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Q90Z16

- OPTN_CHICK

UniProt

Q90Z16 - OPTN_CHICK

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Protein

Optineurin

Gene

OPTN

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family.2 Publications

GO - Biological processi

  1. autophagy Source: UniProtKB-KW
  2. Golgi ribbon formation Source: Ensembl
  3. Golgi to plasma membrane protein transport Source: Ensembl
  4. protein targeting to Golgi Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Autophagy

Enzyme and pathway databases

ReactomeiREACT_197901. Regulation of PLK1 Activity at G2/M Transition.

Names & Taxonomyi

Protein namesi
Recommended name:
Optineurin
Alternative name(s):
Ag9-C5
FIP-2
Gene namesi
Name:OPTN
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. perinuclear region of cytoplasm Source: Ensembl
  3. trans-Golgi network Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556OptineurinPRO_0000058065Add
BLAST

Proteomic databases

PaxDbiQ90Z16.
PRIDEiQ90Z16.

Expressioni

Tissue specificityi

Expressed in erythrocytes, skeletal muscle, heart, spleen and brain. Weakly expressed in lung and liver (at protein level).2 Publications

Interactioni

Subunit structurei

Binds to linear ubiquitin chains. Interacts with LC3 family members (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022287.

Structurei

3D structure databases

ProteinModelPortaliQ90Z16.
SMRiQ90Z16. Positions 530-556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili38 – 164127Sequence AnalysisAdd
BLAST
Coiled coili219 – 487269Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi168 – 1736LIR
Motifi453 – 4586UBAN

Domaini

The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins.By similarity
Ubiquitin-binding motif (UBAN) is essential for its inhibitory function, subcellular localization and interaction with TBK1.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG138369.
GeneTreeiENSGT00530000063808.
HOGENOMiHOG000231899.
HOVERGENiHBG106481.
InParanoidiQ90Z16.
PhylomeDBiQ90Z16.

Family and domain databases

InterProiIPR021063. NEMO_N.
[Graphical view]
PfamiPF11577. NEMO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90Z16-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSKPQIRPA ENGEHCRSKM ENGMDSMAPP TLSTYTPEEM VQQMKELITE
60 70 80 90 100
NNELKEAMKL HNQAMKDRYE ELSIWREKQK EEREFYETKF KEAKQCLLAK
110 120 130 140 150
CVENEQLQQQ LQSLKEREEG AEMEGCATPE KEARQLKSKV QRLQAEKADL
160 170 180 190 200
LAIISELQVK LNIASAEDSF VEIGMNEEVN RTARENQDNS SEMASNIAVY
210 220 230 240 250
IRSKSADESK NLESEELTVS QLLCCLRNET QRREKLEKEL QDHKERLSKM
260 270 280 290 300
ENETSNCLES GTQTNQEEES SEAIGSEVES LKKQICALFK ELQEAHEKLK
310 320 330 340 350
EAELIQKKLQ EKCQTLEKVN SAAATELEEK QQLIYTIKKL ELQVESVQAE
360 370 380 390 400
VKLEQAKTQD EKTRYSSLQD AYNKLLAELT EAMKTISEMK VKEHDRVDKV
410 420 430 440 450
VVEELNAKVL LAEQALAAKQ LQMDEMKQLI AKQEEDLETM AVLRAQMEVY
460 470 480 490 500
CSDFHAERAA REKIHEEKEQ LAVQLAYLLK EQQNLEDLGR SSLAEMQNRH
510 520 530 540 550
GARAPDREHS PRLVQRGTGS QEWPEQRNIS IYSCPKCEEI LPDLDTLQIH

VMDCIN
Length:556
Mass (Da):64,087
Last modified:December 1, 2001 - v1
Checksum:i77CDD7F750D01F8F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF380358 mRNA. Translation: AAK69306.1.
AF389351 mRNA. Translation: AAM73640.1.
RefSeqiNP_989567.1. NM_204236.1.
UniGeneiGga.4189.

Genome annotation databases

EnsembliENSGALT00000022327; ENSGALP00000022287; ENSGALG00000013738.
GeneIDi374079.
KEGGigga:374079.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF380358 mRNA. Translation: AAK69306.1 .
AF389351 mRNA. Translation: AAM73640.1 .
RefSeqi NP_989567.1. NM_204236.1.
UniGenei Gga.4189.

3D structure databases

ProteinModelPortali Q90Z16.
SMRi Q90Z16. Positions 530-556.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000022287.

Proteomic databases

PaxDbi Q90Z16.
PRIDEi Q90Z16.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000022327 ; ENSGALP00000022287 ; ENSGALG00000013738 .
GeneIDi 374079.
KEGGi gga:374079.

Organism-specific databases

CTDi 10133.

Phylogenomic databases

eggNOGi NOG138369.
GeneTreei ENSGT00530000063808.
HOGENOMi HOG000231899.
HOVERGENi HBG106481.
InParanoidi Q90Z16.
PhylomeDBi Q90Z16.

Enzyme and pathway databases

Reactomei REACT_197901. Regulation of PLK1 Activity at G2/M Transition.

Miscellaneous databases

NextBioi 20813600.
PROi Q90Z16.

Family and domain databases

InterProi IPR021063. NEMO_N.
[Graphical view ]
Pfami PF11577. NEMO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Differential localization of chicken FIP2 homologue, Ag-9C5, in secretory epithelial cells."
    Li B., Gallin W.J.
    Exp. Cell Res. 272:135-145(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "FIP-2, an IkappaB-kinase-gamma-related protein, is associated with the Golgi apparatus and translocates to the marginal band during chicken erythroblast differentiation."
    Stroissnigg H., Repitz M., Miloloza A., Linhartova I., Beug H., Wiche G., Propst F.
    Exp. Cell Res. 278:133-145(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiOPTN_CHICK
AccessioniPrimary (citable) accession number: Q90Z16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3