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Q90ZK6 (ACVR1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Activin receptor type-1

EC=2.7.11.30
Alternative name(s):
Activin receptor type I
Type I TGF B receptor
Gene names
Name:ACVR1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin By similarity.

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor

Magnesium or manganese By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 GS domain.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   LigandATP-binding
Magnesium
Manganese
Metal-binding
Nucleotide-binding
   Molecular functionKinase
Receptor
Serine/threonine-protein kinase
Transferase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from electronic annotation. Source: Ensembl

G1/S transition of mitotic cell cycle

Inferred from electronic annotation. Source: Ensembl

acute inflammatory response

Inferred from electronic annotation. Source: Ensembl

atrial septum primum morphogenesis

Inferred from electronic annotation. Source: Ensembl

cardiac epithelial to mesenchymal transition

Inferred from mutant phenotype PubMed 10885742PubMed 15766759. Source: AgBase

cardiac muscle cell fate commitment

Inferred from electronic annotation. Source: Ensembl

cell migration

Inferred from mutant phenotype PubMed 10885742. Source: AgBase

determination of left/right symmetry

Inferred from electronic annotation. Source: Ensembl

embryonic heart tube morphogenesis

Inferred from electronic annotation. Source: Ensembl

endocardial cushion cell fate commitment

Inferred from electronic annotation. Source: Ensembl

endothelial cell activation

Inferred from mutant phenotype PubMed 15766759. Source: AgBase

gastrulation with mouth forming second

Inferred from electronic annotation. Source: Ensembl

germ cell development

Inferred from electronic annotation. Source: Ensembl

heart development

Inferred from mutant phenotype PubMed 10885742. Source: AgBase

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

intracellular signal transduction

Inferred from mutant phenotype PubMed 15766759. Source: GOC

mesenchymal cell differentiation

Inferred from mutant phenotype PubMed 10885742. Source: AgBase

mesoderm formation

Inferred from electronic annotation. Source: Ensembl

mitral valve morphogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of activin receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of extrinsic apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

neural crest cell migration

Inferred from electronic annotation. Source: Ensembl

pathway-restricted SMAD protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

patterning of blood vessels

Inferred from electronic annotation. Source: Ensembl

peptidyl-threonine phosphorylation

Inferred from electronic annotation. Source: Ensembl

pharyngeal system development

Inferred from electronic annotation. Source: Ensembl

positive regulation of BMP signaling pathway

Inferred from direct assay PubMed 12968668. Source: AgBase

positive regulation of alkaline phosphatase activity

Inferred from mutant phenotype PubMed 15766759. Source: AgBase

positive regulation of bone mineralization

Inferred from electronic annotation. Source: Ensembl

positive regulation of determination of dorsal identity

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial to mesenchymal transition

Inferred from mutant phenotype PubMed 10885742PubMed 15766759. Source: AgBase

positive regulation of osteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of pathway-restricted SMAD protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from mutant phenotype PubMed 15766759. Source: AgBase

smooth muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

transforming growth factor beta receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentapical part of cell

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

activin binding

Traceable author statement PubMed 12968668. Source: AgBase

activin receptor activity, type I

Inferred from electronic annotation. Source: Ensembl

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction PubMed 12665510. Source: UniProtKB

receptor signaling protein activity

Inferred from mutant phenotype PubMed 15766759. Source: AgBase

receptor signaling protein serine/threonine kinase activity

Inferred from electronic annotation. Source: InterPro

transforming growth factor beta binding

Inferred from physical interaction PubMed 10885742. Source: AgBase

transforming growth factor beta receptor activity, type I

Inferred from direct assay PubMed 10885742. Source: AgBase

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 504488Activin receptor type-1
PRO_0000253593

Regions

Topological domain17 – 119103Extracellular Potential
Transmembrane120 – 14021Helical; Potential
Topological domain141 – 504364Cytoplasmic Potential
Domain173 – 20230GS
Domain203 – 497295Protein kinase
Nucleotide binding209 – 2179ATP By similarity

Sites

Active site3311Proton acceptor By similarity
Binding site2301ATP By similarity

Amino acid modifications

Glycosylation941N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict211 – 2122KG → SN in AAC98806. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q90ZK6 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: C7F045D6A25A071E

FASTA50456,225
        10         20         30         40         50         60 
MALPVLLLLL ALPSRSVQDE ELKLNECVCE GMSCGNGDRC QGQQCFASLS INDGAKVYQK 

        70         80         90        100        110        120 
GCFQVYEQGK MTCKTPPSPD QAVECCQGYL CNMNITAKLP SSKGQTLQGE AAGYSMETLI 

       130        140        150        160        170        180 
IVILAPVVVL VIFSVVAVLI IRRIQKNHME RLNSRDAEYG TIEGLIASNV GDSTLADLLD 

       190        200        210        220        230        240 
HSCTSGSGSG LPFLVQRTVA RQITLVECVG KGRYGEVWRG QWQGENVAVK IFSSRDEKSW 

       250        260        270        280        290        300 
FRETELYNTV LLRHENILGF IASDMTSRNS STQLWLITHY HEMGSLYDYL QLTTLDTVSC 

       310        320        330        340        350        360 
LRIVLSIASG LAHLHIEIFG TQGKPAISHR DLKSKNILVK KNGQCCIADL GLAVMHSQST 

       370        380        390        400        410        420 
NQLDVGNNPR VGTKRYMAPE VLDETIQADC FDSYKRVDIW AFGLVLWEVA RRMVSNGIVE 

       430        440        450        460        470        480 
DYKPPFYDLV PNDPSFEDMR KVVCVDQQRP NIPNRWFSDP TLTSLAKLMK ECWYQNPSAR 

       490        500 
LTALRIKKTL TKIDNSLDKL KADC 

« Hide

References

[1]Brames G.P., Barnett J.V.
Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Leghorn.
Tissue: Heart.
[2]Kuchler K.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Derco brown.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U38622 mRNA. Translation: AAC98806.1.
AJ318064 mRNA. Translation: CAC39433.1.
RefSeqNP_989891.1. NM_204560.1.
UniGeneGga.2875.

3D structure databases

ProteinModelPortalQ90ZK6.
SMRQ90ZK6. Positions 173-493.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000020469.

Proteomic databases

PaxDbQ90ZK6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000020497; ENSGALP00000020469; ENSGALG00000012551.
GeneID395246.
KEGGgga:395246.

Organism-specific databases

CTD90.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00730000110868.
HOGENOMHOG000230587.
HOVERGENHBG054502.
InParanoidQ90ZK6.
KOK04675.
PhylomeDBQ90ZK6.

Family and domain databases

InterProIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERPTHR23255. PTHR23255. 1 hit.
PfamPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
PRINTSPR00653. ACTIVIN2R.
SMARTSM00467. GS. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815335.
PROQ90ZK6.

Entry information

Entry nameACVR1_CHICK
AccessionPrimary (citable) accession number: Q90ZK6
Secondary accession number(s): Q9YH45
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families