Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-6

Gene

IL6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity).By similarity

GO - Molecular functioni

  • cytokine activity Source: AgBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Acute phase

Enzyme and pathway databases

ReactomeiR-GGA-1059683. Interleukin-6 signaling.
R-GGA-112411. MAPK1 (ERK2) activation.
R-GGA-2559582. Senescence-Associated Secretory Phenotype (SASP).

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6
Short name:
ChIL-6
Short name:
IL-6
Gene namesi
Name:IL6
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4646Sequence analysisAdd
BLAST
Chaini47 – 241195Interleukin-6PRO_5000067200Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi122 ↔ 132By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

ExpressionAtlasiQ90YI0. baseline and differential.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: AgBase

Structurei

3D structure databases

ProteinModelPortaliQ90YI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000000878.
HOGENOMiHOG000208208.
InParanoidiQ90YI0.
KOiK05405.
OMAiCENSMEM.
PhylomeDBiQ90YI0.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PANTHERiPTHR11457. PTHR11457. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90YI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFTEGCEAT GRRPGSAGSR RRRAPRPGPV ALLPLLLPLL LPPAAAVPLP
60 70 80 90 100
AAADSSGEVG LEEEAGARRA LLDCEPLARV LRDRAVQLQD EMCKKFTVCE
110 120 130 140 150
NSMEMLVRNN LNLPKVTEED GCLLAGFDEE KCLTKLSSGL FAFQTYLEFI
160 170 180 190 200
QETFDSEKQN VESLCYSTKH LAATIRQMVI NPDEVVIPDS AAQKSLLANL
210 220 230 240
KSDKDWIEKI TMHLILRDFT SFMEKTVRAV RYLKKTRSFS A
Length:241
Mass (Da):26,790
Last modified:December 1, 2001 - v1
Checksum:i657F8049F25BD2F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250838 Genomic DNA. Translation: CAC15566.2.
AJ309540 mRNA. Translation: CAC40812.1.
RefSeqiNP_989959.1. NM_204628.1.
UniGeneiGga.2769.

Genome annotation databases

EnsembliENSGALT00000017759; ENSGALP00000017738; ENSGALG00000010915.
GeneIDi395337.
KEGGigga:395337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250838 Genomic DNA. Translation: CAC15566.2.
AJ309540 mRNA. Translation: CAC40812.1.
RefSeqiNP_989959.1. NM_204628.1.
UniGeneiGga.2769.

3D structure databases

ProteinModelPortaliQ90YI0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000017759; ENSGALP00000017738; ENSGALG00000010915.
GeneIDi395337.
KEGGigga:395337.

Organism-specific databases

CTDi3569.

Phylogenomic databases

GeneTreeiENSGT00390000000878.
HOGENOMiHOG000208208.
InParanoidiQ90YI0.
KOiK05405.
OMAiCENSMEM.
PhylomeDBiQ90YI0.

Enzyme and pathway databases

ReactomeiR-GGA-1059683. Interleukin-6 signaling.
R-GGA-112411. MAPK1 (ERK2) activation.
R-GGA-2559582. Senescence-Associated Secretory Phenotype (SASP).

Miscellaneous databases

NextBioi20815422.
PROiQ90YI0.

Gene expression databases

ExpressionAtlasiQ90YI0. baseline and differential.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PANTHERiPTHR11457. PTHR11457. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Differential cytokine expression in avian cells in response to invasion by Salmonella typhimurium, Salmonella enteritidis and Salmonella gallinarum."
    Kaiser P., Rothwell L., Galyov E.E., Barrow P.A., Burnside J., Wigley P.
    Microbiology 146:3217-3226(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Chicken interleukin-6. cDNA structure and biological properties."
    Schneider K., Klaas R., Kaspers B., Staeheli P.
    Eur. J. Biochem. 268:4200-4206(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiIL6_CHICK
AccessioniPrimary (citable) accession number: Q90YI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.