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Q90XD2 (SPEB_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Agmatinase, mitochondrial

EC=3.5.3.11
Alternative name(s):
Agmatine ureohydrolase
Short name=AUH
Gene names
Name:AGMAT
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Agmatine + H2O = putrescine + urea.

Cofactor

Manganese Potential.

Pathway

Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the arginase family. Agmatinase subfamily.

Ontologies

Keywords
   Biological processPutrescine biosynthesis
Spermidine biosynthesis
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandManganese
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processputrescine biosynthetic process from arginine

Inferred from electronic annotation. Source: UniProtKB-UniPathway

spermidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionagmatinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 340Agmatinase, mitochondrialPRO_0000002090

Sites

Metal binding1501Manganese 1 By similarity
Metal binding1731Manganese 1 By similarity
Metal binding1731Manganese 2 By similarity
Metal binding1751Manganese 2 By similarity
Metal binding1771Manganese 1 By similarity
Metal binding2641Manganese 1 By similarity
Metal binding2641Manganese 2 By similarity
Metal binding2661Manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q90XD2 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 305E113C32F75F89

FASTA34036,488
        10         20         30         40         50         60 
MICLLRTARL SARLLFASAA APCRRASRFN VPPSAEFVAR PVGVCSMLRL PVQTSAEGLD 

        70         80         90        100        110        120 
AAFVGVPLDT GTSNRPGARF GPQQIRAESV MVRRYNASTG AAPFDSLLVA DVGDVNVNLY 

       130        140        150        160        170        180 
NLPDSCRRIR ESYQKIVASG CVPLTLGGDH SITYPILQAV AEKHGPVGLV HVDAHTDTSD 

       190        200        210        220        230        240 
MALGEKIYHG TPFRRCVDEG LLDCSRVVQI GIRGSSYAPN PYKYCWDQGF RVVPAEECWM 

       250        260        270        280        290        300 
KSLVPLMGEV RQQMGDGPVY ISFDIDGLDP AYAPGTGTPE IAGLTPMQAL EIIRGCKGLN 

       310        320        330        340 
IVGCDLVEVA PIYDVSGNTA LLGANLLFEM LCVLPGVKTM 

« Hide

References

[1]"Identification of chicken agmatinase."
Morris S.M. Jr., Kepka-Lenhart D.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF401291 mRNA. Translation: AAK97629.1.
RefSeqNP_989474.1. NM_204143.2.
UniGeneGga.92.

3D structure databases

ProteinModelPortalQ90XD2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000022199.

Proteomic databases

PaxDbQ90XD2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000022238; ENSGALP00000022199; ENSGALG00000013678.
GeneID373942.
KEGGgga:373942.

Organism-specific databases

CTD79814.

Phylogenomic databases

eggNOGCOG0010.
GeneTreeENSGT00530000063082.
HOGENOMHOG000204320.
HOVERGENHBG023165.
InParanoidQ90XD2.
KOK01480.
OMAKPDYSLY.
OrthoDBEOG7M98GH.
PhylomeDBQ90XD2.
TreeFamTF328612.

Enzyme and pathway databases

UniPathwayUPA00534; UER00287.

Family and domain databases

Gene3D3.40.800.10. 1 hit.
InterProIPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERPTHR11358. PTHR11358. 1 hit.
PfamPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFPIRSF036979. Arginase. 1 hit.
PRINTSPR00116. ARGINASE.
TIGRFAMsTIGR01230. agmatinase. 1 hit.
PROSITEPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20813474.
PROQ90XD2.

Entry information

Entry nameSPEB_CHICK
AccessionPrimary (citable) accession number: Q90XD2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways