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Protein

Protein Wnt

Gene

wnt8a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinUniRule annotationSAAS annotation

Keywords - Biological processi

Wnt signaling pathwayUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein WntUniRule annotation
Gene namesi
Name:wnt8aImported
Synonyms:wnt8Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-980526-332. wnt8a.

Subcellular locationi

  • Secretedextracellular spaceextracellular matrix UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrixSAAS annotation, Secreted

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000096426.

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
HOVERGENiHBG001595.
PhylomeDBiQ90YL8.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013301. Wnt8.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF92. PTHR12027:SF92. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01892. WNT8PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90YL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYFFRWAFL FPIWDKAILG HTWTMNNLLI TGPKAYLTYA NSVRVGAQSG
60 70 80 90 100
IHECKHQFAW DRWNCPDTAL QLSTHKGLRS ATRESSFVHA ISAAGVMYTL
110 120 130 140 150
TRNCSLGDLN ECGCDSSRNG RLGGRGWLWG GCSDNVDFGE RISKQFVDAL
160 170 180 190 200
ETGQDARAAV NLHNNEAGRL AVKATMKRIC RCHGMSESCT MQTCWMQLAD
210 220 230 240 250
FREIGNYLKV KHDQAQKLEM DKRRMRAGNS ADNRVTMTDA FGSIARTELI
260 270 280 290 300
YLEDSPDYCA KNLSLGLPGT EGRECVQHGE SLSQWERRSC RRLCHECGLR
310 320 330 340 350
VEERRTEVVS SCNCKFHWCC TVKCENCSQV TVKHVCTRRH GSHGHNRRRP

RGPK
Length:354
Mass (Da):40,110
Last modified:December 1, 2001 - v1
Checksum:iF42951A27AC38A67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032749 Genomic DNA. Translation: AAK70224.1.
RefSeqiNP_001018637.2. NM_001020801.2.
UniGeneiDr.309.

Genome annotation databases

GeneIDi553976.
KEGGidre:553976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032749 Genomic DNA. Translation: AAK70224.1.
RefSeqiNP_001018637.2. NM_001020801.2.
UniGeneiDr.309.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000096426.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi553976.
KEGGidre:553976.

Organism-specific databases

CTDi553976.
ZFINiZDB-GENE-980526-332. wnt8a.

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
HOVERGENiHBG001595.
PhylomeDBiQ90YL8.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013301. Wnt8.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF92. PTHR12027:SF92. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01892. WNT8PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning."
    Lekven A.C., Thorpe C.J., Waxman J.S., Moon R.T.
    Dev. Cell 1:103-114(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ90YL8_DANRE
AccessioniPrimary (citable) accession number: Q90YL8
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.