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Protein
Submitted name:

Bcl-XL-like protein 1

Gene

bcl2l1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • negative regulation of apoptotic process Source: ZFIN
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: ZFIN
  • negative regulation of intrinsic apoptotic signaling pathway Source: ZFIN
  • thyroid gland development Source: ZFIN
  • tissue homeostasis Source: ZFIN
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DRE-111453. BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.
R-DRE-844455. The NLRP1 inflammasome.

Names & Taxonomyi

Protein namesi
Submitted name:
Bcl-XL-like protein 1Imported
Submitted name:
Bcl-xL-like protein 1Imported
Submitted name:
Bcl2l proteinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:bcl2l1Imported
Synonyms:bcl2lImported, blp1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 23

Organism-specific databases

ZFINiZDB-GENE-010730-1. bcl2l1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei216 – 23419HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000119990.

Structurei

3D structure databases

SMRiQ90Z98. Positions 79-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 2218BH4_2InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
GeneTreeiENSGT00530000062935.
HOGENOMiHOG000056452.
HOVERGENiHBG004472.
KOiK04570.
OMAiNGSPSWH.
OrthoDBiEOG70GMGD.
PhylomeDBiQ90Z98.
TreeFamiTF315834.

Family and domain databases

InterProiIPR013279. Apop_reg_BclX.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR003093. Bcl2_BH4.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF12. PTHR11256:SF12. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
PF02180. BH4. 1 hit.
[Graphical view]
PRINTSiPR01864. APOPREGBCLX.
PR01862. BCL2FAMILY.
SMARTiSM00265. BH4. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS50063. BH4_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90Z98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYYNRELVV FFIKYKLSQR NYPCNHIGLT EDTNRTDGAE ENGEGAAGAT
60 70 80 90 100
TLVNGTMNRT NASSTGTPPQ SPASSPQRQT NGSGGLDAVK EALRDSANEF
110 120 130 140 150
ELRYSRAFND LSSQLHITPA TAYQSFESVM DEVFRDGVNW GRIVGLFAFG
160 170 180 190 200
GALCVECVEK EMSPLVGRIA EWMTVYLDNH IQPWIQSQGG WERFAEIFGK
210 220 230
DAAAESRKSQ ESFKKWLFAG MTLLTGVVVG GLIAQKRL
Length:238
Mass (Da):26,253
Last modified:December 1, 2001 - v1
Checksum:i6E58394933EEFDDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR788311 Genomic DNA. No translation available.
BC044130 mRNA. Translation: AAH44130.1.
BC071291 mRNA. Translation: AAH71291.1.
BC165156 mRNA. Translation: AAI65156.1.
AF317837 mRNA. Translation: AAK81706.1.
DQ022560 mRNA. Translation: AAY43152.1.
RefSeqiNP_571882.1. NM_131807.1.
XP_005162083.1. XM_005162026.2.
UniGeneiDr.79623.

Genome annotation databases

EnsembliENSDART00000012507; ENSDARP00000027919; ENSDARG00000008434.
ENSDART00000147617; ENSDARP00000119990; ENSDARG00000008434.
GeneIDi114401.
KEGGidre:114401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR788311 Genomic DNA. No translation available.
BC044130 mRNA. Translation: AAH44130.1.
BC071291 mRNA. Translation: AAH71291.1.
BC165156 mRNA. Translation: AAI65156.1.
AF317837 mRNA. Translation: AAK81706.1.
DQ022560 mRNA. Translation: AAY43152.1.
RefSeqiNP_571882.1. NM_131807.1.
XP_005162083.1. XM_005162026.2.
UniGeneiDr.79623.

3D structure databases

SMRiQ90Z98. Positions 79-203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000119990.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000012507; ENSDARP00000027919; ENSDARG00000008434.
ENSDART00000147617; ENSDARP00000119990; ENSDARG00000008434.
GeneIDi114401.
KEGGidre:114401.

Organism-specific databases

CTDi598.
ZFINiZDB-GENE-010730-1. bcl2l1.

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
GeneTreeiENSGT00530000062935.
HOGENOMiHOG000056452.
HOVERGENiHBG004472.
KOiK04570.
OMAiNGSPSWH.
OrthoDBiEOG70GMGD.
PhylomeDBiQ90Z98.
TreeFamiTF315834.

Enzyme and pathway databases

ReactomeiR-DRE-111453. BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.
R-DRE-844455. The NLRP1 inflammasome.

Family and domain databases

InterProiIPR013279. Apop_reg_BclX.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR003093. Bcl2_BH4.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF12. PTHR11256:SF12. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
PF02180. BH4. 1 hit.
[Graphical view]
PRINTSiPR01864. APOPREGBCLX.
PR01862. BCL2FAMILY.
SMARTiSM00265. BH4. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS50063. BH4_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of zfBLP1, a Bcl-XL homologue from the zebrafish, Danio rerio."
    Chen M.C., Gong H.Y., Cheng C.Y., Wang J.P., Hong J.R., Wu J.L.
    Biochim. Biophys. Acta 1519:127-133(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: ABImported.
    Tissue: Whole bodyImported.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EmbryoImported.
  4. "Splicing isoform of Bcl-XL-like protein 1."
    Takahashi N., Dawid I.B.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ABImported.
  5. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescueImported.
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  7. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ90Z98_DANRE
AccessioniPrimary (citable) accession number: Q90Z98
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.