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Protein

Activin receptor type-1

Gene

ACVR1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin (By similarity).By similarity

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei230ATPPROSITE-ProRule annotation1
Active sitei331Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi209 – 217ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-1 (EC:2.7.11.30)
Alternative name(s):
Activin receptor type I
Type I TGF B receptor
Gene namesi
Name:ACVR1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 119ExtracellularSequence analysisAdd BLAST103
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 504CytoplasmicSequence analysisAdd BLAST364

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000025359317 – 504Activin receptor type-1Add BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ90ZK6
PRIDEiQ90ZK6

Expressioni

Gene expression databases

BgeeiENSGALG00000012551

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020469

Structurei

3D structure databases

ProteinModelPortaliQ90ZK6
SMRiQ90ZK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 202GSPROSITE-ProRule annotationAdd BLAST30
Domaini203 – 497Protein kinasePROSITE-ProRule annotationAdd BLAST295

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2052 Eukaryota
ENOG410XQT0 LUCA
GeneTreeiENSGT00760000118876
HOGENOMiHOG000230587
HOVERGENiHBG054502
InParanoidiQ90ZK6
KOiK04675
OMAiGHLCNMN
OrthoDBiEOG091G0BIU
PhylomeDBiQ90ZK6

Family and domain databases

InterProiView protein in InterPro
IPR003605 GS_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
IPR000333 TGFB_receptor
PANTHERiPTHR23255 PTHR23255, 1 hit
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF08515 TGF_beta_GS, 1 hit
PRINTSiPR00653 ACTIVIN2R
SMARTiView protein in SMART
SM00467 GS, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51256 GS, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90ZK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPVLLLLL ALPSRSVQDE ELKLNECVCE GMSCGNGDRC QGQQCFASLS
60 70 80 90 100
INDGAKVYQK GCFQVYEQGK MTCKTPPSPD QAVECCQGYL CNMNITAKLP
110 120 130 140 150
SSKGQTLQGE AAGYSMETLI IVILAPVVVL VIFSVVAVLI IRRIQKNHME
160 170 180 190 200
RLNSRDAEYG TIEGLIASNV GDSTLADLLD HSCTSGSGSG LPFLVQRTVA
210 220 230 240 250
RQITLVECVG KGRYGEVWRG QWQGENVAVK IFSSRDEKSW FRETELYNTV
260 270 280 290 300
LLRHENILGF IASDMTSRNS STQLWLITHY HEMGSLYDYL QLTTLDTVSC
310 320 330 340 350
LRIVLSIASG LAHLHIEIFG TQGKPAISHR DLKSKNILVK KNGQCCIADL
360 370 380 390 400
GLAVMHSQST NQLDVGNNPR VGTKRYMAPE VLDETIQADC FDSYKRVDIW
410 420 430 440 450
AFGLVLWEVA RRMVSNGIVE DYKPPFYDLV PNDPSFEDMR KVVCVDQQRP
460 470 480 490 500
NIPNRWFSDP TLTSLAKLMK ECWYQNPSAR LTALRIKKTL TKIDNSLDKL

KADC
Length:504
Mass (Da):56,225
Last modified:December 1, 2001 - v1
Checksum:iC7F045D6A25A071E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti211 – 212KG → SN in AAC98806 (Ref. 2) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38622 mRNA Translation: AAC98806.1
AJ318064 mRNA Translation: CAC39433.1
RefSeqiNP_989891.1, NM_204560.1
XP_015145616.1, XM_015290130.1
XP_015145617.1, XM_015290131.1
XP_015145618.1, XM_015290132.1
XP_015145619.1, XM_015290133.1
XP_015145620.1, XM_015290134.1
UniGeneiGga.2875

Genome annotation databases

EnsembliENSGALT00000085664; ENSGALP00000064312; ENSGALG00000037301
GeneIDi395246
KEGGigga:395246

Similar proteinsi

Entry informationi

Entry nameiACVR1_CHICK
AccessioniPrimary (citable) accession number: Q90ZK6
Secondary accession number(s): Q9YH45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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