ID   JAG1B_DANRE             Reviewed;        1213 AA.
AC   Q90Y54;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   27-MAR-2024, entry version 148.
DE   RecName: Full=Protein jagged-1b;
DE            Short=Jagged1b;
DE   AltName: Full=Jagged3;
DE   Flags: Precursor;
GN   Name=jag1b; Synonyms=jag3;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Oda T., Chandrasekharappa S.C.;
RT   "Isolation, characterization and expression analysis of zebrafish Jagged
RT   genes.";
RL   Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Ligand for Notch receptors and involved in the mediation of
CC       Notch signaling (By similarity). Seems to be involved in cell-fate
CC       decisions. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}. Cell membrane
CC       {ECO:0000250|UniProtKB:P78504}.
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DR   EMBL; AF229451; AAL08216.1; -; mRNA.
DR   AlphaFoldDB; Q90Y54; -.
DR   SMR; Q90Y54; -.
DR   STRING; 7955.ENSDARP00000008197; -.
DR   GlyCosmos; Q90Y54; 7 sites, No reported glycans.
DR   PaxDb; 7955-ENSDARP00000008197; -.
DR   AGR; ZFIN:ZDB-GENE-011128-4; -.
DR   ZFIN; ZDB-GENE-011128-4; jag1b.
DR   eggNOG; KOG1217; Eukaryota.
DR   InParanoid; Q90Y54; -.
DR   PhylomeDB; Q90Y54; -.
DR   Reactome; R-DRE-9013149; RAC1 GTPase cycle.
DR   Reactome; R-DRE-9013423; RAC3 GTPase cycle.
DR   SignaLink; Q90Y54; -.
DR   PRO; PR:Q90Y54; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   GO; GO:0016020; C:membrane; NAS:ZFIN.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005112; F:Notch binding; IBA:GO_Central.
DR   GO; GO:0060117; P:auditory receptor cell development; IMP:ZFIN.
DR   GO; GO:0060351; P:cartilage development involved in endochondral bone morphogenesis; IMP:ZFIN.
DR   GO; GO:1904888; P:cranial skeletal system development; IMP:ZFIN.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:ZFIN.
DR   GO; GO:0031017; P:exocrine pancreas development; IGI:ZFIN.
DR   GO; GO:0060325; P:face morphogenesis; IMP:ZFIN.
DR   GO; GO:0031101; P:fin regeneration; IMP:ZFIN.
DR   GO; GO:0042472; P:inner ear morphogenesis; IMP:ZFIN.
DR   GO; GO:0035622; P:intrahepatic bile duct development; IGI:ZFIN.
DR   GO; GO:0001889; P:liver development; IGI:ZFIN.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0032474; P:otolith morphogenesis; IMP:ZFIN.
DR   GO; GO:0031016; P:pancreas development; IGI:ZFIN.
DR   GO; GO:0060872; P:semicircular canal development; IMP:ZFIN.
DR   GO; GO:0048752; P:semicircular canal morphogenesis; IMP:ZFIN.
DR   GO; GO:0030878; P:thyroid gland development; IMP:ZFIN.
DR   CDD; cd00054; EGF_CA; 13.
DR   Gene3D; 2.10.25.140; -; 1.
DR   Gene3D; 2.60.40.3510; -; 1.
DR   Gene3D; 2.10.25.10; Laminin; 15.
DR   InterPro; IPR001774; DSL.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR026219; Jagged/Serrate.
DR   InterPro; IPR011651; Notch_ligand_N.
DR   InterPro; IPR001007; VWF_dom.
DR   PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR   PANTHER; PTHR24044:SF448; PROTEIN JAGGED-1; 1.
DR   Pfam; PF21700; DL-JAG_EGF-like; 1.
DR   Pfam; PF01414; DSL; 1.
DR   Pfam; PF00008; EGF; 8.
DR   Pfam; PF07645; EGF_CA; 1.
DR   Pfam; PF12661; hEGF; 4.
DR   Pfam; PF07657; MNNL; 1.
DR   PRINTS; PR00010; EGFBLOOD.
DR   PRINTS; PR02059; JAGGEDFAMILY.
DR   SMART; SM00051; DSL; 1.
DR   SMART; SM00181; EGF; 16.
DR   SMART; SM00179; EGF_CA; 14.
DR   SMART; SM00214; VWC; 1.
DR   SMART; SM00215; VWC_out; 1.
DR   SUPFAM; SSF57196; EGF/Laminin; 7.
