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Protein

Claudin

Gene

cldne

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • epiboly involved in gastrulation with mouth forming second Source: ZFIN

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
Gene namesi
Name:cldneImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 15

Organism-specific databases

ZFINiZDB-GENE-010328-5 cldne

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 30HelicalUniRule annotationAdd BLAST19
Transmembranei79 – 101HelicalUniRule annotationAdd BLAST23
Transmembranei122 – 144HelicalUniRule annotationAdd BLAST23
Transmembranei164 – 185HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationSAAS annotation, Membrane, Tight junctionUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000043128

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000063319

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IIJR Eukaryota
ENOG410YA61 LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
KOiK06087
OMAiCTNFVEE
OrthoDBiEOG091G0MMR
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR005411 Claudin2
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01589 CLAUDIN2
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q90XR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSMCREILG MCLAIIGFLG AIIICALPMW KVTAFIGANI VTAQTIWEGL
60 70 80 90 100
WMNCVMQSTG QMQCKIYDSL LALPQDLQAA RALVVIAIIV SFFALILGIA
110 120 130 140 150
GGKCTNFVER EDAKAKVSIA SGVIFIIAGV LVLVPVCWSA NTIIRDFYNP
160 170 180 190 200
LLTDAQRREM GASLYIGWGV AALLIIGGGI LCSSCPPKDE KYNMKYSQPR

STATSRAYV
Length:209
Mass (Da):22,593
Last modified:December 1, 2001 - v1
Checksum:iA86F48D852E16CB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382327 Genomic DNA No translation available.
BC062846 mRNA Translation: AAH62846.1
AF359425 mRNA Translation: AAL01832.1
RefSeqiNP_571840.1, NM_131765.1
UniGeneiDr.3454

Genome annotation databases

EnsembliENSDART00000063320; ENSDARP00000063319; ENSDARG00000043128
GeneIDi81584
KEGGidre:81584

Similar proteinsi

Entry informationi

Entry nameiQ90XR9_DANRE
AccessioniPrimary (citable) accession number: Q90XR9
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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