Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q90WY6

- ADA2C_DANRE

UniProt

Q90WY6 - ADA2C_DANRE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Alpha-2C adrenergic receptor

Gene

adra2c

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is dexmedetomidine > norepinephrine > epinephrine.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei115 – 1151Implicated in ligand bindingBy similarity
Sitei198 – 1981Implicated in catechol agonist binding and receptor activationBy similarity
Sitei202 – 2021Implicated in catechol agonist binding and receptor activationBy similarity

GO - Molecular functioni

  1. alpha2-adrenergic receptor activity Source: UniProtKB

GO - Biological processi

  1. adrenergic receptor signaling pathway Source: GOC
  2. G-protein coupled receptor signaling pathway Source: ZFIN
  3. negative regulation of adenylate cyclase activity Source: UniProtKB
  4. platelet activation Source: InterPro
  5. regulation of smooth muscle contraction Source: InterPro
  6. regulation of vasoconstriction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_208824. Adrenaline,noradrenaline inhibits insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2C adrenergic receptor
Alternative name(s):
Alpha-2C adrenoreceptor
Short name:
Alpha-2C adrenoceptor
Short name:
Alpha-2CAR
Gene namesi
Name:adra2c
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 1

Organism-specific databases

ZFINiZDB-GENE-021010-3. adra2c.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Alpha-2C adrenergic receptorPRO_0000069108Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi108 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ90WY6.

Expressioni

Gene expression databases

BgeeiQ90WY6.

Structurei

3D structure databases

ProteinModelPortaliQ90WY6.
SMRiQ90WY6. Positions 120-151.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularBy similarityAdd
BLAST
Topological domaini61 – 7212CytoplasmicBy similarityAdd
BLAST
Topological domaini99 – 10810ExtracellularBy similarity
Topological domaini132 – 15221CytoplasmicBy similarityAdd
BLAST
Topological domaini176 – 19116ExtracellularBy similarityAdd
BLAST
Topological domaini216 – 351136CytoplasmicBy similarityAdd
BLAST
Topological domaini380 – 39213ExtracellularBy similarityAdd
BLAST
Topological domaini414 – 43219CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 6025Helical; Name=1By similarityAdd
BLAST
Transmembranei73 – 9826Helical; Name=2By similarityAdd
BLAST
Transmembranei109 – 13123Helical; Name=3By similarityAdd
BLAST
Transmembranei153 – 17523Helical; Name=4By similarityAdd
BLAST
Transmembranei192 – 21524Helical; Name=5By similarityAdd
BLAST
Transmembranei352 – 37928Helical; Name=6By similarityAdd
BLAST
Transmembranei393 – 41321Helical; Name=7By similarityAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi281 – 33151Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249628.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ90WY6.
KOiK04140.
OMAiICREACE.
OrthoDBiEOG7J9VPT.
PhylomeDBiQ90WY6.
TreeFamiTF316350.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR002233. ADR_fam.
IPR000735. ADRA2C_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF25. PTHR24248:SF25. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00560. ADRENRGCA2CR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90WY6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHNLSYASEE DTYTDTDFTP SGNSTNSTSY SPATIIGLAG LVSFLILFTI
60 70 80 90 100
VGNVLVVIAV LTSRALKPPQ NLFLVSLASA DILVATLIIP FSLANELMGY
110 120 130 140 150
WFFGEVWCNI YLALDVLFCT SSIVHLCAIS LDRYWSVTQA VEYNLKRTPR
160 170 180 190 200
RVKGMIVVVW LISAVISFPP LISMDRNTVD ERRPMCQLND HTWYILYSSI
210 220 230 240 250
GSFFAPCVIM ILVYIRIYQV AKTRTRNMSE KRRDPDGGSG TPRLENGLSR
260 270 280 290 300
EDSRRENGHC SSSPGERKPA EDNPDADLED SSSSDEKAKR SQNETAPSKK
310 320 330 340 350
DRRSSRKNSS SSKHSSRKSR ASSKSLDLFS SRRKRRNTIS RKKISQAREK
360 370 380 390 400
RFTFVLAVVM GVFVVCWFPF FFSYSLYGIC REPCAIPDPL FKFFFWIGYC
410 420 430
NSSLNPVIYT IFNQDFRRAF QKILCKSWKR SF
Length:432
Mass (Da):49,137
Last modified:December 1, 2001 - v1
Checksum:i1A52F0283C663DA7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY048969 Genomic DNA. Translation: AAL07508.1.
RefSeqiNP_997522.1. NM_207639.1.
UniGeneiDr.90038.

Genome annotation databases

EnsembliENSDART00000101562; ENSDARP00000101388; ENSDARG00000069669.
GeneIDi266752.
KEGGidre:266752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY048969 Genomic DNA. Translation: AAL07508.1 .
RefSeqi NP_997522.1. NM_207639.1.
UniGenei Dr.90038.

3D structure databases

ProteinModelPortali Q90WY6.
SMRi Q90WY6. Positions 120-151.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi Q90WY6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000101562 ; ENSDARP00000101388 ; ENSDARG00000069669 .
GeneIDi 266752.
KEGGi dre:266752.

Organism-specific databases

CTDi 152.
ZFINi ZDB-GENE-021010-3. adra2c.

Phylogenomic databases

eggNOGi NOG249628.
GeneTreei ENSGT00760000118795.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi Q90WY6.
KOi K04140.
OMAi ICREACE.
OrthoDBi EOG7J9VPT.
PhylomeDBi Q90WY6.
TreeFami TF316350.

Enzyme and pathway databases

Reactomei REACT_208824. Adrenaline,noradrenaline inhibits insulin secretion.

Miscellaneous databases

NextBioi 20804824.
PROi Q90WY6.

Gene expression databases

Bgeei Q90WY6.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR002233. ADR_fam.
IPR000735. ADRA2C_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24248:SF25. PTHR24248:SF25. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01103. ADRENERGICR.
PR00560. ADRENRGCA2CR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of duplicated fourth alpha2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish."
    Ruuskanen J.O., Xhaard H., Marjamaki A., Salaneck E., Salminen T., Yan Y.-L., Postlethwait J.H., Johnson M.S., Larhammar D., Scheinin M.
    Mol. Biol. Evol. 21:14-28(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Conserved structural, pharmacological and functional properties among the three human and five zebrafish alpha2-adrenoceptors."
    Ruuskanen J.O., Laurila J., Xhaard H., Rantanen V.-V., Vuoriluoto K., Wurster S., Marjamaki A., Vainio M., Johnson M.S., Scheinin M.
    Br. J. Pharmacol. 144:165-177(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, 3D-STRUCTURE MODELING.

Entry informationi

Entry nameiADA2C_DANRE
AccessioniPrimary (citable) accession number: Q90WY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3