DR   SUPFAM; SSF57603; FnI-like domain; 1.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR   PROSITE; PS00010; ASX_HYDROXYL; 10.
DR   PROSITE; PS51051; DSL; 1.
DR   PROSITE; PS00022; EGF_1; 16.
DR   PROSITE; PS01186; EGF_2; 12.
DR   PROSITE; PS50026; EGF_3; 15.
DR   PROSITE; PS01187; EGF_CA; 8.
PE   2: Evidence at transcript level;
KW   Calcium; Cell membrane; Developmental protein; Disulfide bond;
KW   EGF-like domain; Glycoprotein; Membrane; Notch signaling pathway;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..1213
FT                   /note="Protein jagged-1b"
FT                   /id="PRO_0000007631"
FT   TOPO_DOM        27..1064
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1065..1087
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1088..1213
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          182..226
FT                   /note="DSL"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00377"
FT   DOMAIN          227..260
FT                   /note="EGF-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          261..291
FT                   /note="EGF-like 2; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          293..331
FT                   /note="EGF-like 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          333..369
FT                   /note="EGF-like 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          371..407
FT                   /note="EGF-like 5; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          409..445
FT                   /note="EGF-like 6; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          447..482
FT                   /note="EGF-like 7; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          484..520
FT                   /note="EGF-like 8; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          522..558
FT                   /note="EGF-like 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          592..624
FT                   /note="EGF-like 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          626..662
FT                   /note="EGF-like 11; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          664..700
FT                   /note="EGF-like 12; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          702..738
FT                   /note="EGF-like 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          746..777
FT                   /note="EGF-like 14"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          779..815
FT                   /note="EGF-like 15; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          817..853
FT                   /note="EGF-like 16; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          860..914
FT                   /note="VWFC"
FT   DOMAIN          918..956
FT                   /note="EGF-like 17"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   REGION          1181..1202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1188..1202
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        139
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        214
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        556
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        742
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        957
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        988
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1042
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        184..193
FT                   /evidence="ECO:0000250"
FT   DISULFID        197..209
FT                   /evidence="ECO:0000250"
FT   DISULFID        217..226
FT                   /evidence="ECO:0000250"
FT   DISULFID        231..242
FT                   /evidence="ECO:0000250"
FT   DISULFID        235..248
FT                   /evidence="ECO:0000250"
FT   DISULFID        250..259
FT                   /evidence="ECO:0000250"
FT   DISULFID        262..273
FT                   /evidence="ECO:0000250"
FT   DISULFID        268..279
FT                   /evidence="ECO:0000250"
FT   DISULFID        281..290
FT                   /evidence="ECO:0000250"
FT   DISULFID        297..309
FT                   /evidence="ECO:0000250"
FT   DISULFID        303..319
FT                   /evidence="ECO:0000250"
FT   DISULFID        321..330
FT                   /evidence="ECO:0000250"
FT   DISULFID        337..348
FT                   /evidence="ECO:0000250"
FT   DISULFID        342..357
FT                   /evidence="ECO:0000250"
FT   DISULFID        359..368
FT                   /evidence="ECO:0000250"
FT   DISULFID        375..386
FT                   /evidence="ECO:0000250"
FT   DISULFID        380..395
FT                   /evidence="ECO:0000250"
FT   DISULFID        397..406
FT                   /evidence="ECO:0000250"
FT   DISULFID        413..424
FT                   /evidence="ECO:0000250"
FT   DISULFID        418..433
FT                   /evidence="ECO:0000250"
FT   DISULFID        435..444
FT                   /evidence="ECO:0000250"
FT   DISULFID        451..461
FT                   /evidence="ECO:0000250"
FT   DISULFID        455..470
FT                   /evidence="ECO:0000250"
FT   DISULFID        472..481
FT                   /evidence="ECO:0000250"
FT   DISULFID        488..499
FT                   /evidence="ECO:0000250"
FT   DISULFID        493..508
FT                   /evidence="ECO:0000250"
FT   DISULFID        510..519
FT                   /evidence="ECO:0000250"
FT   DISULFID        526..537
FT                   /evidence="ECO:0000250"
FT   DISULFID        531..546
FT                   /evidence="ECO:0000250"
FT   DISULFID        548..557
FT                   /evidence="ECO:0000250"
FT   DISULFID        596..612
FT                   /evidence="ECO:0000250"
FT   DISULFID        614..623
FT                   /evidence="ECO:0000250"
FT   DISULFID        630..641
FT                   /evidence="ECO:0000250"
FT   DISULFID        635..650
FT                   /evidence="ECO:0000250"
FT   DISULFID        652..661
FT                   /evidence="ECO:0000250"
FT   DISULFID        668..679
FT                   /evidence="ECO:0000250"
FT   DISULFID        673..688
FT                   /evidence="ECO:0000250"
FT   DISULFID        690..699
FT                   /evidence="ECO:0000250"
FT   DISULFID        706..717
FT                   /evidence="ECO:0000250"
FT   DISULFID        711..726
FT                   /evidence="ECO:0000250"
FT   DISULFID        728..737
FT                   /evidence="ECO:0000250"
FT   DISULFID        745..756
FT                   /evidence="ECO:0000250"
FT   DISULFID        750..765
FT                   /evidence="ECO:0000250"
FT   DISULFID        767..776
FT                   /evidence="ECO:0000250"
FT   DISULFID        783..794
FT                   /evidence="ECO:0000250"
FT   DISULFID        788..803
FT                   /evidence="ECO:0000250"
FT   DISULFID        805..814
FT                   /evidence="ECO:0000250"
FT   DISULFID        821..832
FT                   /evidence="ECO:0000250"
FT   DISULFID        826..841
FT                   /evidence="ECO:0000250"
FT   DISULFID        843..852
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   1213 AA;  133366 MW;  5C5F16A7E20D9534 CRC64;
     MILRRSSVFS AFYLHAFLLC LRTTVSDASG HFELEILSMQ NANGELQNGA CCDGARNPAD
     RKCTRDECDT YFKVCLKEYQ SRVSSAGACS FGTGSTPVLG GNKFSTKGTR SEKSRIVLPF
     SFAWPRSYTL IVEALDFNNE TASESGKLIE KAYHSGMINP NRQWQRLTHN GPVAQFEYQI
     RVTCLEHYYG FGCNKFCRPR DEFFGHYTCD QNGNKTCLEG WTGPDCNTAI CRQGCSTEHG
     SCKQPGGCKC LYGWQGPYCD KCIPHPGCVH GTCVEPWQCL CDTNWGGQLC DKDLNYCGTH
     QPCLNGGTCS NTGPDKYQCS CEDGYSGVNC ERAEHACLSN PCANGGTCKE TSQGYECHCA
     IGWSGTSCEI NVDDCTPNQC KHGGTCQDLV NGFKCACPPH WTGKTCQIDA NECEDKPCVN
     AKSCHNLIGA YFCECLPGWS GQNCDININD CKGQCLNGGT CKDLVNGYRC LCPPGYTGEQ
     CEKDVDECAS SPCLNGGRCQ DEVNGFQCLC PAGFSGQLCQ LDIDYCKPNP CQNGAQCFNL
     ASDYFCKCPD DYEGKNCSHL KDHCRTTSCQ VIDSCTVAVA SNSTPEGVRY ISSNVCGPHG
     RCRSQAGGQF TCECQEGFRG TYCHENINDC ESNPCRNGGT CIDKVNVYQC ICADGWEGVH
     CEINIDDCSL NPCLNKGACQ DLVNDFYCEC RNGWKGKTCH SRDSQCDEAT CNNGGTCHDE
     GDTFKCRCSP GWEGATCNIA KNSSCLPNPC ENGGTCVVNG DSFNCVCKEG WEGSTCTENT
     NDCNPHPCYN SGTCVDGENW YRCECAPGFA GPDCRININE CQSSPCAFGS TCVDEINGYR
     CLCPPGRIGP DCQEVVGRPC IANGQVTADG AKWEEDCNIC QCQNGRIHCT MMWCGPKSCR
     IGKARGGCPA SQSCVPIKEE QCFVKPCPSL GECWPSAPPP PSKCHASFSY QDDSCANITF
     TFNKENMPQG LSVEHVCNEL RHWYLLKNLS TEYAVSISCE PSSSASNEIH ISISTEEPRT
     DRSPIKDITV QIIDLVSKHN GNSTIIKAIT GVRVHQIPSP KTDYLVPLLS SIFIVLWIFA
     LASAFLWCIH RRRKQNTHSN TATSATEDNT TNNVREQLNQ IKNPIEKHAA HGVPIKDYEG
     KNSIIAKIRT HNSEVEEEDM DKHLQKARFT KQPAYTLVER EERAPNKNPN WTNKQDNRDL
     ETAQSLNRME YIV
//