Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chordin-like protein 1

Gene

CHRDL1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors.1 Publication

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Chordin-like protein 1
Alternative name(s):
Neuralin-1
Neurogenesin-1
Ventroptin
Gene namesi
Name:CHRDL1
Synonyms:NRLN1, VOPT
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 456428Chordin-like protein 1PRO_0000005370Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ90ZD5.

Expressioni

Tissue specificityi

Mainly expressed in the ventral retina.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013090.

Structurei

3D structure databases

ProteinModelPortaliQ90ZD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 10166VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini115 – 18167VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini262 – 32766VWFC 3PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi181 – 1833Cell attachment siteSequence Analysis

Sequence similaritiesi

Contains 3 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG147797.
HOGENOMiHOG000049211.
HOVERGENiHBG051113.
InParanoidiQ90ZD5.
PhylomeDBiQ90ZD5.

Family and domain databases

InterProiIPR030114. Chordin-like_1.
IPR001007. VWF_C.
[Graphical view]
PANTHERiPTHR11339:SF249. PTHR11339:SF249. 1 hit.
PfamiPF00093. VWC. 3 hits.
[Graphical view]
SMARTiSM00214. VWC. 3 hits.
[Graphical view]
PROSITEiPS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90ZD5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRKWRSEDF HFVFFGVLCL LLIDRGKLEQ VKHSDTYCVF QDKKYRVGER
60 70 80 90 100
WHPYLEPYGL VYCVNCLCSE NGNVLCSRIR CPSLHCPSPV HVPQLCCPRC
110 120 130 140 150
PEDSLFSVSS KITGKSCEYN GTTYHHGEMF VAEGLFQNRQ ANQCAQCSCS
160 170 180 190 200
EGNVYCGLKT CPKLTCSFPV SVPESCCPVC RGDGELSWEQ ADGDIFRQPA
210 220 230 240 250
NREARHSYHR PHYELSPSST RQVVNVPRFP SARSNRGVLP DPQQASGTIV
260 270 280 290 300
QIVINNKHKH GRVCVSNGKT YSHGESWHPN LRAFGIVECV LCTCNITKQE
310 320 330 340 350
CKKIHCPEQY PCKYPQKVEG KCCKVCPEEV PSQSFDNKDY FCGKETFPVY
360 370 380 390 400
ESIFTEEGET IRKIAVETEK PPQIEIHVWT IRKGILRHFY IEKMSKREFE
410 420 430 440 450
ELPYFKQITR TTSSQWKIFS EGEAQISQMC ESRVCRTELE DLVKVLYLEK

SEKGHC
Length:456
Mass (Da):52,399
Last modified:December 1, 2001 - v1
Checksum:iD54F6685F3839BC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257352 mRNA. Translation: AAK73359.1.
RefSeqiNP_989502.1. NM_204171.1.
UniGeneiGga.3037.

Genome annotation databases

GeneIDi373985.
KEGGigga:373985.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257352 mRNA. Translation: AAK73359.1.
RefSeqiNP_989502.1. NM_204171.1.
UniGeneiGga.3037.

3D structure databases

ProteinModelPortaliQ90ZD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013090.

Proteomic databases

PaxDbiQ90ZD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373985.
KEGGigga:373985.

Organism-specific databases

CTDi91851.

Phylogenomic databases

eggNOGiNOG147797.
HOGENOMiHOG000049211.
HOVERGENiHBG051113.
InParanoidiQ90ZD5.
PhylomeDBiQ90ZD5.

Miscellaneous databases

NextBioi20813514.
PROiQ90ZD5.

Family and domain databases

InterProiIPR030114. Chordin-like_1.
IPR001007. VWF_C.
[Graphical view]
PANTHERiPTHR11339:SF249. PTHR11339:SF249. 1 hit.
PfamiPF00093. VWC. 3 hits.
[Graphical view]
SMARTiSM00214. VWC. 3 hits.
[Graphical view]
PROSITEiPS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Ventroptin: a BMP-4 antagonist expressed in a double-gradient pattern in the retina."
    Sakuta H., Suzuki R., Takahashi H., Kato A., Shintani T., Iemura S., Yamamoto T.S., Ueno N., Noda M.
    Science 293:111-115(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, FUNCTION.

Entry informationi

Entry nameiCRDL1_CHICK
AccessioniPrimary (citable) accession number: Q90ZD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: December 1, 2001
Last modified: February 4, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.