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Protein

Protein jagged-1b

Gene

jag1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions.By similarity

GO - Molecular functioni

GO - Biological processi

  • auditory receptor cell development Source: ZFIN
  • cartilage development involved in endochondral bone morphogenesis Source: ZFIN
  • dorsal/ventral pattern formation Source: ZFIN
  • face morphogenesis Source: ZFIN
  • fin regeneration Source: ZFIN
  • inner ear morphogenesis Source: ZFIN
  • liver development Source: ZFIN
  • Notch signaling pathway Source: UniProtKB-KW
  • otolith morphogenesis Source: ZFIN
  • pancreas development Source: ZFIN
  • semicircular canal development Source: ZFIN
  • semicircular canal morphogenesis Source: ZFIN
  • thyroid gland development Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Notch signaling pathway

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein jagged-1b
Short name:
Jagged1b
Alternative name(s):
Jagged3
Gene namesi
Name:jag1b
Synonyms:jag3
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-011128-4. jag1b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 1064ExtracellularSequence analysisAdd BLAST1038
Transmembranei1065 – 1087HelicalSequence analysisAdd BLAST23
Topological domaini1088 – 1213CytoplasmicSequence analysisAdd BLAST126

GO - Cellular componenti

  • integral component of membrane Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000000763127 – 1213Protein jagged-1bAdd BLAST1187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi139N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi184 ↔ 193By similarity
Disulfide bondi197 ↔ 209By similarity
Glycosylationi214N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi217 ↔ 226By similarity
Disulfide bondi231 ↔ 242By similarity
Disulfide bondi235 ↔ 248By similarity
Disulfide bondi250 ↔ 259By similarity
Disulfide bondi262 ↔ 273By similarity
Disulfide bondi268 ↔ 279By similarity
Disulfide bondi281 ↔ 290By similarity
Disulfide bondi297 ↔ 309By similarity
Disulfide bondi303 ↔ 319By similarity
Disulfide bondi321 ↔ 330By similarity
Disulfide bondi337 ↔ 348By similarity
Disulfide bondi342 ↔ 357By similarity
Disulfide bondi359 ↔ 368By similarity
Disulfide bondi375 ↔ 386By similarity
Disulfide bondi380 ↔ 395By similarity
Disulfide bondi397 ↔ 406By similarity
Disulfide bondi413 ↔ 424By similarity
Disulfide bondi418 ↔ 433By similarity
Disulfide bondi435 ↔ 444By similarity
Disulfide bondi451 ↔ 461By similarity
Disulfide bondi455 ↔ 470By similarity
Disulfide bondi472 ↔ 481By similarity
Disulfide bondi488 ↔ 499By similarity
Disulfide bondi493 ↔ 508By similarity
Disulfide bondi510 ↔ 519By similarity
Disulfide bondi526 ↔ 537By similarity
Disulfide bondi531 ↔ 546By similarity
Disulfide bondi548 ↔ 557By similarity
Glycosylationi556N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi596 ↔ 612By similarity
Disulfide bondi614 ↔ 623By similarity
Disulfide bondi630 ↔ 641By similarity
Disulfide bondi635 ↔ 650By similarity
Disulfide bondi652 ↔ 661By similarity
Disulfide bondi668 ↔ 679By similarity
Disulfide bondi673 ↔ 688By similarity
Disulfide bondi690 ↔ 699By similarity
Disulfide bondi706 ↔ 717By similarity
Disulfide bondi711 ↔ 726By similarity
Disulfide bondi728 ↔ 737By similarity
Glycosylationi742N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi745 ↔ 756By similarity
Disulfide bondi750 ↔ 765By similarity
Disulfide bondi767 ↔ 776By similarity
Disulfide bondi783 ↔ 794By similarity
Disulfide bondi788 ↔ 803By similarity
Disulfide bondi805 ↔ 814By similarity
Disulfide bondi821 ↔ 832By similarity
Disulfide bondi826 ↔ 841By similarity
Disulfide bondi843 ↔ 852By similarity
Glycosylationi957N-linked (GlcNAc...)Sequence analysis1
Glycosylationi988N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1042N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ90Y54.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000008197.

Structurei

3D structure databases

ProteinModelPortaliQ90Y54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 226DSLPROSITE-ProRule annotationAdd BLAST45
Domaini227 – 260EGF-like 1PROSITE-ProRule annotationAdd BLAST34
Domaini261 – 291EGF-like 2; atypicalPROSITE-ProRule annotationAdd BLAST31
Domaini293 – 331EGF-like 3PROSITE-ProRule annotationAdd BLAST39
Domaini333 – 369EGF-like 4PROSITE-ProRule annotationAdd BLAST37
Domaini371 – 407EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini409 – 445EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini447 – 482EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini484 – 520EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini522 – 558EGF-like 9PROSITE-ProRule annotationAdd BLAST37
Domaini592 – 624EGF-like 10PROSITE-ProRule annotationAdd BLAST33
Domaini626 – 662EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini664 – 700EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini702 – 738EGF-like 13PROSITE-ProRule annotationAdd BLAST37
Domaini746 – 777EGF-like 14PROSITE-ProRule annotationAdd BLAST32
Domaini779 – 815EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini817 – 853EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini860 – 914VWFCAdd BLAST55
Domaini918 – 956EGF-like 17PROSITE-ProRule annotationAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi938 – 941Poly-Pro4

