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Protein
Submitted name:

E-cadherin

Gene

cdh1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins.UniRule annotation

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • G-protein alpha-subunit binding Source: ZFIN

GO - Biological processi

  • adherens junction maintenance Source: ZFIN
  • cell adhesion Source: ZFIN
  • cell-cell adhesion involved in gastrulation Source: ZFIN
  • cell-cell adhesion involved in mesendodermal cell migration Source: ZFIN
  • cell migration involved in gastrulation Source: ZFIN
  • ectoderm development Source: ZFIN
  • epiboly involved in gastrulation with mouth forming second Source: ZFIN
  • gastrulation with mouth forming second Source: ZFIN
  • germ cell migration Source: ZFIN
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • neural tube formation Source: ZFIN
  • neuron migration Source: ZFIN
  • single organismal cell-cell adhesion Source: ZFIN
Complete GO annotation...

Keywords - Biological processi

Cell adhesionUniRule annotationSAAS annotation

Keywords - Ligandi

CalciumUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
E-cadherinImported
Gene namesi
Name:cdh1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-010606-1. cdh1.

Subcellular locationi

  • Cell membrane UniRule annotationSAAS annotation; Single-pass type I membrane protein UniRule annotationSAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei690 – 71425HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • catenin complex Source: ZFIN
  • cell-cell adherens junction Source: ZFIN
  • cell cortex Source: ZFIN
  • integral component of membrane Source: ZFIN
  • membrane Source: ZFIN
  • microvillus Source: ZFIN
  • plasma membrane Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 864842Sequence analysisPRO_5004319141Add
BLAST

Proteomic databases

PaxDbiQ90Z37.
PRIDEiQ90Z37.

Interactioni

GO - Molecular functioni

  • G-protein alpha-subunit binding Source: ZFIN

Protein-protein interaction databases

STRINGi7955.ENSDARP00000088490.

Structurei

3D structure databases

ProteinModelPortaliQ90Z37.
SMRiQ90Z37. Positions 143-353, 765-859.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini147 – 248102CadherinInterPro annotationAdd
BLAST
Domaini249 – 361113CadherinInterPro annotationAdd
BLAST
Domaini362 – 473112CadherinInterPro annotationAdd
BLAST
Domaini474 – 581108CadherinInterPro annotationAdd
BLAST

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
KOiK05689.
PhylomeDBiQ90Z37.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 4 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90Z37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACVTTVGLG VIFFLFRVFS SGYTHMSICT PGFELEEFVF KVHRNHLHSG
60 70 80 90 100
KRLGKVTFNN CDGRTRTLFQ SIDKRFEINT DGTVTLKRQV TLHEGHKVFS
110 120 130 140 150
VHAWDSSGMK HTASVRVERV PAQVESSSDV DLTKNKRVKR GWIIPPISVS
160 170 180 190 200
ENSKGPFPMR LVQIKSDYAI ETRLAYKITG EGADLDPKGI FTIDRLSGWV
210 220 230 240 250
SVTQLLDREK KASYKLRAHA NGVDADVTEK PMDIIVTVTD QNDNKPVFTQ
260 270 280 290 300
NPFNGNVPEA LEKGEVFMTV TATDADDKEN TDNADISYVI ISQDPPSPKP
310 320 330 340 350
NMFAINPVSG GISVLEKGLD REQWFRYTLV ITATDMNGEG LSTTGTAVIT
360 370 380 390 400
VTDSNDNAPL FEQSSYTASV PENQVGVEVA KLPVTDGDEP ESTAWSTKYQ
410 420 430 440 450
IIAGDKGGFF NISTGPSRLE GIITTVKPLD YEKTKQYILS VIVVNDDKFV
460 470 480 490 500
GPLPTSTATV TVNVKDVNEP PEFIPKEKFI SRPENLPVGS NLIPFTAIDP
510 520 530 540 550
DTEKKQNITY RIGNDPSDWL NITGSGQIQV KNALDRESSN VKDGKYKALI
560 570 580 590 600
LALDNDVESP ATGTGTLVIE LQDVNDNAPV INERTIKLCN RESAPVLLSI
610 620 630 640 650
TDKDLPPFAG PFKVEPQGDT SKNWSVFFNE TGHFLNIKPQ SQLEQGEYKV
660 670 680 690 700
VLRVADREGE SQENIIQASV CDCKGEAFQC TDKQVAGIPL FGVLGVLGGI
710 720 730 740 750
LLLLLLALLL LMFLRRKSNS KKEPLLPEDD VRDNIYYYDE EGGGEDDQDF
760 770 780 790 800
DLSVLHRGLD NRPEVFRNDV APTFMPAPQY RPRPANPEEI GTFIDDNLKA
810 820 830 840 850
ADNDPTAPPY DSLLVFDYEG GGSDAGSLSS LNTSSSGNDQ DYDFLNEWGP
860
RFKKLADMYG GGED
Length:864
Mass (Da):95,255
Last modified:December 1, 2001 - v1
Checksum:i5ACA19538396397C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF364811 mRNA. Translation: AAK52054.1.
RefSeqiNP_571895.1. NM_131820.1.
UniGeneiDr.78411.

Genome annotation databases

GeneIDi114424.
KEGGidre:114424.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF364811 mRNA. Translation: AAK52054.1.
RefSeqiNP_571895.1. NM_131820.1.
UniGeneiDr.78411.

3D structure databases

ProteinModelPortaliQ90Z37.
SMRiQ90Z37. Positions 143-353, 765-859.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000088490.

Proteomic databases

PaxDbiQ90Z37.
PRIDEiQ90Z37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi114424.
KEGGidre:114424.

Organism-specific databases

CTDi999.
ZFINiZDB-GENE-010606-1. cdh1.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
KOiK05689.
PhylomeDBiQ90Z37.

Miscellaneous databases

NextBioi20796912.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 4 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Zebrafish E-cadherin: expression during early embryogenesis and regulation during brain development."
    Babb S.G., Barnett J., Doedens A.L., Cobb N., Liu Q., Sorkin B.C., Yelick P.C., Raymond P.A., Marrs J.A.
    Dev. Dyn. 221:231-237(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ90Z37_DANRE
AccessioniPrimary (citable) accession number: Q90Z37
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.