Q90XG0 (TPISB_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Triosephosphate isomerase B
Short name=TIM-B
EC=5.3.1.1

Alternative name(s):
Triose-phosphate isomerase B

Gene names

Name:

tpi1b

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	D-glyceraldehyde 3-phosphate = glycerone phosphate.
Pathway	Carbohydrate biosynthesis; gluconeogenesis. Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the triosephosphate isomerase family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis Pentose shunt
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	triose-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 248	247	Triosephosphate isomerase B		PRO_0000345141
Sites
	Active site	95	1	Electrophile By similarity
	Active site	165	1	Proton acceptor By similarity
	Binding site	11	1	Substrate By similarity
	Binding site	13	1	Substrate By similarity
Experimental info
	Sequence conflict	56	1	D → N in AAH53294. Ref.2
	Sequence conflict	56	1	D → N in AAI52272. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q90XG0 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: CFD29D9A6E7918C8	FASTA	248	26,828
	10 20 30 40 50 60 MSGRKFFVGG NWKMNGDKKS IEELANTLNS AKLNPDTEVV CGAPTIYLDY ARSKLDPNID 70 80 90 100 110 120 VAAQNCYKVA KGAFTGEISP AMIKDCGVKW VILGHSERRH VFGESDELIG QKVAHALENG 130 140 150 160 170 180 LGVIACIGEK LDEREAGITE KVVFAQTKFI ADNVKDWSKV VLAYEPVWAI GTGKTASPQQ 190 200 210 220 230 240 AQEVHDKLRQ WLKTNVSEAV ANSVRIIYGG SVTGGTCKEL ASQKDLDGFL VGGASLKPEF IDIINAKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evidence for a period of directional selection following gene duplication in a neurally expressed locus of triosephosphate isomerase." Merritt T.J.S., Quattro J.M. Genetics 159:689-697(2001) [PubMed: 11606544] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo and Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF387819 mRNA. Translation: AAK85202.1. BC152271 mRNA. Translation: AAI52272.1. BC053294 mRNA. Translation: AAH53294.1.
IPI	IPI00484161.
RefSeq	NP_705954.2. NM_153668.4.
UniGene	Dr.4157.
3D structure databases
HSSP	HSSP built from PDB template 1TPH based on UniProtKB P00940.
ProteinModelPortal	Q90XG0.
SMR	Q90XG0. Positions 4-247.
ModBase	Search...
Protein-protein interaction databases
STRING	Q90XG0.
Proteomic databases
PRIDE	Q90XG0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000060056; ENSDARP00000060055; ENSDARG00000040988.
GeneID	560753.
KEGG	dre:560753.
Organism-specific databases
CTD	560753.
ZFIN	ZDB-GENE-020416-4. tpi1b.
Phylogenomic databases
eggNOG	fiNOG12965.
GeneTree	ENSGT00390000013354.
HOGENOM	HBG708281.
HOVERGEN	HBG002599.
InParanoid	Q90XG0.
OrthoDB	EOG40S0GF.
Gene expression databases
ArrayExpress	Q90XG0.
Bgee	Q90XG0.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR022896. TrioseP_Isoase_bac/euk. IPR000652. Triosephosphate_isomerase. IPR020861. Triosephosphate_isomerase_AS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01803.
PANTHER	PTHR21139. Triophos_ismrse. 1 hit.
Pfam	PF00121. TIM. 1 hit. [Graphical view]
SUPFAM	SSF51351. Triophos_ismrse. 1 hit.
TIGRFAMs	TIGR00419. Tim. 1 hit.
PROSITE	PS00171. TIM_1. 1 hit. PS51440. TIM_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPISB_DANRE

Accession

Primary (citable) accession number: Q90XG0
Secondary accession number(s): Q7T315

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	December 1, 2001
Last modified:	November 16, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program