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Protein

Cytoplasmic FMR1-interacting protein 1 homolog

Gene

cyfip1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell shape, Differentiation, Neurogenesis

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic FMR1-interacting protein 1 homolog
Gene namesi
Name:cyfip1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030131-8557. cyfip1.

Subcellular locationi

  • Cytoplasm By similarity
  • Cytoplasmperinuclear region By similarity
  • Cell projectionlamellipodium By similarity
  • Cell projectionruffle By similarity
  • Cell junctionsynapsesynaptosome By similarity

  • Note: Highly expressed in the perinuclear region (By similarity). Enriched in synaptosomes (By similarity). Also enriched in membrane ruffles and at the tips of lamellipodia (By similarity).By similarity

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB
  • lamellipodium Source: UniProtKB-SubCell
  • neuron projection Source: UniProtKB-SubCell
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
  • ruffle Source: UniProtKB-SubCell
  • synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12531253Cytoplasmic FMR1-interacting protein 1 homologPRO_0000279708Add
BLAST

Proteomic databases

PaxDbiQ90YM8.
PRIDEiQ90YM8.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000095008.

Family & Domainsi

Sequence similaritiesi

Belongs to the CYFIP family.Sequence analysis

Phylogenomic databases

eggNOGiKOG3534. Eukaryota.
ENOG410XPKW. LUCA.
HOGENOMiHOG000272573.
HOVERGENiHBG053209.
InParanoidiQ90YM8.
KOiK05749.
PhylomeDBiQ90YM8.

Family and domain databases

InterProiIPR008081. Cytoplasmic_FMR1-int.
IPR009828. DUF1394.
[Graphical view]
PANTHERiPTHR12195. PTHR12195. 1 hit.
PfamiPF07159. DUF1394. 1 hit.
PF05994. FragX_IP. 1 hit.
[Graphical view]
PIRSFiPIRSF008153. FMR1_interacting. 1 hit.
PRINTSiPR01698. CYTOFMRPINTP.

Sequencei

Sequence statusi: Complete.

Q90YM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTVTLEDA LSNVDLLEEL PLPDQQPCIE PLPSSLIYQP NFNTNFEDRN
60 70 80 90 100
AFVTGIARYI EQATVHSSMN DMLEEGQQYA VMLYTWRCCS RAIPQVKCNE
110 120 130 140 150
QPNRVEIYEK TVEVLEPEVN KLMNFMYFQR TAIDRFCGEV RRLCHAERRK
160 170 180 190 200
DFVSEAYLLT LGKFINMFAV LDELKNMKCS VKNDHSAYKR AAQFLRKMSE
210 220 230 240 250
PSSIQESQNL SMFLANHNKI TQSLQQQLEV INGYDELLAD IVNLCVDYYE
260 270 280 290 300
NKMYLTPSER HMLLKVMGFG LYLMDGSNSN IYKLEAKKRI NLTKIDKFFK
310 320 330 340 350
QLQVVPLFGD MQIELARYIK TSAHYEENKS RWSCTSTGSS PQYNVCEQMI
360 370 380 390 400
QIREGHMRFI SELARYSNSE VVTGSGRQDA QKTDSEYRKL FDLALQGLQL
410 420 430 440 450
LSQWSAQIME VYSWKLVHPT DKYSNKECPD NAEEYERATR YNYTSEEKFA
460 470 480 490 500
LVEVLAMIKG LQVLMGRMES VFNHAIRHTI YSALQDFAQV TLREPLRQAI
510 520 530 540 550
KKKKNVVQSV LQAIRKTVCD WETGREPHND PALRGEKDPK GGFDIKVPRR
560 570 580 590 600
AVGPSSTQLY MVRTMLESLV ADKSGSKKTL RSSLEGPTIL DIEKFHRESF
610 620 630 640 650
FYTHLLNFSE TLQQCCDLSQ LWFREFFLEL TMGRRIQFPI EMSMPWILTD
660 670 680 690 700
HILETKEASM MEYVLYSLDL YNDSAHYALT KFKKQFLYDE IEAEVNLCFD
710 720 730 740 750
QFVYKLADQI FAYYKVIAGS LLLDKRLRAE CKNQGANISW PSSNRYETLL
760 770 780 790 800
KQRHVQLLGR SIDLNRLITQ RVSSALYKSL ELAISRFESE DLTSIMELEG
810 820 830 840 850
LLDINRMTHK LLSKYLTLDS IDAMFREANH NVSAPYGRIT LHVFWELNYD
860 870 880 890 900
FLPNYCYNGS TNRFVRTILP FSQEFQRDKP PNAQPQYLYG SKALNLAYSS
910 920 930 940 950
IYSLYRNFVG PPHIKAICRL LGYQGIAVVM EELLKVVKSL LQGTILQYVK
960 970 980 990 1000
TLMEVMPKIC RLPRHEYGSP GILEFFHHQL KDIVEYAELK SVCFQNLREV
1010 1020 1030 1040 1050
GNALLFCLLT EQSLSQEEVC DLLHAAPFQN ILPRVHVKEG ERLDAKMKRL
1060 1070 1080 1090 1100
EAKYTALHLV PLIERLGTPQ QIAIAREGDL LTKERLCCGL SIFEVILTRV
1110 1120 1130 1140 1150
RAYLDDPIWR GPLPSNGVMH VDECVEFHRL WSAMQFVYCI PVGAHEFTVE
1160 1170 1180 1190 1200
QCFGDGLNWA GCMIITLLGQ HRRFDILDFS YHLLKVQKHD GKDEIIKSVP
1210 1220 1230 1240 1250
LKKMVDRIRK FQILNDEIFA ILNKYLKSGD GENMPVEHVR CFQPPIHQSL

