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Q90Y54 (JAG1B_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein jagged-1b
Short name=Jagged1b
Alternative name(s):
Jagged3
Gene names
Name:jag1b
Synonyms:jag3
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length1213 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ligand for Notch receptors and involved in the mediation of Notch signaling By similarity. Seems to be involved in cell-fate decisions.

Subcellular location

Membrane; Single-pass type I membrane protein Probable.

Sequence similarities

Contains 1 DSL domain.

Contains 17 EGF-like domains.

Contains 1 VWFC domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 12131187Protein jagged-1b
PRO_0000007631

Regions

Topological domain27 – 10641038Extracellular Potential
Transmembrane1065 – 108723Helical; Potential
Topological domain1088 – 1213126Cytoplasmic Potential
Domain182 – 22645DSL
Domain227 – 26034EGF-like 1
Domain261 – 29131EGF-like 2; atypical
Domain293 – 33139EGF-like 3
Domain333 – 36937EGF-like 4
Domain371 – 40737EGF-like 5; calcium-binding Potential
Domain409 – 44537EGF-like 6; calcium-binding Potential
Domain447 – 48236EGF-like 7; calcium-binding Potential
Domain484 – 52037EGF-like 8; calcium-binding Potential
Domain522 – 55837EGF-like 9
Domain592 – 62433EGF-like 10
Domain626 – 66237EGF-like 11; calcium-binding Potential
Domain664 – 70037EGF-like 12; calcium-binding Potential
Domain702 – 73837EGF-like 13
Domain746 – 77732EGF-like 14
Domain779 – 81537EGF-like 15; calcium-binding Potential
Domain817 – 85337EGF-like 16; calcium-binding Potential
Domain860 – 91455VWFC
Domain918 – 95639EGF-like 17
Compositional bias938 – 9414Poly-Pro

Amino acid modifications

Glycosylation1391N-linked (GlcNAc...) Potential
Glycosylation2141N-linked (GlcNAc...) Potential
Glycosylation5561N-linked (GlcNAc...) Potential
Glycosylation7421N-linked (GlcNAc...) Potential
Glycosylation9571N-linked (GlcNAc...) Potential
Glycosylation9881N-linked (GlcNAc...) Potential
Glycosylation10421N-linked (GlcNAc...) Potential
Disulfide bond184 ↔ 193 By similarity
Disulfide bond197 ↔ 209 By similarity
Disulfide bond217 ↔ 226 By similarity
Disulfide bond231 ↔ 242 By similarity
Disulfide bond235 ↔ 248 By similarity
Disulfide bond250 ↔ 259 By similarity
Disulfide bond262 ↔ 273 By similarity
Disulfide bond268 ↔ 279 By similarity
Disulfide bond281 ↔ 290 By similarity
Disulfide bond297 ↔ 309 By similarity
Disulfide bond303 ↔ 319 By similarity
Disulfide bond321 ↔ 330 By similarity
Disulfide bond337 ↔ 348 By similarity
Disulfide bond342 ↔ 357 By similarity
Disulfide bond359 ↔ 368 By similarity
Disulfide bond375 ↔ 386 By similarity
Disulfide bond380 ↔ 395 By similarity
Disulfide bond397 ↔ 406 By similarity
Disulfide bond413 ↔ 424 By similarity
Disulfide bond418 ↔ 433 By similarity
Disulfide bond435 ↔ 444 By similarity
Disulfide bond451 ↔ 461 By similarity
Disulfide bond455 ↔ 470 By similarity
Disulfide bond472 ↔ 481 By similarity
Disulfide bond488 ↔ 499 By similarity
Disulfide bond493 ↔ 508 By similarity
Disulfide bond510 ↔ 519 By similarity
Disulfide bond526 ↔ 537 By similarity
Disulfide bond531 ↔ 546 By similarity
Disulfide bond548 ↔ 557 By similarity
Disulfide bond596 ↔ 612 By similarity
Disulfide bond614 ↔ 623 By similarity
Disulfide bond630 ↔ 641 By similarity
Disulfide bond635 ↔ 650 By similarity
Disulfide bond652 ↔ 661 By similarity
Disulfide bond668 ↔ 679 By similarity
Disulfide bond673 ↔ 688 By similarity
Disulfide bond690 ↔ 699 By similarity
Disulfide bond706 ↔ 717 By similarity
Disulfide bond711 ↔ 726 By similarity
Disulfide bond728 ↔ 737 By similarity
Disulfide bond745 ↔ 756 By similarity
Disulfide bond750 ↔ 765 By similarity
Disulfide bond767 ↔ 776 By similarity
Disulfide bond783 ↔ 794 By similarity
Disulfide bond788 ↔ 803 By similarity
Disulfide bond805 ↔ 814 By similarity
Disulfide bond821 ↔ 832 By similarity
Disulfide bond826 ↔ 841 By similarity
Disulfide bond843 ↔ 852 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q90Y54 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 5C5F16A7E20D9534

FASTA1,213133,366
        10         20         30         40         50         60 
MILRRSSVFS AFYLHAFLLC LRTTVSDASG HFELEILSMQ NANGELQNGA CCDGARNPAD 

