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Q90YJ9

- CLAT_CHICK

UniProt

Q90YJ9 - CLAT_CHICK

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Protein

Choline O-acetyltransferase

Gene

CHAT

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.By similarity

Catalytic activityi

Acetyl-CoA + choline = CoA + O-acetylcholine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei334 – 3341Proton acceptorBy similarity
Binding sitei450 – 4501Coenzyme ABy similarity
Binding sitei551 – 5511Coenzyme ABy similarity

GO - Molecular functioni

  1. choline O-acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. neurotransmitter biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Neurotransmitter biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Choline O-acetyltransferase (EC:2.3.1.6)
Short name:
CHOACTase
Short name:
ChAT
Short name:
Choline acetylase
Gene namesi
Name:CHAT
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 640640Choline O-acetyltransferasePRO_0000351549Add
BLAST

Proteomic databases

PaxDbiQ90YJ9.
PRIDEiQ90YJ9.

Expressioni

Tissue specificityi

Detected in brain and in embryonic retina.1 Publication

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ90YJ9.
SMRiQ90YJ9. Positions 20-615.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni412 – 42413Coenzyme A bindingBy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG70127.
HOGENOMiHOG000233845.
HOVERGENiHBG107717.
InParanoidiQ90YJ9.
KOiK00623.
PhylomeDBiQ90YJ9.

Family and domain databases

InterProiIPR000542. Carn_acyl_trans.
[Graphical view]
PANTHERiPTHR22589. PTHR22589. 1 hit.
PfamiPF00755. Carn_acyltransf. 1 hit.
[Graphical view]
PROSITEiPS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90YJ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPDLEKDMQK KEKDSRSKDE PAVPKLPVPP LQQTLQMYLQ CMKHLVPEEQ
60 70 80 90 100
FRKTKSIVEQ FGVAGGLGES LQLILEERRE ETTNWVFNYW LDDMYLNNRL
110 120 130 140 150
ALPVNSSPAI IFARQNFKDV NDQLRFAANL ISGVQDYKAL LDSHALPVDF
160 170 180 190 200
ARGQLSGQPL CMKQYYGLFS SYRLPGHTKD TLVAQKSCVM PEPEHIIVAC
210 220 230 240 250
NNQLFVLDVG INFRRLSEGD LFTQLRKIAK MAENEEEMLP PIGLLTTDGR
260 270 280 290 300
TEWAEARTIL MKDSTNRDSL DMIERCICLV CLDGTSGVEL NDTNMALQLL
310 320 330 340 350
HGGGYHKNGA NRWYDKPMQF VVGRDGVCGT VCEHSPFDGI VLVQCTEHLL
360 370 380 390 400
KHMKESSKKL LRADSVSELP APRRLRWKCS PEIQAHLASS AEKLQRIVKN
410 420 430 440 450
LDFIAYKFVN YGKEFIKKQK TSPDAYIQVA LQLAFYRCHR RLVPTYESAS
460 470 480 490 500
IRRFDEGRVD NIRSATAEAF AFVKAMIDDK PALSDSEKMQ RFKDAIAAQT
510 520 530 540 550
NYTILAITGM AIDNHLLGLR EVAREHFKEL PEIFTDETYL TSNRFILSTS
560 570 580 590 600
QVPTPMEMFC CYGPVVPNGY GACYNPQPEH ILFCISSFKD CKETSSDMLA
610 620 630 640
KAVEESLLEI RDLCNKCSSS TAKSLAKQEE ATQLRSDRKL
Length:640
Mass (Da):72,623
Last modified:December 1, 2001 - v1
Checksum:i5D07FB959F4020E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044155 mRNA. Translation: AAK94673.1.
RefSeqiNP_989941.1. NM_204610.1.
UniGeneiGga.1849.

Genome annotation databases

GeneIDi395314.
KEGGigga:395314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044155 mRNA. Translation: AAK94673.1 .
RefSeqi NP_989941.1. NM_204610.1.
UniGenei Gga.1849.

3D structure databases

ProteinModelPortali Q90YJ9.
SMRi Q90YJ9. Positions 20-615.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q90YJ9.
ChEMBLi CHEMBL2944.

Proteomic databases

PaxDbi Q90YJ9.
PRIDEi Q90YJ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395314.
KEGGi gga:395314.

Organism-specific databases

CTDi 1103.

Phylogenomic databases

eggNOGi NOG70127.
HOGENOMi HOG000233845.
HOVERGENi HBG107717.
InParanoidi Q90YJ9.
KOi K00623.
PhylomeDBi Q90YJ9.

Miscellaneous databases

NextBioi 20815399.
PROi Q90YJ9.

Family and domain databases

InterProi IPR000542. Carn_acyl_trans.
[Graphical view ]
PANTHERi PTHR22589. PTHR22589. 1 hit.
Pfami PF00755. Carn_acyltransf. 1 hit.
[Graphical view ]
PROSITEi PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of chicken choline acetyltransferase and its expression in early embryonic retina."
    Mukherjee R.S., Hausman R.E.
    Brain Res. Mol. Brain Res. 129:54-66(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain.

Entry informationi

Entry nameiCLAT_CHICK
AccessioniPrimary (citable) accession number: Q90YJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3