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Protein

Anti-apoptotic protein NR13

Gene

NR13

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-apoptotic protein NR13
Alternative name(s):
Apoptosis regulator Nr-13
Gene namesi
Name:NR13
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei86 – 10621HelicalSequence analysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177Anti-apoptotic protein NR13PRO_0000143070Add
BLAST

Expressioni

Tissue specificityi

Expressed preferentially in heart, skeletal muscle, retina, optical tectum and bursa of Fabricius.

Interactioni

Subunit structurei

Interacts with BAX.1 Publication

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ90ZN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi75 – 9420BH1By similarityAdd
BLAST
Motifi126 – 14116BH2By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG006528.
InParanoidiQ90ZN1.
KOiK18451.
PhylomeDBiQ90ZN1.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR020726. Bcl2_BH2_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90ZN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGSLKEETA LLLEDYFQHR AGGAALPPSA TAAELRRAAA ELERRERPFF
60 70 80 90 100
RSCAPLARAE PREAAALLRK VAAQLEAEGG LNWGRLLALV VFTGTLAAAL
110 120 130 140 150
AESGCEEGPS RLAAALAAYL AEEQGEWLEE HGGWDGFCRF FGRHGSQPAD
160 170
QNSTLSNAIM AAAGFGIAGL AFLLVVR
Length:177
Mass (Da):18,778
Last modified:December 1, 2001 - v1
Checksum:iF06EF9C8E1AF250D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF375661 mRNA. Translation: AAK54806.1.
RefSeqiNP_989853.1. NM_204522.1.
UniGeneiGga.22069.

Genome annotation databases

GeneIDi395193.
KEGGigga:395193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF375661 mRNA. Translation: AAK54806.1.
RefSeqiNP_989853.1. NM_204522.1.
UniGeneiGga.22069.

3D structure databases

ProteinModelPortaliQ90ZN1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395193.
KEGGigga:395193.

Organism-specific databases

CTDi100194793.

Phylogenomic databases

HOVERGENiHBG006528.
InParanoidiQ90ZN1.
KOiK18451.
PhylomeDBiQ90ZN1.

Miscellaneous databases

PROiQ90ZN1.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR020726. Bcl2_BH2_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evidence for crucial electrostatic interactions between Bcl-2 homology domains BH3 and BH4 in the anti-apoptotic Nr-13 protein."
    Lalle P., Aouacheria A., Dumont-Miscopein A., Jambon M., Venet S., Bobichon H., Colas P., Deleage G., Geourjon C., Gillet G.
    Biochem. J. 368:213-221(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Role of Nr13 in regulation of programmed cell death in the bursa of Fabricius."
    Lee R.M., Gillet G., Burnside J., Thomas S.J., Neiman P.
    Genes Dev. 13:718-728(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH BAX.

Entry informationi

Entry nameiNR13_CHICK
AccessioniPrimary (citable) accession number: Q90ZN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.