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Protein

Oligodendrocyte transcription factor 2

Gene

OLIG2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for oligodendrocyte and motor neuron specification in the spinal cord.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oligodendrocyte transcription factor 2
Short name:
Oligo2
Gene namesi
Name:OLIG2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • nucleus Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Oligodendrocyte transcription factor 2PRO_0000127416Add
BLAST

Proteomic databases

PRIDEiQ90XB3.

Structurei

3D structure databases

ProteinModelPortaliQ90XB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini106 – 16055bHLHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi24 – 4219Gly-richAdd
BLAST
Compositional biasi45 – 9248Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000063239.
HOVERGENiHBG053370.
InParanoidiQ90XB3.
KOiK09085.
OMAiSFQHWGG.
PhylomeDBiQ90XB3.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR032658. Olig2.
[Graphical view]
PANTHERiPTHR19290:SF32. PTHR19290:SF32. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90XB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDASLVSS RPSSPEPDEL FLAGRNKGGG GGGGGGGGFT GGTVSSSTQS
60 70 80 90 100
DSPPELSAEL RSAMSAAGVV VVDKLGFKSS SSSASSASSA SSKKDKKQMT
110 120 130 140 150
EPELQQLRLK INSRERKRMH DLNIAMDGLR EVMPYAHGPS VRKLSKIATL
160 170 180 190 200
LLARNYILML TNSLEEMKRL VSEIYGGHHA AFHPAACPAG MGAHSAPLPA
210 220 230 240 250
HPGHPASHPA HHPILPPAAV SSASLPGSGL SAVGSIRPPH GLLKSPSAAA
260 270 280 290
AAPGLGGGFQ HWGGMPCPCS MCQVAAPPHH HVSAMGGAAL PRLASDAK
Length:298
Mass (Da):30,319
Last modified:December 1, 2001 - v1
Checksum:i5790A79F2764F5D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411041 mRNA. Translation: AAL11883.1.
AF405699 mRNA. Translation: AAL02428.1.
RefSeqiNP_001026697.1. NM_001031526.1.
UniGeneiGga.4947.
Gga.51492.

Genome annotation databases

EnsembliENSGALT00000045985; ENSGALP00000043426; ENSGALG00000027381.
GeneIDi428612.
KEGGigga:428612.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411041 mRNA. Translation: AAL11883.1.
AF405699 mRNA. Translation: AAL02428.1.
RefSeqiNP_001026697.1. NM_001031526.1.
UniGeneiGga.4947.
Gga.51492.

3D structure databases

ProteinModelPortaliQ90XB3.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ90XB3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000045985; ENSGALP00000043426; ENSGALG00000027381.
GeneIDi428612.
KEGGigga:428612.

Organism-specific databases

CTDi10215.

Phylogenomic databases

GeneTreeiENSGT00530000063239.
HOVERGENiHBG053370.
InParanoidiQ90XB3.
KOiK09085.
OMAiSFQHWGG.
PhylomeDBiQ90XB3.

Miscellaneous databases

PROiQ90XB3.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR032658. Olig2.
[Graphical view]
PANTHERiPTHR19290:SF32. PTHR19290:SF32. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2."
    Zhou Q., Choi G., Anderson D.J.
    Neuron 31:791-807(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2."
    Novitch B.G., Chen A.I., Jessell T.M.
    Neuron 31:773-789(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-161.

Entry informationi

Entry nameiOLIG2_CHICK
AccessioniPrimary (citable) accession number: Q90XB3
Secondary accession number(s): Q90XC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.