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Protein

Optineurin

Gene

OPTN

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy

Enzyme and pathway databases

ReactomeiREACT_278743. Regulation of PLK1 Activity at G2/M Transition.

Names & Taxonomyi

Protein namesi
Recommended name:
Optineurin
Alternative name(s):
Ag9-C5
FIP-2
Gene namesi
Name:OPTN
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556OptineurinPRO_0000058065Add
BLAST

Proteomic databases

PaxDbiQ90Z16.
PRIDEiQ90Z16.

Expressioni

Tissue specificityi

Expressed in erythrocytes, skeletal muscle, heart, spleen and brain. Weakly expressed in lung and liver (at protein level).2 Publications

Interactioni

Subunit structurei

Binds to linear ubiquitin chains. Interacts with LC3 family members (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022287.

Structurei

3D structure databases

ProteinModelPortaliQ90Z16.
SMRiQ90Z16. Positions 530-556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili38 – 164127Sequence AnalysisAdd
BLAST
Coiled coili219 – 487269Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi168 – 1736LIR
Motifi453 – 4586UBAN

Domaini

The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins.By similarity
Ubiquitin-binding motif (UBAN) is essential for its inhibitory function, subcellular localization and interaction with TBK1.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG138369.
GeneTreeiENSGT00530000063808.
HOGENOMiHOG000231899.
HOVERGENiHBG106481.
InParanoidiQ90Z16.
OMAiEDLETMT.
PhylomeDBiQ90Z16.

Family and domain databases

InterProiIPR021063. NEMO_N.
[Graphical view]
PfamiPF11577. NEMO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90Z16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKPQIRPA ENGEHCRSKM ENGMDSMAPP TLSTYTPEEM VQQMKELITE
60 70 80 90 100
NNELKEAMKL HNQAMKDRYE ELSIWREKQK EEREFYETKF KEAKQCLLAK
110 120 130 140 150
CVENEQLQQQ LQSLKEREEG AEMEGCATPE KEARQLKSKV QRLQAEKADL
160 170 180 190 200
LAIISELQVK LNIASAEDSF VEIGMNEEVN RTARENQDNS SEMASNIAVY
210 220 230 240 250
IRSKSADESK NLESEELTVS QLLCCLRNET QRREKLEKEL QDHKERLSKM
260 270 280 290 300
ENETSNCLES GTQTNQEEES SEAIGSEVES LKKQICALFK ELQEAHEKLK
310 320 330 340 350
EAELIQKKLQ EKCQTLEKVN SAAATELEEK QQLIYTIKKL ELQVESVQAE
360 370 380 390 400
VKLEQAKTQD EKTRYSSLQD AYNKLLAELT EAMKTISEMK VKEHDRVDKV
410 420 430 440 450
VVEELNAKVL LAEQALAAKQ LQMDEMKQLI AKQEEDLETM AVLRAQMEVY
460 470 480 490 500
CSDFHAERAA REKIHEEKEQ LAVQLAYLLK EQQNLEDLGR SSLAEMQNRH
510 520 530 540 550
GARAPDREHS PRLVQRGTGS QEWPEQRNIS IYSCPKCEEI LPDLDTLQIH

VMDCIN
Length:556
Mass (Da):64,087
Last modified:December 1, 2001 - v1
Checksum:i77CDD7F750D01F8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380358 mRNA. Translation: AAK69306.1.
AF389351 mRNA. Translation: AAM73640.1.
RefSeqiNP_989567.1. NM_204236.1.
UniGeneiGga.4189.

Genome annotation databases

EnsembliENSGALT00000022327; ENSGALP00000022287; ENSGALG00000013738.
GeneIDi374079.
KEGGigga:374079.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380358 mRNA. Translation: AAK69306.1.
AF389351 mRNA. Translation: AAM73640.1.
RefSeqiNP_989567.1. NM_204236.1.
UniGeneiGga.4189.

3D structure databases

ProteinModelPortaliQ90Z16.
SMRiQ90Z16. Positions 530-556.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022287.

Proteomic databases

PaxDbiQ90Z16.
PRIDEiQ90Z16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000022327; ENSGALP00000022287; ENSGALG00000013738.
GeneIDi374079.
KEGGigga:374079.

Organism-specific databases

CTDi10133.

Phylogenomic databases

eggNOGiNOG138369.
GeneTreeiENSGT00530000063808.
HOGENOMiHOG000231899.
HOVERGENiHBG106481.
InParanoidiQ90Z16.
OMAiEDLETMT.
PhylomeDBiQ90Z16.

Enzyme and pathway databases

ReactomeiREACT_278743. Regulation of PLK1 Activity at G2/M Transition.

Miscellaneous databases

NextBioi20813600.
PROiQ90Z16.

Family and domain databases

InterProiIPR021063. NEMO_N.
[Graphical view]
PfamiPF11577. NEMO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Differential localization of chicken FIP2 homologue, Ag-9C5, in secretory epithelial cells."
    Li B., Gallin W.J.
    Exp. Cell Res. 272:135-145(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "FIP-2, an IkappaB-kinase-gamma-related protein, is associated with the Golgi apparatus and translocates to the marginal band during chicken erythroblast differentiation."
    Stroissnigg H., Repitz M., Miloloza A., Linhartova I., Beug H., Wiche G., Propst F.
    Exp. Cell Res. 278:133-145(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiOPTN_CHICK
AccessioniPrimary (citable) accession number: Q90Z16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 1, 2001
Last modified: July 22, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.