700
CATCTGPGPN QCLTCPAHSH FSSLDLSCSH QTQSSRASPA LVEGEGQSEA
710 720 730 740 750
PPPANPLVLI ASLSCVLIVV IFITVFLVLQ VRSGFSLRGV KVYALDSGII
760 770 780
SYKGLPSDIW QEEGPSESDI EECEVHNERT AFIRDQSAL
Length:789
Mass (Da):86,631
Last modified:November 1, 1996 - v1
Checksum:i4CD8B3E960FA04BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03005944 Genomic DNA. No translation available.
Z68093 mRNA. Translation: CAA92109.1.
RefSeqiNP_990046.1. NM_204715.1.
UniGeneiGga.1751.

Genome annotation databases

EnsembliENSGALT00000013581; ENSGALP00000013566; ENSGALG00000008341.
GeneIDi395457.
KEGGigga:395457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03005944 Genomic DNA. No translation available.
Z68093 mRNA. Translation: CAA92109.1.
RefSeqiNP_990046.1. NM_204715.1.
UniGeneiGga.1751.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013566.

Protein family/group databases

MEROPSiS08.071.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000013581; ENSGALP00000013566; ENSGALG00000008341.
GeneIDi395457.
KEGGigga:395457.

Organism-specific databases

CTDi5045.

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
GeneTreeiENSGT00750000117358.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
KOiK01349.
OMAiIDILMEP.
OrthoDBiEOG7BW0JD.
TreeFamiTF314277.

Enzyme and pathway databases

BRENDAi3.4.21.75. 1306.
ReactomeiR-GGA-1442490. Collagen degradation.
R-GGA-1566948. Elastic fibre formation.
R-GGA-1592389. Activation of Matrix Metalloproteinases.
R-GGA-159782. Removal of aminoterminal propeptides from gamma-carboxylated proteins.
R-GGA-167060. NGF processing.
R-GGA-186797. Signaling by PDGF.
R-GGA-1912420. Pre-NOTCH Processing in Golgi.

Miscellaneous databases

NextBioi20815541.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.30.70.850. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR006212. Furin_repeat.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 3 hits.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF16470. S8_pro-domain. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SMARTiSM00261. FU. 2 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Targeted infection of endothelial cells by avian influenza virus A/FPV/Rostock/34 (H7N1) in chicken embryos."
    Feldmann A., Schafer M.K., Garten W., Klenk H.D.
    J. Virol. 74:8018-8027(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.
  2. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    International Chicken Genome Sequencing Consortium
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Red jungle fowlImported.
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Red jungle fowlImported.

Entry informationi

Entry nameiQ91000_CHICK
AccessioniPrimary (citable) accession number: Q91000
Secondary accession number(s): F1NXT1
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.