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Protein

Interleukin-6

Gene

IL6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity).By similarity

GO - Molecular functioni

  • cytokine activity Source: AgBase
  • growth factor activity Source: UniProtKB-KW
  • interleukin-6 receptor binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processAcute phase

Enzyme and pathway databases

ReactomeiR-GGA-1059683 Interleukin-6 signaling
R-GGA-112411 MAPK1 (ERK2) activation
R-GGA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-GGA-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6
Short name:
ChIL-6
Short name:
IL-6
Gene namesi
Name:IL6
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 46Sequence analysisAdd BLAST46
ChainiPRO_500006720047 – 241Interleukin-6Add BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi122 ↔ 132By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

BgeeiENSGALG00000010915
ExpressionAtlasiQ90YI0 differential

Interactioni

GO - Molecular functioni

  • cytokine activity Source: AgBase
  • growth factor activity Source: UniProtKB-KW
  • interleukin-6 receptor binding Source: Ensembl

Structurei

3D structure databases

ProteinModelPortaliQ90YI0
SMRiQ90YI0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000000878
HOGENOMiHOG000208208
InParanoidiQ90YI0
KOiK05405
OMAiCENSMEM
OrthoDBiEOG091G0NW5
PhylomeDBiQ90YI0

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR003574 IL-6
IPR030474 IL-6/GCSF/MGF
IPR030473 IL6/GCSF/MGF_CS
PANTHERiPTHR45110 PTHR45110, 1 hit
PfamiView protein in Pfam
PF00489 IL6, 1 hit
PRINTSiPR00433 IL6GCSFMGF
SMARTiView protein in SMART
SM00126 IL6, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00254 INTERLEUKIN_6, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90YI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFTEGCEAT GRRPGSAGSR RRRAPRPGPV ALLPLLLPLL LPPAAAVPLP
60 70 80 90 100
AAADSSGEVG LEEEAGARRA LLDCEPLARV LRDRAVQLQD EMCKKFTVCE
110 120 130 140 150
NSMEMLVRNN LNLPKVTEED GCLLAGFDEE KCLTKLSSGL FAFQTYLEFI
160 170 180 190 200
QETFDSEKQN VESLCYSTKH LAATIRQMVI NPDEVVIPDS AAQKSLLANL
210 220 230 240
KSDKDWIEKI TMHLILRDFT SFMEKTVRAV RYLKKTRSFS A
Length:241
Mass (Da):26,790
Last modified:December 1, 2001 - v1
Checksum:i657F8049F25BD2F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250838 Genomic DNA Translation: CAC15566.2
AJ309540 mRNA Translation: CAC40812.1
RefSeqiNP_989959.1, NM_204628.1
UniGeneiGga.2769

Genome annotation databases

EnsembliENSGALT00000017759; ENSGALP00000017738; ENSGALG00000010915
GeneIDi395337
KEGGigga:395337

Similar proteinsi

Entry informationi

Entry nameiIL6_CHICK
AccessioniPrimary (citable) accession number: Q90YI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health