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Q90ZK6

- ACVR1_CHICK

UniProt

Q90ZK6 - ACVR1_CHICK

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Protein
Activin receptor type-1
Gene
ACVR1
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin By similarity.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei230 – 2301ATP By similarity
Active sitei331 – 3311Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi209 – 2179ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. activin binding Source: AgBase
  3. activin receptor activity, type I Source: Ensembl
  4. metal ion binding Source: UniProtKB-KW
  5. protein binding Source: UniProtKB
  6. receptor signaling protein activity Source: AgBase
  7. receptor signaling protein serine/threonine kinase activity Source: InterPro
  8. transforming growth factor beta binding Source: AgBase
  9. transforming growth factor beta receptor activity, type I Source: AgBase
Complete GO annotation...

GO - Biological processi

  1. BMP signaling pathway Source: Ensembl
  2. G1/S transition of mitotic cell cycle Source: Ensembl
  3. acute inflammatory response Source: Ensembl
  4. atrial septum primum morphogenesis Source: Ensembl
  5. cardiac epithelial to mesenchymal transition Source: AgBase
  6. cardiac muscle cell fate commitment Source: Ensembl
  7. cell migration Source: AgBase
  8. determination of left/right symmetry Source: Ensembl
  9. embryonic heart tube morphogenesis Source: Ensembl
  10. endocardial cushion cell fate commitment Source: Ensembl
  11. endothelial cell activation Source: AgBase
  12. gastrulation with mouth forming second Source: Ensembl
  13. germ cell development Source: Ensembl
  14. heart development Source: AgBase
  15. in utero embryonic development Source: Ensembl
  16. intracellular signal transduction Source: GOC
  17. mesenchymal cell differentiation Source: AgBase
  18. mesoderm formation Source: Ensembl
  19. mitral valve morphogenesis Source: Ensembl
  20. negative regulation of activin receptor signaling pathway Source: Ensembl
  21. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  22. neural crest cell migration Source: Ensembl
  23. pathway-restricted SMAD protein phosphorylation Source: Ensembl
  24. patterning of blood vessels Source: Ensembl
  25. peptidyl-threonine phosphorylation Source: Ensembl
  26. pharyngeal system development Source: Ensembl
  27. positive regulation of BMP signaling pathway Source: AgBase
  28. positive regulation of alkaline phosphatase activity Source: AgBase
  29. positive regulation of bone mineralization Source: Ensembl
  30. positive regulation of determination of dorsal identity Source: Ensembl
  31. positive regulation of epithelial to mesenchymal transition Source: AgBase
  32. positive regulation of osteoblast differentiation Source: Ensembl
  33. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  34. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  35. positive regulation of transcription, DNA-templated Source: AgBase
  36. smooth muscle cell differentiation Source: Ensembl
  37. transforming growth factor beta receptor signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-1 (EC:2.7.11.30)
Alternative name(s):
Activin receptor type I
Type I TGF B receptor
Gene namesi
Name:ACVR1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 119103Extracellular Reviewed prediction
Add
BLAST
Transmembranei120 – 14021Helical; Reviewed prediction
Add
BLAST
Topological domaini141 – 504364Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical part of cell Source: Ensembl
  2. integral component of plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed prediction
Add
BLAST
Chaini17 – 504488Activin receptor type-1
PRO_0000253593Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi94 – 941N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ90ZK6.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020469.

Structurei

3D structure databases

ProteinModelPortaliQ90ZK6.
SMRiQ90ZK6. Positions 173-493.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini173 – 20230GS
Add
BLAST
Domaini203 – 497295Protein kinase
Add
BLAST

Sequence similaritiesi

Contains 1 GS domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00730000110868.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiQ90ZK6.
KOiK04675.
PhylomeDBiQ90ZK6.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90ZK6-1 [UniParc]FASTAAdd to Basket

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MALPVLLLLL ALPSRSVQDE ELKLNECVCE GMSCGNGDRC QGQQCFASLS    50
INDGAKVYQK GCFQVYEQGK MTCKTPPSPD QAVECCQGYL CNMNITAKLP 100
SSKGQTLQGE AAGYSMETLI IVILAPVVVL VIFSVVAVLI IRRIQKNHME 150
RLNSRDAEYG TIEGLIASNV GDSTLADLLD HSCTSGSGSG LPFLVQRTVA 200
RQITLVECVG KGRYGEVWRG QWQGENVAVK IFSSRDEKSW FRETELYNTV 250
LLRHENILGF IASDMTSRNS STQLWLITHY HEMGSLYDYL QLTTLDTVSC 300
LRIVLSIASG LAHLHIEIFG TQGKPAISHR DLKSKNILVK KNGQCCIADL 350
GLAVMHSQST NQLDVGNNPR VGTKRYMAPE VLDETIQADC FDSYKRVDIW 400
AFGLVLWEVA RRMVSNGIVE DYKPPFYDLV PNDPSFEDMR KVVCVDQQRP 450
NIPNRWFSDP TLTSLAKLMK ECWYQNPSAR LTALRIKKTL TKIDNSLDKL 500
KADC 504
Length:504
Mass (Da):56,225
Last modified:December 1, 2001 - v1
Checksum:iC7F045D6A25A071E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti211 – 2122KG → SN in AAC98806. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38622 mRNA. Translation: AAC98806.1.
AJ318064 mRNA. Translation: CAC39433.1.
RefSeqiNP_989891.1. NM_204560.1.
UniGeneiGga.2875.

Genome annotation databases

EnsembliENSGALT00000020497; ENSGALP00000020469; ENSGALG00000012551.
GeneIDi395246.
KEGGigga:395246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38622 mRNA. Translation: AAC98806.1 .
AJ318064 mRNA. Translation: CAC39433.1 .
RefSeqi NP_989891.1. NM_204560.1.
UniGenei Gga.2875.

3D structure databases

ProteinModelPortali Q90ZK6.
SMRi Q90ZK6. Positions 173-493.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000020469.

Proteomic databases

PaxDbi Q90ZK6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000020497 ; ENSGALP00000020469 ; ENSGALG00000012551 .
GeneIDi 395246.
KEGGi gga:395246.

Organism-specific databases

CTDi 90.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00730000110868.
HOGENOMi HOG000230587.
HOVERGENi HBG054502.
InParanoidi Q90ZK6.
KOi K04675.
PhylomeDBi Q90ZK6.

Miscellaneous databases

NextBioi 20815335.
PROi Q90ZK6.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view ]
PRINTSi PR00653. ACTIVIN2R.
SMARTi SM00467. GS. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Brames G.P., Barnett J.V.
    Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Leghorn.
    Tissue: Heart.
  2. Kuchler K.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Derco brown.

Entry informationi

Entry nameiACVR1_CHICK
AccessioniPrimary (citable) accession number: Q90ZK6
Secondary accession number(s): Q9YH45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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