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Protein

Activin receptor type-1

Gene

ACVR1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin (By similarity).By similarity

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei230 – 2301ATPPROSITE-ProRule annotation
Active sitei331 – 3311Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi209 – 2179ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. activin binding Source: AgBase
  2. activin receptor activity, type I Source: Ensembl
  3. ATP binding Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW
  5. receptor signaling protein activity Source: AgBase
  6. receptor signaling protein serine/threonine kinase activity Source: InterPro
  7. transforming growth factor beta binding Source: AgBase
  8. transforming growth factor beta receptor activity, type I Source: AgBase

GO - Biological processi

  1. activin receptor signaling pathway Source: AgBase
  2. acute inflammatory response Source: Ensembl
  3. atrial septum primum morphogenesis Source: Ensembl
  4. BMP signaling pathway Source: Ensembl
  5. cardiac epithelial to mesenchymal transition Source: AgBase
  6. cardiac muscle cell fate commitment Source: Ensembl
  7. cell migration Source: AgBase
  8. determination of left/right symmetry Source: Ensembl
  9. embryonic heart tube morphogenesis Source: Ensembl
  10. endocardial cushion cell fate commitment Source: Ensembl
  11. endothelial cell activation Source: AgBase
  12. G1/S transition of mitotic cell cycle Source: Ensembl
  13. gastrulation with mouth forming second Source: Ensembl
  14. germ cell development Source: Ensembl
  15. heart development Source: AgBase
  16. intracellular signal transduction Source: AgBase
  17. mesenchymal cell differentiation Source: AgBase
  18. mesoderm formation Source: Ensembl
  19. mitral valve morphogenesis Source: Ensembl
  20. negative regulation of activin receptor signaling pathway Source: Ensembl
  21. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  22. neural crest cell migration Source: Ensembl
  23. pathway-restricted SMAD protein phosphorylation Source: Ensembl
  24. patterning of blood vessels Source: Ensembl
  25. peptidyl-threonine phosphorylation Source: Ensembl
  26. pharyngeal system development Source: Ensembl
  27. positive regulation of alkaline phosphatase activity Source: AgBase
  28. positive regulation of BMP signaling pathway Source: AgBase
  29. positive regulation of bone mineralization Source: Ensembl
  30. positive regulation of determination of dorsal identity Source: Ensembl
  31. positive regulation of epithelial to mesenchymal transition Source: AgBase
  32. positive regulation of osteoblast differentiation Source: Ensembl
  33. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  34. positive regulation of transcription, DNA-templated Source: AgBase
  35. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  36. smooth muscle cell differentiation Source: Ensembl
  37. transforming growth factor beta receptor signaling pathway Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-1 (EC:2.7.11.30)
Alternative name(s):
Activin receptor type I
Type I TGF B receptor
Gene namesi
Name:ACVR1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Chromosome 7

Subcellular locationi

  1. Membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 119103ExtracellularSequence AnalysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence AnalysisAdd
BLAST
Topological domaini141 – 504364CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. activin receptor complex Source: Ensembl
  2. apical part of cell Source: Ensembl
  3. membrane Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 504488Activin receptor type-1PRO_0000253593Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ90ZK6.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020469.

Structurei

3D structure databases

ProteinModelPortaliQ90ZK6.
SMRiQ90ZK6. Positions 173-493.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini173 – 20230GSPROSITE-ProRule annotationAdd
BLAST
Domaini203 – 497295Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GS domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiQ90ZK6.
KOiK04675.
OMAiVCEGMSC.
PhylomeDBiQ90ZK6.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000472. TFB_recept_I/II_C.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90ZK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPVLLLLL ALPSRSVQDE ELKLNECVCE GMSCGNGDRC QGQQCFASLS
60 70 80 90 100
INDGAKVYQK GCFQVYEQGK MTCKTPPSPD QAVECCQGYL CNMNITAKLP
110 120 130 140 150
SSKGQTLQGE AAGYSMETLI IVILAPVVVL VIFSVVAVLI IRRIQKNHME
160 170 180 190 200
RLNSRDAEYG TIEGLIASNV GDSTLADLLD HSCTSGSGSG LPFLVQRTVA
210 220 230 240 250
RQITLVECVG KGRYGEVWRG QWQGENVAVK IFSSRDEKSW FRETELYNTV
260 270 280 290 300
LLRHENILGF IASDMTSRNS STQLWLITHY HEMGSLYDYL QLTTLDTVSC
310 320 330 340 350
LRIVLSIASG LAHLHIEIFG TQGKPAISHR DLKSKNILVK KNGQCCIADL
360 370 380 390 400
GLAVMHSQST NQLDVGNNPR VGTKRYMAPE VLDETIQADC FDSYKRVDIW
410 420 430 440 450
AFGLVLWEVA RRMVSNGIVE DYKPPFYDLV PNDPSFEDMR KVVCVDQQRP
460 470 480 490 500
NIPNRWFSDP TLTSLAKLMK ECWYQNPSAR LTALRIKKTL TKIDNSLDKL

KADC
Length:504
Mass (Da):56,225
Last modified:December 1, 2001 - v1
Checksum:iC7F045D6A25A071E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti211 – 2122KG → SN in AAC98806 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38622 mRNA. Translation: AAC98806.1.
AJ318064 mRNA. Translation: CAC39433.1.
RefSeqiNP_989891.1. NM_204560.1.
UniGeneiGga.2875.

Genome annotation databases

EnsembliENSGALT00000020497; ENSGALP00000020469; ENSGALG00000012551.
GeneIDi395246.
KEGGigga:395246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38622 mRNA. Translation: AAC98806.1.
AJ318064 mRNA. Translation: CAC39433.1.
RefSeqiNP_989891.1. NM_204560.1.
UniGeneiGga.2875.

3D structure databases

ProteinModelPortaliQ90ZK6.
SMRiQ90ZK6. Positions 173-493.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020469.

Proteomic databases

PaxDbiQ90ZK6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000020497; ENSGALP00000020469; ENSGALG00000012551.
GeneIDi395246.
KEGGigga:395246.

Organism-specific databases

CTDi90.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiQ90ZK6.
KOiK04675.
OMAiVCEGMSC.
PhylomeDBiQ90ZK6.

Miscellaneous databases

NextBioi20815335.
PROiQ90ZK6.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000472. TFB_recept_I/II_C.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Brames G.P., Barnett J.V.
    Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Leghorn.
    Tissue: Heart.
  2. Kuchler K.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Derco brown.

Entry informationi

Entry nameiACVR1_CHICK
AccessioniPrimary (citable) accession number: Q90ZK6
Secondary accession number(s): Q9YH45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 1, 2001
Last modified: April 1, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.