Unreviewed, UniProtKB/TrEMBL Q90X96 (Q90X96_XENLA)

Names and origin

Protein names

Submitted name:
    Breast and ovarian cancer susceptibility protein EMBL AAL13037.1

Gene names

Name:	brca1 Xenbase XB-FEAT-490623
Synonyms:	BRCA1 EMBL AAL13037.1

Organism

Xenopus laevis (African clawed frog) EMBL AAL13037.1

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	1579 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

Ontologies

Keywords
Domain	Zinc-finger RuleBase RU000353V2
Ligand	Metal-binding Zinc
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BARD1	Q90X95	1	EBI-1165296,EBI-1165318
TPX2	Q6NUF4	1	EBI-1165296,EBI-1165419

Sequences

	Sequence		Length	Mass (Da)
	Q90X96-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: B65951D7FA37D255	FASTA	1,579	175,705
	10 20 30 40 50 60 MTCSRMDIEG ICSVISVMQK NLECPICLEL MKEPVATKCD HIFCKFCMLQ LLSKKKKGTV 70 80 90 100 110 120 PCPLCKTEVT RRSLQESHRF KLLVEGQLKI IKAFEFDSGY KFFPSQEHTK GLDSTIEDVL 130 140 150 160 170 180 VKEDQSIVHC KGYRNRKKGV FNRKTYEETG MLSVSKAEEQ FAKEVTRLIP CRQKKPKKEA 190 200 210 220 230 240 ALIFSNCVPD SSDGDLLNKE NGLRNDCSPL HYEKEDTQIP EMEEMVESDL AECEFAESAG 250 260 270 280 290 300 SNLLGFDGPE GIPEISAETS INAAGNCDFY GRKTEQFPND HHCSFKQNIA DAEQNKRNQH 310 320 330 340 350 360 CGNVPFAPMG KSNLDEKETV ETDFDNQHND SNPENNDPLG KVTKLMRRST ERVNEWLLKT 370 380 390 400 410 420 NQDFSTLSAE EDPILDALAL QNKETSDKRS CSSDDSELMP VLHKHAEKGI SGGGFDKPAV 430 440 450 460 470 480 GVKDKIFCKV YKRERKAMPP NNITCVAEVH HDSALETGKE NMTLEYGTGM SHLMSKRKMV 490 500 510 520 530 540 YSLNPENTSK KNDLANINGS INVFPDCISD ANLELEDKSE ADSNSADACQ SDIVHSSNTQ 550 560 570 580 590 600 IKQQCVESLA NAGETRKKQE LSCERSQEEK DFTQSGALGP KTRSQKSPYG HSELHIESSQ 610 620 630 640 650 660 ISNEPSNVTK QVEVRRSRRL LMLPKGPGNK SNSNAVKEMN EQENIAQIPE FRVKDTNKNN 670 680 690 700 710 720 EISDTVPSQL KKKDTYFPPC TSEDTGELEN GIPVRKISDQ NASLDNPIDP CKDEYSDTLL 730 740 750 760 770 780 HVAGDNVQPD YMETEESELE TQHIVKMFKT SKRTSFILES KEAENENRVN SAVEISQVET 790 800 810 820 830 840 SNELPNVAEC RHTSLLSSAK EQSGALLKQG SPSSEPKKTS PIHMLKKTES KHSKMSRNRR 850 860 870 880 890 900 GKVKPSSNSA KNTTGQPDNL NNPTQGVTGS LYNKQVMSDF PMRLNVDEEH TNASAKGSQS 910 920 930 940 950 960 SVADKSTAHS NVNTDFISDI NSATPDGLLH YMDKAEGNSS PWDTTRDKNA ALLESCLPSA 970 980 990 1000 1010 1020 YGSTGEKTPI PKVQSSEEGS SQGLFNQKPK CSSSGKADQK NSSKNPGKSQ CRILSDFSGS 1030 1040 1050 1060 1070 1080 SNNGKCSSQE MLSKAAFPSL SQESQCSVSL FSTQSNMSQQ SVDEDHKQDV LQDELVSPNK 1090 1100 1110 1120 1130 1140 TKRTAISGTE ETQISPLRDQ YQNPDIDEAS ECESEASHTG DSSILSSQDE LLNTQQRNYM 1150 1160 1170 1180 1190 1200 KDSLKKLQQE MAALEAVLGQ HGTQKLEAET TCIPSSEHVT EMQEATEEEE EETYQGENLF 1210 1220 1230 1240 1250 1260 VKTPPEHVAN GSTLIGQSTD NGLQGRNRPV SPSFLCQTRI EKDTPEIVCP AMGISKKSLL 1270 1280 1290 1300 1310 1320 TQKELPSQHK QEIRPDLETV NVTPTNPIDA QESLRQSSKN KRGSRMLHNK RSTSNQGSFC 1330 1340 1350 1360 1370 1380 LSVEAAESPQ IPKQNKAEFG IARKSTSPTF ASPARAKVPS VGFKSPVVSS RRNLSFVASG 1390 1400 1410 1420 1430 1440 LNQCEMALVQ RFSKTTQSIL SSRITDSTTH VIMKTDAELV CERTLKYFQG IASRKWVVSY 1450 1460 1470 1480 1490 1500 EWVVQSFREG QILDEYDFEV KGDVINGRNH RGPRRSRLGS DGLLLIDFEI CFFGSFTDMT 1510 1520 1530 1540 1550 1560 LDDLEWMVSE CGATVVKKLQ FFKKKHNVTS LVIVQPDAST EVRDYTEIRK KHKALVVTRE 1570 WLMDSVATYR LQKFDAYLA

References

[1]	"Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development." Joukov V., Chen J., Fox E.A., Green J.B., Livingston D.M. Proc. Natl. Acad. Sci. U.S.A. 98:12078-12083(2001) [PubMed: 11593018] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF416868 mRNA. Translation: AAL13037.1.
RefSeq	NP_001084248.1.
UniGene	Xl.12105
3D structure databases
HSSP	HSSP built from PDB template 1JM7 based on UniProtKB P38398.
SMR	Q90X96. Positions 1-102, 1374-1578.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q90X96. 4 interactions.
Genome annotation databases
GeneID	399391.
KEGG	xla:399391.
Organism-specific databases
CTD	399391.
Xenbase	XB-FEAT-490623. brca1.
Phylogenomic databases
HOVERGEN	Q90X96.
Family and domain databases
InterPro	IPR011364. BRCA1. IPR001357. BRCT. IPR002378. Brst_cancerI. IPR018957. Znf_C3HC4_RING-type. IPR001841. Znf_RING. IPR017907. Znf_RING_CS. [Graphical view]
PANTHER	PTHR13763. BRCA1. 1 hit.
Pfam	PF00533. BRCT. 1 hit. PF00097. zf-C3HC4. 1 hit. [Graphical view]
PIRSF	PIRSF001734. BRCA1. 1 hit.
PRINTS	PR00493. BRSTCANCERI.
SMART	SM00292. BRCT. 2 hits. SM00184. RING. 1 hit. [Graphical view]
PROSITE	PS50172. BRCT. 2 hits. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q90X96_XENLA

Accession

Primary (citable) accession number: Q90X96

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	January 19, 2010
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)