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Protein

Claudin

Gene

cldn1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
Gene namesi
Name:cldn1Imported
Synonyms:cldn19Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-010328-11 cldn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei83 – 106HelicalUniRule annotationAdd BLAST24
Transmembranei118 – 140HelicalUniRule annotationAdd BLAST23
Transmembranei166 – 187HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationSAAS annotation, Membrane, Tight junctionUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_501014733829 – 210ClaudinSequence analysisAdd BLAST182

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000220937
HOVERGENiHBG000643
KOiK06087

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003548 Claudin1
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF92 PTHR12002:SF92, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q90XQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHAGLQMLG YCLGFLGLLG LIASTAMAEW KMSSYAGDNI ITAQAQYEGL
60 70 80 90 100
WQSCVSQSTG QLQCKKYDSL LKLPGEIQGA RGLMLTGIFL CGLSTLVSFV
110 120 130 140 150
GMKCTTCLSE APQVKSKVAL AGGVLFITGG LFALIATSWY GEKIRQKFFD
160 170 180 190 200
PFTPTNARYE FGKALYVGWG SSALSIIGGS LLCCICGSEA SEKPSYPPAR
210
AAGRPGTDRV
Length:210
Mass (Da):22,253
Last modified:December 1, 2001 - v1
Checksum:iFEFFB51CE7A98D47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097096 mRNA Translation: AAH97096.1
BC098526 mRNA Translation: AAH98526.1
AF359436 mRNA Translation: AAL01843.1
RefSeqiNP_571845.1, NM_131770.1
UniGeneiDr.75668

Genome annotation databases

GeneIDi81590
KEGGidre:81590

Similar proteinsi

Entry informationi

Entry nameiQ90XQ8_DANRE
AccessioniPrimary (citable) accession number: Q90XQ8
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health