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Protein

Claudin

Gene

cldn1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
Gene namesi
Name:cldn1Imported
Synonyms:cldn19Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-010328-11. cldn1.

Subcellular locationi

  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei83 – 106HelicalUniRule annotationAdd BLAST24
Transmembranei118 – 140HelicalUniRule annotationAdd BLAST23
Transmembranei166 – 187HelicalUniRule annotationAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationSAAS annotation, Membrane, Tight junctionUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500771550129 – 210ClaudinSequence analysisAdd BLAST182

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000220937.
HOVERGENiHBG000643.
KOiK06087.
PhylomeDBiQ90XQ8.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003548. Claudin1.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF92. PTHR12002:SF92. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90XQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHAGLQMLG YCLGFLGLLG LIASTAMAEW KMSSYAGDNI ITAQAQYEGL
60 70 80 90 100
WQSCVSQSTG QLQCKKYDSL LKLPGEIQGA RGLMLTGIFL CGLSTLVSFV
110 120 130 140 150
GMKCTTCLSE APQVKSKVAL AGGVLFITGG LFALIATSWY GEKIRQKFFD
160 170 180 190 200
PFTPTNARYE FGKALYVGWG SSALSIIGGS LLCCICGSEA SEKPSYPPAR
210
AAGRPGTDRV
Length:210
Mass (Da):22,253
Last modified:December 1, 2001 - v1
Checksum:iFEFFB51CE7A98D47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097096 mRNA. Translation: AAH97096.1.
BC098526 mRNA. Translation: AAH98526.1.
AF359436 mRNA. Translation: AAL01843.1.
RefSeqiNP_571845.1. NM_131770.1.
UniGeneiDr.75668.

Genome annotation databases

GeneIDi81590.
KEGGidre:81590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097096 mRNA. Translation: AAH97096.1.
BC098526 mRNA. Translation: AAH98526.1.
AF359436 mRNA. Translation: AAL01843.1.
RefSeqiNP_571845.1. NM_131770.1.
UniGeneiDr.75668.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81590.
KEGGidre:81590.

Organism-specific databases

CTDi9076.
ZFINiZDB-GENE-010328-11. cldn1.

Phylogenomic databases

HOGENOMiHOG000220937.
HOVERGENiHBG000643.
KOiK06087.
PhylomeDBiQ90XQ8.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003548. Claudin1.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF92. PTHR12002:SF92. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ90XQ8_DANRE
AccessioniPrimary (citable) accession number: Q90XQ8
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.