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Q90Z16

- OPTN_CHICK

UniProt

Q90Z16 - OPTN_CHICK

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Protein
Optineurin
Gene
OPTN
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis.2 Publications

GO - Biological processi

  1. Golgi ribbon formation Source: Ensembl
  2. Golgi to plasma membrane protein transport Source: Ensembl
  3. protein targeting to Golgi Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_197901. Regulation of PLK1 Activity at G2/M Transition.

Names & Taxonomyi

Protein namesi
Recommended name:
Optineurin
Alternative name(s):
Ag9-C5
FIP-2
Gene namesi
Name:OPTN
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 1

Subcellular locationi

Cytoplasm. Golgi apparatus 2 Publications

GO - Cellular componenti

  1. perinuclear region of cytoplasm Source: Ensembl
  2. trans-Golgi network Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Optineurin
PRO_0000058065Add
BLAST

Proteomic databases

PaxDbiQ90Z16.
PRIDEiQ90Z16.

Expressioni

Tissue specificityi

Expressed in erythrocytes, skeletal muscle, heart, spleen and brain. Weakly expressed in lung and liver (at protein level).2 Publications

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022287.

Structurei

3D structure databases

ProteinModelPortaliQ90Z16.
SMRiQ90Z16. Positions 530-556.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili38 – 164127 Reviewed prediction
Add
BLAST
Coiled coili219 – 487269 Reviewed prediction
Add
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG138369.
GeneTreeiENSGT00530000063808.
HOGENOMiHOG000231899.
HOVERGENiHBG106481.
InParanoidiQ90Z16.
PhylomeDBiQ90Z16.

Family and domain databases

InterProiIPR021063. NEMO_N.
[Graphical view]
PfamiPF11577. NEMO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90Z16-1 [UniParc]FASTAAdd to Basket

« Hide

MSSKPQIRPA ENGEHCRSKM ENGMDSMAPP TLSTYTPEEM VQQMKELITE    50
NNELKEAMKL HNQAMKDRYE ELSIWREKQK EEREFYETKF KEAKQCLLAK 100
CVENEQLQQQ LQSLKEREEG AEMEGCATPE KEARQLKSKV QRLQAEKADL 150
LAIISELQVK LNIASAEDSF VEIGMNEEVN RTARENQDNS SEMASNIAVY 200
IRSKSADESK NLESEELTVS QLLCCLRNET QRREKLEKEL QDHKERLSKM 250
ENETSNCLES GTQTNQEEES SEAIGSEVES LKKQICALFK ELQEAHEKLK 300
EAELIQKKLQ EKCQTLEKVN SAAATELEEK QQLIYTIKKL ELQVESVQAE 350
VKLEQAKTQD EKTRYSSLQD AYNKLLAELT EAMKTISEMK VKEHDRVDKV 400
VVEELNAKVL LAEQALAAKQ LQMDEMKQLI AKQEEDLETM AVLRAQMEVY 450
CSDFHAERAA REKIHEEKEQ LAVQLAYLLK EQQNLEDLGR SSLAEMQNRH 500
GARAPDREHS PRLVQRGTGS QEWPEQRNIS IYSCPKCEEI LPDLDTLQIH 550
VMDCIN 556
Length:556
Mass (Da):64,087
Last modified:December 1, 2001 - v1
Checksum:i77CDD7F750D01F8F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF380358 mRNA. Translation: AAK69306.1.
AF389351 mRNA. Translation: AAM73640.1.
RefSeqiNP_989567.1. NM_204236.1.
UniGeneiGga.4189.

Genome annotation databases

EnsembliENSGALT00000022327; ENSGALP00000022287; ENSGALG00000013738.
GeneIDi374079.
KEGGigga:374079.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF380358 mRNA. Translation: AAK69306.1 .
AF389351 mRNA. Translation: AAM73640.1 .
RefSeqi NP_989567.1. NM_204236.1.
UniGenei Gga.4189.

3D structure databases

ProteinModelPortali Q90Z16.
SMRi Q90Z16. Positions 530-556.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000022287.

Proteomic databases

PaxDbi Q90Z16.
PRIDEi Q90Z16.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000022327 ; ENSGALP00000022287 ; ENSGALG00000013738 .
GeneIDi 374079.
KEGGi gga:374079.

Organism-specific databases

CTDi 10133.

Phylogenomic databases

eggNOGi NOG138369.
GeneTreei ENSGT00530000063808.
HOGENOMi HOG000231899.
HOVERGENi HBG106481.
InParanoidi Q90Z16.
PhylomeDBi Q90Z16.

Enzyme and pathway databases

Reactomei REACT_197901. Regulation of PLK1 Activity at G2/M Transition.

Miscellaneous databases

NextBioi 20813600.
PROi Q90Z16.

Family and domain databases

InterProi IPR021063. NEMO_N.
[Graphical view ]
Pfami PF11577. NEMO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Differential localization of chicken FIP2 homologue, Ag-9C5, in secretory epithelial cells."
    Li B., Gallin W.J.
    Exp. Cell Res. 272:135-145(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "FIP-2, an IkappaB-kinase-gamma-related protein, is associated with the Golgi apparatus and translocates to the marginal band during chicken erythroblast differentiation."
    Stroissnigg H., Repitz M., Miloloza A., Linhartova I., Beug H., Wiche G., Propst F.
    Exp. Cell Res. 278:133-145(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiOPTN_CHICK
AccessioniPrimary (citable) accession number: Q90Z16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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