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Protein

Activin receptor type-1

Gene

ACVR1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin (By similarity).By similarity

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei230ATPPROSITE-ProRule annotation1
Active sitei331Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi209 – 217ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-1 (EC:2.7.11.30)
Alternative name(s):
Activin receptor type I
Type I TGF B receptor
Gene namesi
Name:ACVR1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 119ExtracellularSequence analysisAdd BLAST103
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 504CytoplasmicSequence analysisAdd BLAST364

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000025359317 – 504Activin receptor type-1Add BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi94N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ90ZK6.

Expressioni

Gene expression databases

BgeeiENSGALG00000012551.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020469.

Structurei

3D structure databases

ProteinModelPortaliQ90ZK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 202GSPROSITE-ProRule annotationAdd BLAST30
Domaini203 – 497Protein kinasePROSITE-ProRule annotationAdd BLAST295

Sequence similaritiesi

Contains 1 GS domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2052. Eukaryota.
ENOG410XQT0. LUCA.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiQ90ZK6.
KOiK04675.
OMAiGHLCNMN.
OrthoDBiEOG091G0BIU.
PhylomeDBiQ90ZK6.

Family and domain databases

InterProiIPR003605. GS_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00467. GS. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90ZK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPVLLLLL ALPSRSVQDE ELKLNECVCE GMSCGNGDRC QGQQCFASLS
60 70 80 90 100
INDGAKVYQK GCFQVYEQGK MTCKTPPSPD QAVECCQGYL CNMNITAKLP
110 120 130 140 150
SSKGQTLQGE AAGYSMETLI IVILAPVVVL VIFSVVAVLI IRRIQKNHME
160 170 180 190 200
RLNSRDAEYG TIEGLIASNV GDSTLADLLD HSCTSGSGSG LPFLVQRTVA
210 220 230 240 250
RQITLVECVG KGRYGEVWRG QWQGENVAVK IFSSRDEKSW FRETELYNTV
260 270 280 290 300
LLRHENILGF IASDMTSRNS STQLWLITHY HEMGSLYDYL QLTTLDTVSC
310 320 330 340 350
LRIVLSIASG LAHLHIEIFG TQGKPAISHR DLKSKNILVK KNGQCCIADL
360 370 380 390 400
GLAVMHSQST NQLDVGNNPR VGTKRYMAPE VLDETIQADC FDSYKRVDIW
410 420 430 440 450
AFGLVLWEVA RRMVSNGIVE DYKPPFYDLV PNDPSFEDMR KVVCVDQQRP
460 470 480 490 500
NIPNRWFSDP TLTSLAKLMK ECWYQNPSAR LTALRIKKTL TKIDNSLDKL

KADC
Length:504
Mass (Da):56,225
Last modified:December 1, 2001 - v1
Checksum:iC7F045D6A25A071E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti211 – 212KG → SN in AAC98806 (Ref. 2) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38622 mRNA. Translation: AAC98806.1.
AJ318064 mRNA. Translation: CAC39433.1.
RefSeqiNP_989891.1. NM_204560.1.
XP_015145616.1. XM_015290130.1.
XP_015145617.1. XM_015290131.1.
XP_015145618.1. XM_015290132.1.
XP_015145619.1. XM_015290133.1.
XP_015145620.1. XM_015290134.1.
UniGeneiGga.2875.

Genome annotation databases

GeneIDi395246.
KEGGigga:395246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38622 mRNA. Translation: AAC98806.1.
AJ318064 mRNA. Translation: CAC39433.1.
RefSeqiNP_989891.1. NM_204560.1.
XP_015145616.1. XM_015290130.1.
XP_015145617.1. XM_015290131.1.
XP_015145618.1. XM_015290132.1.
XP_015145619.1. XM_015290133.1.
XP_015145620.1. XM_015290134.1.
UniGeneiGga.2875.

3D structure databases

ProteinModelPortaliQ90ZK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020469.

Proteomic databases

PaxDbiQ90ZK6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395246.
KEGGigga:395246.

Organism-specific databases

CTDi395246.

Phylogenomic databases

eggNOGiKOG2052. Eukaryota.
ENOG410XQT0. LUCA.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiQ90ZK6.
KOiK04675.
OMAiGHLCNMN.
OrthoDBiEOG091G0BIU.
PhylomeDBiQ90ZK6.

Miscellaneous databases

PROiQ90ZK6.

Gene expression databases

BgeeiENSGALG00000012551.

Family and domain databases

InterProiIPR003605. GS_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00467. GS. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACVR1_CHICK
AccessioniPrimary (citable) accession number: Q90ZK6
Secondary accession number(s): Q9YH45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.