Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q90YJ9

- CLAT_CHICK

UniProt

Q90YJ9 - CLAT_CHICK

Protein

Choline O-acetyltransferase

Gene

CHAT

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.By similarity

    Catalytic activityi

    Acetyl-CoA + choline = CoA + O-acetylcholine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei334 – 3341Proton acceptorBy similarity
    Binding sitei450 – 4501Coenzyme ABy similarity
    Binding sitei551 – 5511Coenzyme ABy similarity

    GO - Molecular functioni

    1. choline O-acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. neurotransmitter biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Neurotransmitter biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Choline O-acetyltransferase (EC:2.3.1.6)
    Short name:
    CHOACTase
    Short name:
    ChAT
    Short name:
    Choline acetylase
    Gene namesi
    Name:CHAT
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 640640Choline O-acetyltransferasePRO_0000351549Add
    BLAST

    Proteomic databases

    PaxDbiQ90YJ9.
    PRIDEiQ90YJ9.

    Expressioni

    Tissue specificityi

    Detected in brain and in embryonic retina.1 Publication

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ90YJ9.
    SMRiQ90YJ9. Positions 20-615.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni412 – 42413Coenzyme A bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG70127.
    HOGENOMiHOG000233845.
    HOVERGENiHBG107717.
    InParanoidiQ90YJ9.
    KOiK00623.
    PhylomeDBiQ90YJ9.

    Family and domain databases

    InterProiIPR000542. Carn_acyl_trans.
    [Graphical view]
    PANTHERiPTHR22589. PTHR22589. 1 hit.
    PfamiPF00755. Carn_acyltransf. 1 hit.
    [Graphical view]
    PROSITEiPS00440. ACYLTRANSF_C_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q90YJ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPDLEKDMQK KEKDSRSKDE PAVPKLPVPP LQQTLQMYLQ CMKHLVPEEQ    50
    FRKTKSIVEQ FGVAGGLGES LQLILEERRE ETTNWVFNYW LDDMYLNNRL 100
    ALPVNSSPAI IFARQNFKDV NDQLRFAANL ISGVQDYKAL LDSHALPVDF 150
    ARGQLSGQPL CMKQYYGLFS SYRLPGHTKD TLVAQKSCVM PEPEHIIVAC 200
    NNQLFVLDVG INFRRLSEGD LFTQLRKIAK MAENEEEMLP PIGLLTTDGR 250
    TEWAEARTIL MKDSTNRDSL DMIERCICLV CLDGTSGVEL NDTNMALQLL 300
    HGGGYHKNGA NRWYDKPMQF VVGRDGVCGT VCEHSPFDGI VLVQCTEHLL 350
    KHMKESSKKL LRADSVSELP APRRLRWKCS PEIQAHLASS AEKLQRIVKN 400
    LDFIAYKFVN YGKEFIKKQK TSPDAYIQVA LQLAFYRCHR RLVPTYESAS 450
    IRRFDEGRVD NIRSATAEAF AFVKAMIDDK PALSDSEKMQ RFKDAIAAQT 500
    NYTILAITGM AIDNHLLGLR EVAREHFKEL PEIFTDETYL TSNRFILSTS 550
    QVPTPMEMFC CYGPVVPNGY GACYNPQPEH ILFCISSFKD CKETSSDMLA 600
    KAVEESLLEI RDLCNKCSSS TAKSLAKQEE ATQLRSDRKL 640
    Length:640
    Mass (Da):72,623
    Last modified:December 1, 2001 - v1
    Checksum:i5D07FB959F4020E4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY044155 mRNA. Translation: AAK94673.1.
    RefSeqiNP_989941.1. NM_204610.1.
    UniGeneiGga.1849.

    Genome annotation databases

    GeneIDi395314.
    KEGGigga:395314.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY044155 mRNA. Translation: AAK94673.1 .
    RefSeqi NP_989941.1. NM_204610.1.
    UniGenei Gga.1849.

    3D structure databases

    ProteinModelPortali Q90YJ9.
    SMRi Q90YJ9. Positions 20-615.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q90YJ9.
    ChEMBLi CHEMBL2944.

    Proteomic databases

    PaxDbi Q90YJ9.
    PRIDEi Q90YJ9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395314.
    KEGGi gga:395314.

    Organism-specific databases

    CTDi 1103.

    Phylogenomic databases

    eggNOGi NOG70127.
    HOGENOMi HOG000233845.
    HOVERGENi HBG107717.
    InParanoidi Q90YJ9.
    KOi K00623.
    PhylomeDBi Q90YJ9.

    Miscellaneous databases

    NextBioi 20815399.
    PROi Q90YJ9.

    Family and domain databases

    InterProi IPR000542. Carn_acyl_trans.
    [Graphical view ]
    PANTHERi PTHR22589. PTHR22589. 1 hit.
    Pfami PF00755. Carn_acyltransf. 1 hit.
    [Graphical view ]
    PROSITEi PS00440. ACYLTRANSF_C_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of chicken choline acetyltransferase and its expression in early embryonic retina."
      Mukherjee R.S., Hausman R.E.
      Brain Res. Mol. Brain Res. 129:54-66(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Brain.

    Entry informationi

    Entry nameiCLAT_CHICK
    AccessioniPrimary (citable) accession number: Q90YJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 14, 2008
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3