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Reviewed, UniProtKB/Swiss-Prot Q90YJ9 (CLAT_CHICK)

Last modified September 1, 2009. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Choline O-acetyltransferase
      Short name=Choline acetylase
      Short name=CHOACTase
      Short name=ChAT
    EC=2.3.1.6
Gene names
Name: CHAT
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length640 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses By similarity.

Catalytic activity

Acetyl-CoA + choline = CoA + O-acetylcholine.

Tissue specificity

Detected in brain and in embryonic retina. Ref.1

Sequence similarities

Belongs to the carnitine/choline acetyltransferase family.

Ontologies

Keywords
   Biological processNeurotransmitter biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological processneurotransmitter biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioncholine O-acetyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 640640Choline O-acetyltransferase
PRO_0000351549

Regions

Region412 – 42413Coenzyme A binding By similarity

Sites

Active site3341Proton acceptor By similarity
Binding site4501Coenzyme A By similarity
Binding site5511Coenzyme A By similarity

Sequences

Sequence LengthMass (Da)Tools
Q90YJ9-1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 5D07FB959F4020E4

FASTA64072,623
        10         20         30         40         50         60 
MPDLEKDMQK KEKDSRSKDE PAVPKLPVPP LQQTLQMYLQ CMKHLVPEEQ FRKTKSIVEQ 

        70         80         90        100        110        120 
FGVAGGLGES LQLILEERRE ETTNWVFNYW LDDMYLNNRL ALPVNSSPAI IFARQNFKDV 

       130        140        150        160        170        180 
NDQLRFAANL ISGVQDYKAL LDSHALPVDF ARGQLSGQPL CMKQYYGLFS SYRLPGHTKD 

       190        200        210        220        230        240 
TLVAQKSCVM PEPEHIIVAC NNQLFVLDVG INFRRLSEGD LFTQLRKIAK MAENEEEMLP 

       250        260        270        280        290        300 
PIGLLTTDGR TEWAEARTIL MKDSTNRDSL DMIERCICLV CLDGTSGVEL NDTNMALQLL 

       310        320        330        340        350        360 
HGGGYHKNGA NRWYDKPMQF VVGRDGVCGT VCEHSPFDGI VLVQCTEHLL KHMKESSKKL 

       370        380        390        400        410        420 
LRADSVSELP APRRLRWKCS PEIQAHLASS AEKLQRIVKN LDFIAYKFVN YGKEFIKKQK 

       430        440        450        460        470        480 
TSPDAYIQVA LQLAFYRCHR RLVPTYESAS IRRFDEGRVD NIRSATAEAF AFVKAMIDDK 

       490        500        510        520        530        540 
PALSDSEKMQ RFKDAIAAQT NYTILAITGM AIDNHLLGLR EVAREHFKEL PEIFTDETYL 

       550        560        570        580        590        600 
TSNRFILSTS QVPTPMEMFC CYGPVVPNGY GACYNPQPEH ILFCISSFKD CKETSSDMLA 

       610        620        630        640 
KAVEESLLEI RDLCNKCSSS TAKSLAKQEE ATQLRSDRKL 

« Hide

References

[1]"Cloning of chicken choline acetyltransferase and its expression in early embryonic retina."
Mukherjee R.S., Hausman R.E.
Brain Res. Mol. Brain Res. 129:54-66(2004) [PubMed: 15469882] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Brain.

Cross-references

Sequence databases

AY044155 mRNA. Translation: AAK94673.1.
IPIIPI00593659.
RefSeqNP_989941.1.
UniGeneGga.1849

3D structure databases

HSSPHSSP built from PDB template 1NM8 based on UniProtKB P43155.
SMRQ90YJ9. Positions 19-615.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ90YJ9.

Genome annotation databases

EnsemblENSGALT00000003601; ENSGALP00000003594; ENSGALG00000002289; Gallus gallus. [Genome view]
GeneID395314.
KEGGgga:395314.

Organism-specific databases

CTD395314.

Phylogenomic databases

HOVERGENQ90YJ9.

Family and domain databases

InterProIPR000542. Carn_acyl_trans.
[Graphical view]
PANTHERPTHR22589. Carn_acyl_trans. 1 hit.
PfamPF00755. Carn_acyltransf. 1 hit.
[Graphical view]
PROSITEPS00439. ACYLTRANSF_C_1. False negative.
PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCLAT_CHICK
AccessionPrimary (citable) accession number: Q90YJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: December 1, 2001
Last modified: September 1, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents