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Q90Z16

- OPTN_CHICK

UniProt

Q90Z16 - OPTN_CHICK

Protein

Optineurin

Gene

OPTN

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family.2 Publications

    GO - Biological processi

    1. Golgi ribbon formation Source: Ensembl
    2. Golgi to plasma membrane protein transport Source: Ensembl
    3. protein targeting to Golgi Source: Ensembl

    Keywords - Biological processi

    Autophagy

    Enzyme and pathway databases

    ReactomeiREACT_197901. Regulation of PLK1 Activity at G2/M Transition.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Optineurin
    Alternative name(s):
    Ag9-C5
    FIP-2
    Gene namesi
    Name:OPTN
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. perinuclear region of cytoplasm Source: Ensembl
    2. trans-Golgi network Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Golgi apparatus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556OptineurinPRO_0000058065Add
    BLAST

    Proteomic databases

    PaxDbiQ90Z16.
    PRIDEiQ90Z16.

    Expressioni

    Tissue specificityi

    Expressed in erythrocytes, skeletal muscle, heart, spleen and brain. Weakly expressed in lung and liver (at protein level).2 Publications

    Interactioni

    Subunit structurei

    Binds to linear ubiquitin chains. Interacts with LC3 family members By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000022287.

    Structurei

    3D structure databases

    ProteinModelPortaliQ90Z16.
    SMRiQ90Z16. Positions 530-556.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili38 – 164127Sequence AnalysisAdd
    BLAST
    Coiled coili219 – 487269Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi168 – 1736LIR
    Motifi453 – 4586UBAN

    Domaini

    The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins.By similarity
    Ubiquitin-binding motif (UBAN) is essential for its inhibitory function, subcellular localization and interaction with TBK1.By similarity

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG138369.
    GeneTreeiENSGT00530000063808.
    HOGENOMiHOG000231899.
    HOVERGENiHBG106481.
    InParanoidiQ90Z16.
    PhylomeDBiQ90Z16.

    Family and domain databases

    InterProiIPR021063. NEMO_N.
    [Graphical view]
    PfamiPF11577. NEMO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q90Z16-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSKPQIRPA ENGEHCRSKM ENGMDSMAPP TLSTYTPEEM VQQMKELITE    50
    NNELKEAMKL HNQAMKDRYE ELSIWREKQK EEREFYETKF KEAKQCLLAK 100
    CVENEQLQQQ LQSLKEREEG AEMEGCATPE KEARQLKSKV QRLQAEKADL 150
    LAIISELQVK LNIASAEDSF VEIGMNEEVN RTARENQDNS SEMASNIAVY 200
    IRSKSADESK NLESEELTVS QLLCCLRNET QRREKLEKEL QDHKERLSKM 250
    ENETSNCLES GTQTNQEEES SEAIGSEVES LKKQICALFK ELQEAHEKLK 300
    EAELIQKKLQ EKCQTLEKVN SAAATELEEK QQLIYTIKKL ELQVESVQAE 350
    VKLEQAKTQD EKTRYSSLQD AYNKLLAELT EAMKTISEMK VKEHDRVDKV 400
    VVEELNAKVL LAEQALAAKQ LQMDEMKQLI AKQEEDLETM AVLRAQMEVY 450
    CSDFHAERAA REKIHEEKEQ LAVQLAYLLK EQQNLEDLGR SSLAEMQNRH 500
    GARAPDREHS PRLVQRGTGS QEWPEQRNIS IYSCPKCEEI LPDLDTLQIH 550
    VMDCIN 556
    Length:556
    Mass (Da):64,087
    Last modified:December 1, 2001 - v1
    Checksum:i77CDD7F750D01F8F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF380358 mRNA. Translation: AAK69306.1.
    AF389351 mRNA. Translation: AAM73640.1.
    RefSeqiNP_989567.1. NM_204236.1.
    UniGeneiGga.4189.

    Genome annotation databases

    EnsembliENSGALT00000022327; ENSGALP00000022287; ENSGALG00000013738.
    GeneIDi374079.
    KEGGigga:374079.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF380358 mRNA. Translation: AAK69306.1 .
    AF389351 mRNA. Translation: AAM73640.1 .
    RefSeqi NP_989567.1. NM_204236.1.
    UniGenei Gga.4189.

    3D structure databases

    ProteinModelPortali Q90Z16.
    SMRi Q90Z16. Positions 530-556.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000022287.

    Proteomic databases

    PaxDbi Q90Z16.
    PRIDEi Q90Z16.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000022327 ; ENSGALP00000022287 ; ENSGALG00000013738 .
    GeneIDi 374079.
    KEGGi gga:374079.

    Organism-specific databases

    CTDi 10133.

    Phylogenomic databases

    eggNOGi NOG138369.
    GeneTreei ENSGT00530000063808.
    HOGENOMi HOG000231899.
    HOVERGENi HBG106481.
    InParanoidi Q90Z16.
    PhylomeDBi Q90Z16.

    Enzyme and pathway databases

    Reactomei REACT_197901. Regulation of PLK1 Activity at G2/M Transition.

    Miscellaneous databases

    NextBioi 20813600.
    PROi Q90Z16.

    Family and domain databases

    InterProi IPR021063. NEMO_N.
    [Graphical view ]
    Pfami PF11577. NEMO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential localization of chicken FIP2 homologue, Ag-9C5, in secretory epithelial cells."
      Li B., Gallin W.J.
      Exp. Cell Res. 272:135-145(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "FIP-2, an IkappaB-kinase-gamma-related protein, is associated with the Golgi apparatus and translocates to the marginal band during chicken erythroblast differentiation."
      Stroissnigg H., Repitz M., Miloloza A., Linhartova I., Beug H., Wiche G., Propst F.
      Exp. Cell Res. 278:133-145(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiOPTN_CHICK
    AccessioniPrimary (citable) accession number: Q90Z16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3