SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q90YJ9

- CLAT_CHICK

UniProt

Q90YJ9 - CLAT_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Choline O-acetyltransferase
Gene
CHAT
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses By similarity.

Catalytic activityi

Acetyl-CoA + choline = CoA + O-acetylcholine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei334 – 3341Proton acceptor By similarity
Binding sitei450 – 4501Coenzyme A By similarity
Binding sitei551 – 5511Coenzyme A By similarity

GO - Molecular functioni

  1. choline O-acetyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. neurotransmitter biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Neurotransmitter biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Choline O-acetyltransferase (EC:2.3.1.6)
Short name:
CHOACTase
Short name:
ChAT
Short name:
Choline acetylase
Gene namesi
Name:CHAT
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 640640Choline O-acetyltransferase
PRO_0000351549Add
BLAST

Proteomic databases

PaxDbiQ90YJ9.
PRIDEiQ90YJ9.

Expressioni

Tissue specificityi

Detected in brain and in embryonic retina.1 Publication

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ90YJ9.
SMRiQ90YJ9. Positions 20-615.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni412 – 42413Coenzyme A binding By similarity
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG70127.
HOGENOMiHOG000233845.
HOVERGENiHBG107717.
InParanoidiQ90YJ9.
KOiK00623.
PhylomeDBiQ90YJ9.

Family and domain databases

InterProiIPR000542. Carn_acyl_trans.
[Graphical view]
PANTHERiPTHR22589. PTHR22589. 1 hit.
PfamiPF00755. Carn_acyltransf. 1 hit.
[Graphical view]
PROSITEiPS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90YJ9-1 [UniParc]FASTAAdd to Basket

« Hide

MPDLEKDMQK KEKDSRSKDE PAVPKLPVPP LQQTLQMYLQ CMKHLVPEEQ    50
FRKTKSIVEQ FGVAGGLGES LQLILEERRE ETTNWVFNYW LDDMYLNNRL 100
ALPVNSSPAI IFARQNFKDV NDQLRFAANL ISGVQDYKAL LDSHALPVDF 150
ARGQLSGQPL CMKQYYGLFS SYRLPGHTKD TLVAQKSCVM PEPEHIIVAC 200
NNQLFVLDVG INFRRLSEGD LFTQLRKIAK MAENEEEMLP PIGLLTTDGR 250
TEWAEARTIL MKDSTNRDSL DMIERCICLV CLDGTSGVEL NDTNMALQLL 300
HGGGYHKNGA NRWYDKPMQF VVGRDGVCGT VCEHSPFDGI VLVQCTEHLL 350
KHMKESSKKL LRADSVSELP APRRLRWKCS PEIQAHLASS AEKLQRIVKN 400
LDFIAYKFVN YGKEFIKKQK TSPDAYIQVA LQLAFYRCHR RLVPTYESAS 450
IRRFDEGRVD NIRSATAEAF AFVKAMIDDK PALSDSEKMQ RFKDAIAAQT 500
NYTILAITGM AIDNHLLGLR EVAREHFKEL PEIFTDETYL TSNRFILSTS 550
QVPTPMEMFC CYGPVVPNGY GACYNPQPEH ILFCISSFKD CKETSSDMLA 600
KAVEESLLEI RDLCNKCSSS TAKSLAKQEE ATQLRSDRKL 640
Length:640
Mass (Da):72,623
Last modified:December 1, 2001 - v1
Checksum:i5D07FB959F4020E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY044155 mRNA. Translation: AAK94673.1.
RefSeqiNP_989941.1. NM_204610.1.
UniGeneiGga.1849.

Genome annotation databases

GeneIDi395314.
KEGGigga:395314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY044155 mRNA. Translation: AAK94673.1 .
RefSeqi NP_989941.1. NM_204610.1.
UniGenei Gga.1849.

3D structure databases

ProteinModelPortali Q90YJ9.
SMRi Q90YJ9. Positions 20-615.
ModBasei Search...

Chemistry

BindingDBi Q90YJ9.
ChEMBLi CHEMBL2944.

Proteomic databases

PaxDbi Q90YJ9.
PRIDEi Q90YJ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395314.
KEGGi gga:395314.

Organism-specific databases

CTDi 1103.

Phylogenomic databases

eggNOGi NOG70127.
HOGENOMi HOG000233845.
HOVERGENi HBG107717.
InParanoidi Q90YJ9.
KOi K00623.
PhylomeDBi Q90YJ9.

Miscellaneous databases

NextBioi 20815399.
PROi Q90YJ9.

Family and domain databases

InterProi IPR000542. Carn_acyl_trans.
[Graphical view ]
PANTHERi PTHR22589. PTHR22589. 1 hit.
Pfami PF00755. Carn_acyltransf. 1 hit.
[Graphical view ]
PROSITEi PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of chicken choline acetyltransferase and its expression in early embryonic retina."
    Mukherjee R.S., Hausman R.E.
    Brain Res. Mol. Brain Res. 129:54-66(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain.

Entry informationi

Entry nameiCLAT_CHICK
AccessioniPrimary (citable) accession number: Q90YJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi