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Q90Y54

- JAG1B_DANRE

UniProt

Q90Y54 - JAG1B_DANRE

Protein

Protein jagged-1b

Gene

jag1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Ligand for Notch receptors and involved in the mediation of Notch signaling By similarity. Seems to be involved in cell-fate decisions.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. auditory receptor cell development Source: ZFIN
    2. cartilage development involved in endochondral bone morphogenesis Source: ZFIN
    3. dorsal/ventral pattern formation Source: ZFIN
    4. face morphogenesis Source: ZFIN
    5. inner ear morphogenesis Source: ZFIN
    6. liver development Source: ZFIN
    7. Notch signaling pathway Source: UniProtKB-KW
    8. otolith morphogenesis Source: ZFIN
    9. pancreas development Source: ZFIN
    10. semicircular canal morphogenesis Source: ZFIN
    11. thyroid gland development Source: ZFIN

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Notch signaling pathway

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein jagged-1b
    Short name:
    Jagged1b
    Alternative name(s):
    Jagged3
    Gene namesi
    Name:jag1b
    Synonyms:jag3
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-011128-4. jag1b.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: ZFIN

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 12131187Protein jagged-1bPRO_0000007631Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi184 ↔ 193By similarity
    Disulfide bondi197 ↔ 209By similarity
    Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi217 ↔ 226By similarity
    Disulfide bondi231 ↔ 242By similarity
    Disulfide bondi235 ↔ 248By similarity
    Disulfide bondi250 ↔ 259By similarity
    Disulfide bondi262 ↔ 273By similarity
    Disulfide bondi268 ↔ 279By similarity
    Disulfide bondi281 ↔ 290By similarity
    Disulfide bondi297 ↔ 309By similarity
    Disulfide bondi303 ↔ 319By similarity
    Disulfide bondi321 ↔ 330By similarity
    Disulfide bondi337 ↔ 348By similarity
    Disulfide bondi342 ↔ 357By similarity
    Disulfide bondi359 ↔ 368By similarity
    Disulfide bondi375 ↔ 386By similarity
    Disulfide bondi380 ↔ 395By similarity
    Disulfide bondi397 ↔ 406By similarity
    Disulfide bondi413 ↔ 424By similarity
    Disulfide bondi418 ↔ 433By similarity
    Disulfide bondi435 ↔ 444By similarity
    Disulfide bondi451 ↔ 461By similarity
    Disulfide bondi455 ↔ 470By similarity
    Disulfide bondi472 ↔ 481By similarity
    Disulfide bondi488 ↔ 499By similarity
    Disulfide bondi493 ↔ 508By similarity
    Disulfide bondi510 ↔ 519By similarity
    Disulfide bondi526 ↔ 537By similarity
    Disulfide bondi531 ↔ 546By similarity
    Disulfide bondi548 ↔ 557By similarity
    Glycosylationi556 – 5561N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi596 ↔ 612By similarity
    Disulfide bondi614 ↔ 623By similarity
    Disulfide bondi630 ↔ 641By similarity
    Disulfide bondi635 ↔ 650By similarity
    Disulfide bondi652 ↔ 661By similarity
    Disulfide bondi668 ↔ 679By similarity
    Disulfide bondi673 ↔ 688By similarity
    Disulfide bondi690 ↔ 699By similarity
    Disulfide bondi706 ↔ 717By similarity
    Disulfide bondi711 ↔ 726By similarity
    Disulfide bondi728 ↔ 737By similarity
    Glycosylationi742 – 7421N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi745 ↔ 756By similarity
    Disulfide bondi750 ↔ 765By similarity
    Disulfide bondi767 ↔ 776By similarity
    Disulfide bondi783 ↔ 794By similarity
    Disulfide bondi788 ↔ 803By similarity
    Disulfide bondi805 ↔ 814By similarity
    Disulfide bondi821 ↔ 832By similarity
    Disulfide bondi826 ↔ 841By similarity
    Disulfide bondi843 ↔ 852By similarity
    Glycosylationi957 – 9571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi988 – 9881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1042 – 10421N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ90Y54.
    SMRiQ90Y54. Positions 183-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 10641038ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1088 – 1213126CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1065 – 108723HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini182 – 22645DSLPROSITE-ProRule annotationAdd
    BLAST
    Domaini227 – 26034EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini261 – 29131EGF-like 2; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Domaini293 – 33139EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini333 – 36937EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini371 – 40737EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini409 – 44537EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini447 – 48236EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini484 – 52037EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini522 – 55837EGF-like 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini592 – 62433EGF-like 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini626 – 66237EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini664 – 70037EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini702 – 73837EGF-like 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini746 – 77732EGF-like 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini779 – 81537EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini817 – 85337EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini860 – 91455VWFCAdd
    BLAST
    Domaini918 – 95639EGF-like 17PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi938 – 9414Poly-Pro

    Sequence similaritiesi

    Contains 1 DSL domain.PROSITE-ProRule annotation
    Contains 17 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 VWFC domain.Curated

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000113124.
    HOVERGENiHBG031645.
    InParanoidiQ90Y54.
    KOiK06052.
    PhylomeDBiQ90Y54.

