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Protein

Kininogen-1b

Gene
N/A
Organism
Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In vitro, produces constriction of guinea pig ileum smooth muscle. May target bradykinin receptors (BDKRB).1 Publication

GO - Molecular functioni

  • hormone activity Source: UniProtKB

GO - Biological processi

  • defense response Source: UniProtKB
  • positive regulation of smooth muscle contraction Source: UniProtKB
  • vasodilation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Amphibian defense peptide, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

Names & Taxonomyi

Protein namesi
Recommended name:
Kininogen-1b
Cleaved into the following 2 chains:
Alternative name(s):
Bombinakinin M
OrganismiBombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Taxonomic identifieri161274 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000340324 – 208Kininogen-1bSequence analysisAdd BLAST185
PeptideiPRO_000000340441 – 59Maximakinin1 PublicationAdd BLAST19
PeptideiPRO_000000340551 – 59Bradykinin1 Publication9
PeptideiPRO_000000340669 – 87Maximakinin1 PublicationAdd BLAST19
PeptideiPRO_000000340779 – 87Bradykinin1 Publication9
PeptideiPRO_000000340897 – 115Maximakinin1 PublicationAdd BLAST19
PeptideiPRO_0000003409107 – 115Bradykinin1 Publication9
PeptideiPRO_0000003410125 – 143Maximakinin1 PublicationAdd BLAST19
PeptideiPRO_0000003411135 – 143Bradykinin1 Publication9
PeptideiPRO_0000003412153 – 171Maximakinin1 PublicationAdd BLAST19
PeptideiPRO_0000003413163 – 171Bradykinin1 Publication9
PeptideiPRO_0000003414181 – 199Maximakinin1 PublicationAdd BLAST19
PeptideiPRO_0000003415191 – 199Bradykinin1 Publication9

Expressioni

Tissue specificityi

Expressed by the skin glands.1 Publication

Interactioni

GO - Molecular functioni

  • hormone activity Source: UniProtKB

Family & Domainsi

Sequence similaritiesi

Belongs to the bradykinin-related peptide family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG031664.

Family and domain databases

InterProiIPR009608. Bradykinin.
[Graphical view]
PfamiPF06753. Bradykinin. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90WZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLWFCLSFF IVLCLEHFPE TLADERNVPE SEEKTEQYLR DLPKINRKGP
60 70 80 90 100
RPPGFSPFRG KFHSQSLRDL PKINRKGPRP PGFSPFRGKF HSQSLRDLPK
110 120 130 140 150
INRKGPRPPG FSPFRGKFHS QSLRDLPKIN RKGPRPPGFS PFRGKFHSQS
160 170 180 190 200
LRDLPKINRK GPRPPGFSPF RGKFHSQSLR DLPKINRKGP RPPGFSPFRG

KFHSQSHV
Length:208
Mass (Da):24,104
Last modified:December 1, 2001 - v1
Checksum:i4EA9A7773E22711D
GO

Mass spectrometryi

Molecular mass is 2179±0.4 Da from positions 41 - 59. Determined by FAB. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046319 mRNA. Translation: AAL02326.1.
PIRiJC7755.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046319 mRNA. Translation: AAL02326.1.
PIRiJC7755.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG031664.

Family and domain databases

InterProiIPR009608. Bradykinin.
[Graphical view]
PfamiPF06753. Bradykinin. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBRK1B_BOMMX
AccessioniPrimary (citable) accession number: Q90WZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 1, 2001
Last modified: October 1, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.