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Protein
Submitted name:

Bcl-XL-like protein 1

Gene

bcl2l1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
  • negative regulation of apoptotic process Source: ZFIN
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: ZFIN
  • negative regulation of intrinsic apoptotic signaling pathway Source: ZFIN
  • thyroid gland development Source: ZFIN
  • tissue homeostasis Source: ZFIN

Keywordsi

Biological processApoptosisPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-DRE-844455 The NLRP1 inflammasome

Names & Taxonomyi

Protein namesi
Submitted name:
Bcl-XL-like protein 1Imported
Submitted name:
Bcl2-like 1Imported
Submitted name:
Bcl2l proteinImported
Gene namesi
Name:bcl2l1Imported
Synonyms:bcl2lImported, blp1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 23

Organism-specific databases

ZFINiZDB-GENE-010730-1 bcl2l1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei216 – 234HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSDARG00000008434

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000119990

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 22BH4_2InterPro annotationAdd BLAST18

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 22BH4PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4728 Eukaryota
ENOG41123S0 LUCA
GeneTreeiENSGT00530000062935
HOGENOMiHOG000056452
HOVERGENiHBG004472
KOiK04570
OMAiNGSPSWH
OrthoDBiEOG091G0OCU
TreeFamiTF315834

Family and domain databases

InterProiView protein in InterPro
IPR013279 Apop_reg_BclX
IPR002475 Bcl2-like
IPR020717 Bcl2_BH1_motif_CS
IPR003093 Bcl2_BH4
IPR036834 Blc2-like_sf
IPR026298 Blc2_fam
PANTHERiPTHR11256 PTHR11256, 1 hit
PTHR11256:SF12 PTHR11256:SF12, 1 hit
PfamiView protein in Pfam
PF00452 Bcl-2, 1 hit
PF02180 BH4, 1 hit
PRINTSiPR01864 APOPREGBCLX
PR01862 BCL2FAMILY
SMARTiView protein in SMART
SM00265 BH4, 1 hit
SUPFAMiSSF56854 SSF56854, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit
PS01080 BH1, 1 hit
PS50063 BH4_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q90Z98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYYNRELVV FFIKYKLSQR NYPCNHIGLT EDTNRTDGAE ENGEGAAGAT
60 70 80 90 100
TLVNGTMNRT NASSTGTPPQ SPASSPQRQT NGSGGLDAVK EALRDSANEF
110 120 130 140 150
ELRYSRAFND LSSQLHITPA TAYQSFESVM DEVFRDGVNW GRIVGLFAFG
160 170 180 190 200
GALCVECVEK EMSPLVGRIA EWMTVYLDNH IQPWIQSQGG WERFAEIFGK
210 220 230
DAAAESRKSQ ESFKKWLFAG MTLLTGVVVG GLIAQKRL
Length:238
Mass (Da):26,253
Last modified:December 1, 2001 - v1
Checksum:i6E58394933EEFDDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR788311 Genomic DNA No translation available.
BC044130 mRNA Translation: AAH44130.1
BC071291 mRNA Translation: AAH71291.1
BC165156 mRNA Translation: AAI65156.1
AF317837 mRNA Translation: AAK81706.1
DQ022560 mRNA Translation: AAY43152.1
RefSeqiNP_571882.1, NM_131807.1
XP_005162083.1, XM_005162026.3
UniGeneiDr.79623

Genome annotation databases

EnsembliENSDART00000012507; ENSDARP00000027919; ENSDARG00000008434
ENSDART00000147617; ENSDARP00000119990; ENSDARG00000008434
GeneIDi114401
KEGGidre:114401

Similar proteinsi

Entry informationi

Entry nameiQ90Z98_DANRE
AccessioniPrimary (citable) accession number: Q90Z98
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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