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Q90Y54

- JAG1B_DANRE

UniProt

Q90Y54 - JAG1B_DANRE

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Protein

Protein jagged-1b

Gene
jag1b, jag3
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Ligand for Notch receptors and involved in the mediation of Notch signaling By similarity. Seems to be involved in cell-fate decisions.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. auditory receptor cell development Source: ZFIN
  2. cartilage development involved in endochondral bone morphogenesis Source: ZFIN
  3. dorsal/ventral pattern formation Source: ZFIN
  4. face morphogenesis Source: ZFIN
  5. inner ear morphogenesis Source: ZFIN
  6. liver development Source: ZFIN
  7. Notch signaling pathway Source: UniProtKB-KW
  8. otolith morphogenesis Source: ZFIN
  9. pancreas development Source: ZFIN
  10. semicircular canal morphogenesis Source: ZFIN
  11. thyroid gland development Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Notch signaling pathway

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein jagged-1b
Short name:
Jagged1b
Alternative name(s):
Jagged3
Gene namesi
Name:jag1b
Synonyms:jag3
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-011128-4. jag1b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 10641038Extracellular Reviewed predictionAdd
BLAST
Transmembranei1065 – 108723Helical; Reviewed predictionAdd
BLAST
Topological domaini1088 – 1213126Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed predictionAdd
BLAST
Chaini27 – 12131187Protein jagged-1bPRO_0000007631Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi139 – 1391N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi184 ↔ 193 By similarity
Disulfide bondi197 ↔ 209 By similarity
Glycosylationi214 – 2141N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi217 ↔ 226 By similarity
Disulfide bondi231 ↔ 242 By similarity
Disulfide bondi235 ↔ 248 By similarity
Disulfide bondi250 ↔ 259 By similarity
Disulfide bondi262 ↔ 273 By similarity
Disulfide bondi268 ↔ 279 By similarity
Disulfide bondi281 ↔ 290 By similarity
Disulfide bondi297 ↔ 309 By similarity
Disulfide bondi303 ↔ 319 By similarity
Disulfide bondi321 ↔ 330 By similarity
Disulfide bondi337 ↔ 348 By similarity
Disulfide bondi342 ↔ 357 By similarity
Disulfide bondi359 ↔ 368 By similarity
Disulfide bondi375 ↔ 386 By similarity
Disulfide bondi380 ↔ 395 By similarity
Disulfide bondi397 ↔ 406 By similarity
Disulfide bondi413 ↔ 424 By similarity
Disulfide bondi418 ↔ 433 By similarity
Disulfide bondi435 ↔ 444 By similarity
Disulfide bondi451 ↔ 461 By similarity
Disulfide bondi455 ↔ 470 By similarity
Disulfide bondi472 ↔ 481 By similarity
Disulfide bondi488 ↔ 499 By similarity
Disulfide bondi493 ↔ 508 By similarity
Disulfide bondi510 ↔ 519 By similarity
Disulfide bondi526 ↔ 537 By similarity
Disulfide bondi531 ↔ 546 By similarity
Disulfide bondi548 ↔ 557 By similarity
Glycosylationi556 – 5561N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi596 ↔ 612 By similarity
Disulfide bondi614 ↔ 623 By similarity
Disulfide bondi630 ↔ 641 By similarity
Disulfide bondi635 ↔ 650 By similarity
Disulfide bondi652 ↔ 661 By similarity
Disulfide bondi668 ↔ 679 By similarity
Disulfide bondi673 ↔ 688 By similarity
Disulfide bondi690 ↔ 699 By similarity
Disulfide bondi706 ↔ 717 By similarity
Disulfide bondi711 ↔ 726 By similarity
Disulfide bondi728 ↔ 737 By similarity
Glycosylationi742 – 7421N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi745 ↔ 756 By similarity
Disulfide bondi750 ↔ 765 By similarity
Disulfide bondi767 ↔ 776 By similarity
Disulfide bondi783 ↔ 794 By similarity
Disulfide bondi788 ↔ 803 By similarity
Disulfide bondi805 ↔ 814 By similarity
Disulfide bondi821 ↔ 832 By similarity
Disulfide bondi826 ↔ 841 By similarity
Disulfide bondi843 ↔ 852 By similarity
Glycosylationi957 – 9571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi988 – 9881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1042 – 10421N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ90Y54.
SMRiQ90Y54. Positions 183-331.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini182 – 22645DSLAdd
BLAST
Domaini227 – 26034EGF-like 1Add
BLAST
Domaini261 – 29131EGF-like 2; atypicalAdd
BLAST
Domaini293 – 33139EGF-like 3Add
BLAST
Domaini333 – 36937EGF-like 4Add
BLAST
Domaini371 – 40737EGF-like 5; calcium-binding Reviewed predictionAdd
BLAST
Domaini409 – 44537EGF-like 6; calcium-binding Reviewed predictionAdd
BLAST
Domaini447 – 48236EGF-like 7; calcium-binding Reviewed predictionAdd
BLAST
Domaini484 – 52037EGF-like 8; calcium-binding Reviewed predictionAdd
BLAST
Domaini522 – 55837EGF-like 9Add
BLAST
Domaini592 – 62433EGF-like 10Add
BLAST
Domaini626 – 66237EGF-like 11; calcium-binding Reviewed predictionAdd
BLAST
Domaini664 – 70037EGF-like 12; calcium-binding Reviewed predictionAdd
BLAST
Domaini702 – 73837EGF-like 13Add
BLAST
Domaini746 – 77732EGF-like 14Add
BLAST
Domaini779 – 81537EGF-like 15; calcium-binding Reviewed predictionAdd
BLAST
Domaini817 – 85337EGF-like 16; calcium-binding Reviewed predictionAdd
BLAST
Domaini860 – 91455VWFCAdd
BLAST
Domaini918 – 95639EGF-like 17Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi938 – 9414Poly-Pro

Sequence similaritiesi

Contains 1 DSL domain.
Contains 17 EGF-like domains.
Contains 1 VWFC domain.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000113124.
HOVERGENiHBG031645.
InParanoidiQ90Y54.
KOiK06052.
PhylomeDBiQ90Y54.