    Family and domain databases

    InterProiIPR001774. DSL.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR026219. Jagged/Serrate.
    IPR011651. Notch_ligand_N.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF01414. DSL. 1 hit.
    PF00008. EGF. 9 hits.
    PF07645. EGF_CA. 1 hit.
    PF12661. hEGF. 1 hit.
    PF07657. MNNL. 1 hit.
    [Graphical view]
    PRINTSiPR02059. JAGGEDFAMILY.
    SMARTiSM00051. DSL. 1 hit.
    SM00181. EGF. 5 hits.
    SM00179. EGF_CA. 10 hits.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 2 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
    PS51051. DSL. 1 hit.
    PS00022. EGF_1. 16 hits.
    PS01186. EGF_2. 12 hits.
    PS50026. EGF_3. 15 hits.
    PS01187. EGF_CA. 8 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q90Y54-1 [UniParc]FASTAAdd to Basket

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    MILRRSSVFS AFYLHAFLLC LRTTVSDASG HFELEILSMQ NANGELQNGA     50
    CCDGARNPAD RKCTRDECDT YFKVCLKEYQ SRVSSAGACS FGTGSTPVLG 100
    GNKFSTKGTR SEKSRIVLPF SFAWPRSYTL IVEALDFNNE TASESGKLIE 150
    KAYHSGMINP NRQWQRLTHN GPVAQFEYQI RVTCLEHYYG FGCNKFCRPR 200
    DEFFGHYTCD QNGNKTCLEG WTGPDCNTAI CRQGCSTEHG SCKQPGGCKC 250
    LYGWQGPYCD KCIPHPGCVH GTCVEPWQCL CDTNWGGQLC DKDLNYCGTH 300
    QPCLNGGTCS NTGPDKYQCS CEDGYSGVNC ERAEHACLSN PCANGGTCKE 350
    TSQGYECHCA IGWSGTSCEI NVDDCTPNQC KHGGTCQDLV NGFKCACPPH 400
    WTGKTCQIDA NECEDKPCVN AKSCHNLIGA YFCECLPGWS GQNCDININD 450
    CKGQCLNGGT CKDLVNGYRC LCPPGYTGEQ CEKDVDECAS SPCLNGGRCQ 500
    DEVNGFQCLC PAGFSGQLCQ LDIDYCKPNP CQNGAQCFNL ASDYFCKCPD 550
    DYEGKNCSHL KDHCRTTSCQ VIDSCTVAVA SNSTPEGVRY ISSNVCGPHG 600
    RCRSQAGGQF TCECQEGFRG TYCHENINDC ESNPCRNGGT CIDKVNVYQC 650
    ICADGWEGVH CEINIDDCSL NPCLNKGACQ DLVNDFYCEC RNGWKGKTCH 700
    SRDSQCDEAT CNNGGTCHDE GDTFKCRCSP GWEGATCNIA KNSSCLPNPC 750
    ENGGTCVVNG DSFNCVCKEG WEGSTCTENT NDCNPHPCYN SGTCVDGENW 800
    YRCECAPGFA GPDCRININE CQSSPCAFGS TCVDEINGYR CLCPPGRIGP 850
    DCQEVVGRPC IANGQVTADG AKWEEDCNIC QCQNGRIHCT MMWCGPKSCR 900
    IGKARGGCPA SQSCVPIKEE QCFVKPCPSL GECWPSAPPP PSKCHASFSY 950
    QDDSCANITF TFNKENMPQG LSVEHVCNEL RHWYLLKNLS TEYAVSISCE 1000
    PSSSASNEIH ISISTEEPRT DRSPIKDITV QIIDLVSKHN GNSTIIKAIT 1050
    GVRVHQIPSP KTDYLVPLLS SIFIVLWIFA LASAFLWCIH RRRKQNTHSN 1100
    TATSATEDNT TNNVREQLNQ IKNPIEKHAA HGVPIKDYEG KNSIIAKIRT 1150
    HNSEVEEEDM DKHLQKARFT KQPAYTLVER EERAPNKNPN WTNKQDNRDL 1200
    ETAQSLNRME YIV 1213
    Length:1,213
    Mass (Da):133,366
    Last modified:December 1, 2001 - v1
    Checksum:i5C5F16A7E20D9534
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF229451 mRNA. Translation: AAL08216.1.
    RefSeqiNP_571938.1. NM_131863.1.
    UniGeneiDr.12589.

    Genome annotation databases

    GeneIDi140423.
    KEGGidre:140423.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF229451 mRNA. Translation: AAL08216.1 .
    RefSeqi NP_571938.1. NM_131863.1.
    UniGenei Dr.12589.

    3D structure databases

    ProteinModelPortali Q90Y54.
    SMRi Q90Y54. Positions 183-331.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 140423.
    KEGGi dre:140423.

    Organism-specific databases

    CTDi 140423.
    ZFINi ZDB-GENE-011128-4. jag1b.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000113124.
    HOVERGENi HBG031645.
    InParanoidi Q90Y54.
    KOi K06052.
    PhylomeDBi Q90Y54.

    Miscellaneous databases

    NextBioi 20796977.
    PROi Q90Y54.

    Family and domain databases

    InterProi IPR001774. DSL.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR026219. Jagged/Serrate.
    IPR011651. Notch_ligand_N.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF01414. DSL. 1 hit.
    PF00008. EGF. 9 hits.
    PF07645. EGF_CA. 1 hit.
    PF12661. hEGF. 1 hit.
    PF07657. MNNL. 1 hit.
    [Graphical view ]
    PRINTSi PR02059. JAGGEDFAMILY.
    SMARTi SM00051. DSL. 1 hit.
    SM00181. EGF. 5 hits.
    SM00179. EGF_CA. 10 hits.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 2 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 10 hits.
    PS51051. DSL. 1 hit.
    PS00022. EGF_1. 16 hits.
    PS01186. EGF_2. 12 hits.
    PS50026. EGF_3. 15 hits.
    PS01187. EGF_CA. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, characterization and expression analysis of zebrafish Jagged genes."
      Oda T., Chandrasekharappa S.C.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiJAG1B_DANRE
    AccessioniPrimary (citable) accession number: Q90Y54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3