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Protein

Interleukin-6

Gene

IL6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity).By similarity

GO - Molecular functioni

  • cytokine activity Source: AgBase
  • growth factor activity Source: UniProtKB-KW
  • interleukin-6 receptor binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processAcute phase

Enzyme and pathway databases

ReactomeiR-GGA-112411. MAPK1 (ERK2) activation.
R-GGA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-GGA-6783589. Interleukin-6 family signaling.
R-GGA-8957275. Post-translational protein phosphorylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6
Short name:
ChIL-6
Short name:
IL-6
Gene namesi
Name:IL6
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 46Sequence analysisAdd BLAST46
ChainiPRO_500006720047 – 241Interleukin-6Add BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi122 ↔ 132By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

BgeeiENSGALG00000010915.
ExpressionAtlasiQ90YI0. differential.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: AgBase
  • growth factor activity Source: UniProtKB-KW
  • interleukin-6 receptor binding Source: Ensembl

Structurei

3D structure databases

ProteinModelPortaliQ90YI0.
SMRiQ90YI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000000878.
HOGENOMiHOG000208208.
InParanoidiQ90YI0.
KOiK05405.
OMAiCENSMEM.
OrthoDBiEOG091G0NW5.
PhylomeDBiQ90YI0.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
PANTHERiPTHR10078:SF51. PTHR10078:SF51. 1 hit.
PfamiView protein in Pfam
PF00489. IL6. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiView protein in SMART
SM00126. IL6. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00254. INTERLEUKIN_6. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90YI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFTEGCEAT GRRPGSAGSR RRRAPRPGPV ALLPLLLPLL LPPAAAVPLP
60 70 80 90 100
AAADSSGEVG LEEEAGARRA LLDCEPLARV LRDRAVQLQD EMCKKFTVCE
110 120 130 140 150
NSMEMLVRNN LNLPKVTEED GCLLAGFDEE KCLTKLSSGL FAFQTYLEFI
160 170 180 190 200
QETFDSEKQN VESLCYSTKH LAATIRQMVI NPDEVVIPDS AAQKSLLANL
210 220 230 240
KSDKDWIEKI TMHLILRDFT SFMEKTVRAV RYLKKTRSFS A
Length:241
Mass (Da):26,790
Last modified:December 1, 2001 - v1
Checksum:i657F8049F25BD2F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250838 Genomic DNA. Translation: CAC15566.2.
AJ309540 mRNA. Translation: CAC40812.1.
RefSeqiNP_989959.1. NM_204628.1.
UniGeneiGga.2769.

Genome annotation databases

EnsembliENSGALT00000017759; ENSGALP00000017738; ENSGALG00000010915.
GeneIDi395337.
KEGGigga:395337.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiIL6_CHICK
AccessioniPrimary (citable) accession number: Q90YI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: December 1, 2001
Last modified: June 7, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families