Reviewed, UniProtKB/Swiss-Prot Q90XD2 (SPEB_CHICK)

Names and origin

Protein names

Recommended name:
    Agmatinase, mitochondrial
    EC=3.5.3.11
Alternative name(s):
    Agmatine ureohydrolase
      Short name=AUH

Gene names

Name:

AGMAT

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Agmatine + H2O = putrescine + urea.
Cofactor	Manganese Potential.
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the arginase family. Agmatinase subfamily.

Ontologies

Keywords
Biological process	Putrescine biosynthesis Spermidine biosynthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Manganese Metal-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	putrescine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW spermidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	agmatinase activity Inferred from electronic annotation. Source: EC manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 340		Agmatinase, mitochondrial		PRO_0000002090
Sites
	Metal binding	150	1	Manganese 1 By similarity
	Metal binding	173	1	Manganese 1 By similarity
	Metal binding	173	1	Manganese 2 By similarity
	Metal binding	175	1	Manganese 2 By similarity
	Metal binding	177	1	Manganese 1 By similarity
	Metal binding	264	1	Manganese 1 By similarity
	Metal binding	264	1	Manganese 2 By similarity
	Metal binding	266	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q90XD2-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 305E113C32F75F89	FASTA	340	36,488
	10 20 30 40 50 60 MICLLRTARL SARLLFASAA APCRRASRFN VPPSAEFVAR PVGVCSMLRL PVQTSAEGLD 70 80 90 100 110 120 AAFVGVPLDT GTSNRPGARF GPQQIRAESV MVRRYNASTG AAPFDSLLVA DVGDVNVNLY 130 140 150 160 170 180 NLPDSCRRIR ESYQKIVASG CVPLTLGGDH SITYPILQAV AEKHGPVGLV HVDAHTDTSD 190 200 210 220 230 240 MALGEKIYHG TPFRRCVDEG LLDCSRVVQI GIRGSSYAPN PYKYCWDQGF RVVPAEECWM 250 260 270 280 290 300 KSLVPLMGEV RQQMGDGPVY ISFDIDGLDP AYAPGTGTPE IAGLTPMQAL EIIRGCKGLN 310 320 330 340 IVGCDLVEVA PIYDVSGNTA LLGANLLFEM LCVLPGVKTM

References

[1]	"Identification of chicken agmatinase." Morris S.M. Jr., Kepka-Lenhart D. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF401291 mRNA. Translation: AAK97629.1.
IPI	IPI00594724.
RefSeq	NP_989474.1.
UniGene	Gga.39549
3D structure databases
HSSP	HSSP built from PDB template 1GQ6 based on UniProtKB P37819.
ModBase	Search...
Protein-protein interaction databases
STRING	Q90XD2.
Genome annotation databases
Ensembl	ENSGALT00000022238; ENSGALP00000022199; ENSGALG00000013678; Gallus gallus. [Genome view]
GeneID	373942.
KEGG	gga:373942.
Organism-specific databases
CTD	373942.
Phylogenomic databases
HOGENOM	Q90XD2.
HOVERGEN	Q90XD2.
OMA	FGAEYTH.
Enzyme and pathway databases
BRENDA	3.5.3.11. 4.
Family and domain databases
InterPro	IPR005925. Agmatinase. IPR005924. Arginase. IPR006035. Ureohydrolase. [Graphical view]
Gene3D	G3DSA:3.40.800.10. Ureohydrolase. 1 hit.
PANTHER	PTHR11358. Ureohydrolase. 1 hit.
Pfam	PF00491. Arginase. 1 hit. [Graphical view]
PRINTS	PR00116. ARGINASE.
TIGRFAMs	TIGR01230. agmatinase. 1 hit.
PROSITE	PS01053. ARGINASE_1. 1 hit. PS51409. ARGINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPEB_CHICK

Accession

Primary (citable) accession number: Q90XD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	December 1, 2001
Last modified:	November 3, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)