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Protein

Agmatinase, mitochondrial

Gene

AGMAT

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Agmatine + H2O = putrescine + urea.By similarity

Cofactori

Mn2+PROSITE-ProRule annotation

Pathwayi: putrescine biosynthesis via agmatine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from agmatine.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Agmatinase, mitochondrial (AGMAT)
This subpathway is part of the pathway putrescine biosynthesis via agmatine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from agmatine, the pathway putrescine biosynthesis via agmatine pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi150Manganese 1PROSITE-ProRule annotation1
Metal bindingi173Manganese 1PROSITE-ProRule annotation1
Metal bindingi173Manganese 2PROSITE-ProRule annotation1
Metal bindingi175Manganese 2PROSITE-ProRule annotation1
Metal bindingi177Manganese 1PROSITE-ProRule annotation1
Metal bindingi264Manganese 1PROSITE-ProRule annotation1
Metal bindingi264Manganese 2PROSITE-ProRule annotation1
Metal bindingi266Manganese 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPutrescine biosynthesis, Spermidine biosynthesis
LigandManganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00534; UER00287

Names & Taxonomyi

Protein namesi
Recommended name:
Agmatinase, mitochondrial (EC:3.5.3.11By similarity)
Alternative name(s):
Agmatine ureohydrolase
Short name:
AUH
Gene namesi
Name:AGMAT
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000002090? – 340Agmatinase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ90XD2

Expressioni

Gene expression databases

BgeeiENSGALG00000013678

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022199

Structurei

3D structure databases

ProteinModelPortaliQ90XD2
SMRiQ90XD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family. Agmatinase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2964 Eukaryota
COG0010 LUCA
HOGENOMiHOG000204320
HOVERGENiHBG023165
InParanoidiQ90XD2
KOiK01480
OMAiDTYFGAE
OrthoDBiEOG091G0HCM
PhylomeDBiQ90XD2
TreeFamiTF328612

Family and domain databases

InterProiView protein in InterPro
IPR005925 Agmatinase-rel
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
IPR020855 Ureohydrolase_Mn_BS
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PIRSFiPIRSF036979 Arginase, 1 hit
PRINTSiPR00116 ARGINASE
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01230 agmatinase, 1 hit
PROSITEiView protein in PROSITE
PS01053 ARGINASE_1, 1 hit
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90XD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MICLLRTARL SARLLFASAA APCRRASRFN VPPSAEFVAR PVGVCSMLRL
60 70 80 90 100
PVQTSAEGLD AAFVGVPLDT GTSNRPGARF GPQQIRAESV MVRRYNASTG
110 120 130 140 150
AAPFDSLLVA DVGDVNVNLY NLPDSCRRIR ESYQKIVASG CVPLTLGGDH
160 170 180 190 200
SITYPILQAV AEKHGPVGLV HVDAHTDTSD MALGEKIYHG TPFRRCVDEG
210 220 230 240 250
LLDCSRVVQI GIRGSSYAPN PYKYCWDQGF RVVPAEECWM KSLVPLMGEV
260 270 280 290 300
RQQMGDGPVY ISFDIDGLDP AYAPGTGTPE IAGLTPMQAL EIIRGCKGLN
310 320 330 340
IVGCDLVEVA PIYDVSGNTA LLGANLLFEM LCVLPGVKTM
Length:340
Mass (Da):36,488
Last modified:December 1, 2001 - v1
Checksum:i305E113C32F75F89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF401291 mRNA Translation: AAK97629.1
RefSeqiNP_989474.1, NM_204143.2
UniGeneiGga.92

Genome annotation databases

GeneIDi373942
KEGGigga:373942

Similar proteinsi

Entry informationi

Entry nameiSPEB_CHICK
AccessioniPrimary (citable) accession number: Q90XD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health