        70         80         90        100        110        120 
RKCTRDECDT YFKVCLKEYQ SRVSSAGACS FGTGSTPVLG GNKFSTKGTR SEKSRIVLPF 

       130        140        150        160        170        180 
SFAWPRSYTL IVEALDFNNE TASESGKLIE KAYHSGMINP NRQWQRLTHN GPVAQFEYQI 

       190        200        210        220        230        240 
RVTCLEHYYG FGCNKFCRPR DEFFGHYTCD QNGNKTCLEG WTGPDCNTAI CRQGCSTEHG 

       250        260        270        280        290        300 
SCKQPGGCKC LYGWQGPYCD KCIPHPGCVH GTCVEPWQCL CDTNWGGQLC DKDLNYCGTH 

       310        320        330        340        350        360 
QPCLNGGTCS NTGPDKYQCS CEDGYSGVNC ERAEHACLSN PCANGGTCKE TSQGYECHCA 

       370        380        390        400        410        420 
IGWSGTSCEI NVDDCTPNQC KHGGTCQDLV NGFKCACPPH WTGKTCQIDA NECEDKPCVN 

       430        440        450        460        470        480 
AKSCHNLIGA YFCECLPGWS GQNCDININD CKGQCLNGGT CKDLVNGYRC LCPPGYTGEQ 

       490        500        510        520        530        540 
CEKDVDECAS SPCLNGGRCQ DEVNGFQCLC PAGFSGQLCQ LDIDYCKPNP CQNGAQCFNL 

       550        560        570        580        590        600 
ASDYFCKCPD DYEGKNCSHL KDHCRTTSCQ VIDSCTVAVA SNSTPEGVRY ISSNVCGPHG 

       610        620        630        640        650        660 
RCRSQAGGQF TCECQEGFRG TYCHENINDC ESNPCRNGGT CIDKVNVYQC ICADGWEGVH 

       670        680        690        700        710        720 
CEINIDDCSL NPCLNKGACQ DLVNDFYCEC RNGWKGKTCH SRDSQCDEAT CNNGGTCHDE 

       730        740        750        760        770        780 
GDTFKCRCSP GWEGATCNIA KNSSCLPNPC ENGGTCVVNG DSFNCVCKEG WEGSTCTENT 

       790        800        810        820        830        840 
NDCNPHPCYN SGTCVDGENW YRCECAPGFA GPDCRININE CQSSPCAFGS TCVDEINGYR 

       850        860        870        880        890        900 
CLCPPGRIGP DCQEVVGRPC IANGQVTADG AKWEEDCNIC QCQNGRIHCT MMWCGPKSCR 

       910        920        930        940        950        960 
IGKARGGCPA SQSCVPIKEE QCFVKPCPSL GECWPSAPPP PSKCHASFSY QDDSCANITF 

       970        980        990       1000       1010       1020 
TFNKENMPQG LSVEHVCNEL RHWYLLKNLS TEYAVSISCE PSSSASNEIH ISISTEEPRT 

      1030       1040       1050       1060       1070       1080 
DRSPIKDITV QIIDLVSKHN GNSTIIKAIT GVRVHQIPSP KTDYLVPLLS SIFIVLWIFA 

      1090       1100       1110       1120       1130       1140 
LASAFLWCIH RRRKQNTHSN TATSATEDNT TNNVREQLNQ IKNPIEKHAA HGVPIKDYEG 

      1150       1160       1170       1180       1190       1200 
KNSIIAKIRT HNSEVEEEDM DKHLQKARFT KQPAYTLVER EERAPNKNPN WTNKQDNRDL 

      1210 
ETAQSLNRME YIV

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References

[1]"Isolation, characterization and expression analysis of zebrafish Jagged genes."
Oda T., Chandrasekharappa S.C.
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF229451 mRNA. Translation: AAL08216.1.
IPIIPI00507407.
RefSeqNP_571938.1. NM_131863.1.
UniGeneDr.12589.

3D structure databases

ProteinModelPortalQ90Y54.
SMRQ90Y54. Positions 183-331.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID140423.
KEGGdre:140423.

Organism-specific databases

CTD140423.
ZFINZDB-GENE-011128-4. jag1b.

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000113124.
HOVERGENHBG031645.
InParanoidQ90Y54.
KOK06052.
OrthoDBEOG4H729Q.

Family and domain databases

InterProIPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_C.
[Graphical view]
PfamPF01414. DSL. 1 hit.
PF00008. EGF. 9 hits.
PF07645. EGF_CA. 1 hit.
PF12661. hEGF. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSPR02059. JAGGEDFAMILY.
SMARTSM00051. DSL. 1 hit.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 10 hits.
SM00214. VWC. 1 hit.
[Graphical view]
PROSITEPS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 12 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 8 hits.
PS01208. VWFC_1. False negative.
PS50184. VWFC_2. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio20796977.

Entry information

Entry nameJAG1B_DANRE
AccessionPrimary (citable) accession number: Q90Y54
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: April 3, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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