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Q90Y54

- JAG1B_DANRE

UniProt

Q90Y54 - JAG1B_DANRE

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Protein

Protein jagged-1b

Gene

jag1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions.By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. auditory receptor cell development Source: ZFIN
  2. cartilage development involved in endochondral bone morphogenesis Source: ZFIN
  3. dorsal/ventral pattern formation Source: ZFIN
  4. face morphogenesis Source: ZFIN
  5. inner ear morphogenesis Source: ZFIN
  6. liver development Source: ZFIN
  7. Notch signaling pathway Source: UniProtKB-KW
  8. otolith morphogenesis Source: ZFIN
  9. pancreas development Source: ZFIN
  10. semicircular canal morphogenesis Source: ZFIN
  11. thyroid gland development Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Notch signaling pathway

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein jagged-1b
Short name:
Jagged1b
Alternative name(s):
Jagged3
Gene namesi
Name:jag1b
Synonyms:jag3
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-011128-4. jag1b.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 12131187Protein jagged-1bPRO_0000007631Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi184 ↔ 193By similarity
Disulfide bondi197 ↔ 209By similarity
Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi217 ↔ 226By similarity
Disulfide bondi231 ↔ 242By similarity
Disulfide bondi235 ↔ 248By similarity
Disulfide bondi250 ↔ 259By similarity
Disulfide bondi262 ↔ 273By similarity
Disulfide bondi268 ↔ 279By similarity
Disulfide bondi281 ↔ 290By similarity
Disulfide bondi297 ↔ 309By similarity
Disulfide bondi303 ↔ 319By similarity
Disulfide bondi321 ↔ 330By similarity
Disulfide bondi337 ↔ 348By similarity
Disulfide bondi342 ↔ 357By similarity
Disulfide bondi359 ↔ 368By similarity
Disulfide bondi375 ↔ 386By similarity
Disulfide bondi380 ↔ 395By similarity
Disulfide bondi397 ↔ 406By similarity
Disulfide bondi413 ↔ 424By similarity
Disulfide bondi418 ↔ 433By similarity
Disulfide bondi435 ↔ 444By similarity
Disulfide bondi451 ↔ 461By similarity
Disulfide bondi455 ↔ 470By similarity
Disulfide bondi472 ↔ 481By similarity
Disulfide bondi488 ↔ 499By similarity
Disulfide bondi493 ↔ 508By similarity
Disulfide bondi510 ↔ 519By similarity
Disulfide bondi526 ↔ 537By similarity
Disulfide bondi531 ↔ 546By similarity
Disulfide bondi548 ↔ 557By similarity
Glycosylationi556 – 5561N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi596 ↔ 612By similarity
Disulfide bondi614 ↔ 623By similarity
Disulfide bondi630 ↔ 641By similarity
Disulfide bondi635 ↔ 650By similarity
Disulfide bondi652 ↔ 661By similarity
Disulfide bondi668 ↔ 679By similarity
Disulfide bondi673 ↔ 688By similarity
Disulfide bondi690 ↔ 699By similarity
Disulfide bondi706 ↔ 717By similarity
Disulfide bondi711 ↔ 726By similarity
Disulfide bondi728 ↔ 737By similarity
Glycosylationi742 – 7421N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi745 ↔ 756By similarity
Disulfide bondi750 ↔ 765By similarity
Disulfide bondi767 ↔ 776By similarity
Disulfide bondi783 ↔ 794By similarity
Disulfide bondi788 ↔ 803By similarity
Disulfide bondi805 ↔ 814By similarity
Disulfide bondi821 ↔ 832By similarity
Disulfide bondi826 ↔ 841By similarity
Disulfide bondi843 ↔ 852By similarity
Glycosylationi957 – 9571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi988 – 9881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1042 – 10421N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ90Y54.
SMRiQ90Y54. Positions 183-331.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 10641038ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1088 – 1213126CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1065 – 108723HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini182 – 22645DSLPROSITE-ProRule annotationAdd
BLAST
Domaini227 – 26034EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini261 – 29131EGF-like 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Domaini293 – 33139EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini333 – 36937EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini371 – 40737EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini409 – 44537EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini447 – 48236EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini484 – 52037EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini522 – 55837EGF-like 9PROSITE-ProRule annotationAdd
BLAST
Domaini592 – 62433EGF-like 10PROSITE-ProRule annotationAdd
BLAST
Domaini626 – 66237EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini664 – 70037EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini702 – 73837EGF-like 13PROSITE-ProRule annotationAdd
BLAST
Domaini746 – 77732EGF-like 14PROSITE-ProRule annotationAdd
BLAST
Domaini779 – 81537EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini817 – 85337EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini860 – 91455VWFCAdd
BLAST
Domaini918 – 95639EGF-like 17PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi938 – 9414Poly-Pro

Sequence similaritiesi

Contains 1 DSL domain.PROSITE-ProRule annotation
Contains 17 EGF-like domains.PROSITE-ProRule annotation
Contains 1 VWFC domain.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000113124.
HOVERGENiHBG031645.
InParanoidiQ90Y54.
KOiK06052.
PhylomeDBiQ90Y54.