ASN
Length:1,253
Mass (Da):145,174
Last modified:December 1, 2001 - v1
Checksum:iABE478AAB264B32D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti260 – 2601R → K in AAH91781 (Ref. 2) Curated
Sequence conflicti323 – 3231A → T in AAH91781 (Ref. 2) Curated
Sequence conflicti337 – 3371T → A in AAH91781 (Ref. 2) Curated
Sequence conflicti355 – 3551G → D in AAH91781 (Ref. 2) Curated
Sequence conflicti505 – 5106NVVQSV → KKKKKK in AAH91781 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY017342 mRNA. Translation: AAG61253.1.
BC091781 mRNA. Translation: AAH91781.1.
RefSeqiNP_997924.1. NM_212759.1.
UniGeneiDr.1164.

Genome annotation databases

GeneIDi336613.
KEGGidre:336613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY017342 mRNA. Translation: AAG61253.1.
BC091781 mRNA. Translation: AAH91781.1.
RefSeqiNP_997924.1. NM_212759.1.
UniGeneiDr.1164.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000095008.

Proteomic databases

PaxDbiQ90YM8.
PRIDEiQ90YM8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi336613.
KEGGidre:336613.

Organism-specific databases

CTDi23191.
ZFINiZDB-GENE-030131-8557. cyfip1.

Phylogenomic databases

eggNOGiKOG3534. Eukaryota.
ENOG410XPKW. LUCA.
HOGENOMiHOG000272573.
HOVERGENiHBG053209.
InParanoidiQ90YM8.
KOiK05749.
PhylomeDBiQ90YM8.

Miscellaneous databases

PROiQ90YM8.

Family and domain databases

InterProiIPR008081. Cytoplasmic_FMR1-int.
IPR009828. DUF1394.
[Graphical view]
PANTHERiPTHR12195. PTHR12195. 1 hit.
PfamiPF07159. DUF1394. 1 hit.
PF05994. FragX_IP. 1 hit.
[Graphical view]
PIRSFiPIRSF008153. FMR1_interacting. 1 hit.
PRINTSiPR01698. CYTOFMRPINTP.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P."
    Schenck A., Bardoni B., Moro A., Bagni C., Mandel J.-L.
    Proc. Natl. Acad. Sci. U.S.A. 98:8844-8849(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-510.
    Tissue: EmbryoImported.

Entry informationi

Entry nameiCYFP1_DANRE
AccessioniPrimary (citable) accession number: Q90YM8
Secondary accession number(s): Q58ES3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.