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Protein

Claudin

Gene

cldnh

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
Gene namesi
Name:cldnhImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-010328-8. cldnh.

Subcellular locationi

  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2923HelicalUniRule annotationAdd
BLAST
Transmembranei81 – 10424HelicalUniRule annotationAdd
BLAST
Transmembranei116 – 13924HelicalUniRule annotationAdd
BLAST
Transmembranei159 – 18224HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationSAAS annotation, Membrane, Tight junctionUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ90XR0.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000091985.

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IIJR. Eukaryota.
ENOG410YA61. LUCA.
HOVERGENiHBG000643.
KOiK06087.
PhylomeDBiQ90XR0.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003549. Claudin3.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01378. CLAUDIN3.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90XR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMGLEIGGI ALGIIGWIIS IVACALPMWR VSAFVGANIV TAQVIWEGLW
60 70 80 90 100
MNCVVQSTGQ MQCKVYDSML ALGQDLQASR AMTVIAIILA VLGVMISVMG
110 120 130 140 150
AKCTNCIEDE GAKAKVMIVS GIMFIIAGIL DLIPSAWVAN QIIRDFYNPL
160 170 180 190 200
LPGAQQRELG ASIYIGFAAA ALLIIGGAML CCTCPPKEKK YKPARMGYSA
210
PRSASAGYDK KDYV
Length:214
Mass (Da):22,788
Last modified:December 1, 2001 - v1
Checksum:i38163AB7E50BF058
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF359434 mRNA. Translation: AAL01841.1.
RefSeqiNP_571842.1. NM_131767.1.
UniGeneiDr.3267.

Genome annotation databases

GeneIDi81587.
KEGGidre:81587.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF359434 mRNA. Translation: AAL01841.1.
RefSeqiNP_571842.1. NM_131767.1.
UniGeneiDr.3267.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000091985.

Proteomic databases

PaxDbiQ90XR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81587.
KEGGidre:81587.

Organism-specific databases

CTDi81587.
ZFINiZDB-GENE-010328-8. cldnh.

Phylogenomic databases

eggNOGiENOG410IIJR. Eukaryota.
ENOG410YA61. LUCA.
HOVERGENiHBG000643.
KOiK06087.
PhylomeDBiQ90XR0.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003549. Claudin3.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01378. CLAUDIN3.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ90XR0_DANRE
AccessioniPrimary (citable) accession number: Q90XR0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.