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Q90YJ9 (CLAT_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Choline O-acetyltransferase
Short name=CHOACTase
Short name=ChAT
Short name=Choline acetylase
EC=2.3.1.6
Gene names
Name:CHAT
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length640 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses By similarity.

Catalytic activity

Acetyl-CoA + choline = CoA + O-acetylcholine.

Tissue specificity

Detected in brain and in embryonic retina. Ref.1

Sequence similarities

Belongs to the carnitine/choline acetyltransferase family.

Ontologies

Keywords
   Biological processNeurotransmitter biosynthesis
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processneurotransmitter biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncholine O-acetyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 640640Choline O-acetyltransferase
PRO_0000351549

Regions

Region412 – 42413Coenzyme A binding By similarity

Sites

Active site3341Proton acceptor By similarity
Binding site4501Coenzyme A By similarity
Binding site5511Coenzyme A By similarity

Sequences

Sequence LengthMass (Da)Tools
Q90YJ9 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 5D07FB959F4020E4

FASTA64072,623
        10         20         30         40         50         60 
MPDLEKDMQK KEKDSRSKDE PAVPKLPVPP LQQTLQMYLQ CMKHLVPEEQ FRKTKSIVEQ 

        70         80         90        100        110        120 
FGVAGGLGES LQLILEERRE ETTNWVFNYW LDDMYLNNRL ALPVNSSPAI IFARQNFKDV 

       130        140        150        160        170        180 
NDQLRFAANL ISGVQDYKAL LDSHALPVDF ARGQLSGQPL CMKQYYGLFS SYRLPGHTKD 

       190        200        210        220        230        240 
TLVAQKSCVM PEPEHIIVAC NNQLFVLDVG INFRRLSEGD LFTQLRKIAK MAENEEEMLP 

       250        260        270        280        290        300 
PIGLLTTDGR TEWAEARTIL MKDSTNRDSL DMIERCICLV CLDGTSGVEL NDTNMALQLL 

       310        320        330        340        350        360 
HGGGYHKNGA NRWYDKPMQF VVGRDGVCGT VCEHSPFDGI VLVQCTEHLL KHMKESSKKL 

       370        380        390        400        410        420 
LRADSVSELP APRRLRWKCS PEIQAHLASS AEKLQRIVKN LDFIAYKFVN YGKEFIKKQK 

       430        440        450        460        470        480 
TSPDAYIQVA LQLAFYRCHR RLVPTYESAS IRRFDEGRVD NIRSATAEAF AFVKAMIDDK 

       490        500        510        520        530        540 
PALSDSEKMQ RFKDAIAAQT NYTILAITGM AIDNHLLGLR EVAREHFKEL PEIFTDETYL 

       550        560        570        580        590        600 
TSNRFILSTS QVPTPMEMFC CYGPVVPNGY GACYNPQPEH ILFCISSFKD CKETSSDMLA 

       610        620        630        640 
KAVEESLLEI RDLCNKCSSS TAKSLAKQEE ATQLRSDRKL

« Hide

References

[1]"Cloning of chicken choline acetyltransferase and its expression in early embryonic retina."
Mukherjee R.S., Hausman R.E.
Brain Res. Mol. Brain Res. 129:54-66(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY044155 mRNA. Translation: AAK94673.1.
IPIIPI00593659.
RefSeqNP_989941.1. NM_204610.1.
UniGeneGga.1849.

3D structure databases

HSSPHSSP built from PDB template 1Q6X based on UniProtKB P32738.
ProteinModelPortalQ90YJ9.
SMRQ90YJ9. Positions 20-615.
ModBaseSearch...

Proteomic databases

PaxDbQ90YJ9.
PRIDEQ90YJ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID395314.
KEGGgga:395314.

Organism-specific databases

CTD1103.

Phylogenomic databases

eggNOGNOG70127.
HOGENOMHOG000233845.
HOVERGENHBG107717.
InParanoidQ90YJ9.
KOK00623.
OrthoDBEOG45DWP3.

Family and domain databases

InterProIPR000542. Carn_acyl_trans.
[Graphical view]
PANTHERPTHR22589. PTHR22589. 1 hit.
PfamPF00755. Carn_acyltransf. 1 hit.
[Graphical view]
PROSITEPS00439. ACYLTRANSF_C_1. False negative.
PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBQ90YJ9.
ChEMBLCHEMBL2944.
NextBio20815399.

Entry information

Entry nameCLAT_CHICK
AccessionPrimary (citable) accession number: Q90YJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: December 1, 2001
Last modified: April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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