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Q90XD2

- SPEB_CHICK

UniProt

Q90XD2 - SPEB_CHICK

Protein

Agmatinase, mitochondrial

Gene

AGMAT

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Agmatine + H2O = putrescine + urea.

    Cofactori

    Manganese.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi150 – 1501Manganese 1PROSITE-ProRule annotation
    Metal bindingi173 – 1731Manganese 1PROSITE-ProRule annotation
    Metal bindingi173 – 1731Manganese 2PROSITE-ProRule annotation
    Metal bindingi175 – 1751Manganese 2PROSITE-ProRule annotation
    Metal bindingi177 – 1771Manganese 1PROSITE-ProRule annotation
    Metal bindingi264 – 2641Manganese 1PROSITE-ProRule annotation
    Metal bindingi264 – 2641Manganese 2PROSITE-ProRule annotation
    Metal bindingi266 – 2661Manganese 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. agmatinase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. putrescine biosynthetic process from arginine Source: UniProtKB-UniPathway
    2. spermidine biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Putrescine biosynthesis, Spermidine biosynthesis

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-2153-MONOMER.
    UniPathwayiUPA00534; UER00287.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Agmatinase, mitochondrial (EC:3.5.3.11)
    Alternative name(s):
    Agmatine ureohydrolase
    Short name:
    AUH
    Gene namesi
    Name:AGMAT
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 21

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 340Agmatinase, mitochondrialPRO_0000002090
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    PaxDbiQ90XD2.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000022199.

    Structurei

    3D structure databases

    ProteinModelPortaliQ90XD2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the arginase family. Agmatinase subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0010.
    GeneTreeiENSGT00530000063082.
    HOGENOMiHOG000204320.
    HOVERGENiHBG023165.
    InParanoidiQ90XD2.
    KOiK01480.
    OMAiSPPYDPF.
    OrthoDBiEOG7M98GH.
    PhylomeDBiQ90XD2.
    TreeFamiTF328612.

    Family and domain databases

    Gene3Di3.40.800.10. 1 hit.
    InterProiIPR005925. Agmatinase-rel.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view]
    PANTHERiPTHR11358. PTHR11358. 1 hit.
    PfamiPF00491. Arginase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036979. Arginase. 1 hit.
    PRINTSiPR00116. ARGINASE.
    TIGRFAMsiTIGR01230. agmatinase. 1 hit.
    PROSITEiPS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q90XD2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MICLLRTARL SARLLFASAA APCRRASRFN VPPSAEFVAR PVGVCSMLRL    50
    PVQTSAEGLD AAFVGVPLDT GTSNRPGARF GPQQIRAESV MVRRYNASTG 100
    AAPFDSLLVA DVGDVNVNLY NLPDSCRRIR ESYQKIVASG CVPLTLGGDH 150
    SITYPILQAV AEKHGPVGLV HVDAHTDTSD MALGEKIYHG TPFRRCVDEG 200
    LLDCSRVVQI GIRGSSYAPN PYKYCWDQGF RVVPAEECWM KSLVPLMGEV 250
    RQQMGDGPVY ISFDIDGLDP AYAPGTGTPE IAGLTPMQAL EIIRGCKGLN 300
    IVGCDLVEVA PIYDVSGNTA LLGANLLFEM LCVLPGVKTM 340
    Length:340
    Mass (Da):36,488
    Last modified:December 1, 2001 - v1
    Checksum:i305E113C32F75F89
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF401291 mRNA. Translation: AAK97629.1.
    RefSeqiNP_989474.1. NM_204143.2.
    UniGeneiGga.92.

    Genome annotation databases

    EnsembliENSGALT00000022238; ENSGALP00000022199; ENSGALG00000013678.
    GeneIDi373942.
    KEGGigga:373942.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF401291 mRNA. Translation: AAK97629.1 .
    RefSeqi NP_989474.1. NM_204143.2.
    UniGenei Gga.92.

    3D structure databases

    ProteinModelPortali Q90XD2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000022199.

    Proteomic databases

    PaxDbi Q90XD2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000022238 ; ENSGALP00000022199 ; ENSGALG00000013678 .
    GeneIDi 373942.
    KEGGi gga:373942.

    Organism-specific databases

    CTDi 79814.

    Phylogenomic databases

    eggNOGi COG0010.
    GeneTreei ENSGT00530000063082.
    HOGENOMi HOG000204320.
    HOVERGENi HBG023165.
    InParanoidi Q90XD2.
    KOi K01480.
    OMAi SPPYDPF.
    OrthoDBi EOG7M98GH.
    PhylomeDBi Q90XD2.
    TreeFami TF328612.

    Enzyme and pathway databases

    UniPathwayi UPA00534 ; UER00287 .
    BioCyci RETL1328306-WGS:GSTH-2153-MONOMER.

    Miscellaneous databases

    NextBioi 20813474.
    PROi Q90XD2.

    Family and domain databases

    Gene3Di 3.40.800.10. 1 hit.
    InterProi IPR005925. Agmatinase-rel.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view ]
    PANTHERi PTHR11358. PTHR11358. 1 hit.
    Pfami PF00491. Arginase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036979. Arginase. 1 hit.
    PRINTSi PR00116. ARGINASE.
    TIGRFAMsi TIGR01230. agmatinase. 1 hit.
    PROSITEi PS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of chicken agmatinase."
      Morris S.M. Jr., Kepka-Lenhart D.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiSPEB_CHICK
    AccessioniPrimary (citable) accession number: Q90XD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3