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Q90WY6

- ADA2C_DANRE

UniProt

Q90WY6 - ADA2C_DANRE

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Protein
Alpha-2C adrenergic receptor
Gene
adra2c
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is dexmedetomidine > norepinephrine > epinephrine.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei115 – 1151Implicated in ligand binding By similarity
Sitei198 – 1981Implicated in catechol agonist binding and receptor activation By similarity
Sitei202 – 2021Implicated in catechol agonist binding and receptor activation By similarity

GO - Molecular functioni

  1. alpha2-adrenergic receptor activity Source: UniProtKB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ZFIN
  2. adrenergic receptor signaling pathway Source: GOC
  3. negative regulation of adenylate cyclase activity Source: UniProtKB
  4. platelet activation Source: InterPro
  5. regulation of smooth muscle contraction Source: InterPro
  6. regulation of vasoconstriction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_208824. Adrenaline,noradrenaline inhibits insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2C adrenergic receptor
Alternative name(s):
Alpha-2C adrenoreceptor
Short name:
Alpha-2C adrenoceptor
Short name:
Alpha-2CAR
Gene namesi
Name:adra2c
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 1

Organism-specific databases

ZFINiZDB-GENE-021010-3. adra2c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535Extracellular By similarity
Add
BLAST
Transmembranei36 – 6025Helical; Name=1; By similarity
Add
BLAST
Topological domaini61 – 7212Cytoplasmic By similarity
Add
BLAST
Transmembranei73 – 9826Helical; Name=2; By similarity
Add
BLAST
Topological domaini99 – 10810Extracellular By similarity
Transmembranei109 – 13123Helical; Name=3; By similarity
Add
BLAST
Topological domaini132 – 15221Cytoplasmic By similarity
Add
BLAST
Transmembranei153 – 17523Helical; Name=4; By similarity
Add
BLAST
Topological domaini176 – 19116Extracellular By similarity
Add
BLAST
Transmembranei192 – 21524Helical; Name=5; By similarity
Add
BLAST
Topological domaini216 – 351136Cytoplasmic By similarity
Add
BLAST
Transmembranei352 – 37928Helical; Name=6; By similarity
Add
BLAST
Topological domaini380 – 39213Extracellular By similarity
Add
BLAST
Transmembranei393 – 41321Helical; Name=7; By similarity
Add
BLAST
Topological domaini414 – 43219Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Alpha-2C adrenergic receptor
PRO_0000069108Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...) Reviewed prediction
Glycosylationi23 – 231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi26 – 261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi108 ↔ 186 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ90WY6.

Expressioni

Gene expression databases

BgeeiQ90WY6.

Structurei

3D structure databases

ProteinModelPortaliQ90WY6.
SMRiQ90WY6. Positions 120-151.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi281 – 33151Ser-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249628.
GeneTreeiENSGT00750000117640.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
KOiK04140.
OMAiICREACE.
OrthoDBiEOG7J9VPT.
PhylomeDBiQ90WY6.
TreeFamiTF316350.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR002233. ADR_fam.
IPR000735. ADRA2C_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF25. PTHR24248:SF25. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00560. ADRENRGCA2CR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90WY6-1 [UniParc]FASTAAdd to Basket

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MHNLSYASEE DTYTDTDFTP SGNSTNSTSY SPATIIGLAG LVSFLILFTI    50
VGNVLVVIAV LTSRALKPPQ NLFLVSLASA DILVATLIIP FSLANELMGY 100
WFFGEVWCNI YLALDVLFCT SSIVHLCAIS LDRYWSVTQA VEYNLKRTPR 150
RVKGMIVVVW LISAVISFPP LISMDRNTVD ERRPMCQLND HTWYILYSSI 200
GSFFAPCVIM ILVYIRIYQV AKTRTRNMSE KRRDPDGGSG TPRLENGLSR 250
EDSRRENGHC SSSPGERKPA EDNPDADLED SSSSDEKAKR SQNETAPSKK 300
DRRSSRKNSS SSKHSSRKSR ASSKSLDLFS SRRKRRNTIS RKKISQAREK 350
RFTFVLAVVM GVFVVCWFPF FFSYSLYGIC REPCAIPDPL FKFFFWIGYC 400
NSSLNPVIYT IFNQDFRRAF QKILCKSWKR SF 432
Length:432
Mass (Da):49,137
Last modified:December 1, 2001 - v1
Checksum:i1A52F0283C663DA7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY048969 Genomic DNA. Translation: AAL07508.1.
RefSeqiNP_997522.1. NM_207639.1.
UniGeneiDr.90038.

Genome annotation databases

EnsembliENSDART00000101562; ENSDARP00000101388; ENSDARG00000069669.
GeneIDi266752.
KEGGidre:266752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY048969 Genomic DNA. Translation: AAL07508.1 .
RefSeqi NP_997522.1. NM_207639.1.
UniGenei Dr.90038.

3D structure databases

ProteinModelPortali Q90WY6.
SMRi Q90WY6. Positions 120-151.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi Q90WY6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000101562 ; ENSDARP00000101388 ; ENSDARG00000069669 .
GeneIDi 266752.
KEGGi dre:266752.

Organism-specific databases

CTDi 152.
ZFINi ZDB-GENE-021010-3. adra2c.

Phylogenomic databases

eggNOGi NOG249628.
GeneTreei ENSGT00750000117640.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
KOi K04140.
OMAi ICREACE.
OrthoDBi EOG7J9VPT.
PhylomeDBi Q90WY6.
TreeFami TF316350.

Enzyme and pathway databases

Reactomei REACT_208824. Adrenaline,noradrenaline inhibits insulin secretion.

Miscellaneous databases

NextBioi 20804824.
PROi Q90WY6.

Gene expression databases

Bgeei Q90WY6.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR002233. ADR_fam.
IPR000735. ADRA2C_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24248:SF25. PTHR24248:SF25. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01103. ADRENERGICR.
PR00560. ADRENRGCA2CR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of duplicated fourth alpha2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish."
    Ruuskanen J.O., Xhaard H., Marjamaki A., Salaneck E., Salminen T., Yan Y.-L., Postlethwait J.H., Johnson M.S., Larhammar D., Scheinin M.
    Mol. Biol. Evol. 21:14-28(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Conserved structural, pharmacological and functional properties among the three human and five zebrafish alpha2-adrenoceptors."
    Ruuskanen J.O., Laurila J., Xhaard H., Rantanen V.-V., Vuoriluoto K., Wurster S., Marjamaki A., Vainio M., Johnson M.S., Scheinin M.
    Br. J. Pharmacol. 144:165-177(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, 3D-STRUCTURE MODELING.

Entry informationi

Entry nameiADA2C_DANRE
AccessioniPrimary (citable) accession number: Q90WY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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