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Q90ZD5 (CRDL1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chordin-like protein 1
Alternative name(s):
Neuralin-1
Neurogenesin-1
Ventroptin
Gene names
Name:CHRDL1
Synonyms:NRLN1, VOPT
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length456 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Ref.1

Subcellular location

Secreted Ref.1.

Tissue specificity

Mainly expressed in the ventral retina.

Sequence similarities

Contains 3 VWFC domains.

Ontologies

Keywords
   Cellular componentSecreted
   DomainRepeat
Signal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 456428Chordin-like protein 1
PRO_0000005370

Regions

Domain36 – 10166VWFC 1
Domain115 – 18167VWFC 2
Domain262 – 32766VWFC 3
Motif181 – 1833Cell attachment site Potential

Amino acid modifications

Glycosylation1201N-linked (GlcNAc...) Potential
Glycosylation2951N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q90ZD5 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: D54F6685F3839BC6

FASTA45652,399
        10         20         30         40         50         60 
MRRKWRSEDF HFVFFGVLCL LLIDRGKLEQ VKHSDTYCVF QDKKYRVGER WHPYLEPYGL 

        70         80         90        100        110        120 
VYCVNCLCSE NGNVLCSRIR CPSLHCPSPV HVPQLCCPRC PEDSLFSVSS KITGKSCEYN 

       130        140        150        160        170        180 
GTTYHHGEMF VAEGLFQNRQ ANQCAQCSCS EGNVYCGLKT CPKLTCSFPV SVPESCCPVC 

       190        200        210        220        230        240 
RGDGELSWEQ ADGDIFRQPA NREARHSYHR PHYELSPSST RQVVNVPRFP SARSNRGVLP 

       250        260        270        280        290        300 
DPQQASGTIV QIVINNKHKH GRVCVSNGKT YSHGESWHPN LRAFGIVECV LCTCNITKQE 

       310        320        330        340        350        360 
CKKIHCPEQY PCKYPQKVEG KCCKVCPEEV PSQSFDNKDY FCGKETFPVY ESIFTEEGET 

       370        380        390        400        410        420 
IRKIAVETEK PPQIEIHVWT IRKGILRHFY IEKMSKREFE ELPYFKQITR TTSSQWKIFS 

       430        440        450 
EGEAQISQMC ESRVCRTELE DLVKVLYLEK SEKGHC

« Hide

References

[1]"Ventroptin: a BMP-4 antagonist expressed in a double-gradient pattern in the retina."
Sakuta H., Suzuki R., Takahashi H., Kato A., Shintani T., Iemura S., Yamamoto T.S., Ueno N., Noda M.
Science 293:111-115(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF257352 mRNA. Translation: AAK73359.1.
IPIIPI00599980.
RefSeqNP_989502.1. NM_204171.1.
UniGeneGga.3037.

3D structure databases

ProteinModelPortalQ90ZD5.
ModBaseSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000013090.

Proteomic databases

PaxDbQ90ZD5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID373985.
KEGGgga:373985.

Organism-specific databases

CTD91851.

Phylogenomic databases

eggNOGNOG147797.
HOGENOMHOG000049211.
HOVERGENHBG051113.
InParanoidQ90ZD5.
OrthoDBEOG46Q6SD.

Family and domain databases

InterProIPR001007. VWF_C.
[Graphical view]
PfamPF00093. VWC. 3 hits.
[Graphical view]
SMARTSM00214. VWC. 3 hits.
[Graphical view]
PROSITEPS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20813514.

Entry information

Entry nameCRDL1_CHICK
AccessionPrimary (citable) accession number: Q90ZD5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: December 1, 2001
Last modified: April 3, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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