Q91000 (Q91000_CHICK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Trans Golgi network protease furin EMBL CAA92109.1
Organism	Gallus gallus (Chicken) EMBL CAA92109.1
Taxonomic identifier	9031 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	789 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the peptidase S8 family. RuleBase RU003355

Ontologies

Keywords
Molecular function	Hydrolase Protease Serine protease RuleBase RU004261 SAAS SAAS009020
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Golgi apparatus Inferred from Biological aspect of Ancestor. Source: RefGenome extracellular space Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	serine-type endopeptidase activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q91000 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 4CD8B3E960FA04BB	FASTA	789	86,631
	10 20 30 40 50 60 MDLRPCSLLL LWTLVVALAL LAREVLAQRI YTNTWAVLVP AGPLEANRLA RKHGFLNLGP 70 80 90 100 110 120 IFGDYYHFQH RGVVKRSLSP HQPWHSRLAR EPQVHWLEQQ VAKRRTKRDI FMEPTDPKFP 130 140 150 160 170 180 QQWYLYNTNQ RDLNVRQAWE QGYTGKGIVV SILDDGIEKN HPDLEANYDP GASFDVNDQD 190 200 210 220 230 240 PDPQPRYTQM NDNRHGTRCA GEVAAVANNG ICGVGVAYNA RIGGVRMLDG EVTDAVEAHS 250 260 270 280 290 300 LGLNPNHIHI YSASWGPEDD GKTVDGPARL AEEAFFRGVS QGRGGLGSIF VWASGNGGRE 310 320 330 340 350 360 HDSCNCDGYT NSIYTLSISS TTQYGNVPWY SEACSSTLAT TYSSGNQNEK QIVTTDLRQK 370 380 390 400 410 420 CTESHTGTSA SAPLAAGIIA LALEANKNLT WRDMQHLVVQ TSKPAHLNAN DWVTNGVGRK 430 440 450 460 470 480 VSHSYGYGLL DAGAMVSLAR NWITVGPQRK CVIDVLTEPK DIGKRLEVRR KVDACLGKAN 490 500 510 520 530 540 YISRLEHAQA RLTLSYNRRG DLAIHLVSPM GTRSTLLAAR PHDYSADGFN DWAFMTTHSW 550 560 570 580 590 600 DEDPSGEWLL EIENTSDANN YGTLTKFTLV LYGTATDPPG LSNQLESSGC KTLTPSQTCV 610 620 630 640 650 660 VCEEGYYLHQ KSCLKRCPPG FAPGVQNTHY NLENSMEPIA PQLCLPCHPS CATCTGPGPN 670 680 690 700 710 720 QCLTCPAHSH FSSLDLSCSH QTQSSRASPA LVEGEGQSEA PPPANPLVLI ASLSCVLIVV 730 740 750 760 770 780 IFITVFLVLQ VRSGFSLRGV KVYALDSGII SYKGLPSDIW QEEGPSESDI EECEVHNERT AFIRDQSAL

References

[1]	"Targeted infection of endothelial cells by avian influenza virus A/FPV/Rostock/34 (H7N1) in chicken embryos." Feldmann A., Schafer M.K., Garten W., Klenk H.D. J. Virol. 74:8018-8027(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Liver EMBL CAA92109.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z68093 mRNA. Translation: CAA92109.1.
IPI	IPI00587025.
RefSeq	NP_990046.1. NM_204715.1.
UniGene	Gga.1751.
3D structure databases
HSSP	HSSP built from PDB template 1P8J based on UniProtKB P23188.
ProteinModelPortal	Q91000.
SMR	Q91000. Positions 111-575.
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000013566. Q91000.
Protein family/group databases
MEROPS	S08.071.
Proteomic databases
PaxDb	Q91000.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	395457.
KEGG	gga:395457.
Organism-specific databases
CTD	5045.
Phylogenomic databases
eggNOG	COG4935.
HOGENOM	HOG000192536.
HOVERGEN	HBG008705.
InParanoid	Q91000.
KO	K01349.
OrthoDB	EOG4ZW59M.
Family and domain databases
Gene3D	3.40.50.200. 1 hit.
InterPro	IPR006212. Furin_repeat. IPR008979. Galactose-bd-like. IPR009030. Growth_fac_rcpt. IPR000209. Peptidase_S8/S53_dom. IPR023827. Peptidase_S8_Asp-AS. IPR022398. Peptidase_S8_His-AS. IPR023828. Peptidase_S8_Ser-AS. IPR015500. Peptidase_S8_subtilisin-rel. IPR009020. Prot_inh_propept. IPR002884. PrprotnconvertsP. [Graphical view]
PANTHER	PTHR10795. PTHR10795. 1 hit.
Pfam	PF01483. P_proprotein. 1 hit. PF00082. Peptidase_S8. 1 hit. [Graphical view]
PRINTS	PR00723. SUBTILISIN.
SMART	SM00261. FU. 2 hits. [Graphical view]
SUPFAM	SSF49785. Gal_bind_like. 1 hit. SSF57184. Grow_fac_recept. 1 hit. SSF52743. Pept_S8_S53. 1 hit. SSF54897. Prot_inh_propept. 1 hit.
PROSITE	PS00136. SUBTILASE_ASP. 1 hit. PS00137. SUBTILASE_HIS. 1 hit. PS00138. SUBTILASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20815541.
PMAP-CutDB	Q91000.

Entry information

Entry name

Q91000_CHICK

Accession

Primary (citable) accession number: Q91000

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)