Sequence similaritiesi

Contains 1 DSL domain.PROSITE-ProRule annotation
Contains 17 EGF-like domains.PROSITE-ProRule annotation
Contains 1 VWFC domain.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
HOGENOMiHOG000113124.
HOVERGENiHBG031645.
InParanoidiQ90Y54.
PhylomeDBiQ90Y54.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 10 hits.
PF07645. EGF_CA. 1 hit.
PF12661. hEGF. 2 hits.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 16 hits.
SM00179. EGF_CA. 14 hits.
SM00214. VWC. 1 hit.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 12 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90Y54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILRRSSVFS AFYLHAFLLC LRTTVSDASG HFELEILSMQ NANGELQNGA
60 70 80 90 100
CCDGARNPAD RKCTRDECDT YFKVCLKEYQ SRVSSAGACS FGTGSTPVLG
110 120 130 140 150
GNKFSTKGTR SEKSRIVLPF SFAWPRSYTL IVEALDFNNE TASESGKLIE
160 170 180 190 200
KAYHSGMINP NRQWQRLTHN GPVAQFEYQI RVTCLEHYYG FGCNKFCRPR
210 220 230 240 250
DEFFGHYTCD QNGNKTCLEG WTGPDCNTAI CRQGCSTEHG SCKQPGGCKC
260 270 280 290 300
LYGWQGPYCD KCIPHPGCVH GTCVEPWQCL CDTNWGGQLC DKDLNYCGTH
310 320 330 340 350
QPCLNGGTCS NTGPDKYQCS CEDGYSGVNC ERAEHACLSN PCANGGTCKE
360 370 380 390 400
TSQGYECHCA IGWSGTSCEI NVDDCTPNQC KHGGTCQDLV NGFKCACPPH
410 420 430 440 450
WTGKTCQIDA NECEDKPCVN AKSCHNLIGA YFCECLPGWS GQNCDININD
460 470 480 490 500
CKGQCLNGGT CKDLVNGYRC LCPPGYTGEQ CEKDVDECAS SPCLNGGRCQ
510 520 530 540 550
DEVNGFQCLC PAGFSGQLCQ LDIDYCKPNP CQNGAQCFNL ASDYFCKCPD
560 570 580 590 600
DYEGKNCSHL KDHCRTTSCQ VIDSCTVAVA SNSTPEGVRY ISSNVCGPHG
610 620 630 640 650
RCRSQAGGQF TCECQEGFRG TYCHENINDC ESNPCRNGGT CIDKVNVYQC
660 670 680 690 700
ICADGWEGVH CEINIDDCSL NPCLNKGACQ DLVNDFYCEC RNGWKGKTCH
710 720 730 740 750
SRDSQCDEAT CNNGGTCHDE GDTFKCRCSP GWEGATCNIA KNSSCLPNPC
760 770 780 790 800
ENGGTCVVNG DSFNCVCKEG WEGSTCTENT NDCNPHPCYN SGTCVDGENW
810 820 830 840 850
YRCECAPGFA GPDCRININE CQSSPCAFGS TCVDEINGYR CLCPPGRIGP
860 870 880 890 900
DCQEVVGRPC IANGQVTADG AKWEEDCNIC QCQNGRIHCT MMWCGPKSCR
910 920 930 940 950
IGKARGGCPA SQSCVPIKEE QCFVKPCPSL GECWPSAPPP PSKCHASFSY
960 970 980 990 1000
QDDSCANITF TFNKENMPQG LSVEHVCNEL RHWYLLKNLS TEYAVSISCE
1010 1020 1030 1040 1050
PSSSASNEIH ISISTEEPRT DRSPIKDITV QIIDLVSKHN GNSTIIKAIT
1060 1070 1080 1090 1100
GVRVHQIPSP KTDYLVPLLS SIFIVLWIFA LASAFLWCIH RRRKQNTHSN
1110 1120 1130 1140 1150
TATSATEDNT TNNVREQLNQ IKNPIEKHAA HGVPIKDYEG KNSIIAKIRT
1160 1170 1180 1190 1200
HNSEVEEEDM DKHLQKARFT KQPAYTLVER EERAPNKNPN WTNKQDNRDL
1210
ETAQSLNRME YIV
Length:1,213
Mass (Da):133,366
Last modified:December 1, 2001 - v1
Checksum:i5C5F16A7E20D9534
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229451 mRNA. Translation: AAL08216.1.
UniGeneiDr.12589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229451 mRNA. Translation: AAL08216.1.
UniGeneiDr.12589.

3D structure databases

ProteinModelPortaliQ90Y54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000008197.

Proteomic databases

PaxDbiQ90Y54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-011128-4. jag1b.

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
HOGENOMiHOG000113124.
HOVERGENiHBG031645.
InParanoidiQ90Y54.
PhylomeDBiQ90Y54.

Miscellaneous databases

PROiQ90Y54.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 10 hits.
PF07645. EGF_CA. 1 hit.
PF12661. hEGF. 2 hits.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 16 hits.
SM00179. EGF_CA. 14 hits.
SM00214. VWC. 1 hit.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 12 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiJAG1B_DANRE
AccessioniPrimary (citable) accession number: Q90Y54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: October 5, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.