Reviewed, UniProtKB/Swiss-Prot Q90ZK6 (ACVR1_CHICK)

Names and origin

Protein names

Recommended name:
    Activin receptor type-1
    EC=2.7.11.30
Alternative name(s):
    Activin receptor type I
    Type I TGF B receptor

Gene names

Name:

ACVR1

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin By similarity.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane proteinBy similarity.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 504	488	Activin receptor type-1
Regions
	Topological domain	17 – 119	103	Extracellular Potential
	Transmembrane	120 – 140	21	Potential
	Topological domain	141 – 504	364	Cytoplasmic Potential
	Domain	173 – 202	30	GS
	Domain	203 – 497	295	Protein kinase
	Nucleotide binding	209 – 217	9	ATP By similarity
Sites
	Active site	331	1	Proton acceptor By similarity
	Binding site	230	1	ATP By similarity
Amino acid modifications
	Glycosylation	94	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	211 – 212	2	KG → SN in AAC98806. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q90ZK6-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: C7F045D6A25A071E	FASTA	504	56,225
	10 20 30 40 50 60 MALPVLLLLL ALPSRSVQDE ELKLNECVCE GMSCGNGDRC QGQQCFASLS INDGAKVYQK 70 80 90 100 110 120 GCFQVYEQGK MTCKTPPSPD QAVECCQGYL CNMNITAKLP SSKGQTLQGE AAGYSMETLI 130 140 150 160 170 180 IVILAPVVVL VIFSVVAVLI IRRIQKNHME RLNSRDAEYG TIEGLIASNV GDSTLADLLD 190 200 210 220 230 240 HSCTSGSGSG LPFLVQRTVA RQITLVECVG KGRYGEVWRG QWQGENVAVK IFSSRDEKSW 250 260 270 280 290 300 FRETELYNTV LLRHENILGF IASDMTSRNS STQLWLITHY HEMGSLYDYL QLTTLDTVSC 310 320 330 340 350 360 LRIVLSIASG LAHLHIEIFG TQGKPAISHR DLKSKNILVK KNGQCCIADL GLAVMHSQST 370 380 390 400 410 420 NQLDVGNNPR VGTKRYMAPE VLDETIQADC FDSYKRVDIW AFGLVLWEVA RRMVSNGIVE 430 440 450 460 470 480 DYKPPFYDLV PNDPSFEDMR KVVCVDQQRP NIPNRWFSDP TLTSLAKLMK ECWYQNPSAR 490 500 LTALRIKKTL TKIDNSLDKL KADC

References

[1]	Brames G.P., Barnett J.V. Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Leghorn. Tissue: Heart.
[2]	Kuchler K. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Derco brown.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U38622 mRNA. Translation: AAC98806.1. AJ318064 mRNA. Translation: CAC39433.1.
RefSeq	NP_989891.1.
UniGene	Gga.2875
3D structure databases
HSSP	HSSP built from PDB template 1IAS based on UniProtKB P36897.
ModBase	Search...
Genome annotation databases
Ensembl	ENSGALG00000012551. Gallus gallus. [Contig view]
GeneID	395246.
KEGG	gga:395246.
Phylogenomic databases
HOVERGEN	Q90ZK6.
Family and domain databases
InterPro	IPR000333. Activin_II_recpt. IPR000472. Activin_rcpt. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view]
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view]
PRINTS	PR00653. ACTIVIN2R.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00467. GS. 1 hit. [Graphical view]
PROSITE	PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ACVR1_CHICK

Accession

Primary (citable) accession number: Q90ZK6
Secondary accession number(s): Q9YH45

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	December 1, 2001
Last modified:	July 22, 2008
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)