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Q90ZK6

- ACVR1_CHICK

UniProt

Q90ZK6 - ACVR1_CHICK

Protein

Activin receptor type-1

Gene

ACVR1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin By similarity.By similarity

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei230 – 2301ATPPROSITE-ProRule annotation
    Active sitei331 – 3311Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi209 – 2179ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. activin binding Source: AgBase
    2. activin receptor activity, type I Source: Ensembl
    3. ATP binding Source: UniProtKB-KW
    4. metal ion binding Source: UniProtKB-KW
    5. protein binding Source: UniProtKB
    6. receptor signaling protein activity Source: AgBase
    7. receptor signaling protein serine/threonine kinase activity Source: InterPro
    8. transforming growth factor beta binding Source: AgBase
    9. transforming growth factor beta receptor activity, type I Source: AgBase

    GO - Biological processi

    1. acute inflammatory response Source: Ensembl
    2. atrial septum primum morphogenesis Source: Ensembl
    3. BMP signaling pathway Source: Ensembl
    4. cardiac epithelial to mesenchymal transition Source: AgBase
    5. cardiac muscle cell fate commitment Source: Ensembl
    6. cell migration Source: AgBase
    7. determination of left/right symmetry Source: Ensembl
    8. embryonic heart tube morphogenesis Source: Ensembl
    9. endocardial cushion cell fate commitment Source: Ensembl
    10. endothelial cell activation Source: AgBase
    11. G1/S transition of mitotic cell cycle Source: Ensembl
    12. gastrulation with mouth forming second Source: Ensembl
    13. germ cell development Source: Ensembl
    14. heart development Source: AgBase
    15. intracellular signal transduction Source: GOC
    16. in utero embryonic development Source: Ensembl
    17. mesenchymal cell differentiation Source: AgBase
    18. mesoderm formation Source: Ensembl
    19. mitral valve morphogenesis Source: Ensembl
    20. negative regulation of activin receptor signaling pathway Source: Ensembl
    21. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    22. neural crest cell migration Source: Ensembl
    23. pathway-restricted SMAD protein phosphorylation Source: Ensembl
    24. patterning of blood vessels Source: Ensembl
    25. peptidyl-threonine phosphorylation Source: Ensembl
    26. pharyngeal system development Source: Ensembl
    27. positive regulation of alkaline phosphatase activity Source: AgBase
    28. positive regulation of BMP signaling pathway Source: AgBase
    29. positive regulation of bone mineralization Source: Ensembl
    30. positive regulation of determination of dorsal identity Source: Ensembl
    31. positive regulation of epithelial to mesenchymal transition Source: AgBase
    32. positive regulation of osteoblast differentiation Source: Ensembl
    33. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    34. positive regulation of transcription, DNA-templated Source: AgBase
    35. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    36. smooth muscle cell differentiation Source: Ensembl
    37. transforming growth factor beta receptor signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Activin receptor type-1 (EC:2.7.11.30)
    Alternative name(s):
    Activin receptor type I
    Type I TGF B receptor
    Gene namesi
    Name:ACVR1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 7

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. apical part of cell Source: Ensembl
    2. integral component of plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 504488Activin receptor type-1PRO_0000253593Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ90ZK6.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000020469.

    Structurei

    3D structure databases

    ProteinModelPortaliQ90ZK6.
    SMRiQ90ZK6. Positions 173-493.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini17 – 119103ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini141 – 504364CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini173 – 20230GSPROSITE-ProRule annotationAdd
    BLAST
    Domaini203 – 497295Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GS domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00730000110868.
    HOGENOMiHOG000230587.
    HOVERGENiHBG054502.
    InParanoidiQ90ZK6.
    KOiK04675.
    PhylomeDBiQ90ZK6.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view]
    PRINTSiPR00653. ACTIVIN2R.
    SMARTiSM00467. GS. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q90ZK6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALPVLLLLL ALPSRSVQDE ELKLNECVCE GMSCGNGDRC QGQQCFASLS    50
    INDGAKVYQK GCFQVYEQGK MTCKTPPSPD QAVECCQGYL CNMNITAKLP 100
    SSKGQTLQGE AAGYSMETLI IVILAPVVVL VIFSVVAVLI IRRIQKNHME 150
    RLNSRDAEYG TIEGLIASNV GDSTLADLLD HSCTSGSGSG LPFLVQRTVA 200
    RQITLVECVG KGRYGEVWRG QWQGENVAVK IFSSRDEKSW FRETELYNTV 250
    LLRHENILGF IASDMTSRNS STQLWLITHY HEMGSLYDYL QLTTLDTVSC 300
    LRIVLSIASG LAHLHIEIFG TQGKPAISHR DLKSKNILVK KNGQCCIADL 350
    GLAVMHSQST NQLDVGNNPR VGTKRYMAPE VLDETIQADC FDSYKRVDIW 400
    AFGLVLWEVA RRMVSNGIVE DYKPPFYDLV PNDPSFEDMR KVVCVDQQRP 450
    NIPNRWFSDP TLTSLAKLMK ECWYQNPSAR LTALRIKKTL TKIDNSLDKL 500
    KADC 504
    Length:504
    Mass (Da):56,225
    Last modified:December 1, 2001 - v1
    Checksum:iC7F045D6A25A071E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti211 – 2122KG → SN in AAC98806. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38622 mRNA. Translation: AAC98806.1.
    AJ318064 mRNA. Translation: CAC39433.1.
    RefSeqiNP_989891.1. NM_204560.1.
    UniGeneiGga.2875.

    Genome annotation databases

    EnsembliENSGALT00000020497; ENSGALP00000020469; ENSGALG00000012551.
    GeneIDi395246.
    KEGGigga:395246.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38622 mRNA. Translation: AAC98806.1 .
    AJ318064 mRNA. Translation: CAC39433.1 .
    RefSeqi NP_989891.1. NM_204560.1.
    UniGenei Gga.2875.

    3D structure databases

    ProteinModelPortali Q90ZK6.
    SMRi Q90ZK6. Positions 173-493.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000020469.

    Proteomic databases

    PaxDbi Q90ZK6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000020497 ; ENSGALP00000020469 ; ENSGALG00000012551 .
    GeneIDi 395246.
    KEGGi gga:395246.

    Organism-specific databases

    CTDi 90.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00730000110868.
    HOGENOMi HOG000230587.
    HOVERGENi HBG054502.
    InParanoidi Q90ZK6.
    KOi K04675.
    PhylomeDBi Q90ZK6.

    Miscellaneous databases

    NextBioi 20815335.
    PROi Q90ZK6.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view ]
    PRINTSi PR00653. ACTIVIN2R.
    SMARTi SM00467. GS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Brames G.P., Barnett J.V.
      Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Leghorn.
      Tissue: Heart.
    2. Kuchler K.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Derco brown.

    Entry informationi

    Entry nameiACVR1_CHICK
    AccessioniPrimary (citable) accession number: Q90ZK6
    Secondary accession number(s): Q9YH45
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3