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Q90WZ1 (BRK1B_BOMMX) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kininogen-1b

Cleaved into the following 2 chains:

  1. Maximakinin
    Alternative name(s):
    Bombinakinin M
  2. Bradykinin
OrganismBombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Taxonomic identifier161274 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

In vitro, produces constriction of guinea pig ileum smooth muscle. May target bradykinin receptors (BDKRB). Ref.1

Subcellular location

Secreted Ref.1.

Tissue specificity

Expressed by the skin glands. Ref.1

Sequence similarities

Belongs to the bradykinin-related peptide family.

Mass spectrometry

Molecular mass is 2179±0.4 Da from positions 41 - 59. Determined by FAB. Ref.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 208185Kininogen-1b
PRO_0000003403
Peptide41 – 5919Maximakinin Ref.1
PRO_0000003404
Peptide51 – 599Bradykinin Ref.1
PRO_0000003405
Peptide69 – 8719Maximakinin Ref.1
PRO_0000003406
Peptide79 – 879Bradykinin Ref.1
PRO_0000003407
Peptide97 – 11519Maximakinin Ref.1
PRO_0000003408
Peptide107 – 1159Bradykinin Ref.1
PRO_0000003409
Peptide125 – 14319Maximakinin Ref.1
PRO_0000003410
Peptide135 – 1439Bradykinin Ref.1
PRO_0000003411
Peptide153 – 17119Maximakinin Ref.1
PRO_0000003412
Peptide163 – 1719Bradykinin Ref.1
PRO_0000003413
Peptide181 – 19919Maximakinin Ref.1
PRO_0000003414
Peptide191 – 1999Bradykinin Ref.1
PRO_0000003415

Sequences

Sequence LengthMass (Da)Tools
Q90WZ1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 4EA9A7773E22711D

FASTA20824,104
        10         20         30         40         50         60 
MRLWFCLSFF IVLCLEHFPE TLADERNVPE SEEKTEQYLR DLPKINRKGP RPPGFSPFRG 

        70         80         90        100        110        120 
KFHSQSLRDL PKINRKGPRP PGFSPFRGKF HSQSLRDLPK INRKGPRPPG FSPFRGKFHS 

       130        140        150        160        170        180 
QSLRDLPKIN RKGPRPPGFS PFRGKFHSQS LRDLPKINRK GPRPPGFSPF RGKFHSQSLR 

       190        200 
DLPKINRKGP RPPGFSPFRG KFHSQSHV 

« Hide

References

[1]"A novel bradykinin-related peptide from skin secretions of toad Bombina maxima and its precursor containing six identical copies of the final product."
Lai R., Liu H., Lee W.H., Zhang Y.
Biochem. Biophys. Res. Commun. 286:259-263(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 41-59, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY.
Tissue: Skin secretion.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY046319 mRNA. Translation: AAL02326.1.
PIRJC7755.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG031664.

Family and domain databases

InterProIPR009608. Bradykinin.
[Graphical view]
PfamPF06753. Bradykinin. 6 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBRK1B_BOMMX
AccessionPrimary (citable) accession number: Q90WZ1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 1, 2001
Last modified: November 13, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families