Family and domain databases

InterProiIPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_C.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 9 hits.
PF07645. EGF_CA. 1 hit.
PF12661. hEGF. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 10 hits.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 12 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90Y54-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MILRRSSVFS AFYLHAFLLC LRTTVSDASG HFELEILSMQ NANGELQNGA
60 70 80 90 100
CCDGARNPAD RKCTRDECDT YFKVCLKEYQ SRVSSAGACS FGTGSTPVLG
110 120 130 140 150
GNKFSTKGTR SEKSRIVLPF SFAWPRSYTL IVEALDFNNE TASESGKLIE
160 170 180 190 200
KAYHSGMINP NRQWQRLTHN GPVAQFEYQI RVTCLEHYYG FGCNKFCRPR
210 220 230 240 250
DEFFGHYTCD QNGNKTCLEG WTGPDCNTAI CRQGCSTEHG SCKQPGGCKC
260 270 280 290 300
LYGWQGPYCD KCIPHPGCVH GTCVEPWQCL CDTNWGGQLC DKDLNYCGTH
310 320 330 340 350
QPCLNGGTCS NTGPDKYQCS CEDGYSGVNC ERAEHACLSN PCANGGTCKE
360 370 380 390 400
TSQGYECHCA IGWSGTSCEI NVDDCTPNQC KHGGTCQDLV NGFKCACPPH
410 420 430 440 450
WTGKTCQIDA NECEDKPCVN AKSCHNLIGA YFCECLPGWS GQNCDININD
460 470 480 490 500
CKGQCLNGGT CKDLVNGYRC LCPPGYTGEQ CEKDVDECAS SPCLNGGRCQ
510 520 530 540 550
DEVNGFQCLC PAGFSGQLCQ LDIDYCKPNP CQNGAQCFNL ASDYFCKCPD
560 570 580 590 600
DYEGKNCSHL KDHCRTTSCQ VIDSCTVAVA SNSTPEGVRY ISSNVCGPHG
610 620 630 640 650
RCRSQAGGQF TCECQEGFRG TYCHENINDC ESNPCRNGGT CIDKVNVYQC
660 670 680 690 700
ICADGWEGVH CEINIDDCSL NPCLNKGACQ DLVNDFYCEC RNGWKGKTCH
710 720 730 740 750
SRDSQCDEAT CNNGGTCHDE GDTFKCRCSP GWEGATCNIA KNSSCLPNPC
760 770 780 790 800
ENGGTCVVNG DSFNCVCKEG WEGSTCTENT NDCNPHPCYN SGTCVDGENW
810 820 830 840 850
YRCECAPGFA GPDCRININE CQSSPCAFGS TCVDEINGYR CLCPPGRIGP
860 870 880 890 900
DCQEVVGRPC IANGQVTADG AKWEEDCNIC QCQNGRIHCT MMWCGPKSCR
910 920 930 940 950
IGKARGGCPA SQSCVPIKEE QCFVKPCPSL GECWPSAPPP PSKCHASFSY
960 970 980 990 1000
QDDSCANITF TFNKENMPQG LSVEHVCNEL RHWYLLKNLS TEYAVSISCE
1010 1020 1030 1040 1050
PSSSASNEIH ISISTEEPRT DRSPIKDITV QIIDLVSKHN GNSTIIKAIT
1060 1070 1080 1090 1100
GVRVHQIPSP KTDYLVPLLS SIFIVLWIFA LASAFLWCIH RRRKQNTHSN
1110 1120 1130 1140 1150
TATSATEDNT TNNVREQLNQ IKNPIEKHAA HGVPIKDYEG KNSIIAKIRT
1160 1170 1180 1190 1200
HNSEVEEEDM DKHLQKARFT KQPAYTLVER EERAPNKNPN WTNKQDNRDL
1210
ETAQSLNRME YIV
Length:1,213
Mass (Da):133,366
Last modified:December 1, 2001 - v1
Checksum:i5C5F16A7E20D9534
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF229451 mRNA. Translation: AAL08216.1.
RefSeqiNP_571938.1. NM_131863.1.
UniGeneiDr.12589.

Genome annotation databases

GeneIDi140423.
KEGGidre:140423.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF229451 mRNA. Translation: AAL08216.1 .
RefSeqi NP_571938.1. NM_131863.1.
UniGenei Dr.12589.

3D structure databases

ProteinModelPortali Q90Y54.
SMRi Q90Y54. Positions 183-331.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 140423.
KEGGi dre:140423.

Organism-specific databases

CTDi 140423.
ZFINi ZDB-GENE-011128-4. jag1b.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000113124.
HOVERGENi HBG031645.
InParanoidi Q90Y54.
KOi K06052.
PhylomeDBi Q90Y54.

Miscellaneous databases

NextBioi 20796977.
PROi Q90Y54.

Family and domain databases

InterProi IPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF01414. DSL. 1 hit.
PF00008. EGF. 9 hits.
PF07645. EGF_CA. 1 hit.
PF12661. hEGF. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view ]
PRINTSi PR02059. JAGGEDFAMILY.
SMARTi SM00051. DSL. 1 hit.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 10 hits.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 2 hits.
PROSITEi PS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 12 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation, characterization and expression analysis of zebrafish Jagged genes."
    Oda T., Chandrasekharappa S.C.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiJAG1B_DANRE
AccessioniPrimary (citable) accession number: Q90Y54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: October 1, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3