Family and domain databases

InterProiIPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_C.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 9 hits.
PF07645. EGF_CA. 1 hit.
PF12661. hEGF. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 10 hits.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 12 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90Y54-1 [UniParc]FASTAAdd to Basket

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MILRRSSVFS AFYLHAFLLC LRTTVSDASG HFELEILSMQ NANGELQNGA     50
CCDGARNPAD RKCTRDECDT YFKVCLKEYQ SRVSSAGACS FGTGSTPVLG 100
GNKFSTKGTR SEKSRIVLPF SFAWPRSYTL IVEALDFNNE TASESGKLIE 150
KAYHSGMINP NRQWQRLTHN GPVAQFEYQI RVTCLEHYYG FGCNKFCRPR 200
DEFFGHYTCD QNGNKTCLEG WTGPDCNTAI CRQGCSTEHG SCKQPGGCKC 250
LYGWQGPYCD KCIPHPGCVH GTCVEPWQCL CDTNWGGQLC DKDLNYCGTH 300
QPCLNGGTCS NTGPDKYQCS CEDGYSGVNC ERAEHACLSN PCANGGTCKE 350
TSQGYECHCA IGWSGTSCEI NVDDCTPNQC KHGGTCQDLV NGFKCACPPH 400
WTGKTCQIDA NECEDKPCVN AKSCHNLIGA YFCECLPGWS GQNCDININD 450
CKGQCLNGGT CKDLVNGYRC LCPPGYTGEQ CEKDVDECAS SPCLNGGRCQ 500
DEVNGFQCLC PAGFSGQLCQ LDIDYCKPNP CQNGAQCFNL ASDYFCKCPD 550
DYEGKNCSHL KDHCRTTSCQ VIDSCTVAVA SNSTPEGVRY ISSNVCGPHG 600
RCRSQAGGQF TCECQEGFRG TYCHENINDC ESNPCRNGGT CIDKVNVYQC 650
ICADGWEGVH CEINIDDCSL NPCLNKGACQ DLVNDFYCEC RNGWKGKTCH 700
SRDSQCDEAT CNNGGTCHDE GDTFKCRCSP GWEGATCNIA KNSSCLPNPC 750
ENGGTCVVNG DSFNCVCKEG WEGSTCTENT NDCNPHPCYN SGTCVDGENW 800
YRCECAPGFA GPDCRININE CQSSPCAFGS TCVDEINGYR CLCPPGRIGP 850
DCQEVVGRPC IANGQVTADG AKWEEDCNIC QCQNGRIHCT MMWCGPKSCR 900
IGKARGGCPA SQSCVPIKEE QCFVKPCPSL GECWPSAPPP PSKCHASFSY 950
QDDSCANITF TFNKENMPQG LSVEHVCNEL RHWYLLKNLS TEYAVSISCE 1000
PSSSASNEIH ISISTEEPRT DRSPIKDITV QIIDLVSKHN GNSTIIKAIT 1050
GVRVHQIPSP KTDYLVPLLS SIFIVLWIFA LASAFLWCIH RRRKQNTHSN 1100
TATSATEDNT TNNVREQLNQ IKNPIEKHAA HGVPIKDYEG KNSIIAKIRT 1150
HNSEVEEEDM DKHLQKARFT KQPAYTLVER EERAPNKNPN WTNKQDNRDL 1200
ETAQSLNRME YIV 1213
Length:1,213
Mass (Da):133,366
Last modified:December 1, 2001 - v1
Checksum:i5C5F16A7E20D9534
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF229451 mRNA. Translation: AAL08216.1.
RefSeqiNP_571938.1. NM_131863.1.
UniGeneiDr.12589.

Genome annotation databases

GeneIDi140423.
KEGGidre:140423.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF229451 mRNA. Translation: AAL08216.1 .
RefSeqi NP_571938.1. NM_131863.1.
UniGenei Dr.12589.

3D structure databases

ProteinModelPortali Q90Y54.
SMRi Q90Y54. Positions 183-331.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 140423.
KEGGi dre:140423.

Organism-specific databases

CTDi 140423.
ZFINi ZDB-GENE-011128-4. jag1b.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000113124.
HOVERGENi HBG031645.
InParanoidi Q90Y54.
KOi K06052.
PhylomeDBi Q90Y54.

Miscellaneous databases

NextBioi 20796977.
PROi Q90Y54.

Family and domain databases

InterProi IPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF01414. DSL. 1 hit.
PF00008. EGF. 9 hits.
PF07645. EGF_CA. 1 hit.
PF12661. hEGF. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view ]
PRINTSi PR02059. JAGGEDFAMILY.
SMARTi SM00051. DSL. 1 hit.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 10 hits.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 2 hits.
PROSITEi PS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 12 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation, characterization and expression analysis of zebrafish Jagged genes."
    Oda T., Chandrasekharappa S.C.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiJAG1B_DANRE
AccessioniPrimary (citable) accession number: Q90Y54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi