Q90ZL1 (MSGN1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mesogenin-1

Alternative name(s):
MesP-related bHLH factor
Paraxial mesoderm-specific expression and regulatory capacities
pMesogenin1
Short name=pMsgn1

Gene names

Name:	msgn1
Synonyms:	mespo
ORF Names:	si:ch211-222h17.1

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the formation and segmentation of paraxial mesoderm. Seems to be an upstream regulator of at least some elements of the notch and delta signaling pathway By similarity. Ref.1
Subcellular location	Nucleus Potential.
Tissue specificity	Coexpression of ntl and spt is required for expression.
Developmental stage	Expression is first detected in the marginal zone of the blastoderm. Expression becomes more apparent at the germ-ring stage. In the early gastrula, expressed only in hypoblast cells of the germ ring. At mid-gastrula stage, expressed in ventrolateral mesoderm and is subsequently restricted to the segmental plate at late gastrula stage. At the segmentation period, expressed in the presomitic mesoderm including the tailbud. Expression is also detected in the adaxial cells in the vicinity of the presomitic mesoderm. Ref.2
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain.

Ontologies

Keywords
Biological process	Differentiation Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW mesoderm development Inferred from expression pattern Ref.2. Source: ZFIN multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred by curator Ref.2. Source: ZFIN
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 131	131	Mesogenin-1		PRO_0000330033
Regions
	Domain	83 – 125	43	Helix-loop-helix motif
	DNA binding	70 – 82	13	Basic motif
Experimental info
	Sequence conflict	74	1	K → E in AAI53477. Ref.5
	Sequence conflict	115	1	K → R in AAH92683. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q90ZL1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 3D1B5786F42AF66E	FASTA	131	14,994
	10 20 30 40 50 60 MAQIDVDVFT AKVLSHWDWS REDRSFGDSA SSPESESFDS ACSSPDARSS PTAGCEHAEQ 70 80 90 100 110 120 QKPKVKMSMR RRMKASEREK LRMRSLAEAL HQLRDYLPPG YSRRGQPLTK IQTLKYTIQY 130 IKELSGILEQ Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An interacting network of T-box genes directs gene expression and fate in the zebrafish mesoderm." Goering L.M., Hoshijima K., Hug B., Bisgrove B., Kispert A., Grunwald D.J. Proc. Natl. Acad. Sci. U.S.A. 100:9410-9415(2003) [PubMed: 12883008] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[2]	"Characterization and expression of a presomitic mesoderm-specific mespo gene in zebrafish." Yoo K.-W., Kim C.-H., Park H.-C., Kim S.-H., Kim H.-S., Hong S.-K., Han S., Rhee M., Huh T.-L. Dev. Genes Evol. 213:203-206(2003) [PubMed: 12684777] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE. Tissue: Embryo.
[3]	"Danio rerio mRNA for zf-pMesogenin." Alt B., Tautz D., Gajewski M. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	The Danio rerio sequencing project at the Sanger Institute Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AB.
[5]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY150226 mRNA. Translation: AAN65633.1. AF409108 mRNA. Translation: AAN75769.1. AJ309314 mRNA. Translation: CAC38843.1. BX640590 Genomic DNA. Translation: CAH68945.1. BX890562 Genomic DNA. Translation: CAK04569.1. BC092683 mRNA. Translation: AAH92683.1. BC153476 mRNA. Translation: AAI53477.1.
IPI	IPI00488426.
RefSeq	NP_878302.1. NM_182882.1.
UniGene	Dr.106405.
3D structure databases
ProteinModelPortal	Q90ZL1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q90ZL1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000103659; ENSDARP00000094435; ENSDARG00000070546.
GeneID	360135.
KEGG	dre:360135.
Organism-specific databases
CTD	343930.
ZFIN	ZDB-GENE-030722-1. msgn1.
Phylogenomic databases
eggNOG	fiNOG17192.
GeneTree	ENSGT00530000063712.
InParanoid	Q90ZL1.
OMA	HQLRDYL.
OrthoDB	EOG4NGGP8.
Gene expression databases
ArrayExpress	Q90ZL1.
Bgee	Q90ZL1.
Family and domain databases
InterPro	IPR011598. HLH_DNA-bd. [Graphical view]
Gene3D	G3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
KO	K09077.
Pfam	PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. HLH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MSGN1_DANRE

Accession

Primary (citable) accession number: Q90ZL1
Secondary accession number(s): A8E564, Q568W3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	December 1, 2001
Last modified:	November 16, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program