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Q90WZ1

- BRK1B_BOMMX

UniProt

Q90WZ1 - BRK1B_BOMMX

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Protein

Kininogen-1b

Gene
N/A
Organism
Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

In vitro, produces constriction of guinea pig ileum smooth muscle. May target bradykinin receptors (BDKRB).1 Publication

GO - Molecular functioni

  1. hormone activity Source: UniProtKB

GO - Biological processi

  1. defense response Source: UniProtKB
  2. positive regulation of smooth muscle contraction Source: UniProtKB
  3. vasodilation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Amphibian defense peptide, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

Names & Taxonomyi

Protein namesi
Recommended name:
Kininogen-1b
Cleaved into the following 2 chains:
Alternative name(s):
Bombinakinin M
OrganismiBombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Taxonomic identifieri161274 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 208185Kininogen-1bSequence AnalysisPRO_0000003403Add
BLAST
Peptidei41 – 5919Maximakinin1 PublicationPRO_0000003404Add
BLAST
Peptidei51 – 599Bradykinin1 PublicationPRO_0000003405
Peptidei69 – 8719Maximakinin1 PublicationPRO_0000003406Add
BLAST
Peptidei79 – 879Bradykinin1 PublicationPRO_0000003407
Peptidei97 – 11519Maximakinin1 PublicationPRO_0000003408Add
BLAST
Peptidei107 – 1159Bradykinin1 PublicationPRO_0000003409
Peptidei125 – 14319Maximakinin1 PublicationPRO_0000003410Add
BLAST
Peptidei135 – 1439Bradykinin1 PublicationPRO_0000003411
Peptidei153 – 17119Maximakinin1 PublicationPRO_0000003412Add
BLAST
Peptidei163 – 1719Bradykinin1 PublicationPRO_0000003413
Peptidei181 – 19919Maximakinin1 PublicationPRO_0000003414Add
BLAST
Peptidei191 – 1999Bradykinin1 PublicationPRO_0000003415

Expressioni

Tissue specificityi

Expressed by the skin glands.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the bradykinin-related peptide family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG031664.

Family and domain databases

InterProiIPR009608. Bradykinin.
[Graphical view]
PfamiPF06753. Bradykinin. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90WZ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLWFCLSFF IVLCLEHFPE TLADERNVPE SEEKTEQYLR DLPKINRKGP
60 70 80 90 100
RPPGFSPFRG KFHSQSLRDL PKINRKGPRP PGFSPFRGKF HSQSLRDLPK
110 120 130 140 150
INRKGPRPPG FSPFRGKFHS QSLRDLPKIN RKGPRPPGFS PFRGKFHSQS
160 170 180 190 200
LRDLPKINRK GPRPPGFSPF RGKFHSQSLR DLPKINRKGP RPPGFSPFRG

KFHSQSHV
Length:208
Mass (Da):24,104
Last modified:December 1, 2001 - v1
Checksum:i4EA9A7773E22711D
GO

Mass spectrometryi

Molecular mass is 2179±0.4 Da from positions 41 - 59. Determined by FAB. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY046319 mRNA. Translation: AAL02326.1.
PIRiJC7755.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY046319 mRNA. Translation: AAL02326.1 .
PIRi JC7755.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG031664.

Family and domain databases

InterProi IPR009608. Bradykinin.
[Graphical view ]
Pfami PF06753. Bradykinin. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel bradykinin-related peptide from skin secretions of toad Bombina maxima and its precursor containing six identical copies of the final product."
    Lai R., Liu H., Lee W.H., Zhang Y.
    Biochem. Biophys. Res. Commun. 286:259-263(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 41-59, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY.
    Tissue: Skin secretionImported.

Entry informationi

Entry nameiBRK1B_BOMMX
AccessioniPrimary (citable) accession number: Q90WZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 1, 2001
Last modified: October 1, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3