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Q90X99

- LYG_EPICO

UniProt

Q90X99 - LYG_EPICO

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Protein
Lysozyme g
Gene
N/A
Organism
Epinephelus coioides (Orange-spotted grouper) (Epinephelus nebulosus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Has lytic activity against M.lysodeikticus, V.alginolyticus from Epinephelus fario, V.vulnificus from culture water, A.hydrophila from soft-shell turtle, A.hydrophila from goldfish and V.parahaemolyticus, P.fluorescens and V.fluvialis from culture water.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei71 – 711 By similarity
Active sitei84 – 841 By similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH23. Glycoside Hydrolase Family 23.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme g (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase
OrganismiEpinephelus coioides (Orange-spotted grouper) (Epinephelus nebulosus)
Taxonomic identifieri94232 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaPerciformesSerranoideiSerranidaeEpinephelinaeEpinepheliniEpinephelus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194Lysozyme g
PRO_0000193518Add
BLAST

Expressioni

Tissue specificityi

Expressed in intestine, liver, spleen, anterior kidney, posterior kidney, heart, gill, muscle and leukocytes.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ90X99.
SMRiQ90X99. Positions 2-194.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG006299.

Family and domain databases

InterProiIPR002152. Glyco_hydro_23.
IPR023346. Lysozyme-like_dom.
IPR008258. TGlycosylase-like_SLT.
[Graphical view]
PfamiPF01464. SLT. 1 hit.
[Graphical view]
PIRSFiPIRSF001065. Lysozyme_g. 1 hit.
PRINTSiPR00749. LYSOZYMEG.
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

Q90X99-1 [UniParc]FASTAAdd to Basket

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MGYGNIMNVE TTGASWQTAQ QDKLGYSGVR ASHTMANTDS GRMERYRSKI    50
NSVGAKYGID PALIAAIISE ESRAGNVLHD GWGDYDSNRG AYNAWGLMQV 100
DVNPNGGGHT ARGAWDSEEH LSQGAEILVY FIGRIRNKFP GWNTEQQLKG 150
GIAAYNMGDG NVHSYDNVDG RTTGGDYSND VVARAQWYKT QKGF 194
Length:194
Mass (Da):21,179
Last modified:December 1, 2001 - v1
Checksum:i8A12197359127023
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF416458 mRNA. Translation: AAL08021.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF416458 mRNA. Translation: AAL08021.2 .

3D structure databases

ProteinModelPortali Q90X99.
SMRi Q90X99. Positions 2-194.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH23. Glycoside Hydrolase Family 23.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG006299.

Family and domain databases

InterProi IPR002152. Glyco_hydro_23.
IPR023346. Lysozyme-like_dom.
IPR008258. TGlycosylase-like_SLT.
[Graphical view ]
Pfami PF01464. SLT. 1 hit.
[Graphical view ]
PIRSFi PIRSF001065. Lysozyme_g. 1 hit.
PRINTSi PR00749. LYSOZYMEG.
SUPFAMi SSF53955. SSF53955. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning, expression of orange-spotted grouper goose-type lysozyme cDNA, and lytic activity of its recombinant protein."
    Yin Z.X., He J.G., Deng W.X., Chan S.M.
    Dis. Aquat. Organ. 55:117-123(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiLYG_EPICO
AccessioniPrimary (citable) accession number: Q90X99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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