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Protein

Agmatinase, mitochondrial

Gene

AGMAT

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Agmatine + H2O = putrescine + urea.

Cofactori

Mn2+PROSITE-ProRule annotation

Pathway:iputrescine biosynthesis via agmatine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from agmatine.
Proteins known to be involved in this subpathway in this organism are:
  1. Agmatinase, mitochondrial (AGMAT)
This subpathway is part of the pathway putrescine biosynthesis via agmatine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from agmatine, the pathway putrescine biosynthesis via agmatine pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi150 – 1501Manganese 1PROSITE-ProRule annotation
Metal bindingi173 – 1731Manganese 1PROSITE-ProRule annotation
Metal bindingi173 – 1731Manganese 2PROSITE-ProRule annotation
Metal bindingi175 – 1751Manganese 2PROSITE-ProRule annotation
Metal bindingi177 – 1771Manganese 1PROSITE-ProRule annotation
Metal bindingi264 – 2641Manganese 1PROSITE-ProRule annotation
Metal bindingi264 – 2641Manganese 2PROSITE-ProRule annotation
Metal bindingi266 – 2661Manganese 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-2153-MONOMER.
ReactomeiREACT_350014. Agmatine biosynthesis.
UniPathwayiUPA00534; UER00287.

Names & Taxonomyi

Protein namesi
Recommended name:
Agmatinase, mitochondrial (EC:3.5.3.11)
Alternative name(s):
Agmatine ureohydrolase
Short name:
AUH
Gene namesi
Name:AGMAT
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Chromosome 21

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 340Agmatinase, mitochondrialPRO_0000002090
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

PaxDbiQ90XD2.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022199.

Structurei

3D structure databases

ProteinModelPortaliQ90XD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family. Agmatinase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0010.
GeneTreeiENSGT00530000063082.
HOGENOMiHOG000204320.
HOVERGENiHBG023165.
InParanoidiQ90XD2.
KOiK01480.
OMAiKPDYSLY.
OrthoDBiEOG7M98GH.
PhylomeDBiQ90XD2.
TreeFamiTF328612.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01230. agmatinase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90XD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MICLLRTARL SARLLFASAA APCRRASRFN VPPSAEFVAR PVGVCSMLRL
60 70 80 90 100
PVQTSAEGLD AAFVGVPLDT GTSNRPGARF GPQQIRAESV MVRRYNASTG
110 120 130 140 150
AAPFDSLLVA DVGDVNVNLY NLPDSCRRIR ESYQKIVASG CVPLTLGGDH
160 170 180 190 200
SITYPILQAV AEKHGPVGLV HVDAHTDTSD MALGEKIYHG TPFRRCVDEG
210 220 230 240 250
LLDCSRVVQI GIRGSSYAPN PYKYCWDQGF RVVPAEECWM KSLVPLMGEV
260 270 280 290 300
RQQMGDGPVY ISFDIDGLDP AYAPGTGTPE IAGLTPMQAL EIIRGCKGLN
310 320 330 340
IVGCDLVEVA PIYDVSGNTA LLGANLLFEM LCVLPGVKTM
Length:340
Mass (Da):36,488
Last modified:December 1, 2001 - v1
Checksum:i305E113C32F75F89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF401291 mRNA. Translation: AAK97629.1.
RefSeqiNP_989474.1. NM_204143.2.
UniGeneiGga.92.

Genome annotation databases

EnsembliENSGALT00000022238; ENSGALP00000022199; ENSGALG00000013678.
GeneIDi373942.
KEGGigga:373942.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF401291 mRNA. Translation: AAK97629.1.
RefSeqiNP_989474.1. NM_204143.2.
UniGeneiGga.92.

3D structure databases

ProteinModelPortaliQ90XD2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022199.

Proteomic databases

PaxDbiQ90XD2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000022238; ENSGALP00000022199; ENSGALG00000013678.
GeneIDi373942.
KEGGigga:373942.

Organism-specific databases

CTDi79814.

Phylogenomic databases

eggNOGiCOG0010.
GeneTreeiENSGT00530000063082.
HOGENOMiHOG000204320.
HOVERGENiHBG023165.
InParanoidiQ90XD2.
KOiK01480.
OMAiKPDYSLY.
OrthoDBiEOG7M98GH.
PhylomeDBiQ90XD2.
TreeFamiTF328612.

Enzyme and pathway databases

UniPathwayiUPA00534; UER00287.
BioCyciRETL1328306-WGS:GSTH-2153-MONOMER.
ReactomeiREACT_350014. Agmatine biosynthesis.

Miscellaneous databases

NextBioi20813474.
PROiQ90XD2.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01230. agmatinase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of chicken agmatinase."
    Morris S.M. Jr., Kepka-Lenhart D.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiSPEB_CHICK
AccessioniPrimary (citable) accession number: Q90XD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: May 27, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.