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Q90WZ1

- BRK1B_BOMMX

UniProt

Q90WZ1 - BRK1B_BOMMX

Protein

Kininogen-1b

Gene
N/A
Organism
Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    In vitro, produces constriction of guinea pig ileum smooth muscle. May target bradykinin receptors (BDKRB).1 Publication

    GO - Molecular functioni

    1. hormone activity Source: UniProtKB

    GO - Biological processi

    1. defense response Source: UniProtKB
    2. positive regulation of smooth muscle contraction Source: UniProtKB
    3. vasodilation Source: UniProtKB-KW

    Keywords - Molecular functioni

    Amphibian defense peptide, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kininogen-1b
    Cleaved into the following 2 chains:
    Alternative name(s):
    Bombinakinin M
    OrganismiBombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
    Taxonomic identifieri161274 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 208185Kininogen-1bSequence AnalysisPRO_0000003403Add
    BLAST
    Peptidei41 – 5919Maximakinin1 PublicationPRO_0000003404Add
    BLAST
    Peptidei51 – 599Bradykinin1 PublicationPRO_0000003405
    Peptidei69 – 8719Maximakinin1 PublicationPRO_0000003406Add
    BLAST
    Peptidei79 – 879Bradykinin1 PublicationPRO_0000003407
    Peptidei97 – 11519Maximakinin1 PublicationPRO_0000003408Add
    BLAST
    Peptidei107 – 1159Bradykinin1 PublicationPRO_0000003409
    Peptidei125 – 14319Maximakinin1 PublicationPRO_0000003410Add
    BLAST
    Peptidei135 – 1439Bradykinin1 PublicationPRO_0000003411
    Peptidei153 – 17119Maximakinin1 PublicationPRO_0000003412Add
    BLAST
    Peptidei163 – 1719Bradykinin1 PublicationPRO_0000003413
    Peptidei181 – 19919Maximakinin1 PublicationPRO_0000003414Add
    BLAST
    Peptidei191 – 1999Bradykinin1 PublicationPRO_0000003415

    Expressioni

    Tissue specificityi

    Expressed by the skin glands.1 Publication

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the bradykinin-related peptide family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    HOVERGENiHBG031664.

    Family and domain databases

    InterProiIPR009608. Bradykinin.
    [Graphical view]
    PfamiPF06753. Bradykinin. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q90WZ1-1 [UniParc]FASTAAdd to Basket

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    MRLWFCLSFF IVLCLEHFPE TLADERNVPE SEEKTEQYLR DLPKINRKGP    50
    RPPGFSPFRG KFHSQSLRDL PKINRKGPRP PGFSPFRGKF HSQSLRDLPK 100
    INRKGPRPPG FSPFRGKFHS QSLRDLPKIN RKGPRPPGFS PFRGKFHSQS 150
    LRDLPKINRK GPRPPGFSPF RGKFHSQSLR DLPKINRKGP RPPGFSPFRG 200
    KFHSQSHV 208
    Length:208
    Mass (Da):24,104
    Last modified:December 1, 2001 - v1
    Checksum:i4EA9A7773E22711D
    GO

    Mass spectrometryi

    Molecular mass is 2179±0.4 Da from positions 41 - 59. Determined by FAB. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY046319 mRNA. Translation: AAL02326.1.
    PIRiJC7755.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY046319 mRNA. Translation: AAL02326.1 .
    PIRi JC7755.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG031664.

    Family and domain databases

    InterProi IPR009608. Bradykinin.
    [Graphical view ]
    Pfami PF06753. Bradykinin. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel bradykinin-related peptide from skin secretions of toad Bombina maxima and its precursor containing six identical copies of the final product."
      Lai R., Liu H., Lee W.H., Zhang Y.
      Biochem. Biophys. Res. Commun. 286:259-263(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 41-59, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY.
      Tissue: Skin secretionImported.

    Entry informationi

    Entry nameiBRK1B_BOMMX
    AccessioniPrimary (citable) accession number: Q90WZ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3