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Protein

Claudin

Gene

cldni

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
Gene namesi
Name:cldniImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-010328-9. cldni.

Subcellular locationi

  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2722HelicalUniRule annotationAdd
BLAST
Transmembranei79 – 9820HelicalUniRule annotationAdd
BLAST
Transmembranei118 – 14023HelicalUniRule annotationAdd
BLAST
Transmembranei160 – 18122HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationSAAS annotation, Membrane, Tight junctionUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000054616.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000071321.

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410KE6H. Eukaryota.
ENOG4111CGF. LUCA.
GeneTreeiENSGT00800000124227.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
OMAiADFTTCV.
OrthoDBiEOG091G0MMR.
PhylomeDBiQ90XR6.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90XR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSAGVQIVC VALGILGLIA TVVTIAIPQW KTSAFIGQNI ITAQVSEEGL
60 70 80 90 100
WMQCVVQSTG QQQCKSYDSL LILSSDLQAA RAMTIISCML SVLSLLILCG
110 120 130 140 150
GADFTTCIEN EDVKPKVTLV SAIGLILAGL LVIIPVSWAA NNVVRDFNNP
160 170 180 190 200
MVPEAQKREL GPCIYIGWAS GVLLILAGGL LCCFSRPRSS GSSGAAKYYS
210
NSASAPSKNY V
Length:211
Mass (Da):22,174
Last modified:December 1, 2001 - v1
Checksum:i60F9E453891B5639
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX682556 Genomic DNA. No translation available.
BC065448 mRNA. Translation: AAH65448.1.
AF359428 mRNA. Translation: AAL01835.1.
RefSeqiNP_571843.1. NM_131768.2.
UniGeneiDr.1081.

Genome annotation databases

EnsembliENSDART00000076850; ENSDARP00000071321; ENSDARG00000054616.
GeneIDi569084.
KEGGidre:569084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX682556 Genomic DNA. No translation available.
BC065448 mRNA. Translation: AAH65448.1.
AF359428 mRNA. Translation: AAL01835.1.
RefSeqiNP_571843.1. NM_131768.2.
UniGeneiDr.1081.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000071321.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000076850; ENSDARP00000071321; ENSDARG00000054616.
GeneIDi569084.
KEGGidre:569084.

Organism-specific databases

CTDi569084.
ZFINiZDB-GENE-010328-9. cldni.

Phylogenomic databases

eggNOGiENOG410KE6H. Eukaryota.
ENOG4111CGF. LUCA.
GeneTreeiENSGT00800000124227.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
OMAiADFTTCV.
OrthoDBiEOG091G0MMR.
PhylomeDBiQ90XR6.
TreeFamiTF331936.

Gene expression databases

BgeeiENSDARG00000054616.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ90XR6_DANRE
AccessioniPrimary (citable) accession number: Q90XR6
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.