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Q90ZD5

- CRDL1_CHICK

UniProt

Q90ZD5 - CRDL1_CHICK

Protein

Chordin-like protein 1

Gene

CHRDL1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors.1 Publication

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chordin-like protein 1
    Alternative name(s):
    Neuralin-1
    Neurogenesin-1
    Ventroptin
    Gene namesi
    Name:CHRDL1
    Synonyms:NRLN1, VOPT
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 456428Chordin-like protein 1PRO_0000005370Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ90ZD5.

    Expressioni

    Tissue specificityi

    Mainly expressed in the ventral retina.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000013090.

    Structurei

    3D structure databases

    ProteinModelPortaliQ90ZD5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 10166VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini115 – 18167VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini262 – 32766VWFC 3PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi181 – 1833Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Contains 3 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG147797.
    HOGENOMiHOG000049211.
    HOVERGENiHBG051113.
    InParanoidiQ90ZD5.
    PhylomeDBiQ90ZD5.

    Family and domain databases

    InterProiIPR001007. VWF_C.
    [Graphical view]
    PfamiPF00093. VWC. 3 hits.
    [Graphical view]
    SMARTiSM00214. VWC. 3 hits.
    [Graphical view]
    PROSITEiPS01208. VWFC_1. 3 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q90ZD5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRKWRSEDF HFVFFGVLCL LLIDRGKLEQ VKHSDTYCVF QDKKYRVGER    50
    WHPYLEPYGL VYCVNCLCSE NGNVLCSRIR CPSLHCPSPV HVPQLCCPRC 100
    PEDSLFSVSS KITGKSCEYN GTTYHHGEMF VAEGLFQNRQ ANQCAQCSCS 150
    EGNVYCGLKT CPKLTCSFPV SVPESCCPVC RGDGELSWEQ ADGDIFRQPA 200
    NREARHSYHR PHYELSPSST RQVVNVPRFP SARSNRGVLP DPQQASGTIV 250
    QIVINNKHKH GRVCVSNGKT YSHGESWHPN LRAFGIVECV LCTCNITKQE 300
    CKKIHCPEQY PCKYPQKVEG KCCKVCPEEV PSQSFDNKDY FCGKETFPVY 350
    ESIFTEEGET IRKIAVETEK PPQIEIHVWT IRKGILRHFY IEKMSKREFE 400
    ELPYFKQITR TTSSQWKIFS EGEAQISQMC ESRVCRTELE DLVKVLYLEK 450
    SEKGHC 456
    Length:456
    Mass (Da):52,399
    Last modified:December 1, 2001 - v1
    Checksum:iD54F6685F3839BC6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF257352 mRNA. Translation: AAK73359.1.
    RefSeqiNP_989502.1. NM_204171.1.
    UniGeneiGga.3037.

    Genome annotation databases

    GeneIDi373985.
    KEGGigga:373985.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF257352 mRNA. Translation: AAK73359.1 .
    RefSeqi NP_989502.1. NM_204171.1.
    UniGenei Gga.3037.

    3D structure databases

    ProteinModelPortali Q90ZD5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000013090.

    Proteomic databases

    PaxDbi Q90ZD5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 373985.
    KEGGi gga:373985.

    Organism-specific databases

    CTDi 91851.

    Phylogenomic databases

    eggNOGi NOG147797.
    HOGENOMi HOG000049211.
    HOVERGENi HBG051113.
    InParanoidi Q90ZD5.
    PhylomeDBi Q90ZD5.

    Miscellaneous databases

    NextBioi 20813514.
    PROi Q90ZD5.

    Family and domain databases

    InterProi IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00093. VWC. 3 hits.
    [Graphical view ]
    SMARTi SM00214. VWC. 3 hits.
    [Graphical view ]
    PROSITEi PS01208. VWFC_1. 3 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ventroptin: a BMP-4 antagonist expressed in a double-gradient pattern in the retina."
      Sakuta H., Suzuki R., Takahashi H., Kato A., Shintani T., Iemura S., Yamamoto T.S., Ueno N., Noda M.
      Science 293:111-115(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, FUNCTION.

    Entry informationi

    Entry nameiCRDL1_CHICK
    AccessioniPrimary (citable) accession number: Q90ZD5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 17, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3