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Protein

Alpha-2C adrenergic receptor

Gene

adra2c

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is dexmedetomidine > norepinephrine > epinephrine.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei115Implicated in ligand bindingBy similarity1
Sitei198Implicated in catechol agonist binding and receptor activationBy similarity1
Sitei202Implicated in catechol agonist binding and receptor activationBy similarity1

GO - Molecular functioni

  • alpha2-adrenergic receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-DRE-390696 Adrenoceptors
R-DRE-392023 Adrenaline signalling through Alpha-2 adrenergic receptor
R-DRE-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-DRE-418594 G alpha (i) signalling events
R-DRE-418597 G alpha (z) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2C adrenergic receptor
Alternative name(s):
Alpha-2C adrenoreceptor
Short name:
Alpha-2C adrenoceptor
Short name:
Alpha-2CAR
Gene namesi
Name:adra2c
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 1

Organism-specific databases

ZFINiZDB-GENE-021010-3 adra2c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularBy similarityAdd BLAST35
Transmembranei36 – 60Helical; Name=1By similarityAdd BLAST25
Topological domaini61 – 72CytoplasmicBy similarityAdd BLAST12
Transmembranei73 – 98Helical; Name=2By similarityAdd BLAST26
Topological domaini99 – 108ExtracellularBy similarity10
Transmembranei109 – 131Helical; Name=3By similarityAdd BLAST23
Topological domaini132 – 152CytoplasmicBy similarityAdd BLAST21
Transmembranei153 – 175Helical; Name=4By similarityAdd BLAST23
Topological domaini176 – 191ExtracellularBy similarityAdd BLAST16
Transmembranei192 – 215Helical; Name=5By similarityAdd BLAST24
Topological domaini216 – 351CytoplasmicBy similarityAdd BLAST136
Transmembranei352 – 379Helical; Name=6By similarityAdd BLAST28
Topological domaini380 – 392ExtracellularBy similarityAdd BLAST13
Transmembranei393 – 413Helical; Name=7By similarityAdd BLAST21
Topological domaini414 – 432CytoplasmicBy similarityAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691081 – 432Alpha-2C adrenergic receptorAdd BLAST432

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi108 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ90WY6

Expressioni

Gene expression databases

BgeeiENSDARG00000069669
ExpressionAtlasiQ90WY6 baseline

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000101388

Structurei

3D structure databases

ProteinModelPortaliQ90WY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi281 – 331Ser-richAdd BLAST51

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiQ90WY6
KOiK04140
OMAiTWYILYS
OrthoDBiEOG091G06VI
PhylomeDBiQ90WY6
TreeFamiTF316350

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000735 ADRA2C_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF25 PTHR24248:SF25, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00560 ADRENRGCA2CR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q90WY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHNLSYASEE DTYTDTDFTP SGNSTNSTSY SPATIIGLAG LVSFLILFTI
60 70 80 90 100
VGNVLVVIAV LTSRALKPPQ NLFLVSLASA DILVATLIIP FSLANELMGY
110 120 130 140 150
WFFGEVWCNI YLALDVLFCT SSIVHLCAIS LDRYWSVTQA VEYNLKRTPR
160 170 180 190 200
RVKGMIVVVW LISAVISFPP LISMDRNTVD ERRPMCQLND HTWYILYSSI
210 220 230 240 250
GSFFAPCVIM ILVYIRIYQV AKTRTRNMSE KRRDPDGGSG TPRLENGLSR
260 270 280 290 300
EDSRRENGHC SSSPGERKPA EDNPDADLED SSSSDEKAKR SQNETAPSKK
310 320 330 340 350
DRRSSRKNSS SSKHSSRKSR ASSKSLDLFS SRRKRRNTIS RKKISQAREK
360 370 380 390 400
RFTFVLAVVM GVFVVCWFPF FFSYSLYGIC REPCAIPDPL FKFFFWIGYC
410 420 430
NSSLNPVIYT IFNQDFRRAF QKILCKSWKR SF
Length:432
Mass (Da):49,137
Last modified:December 1, 2001 - v1
Checksum:i1A52F0283C663DA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY048969 Genomic DNA Translation: AAL07508.1
RefSeqiNP_997522.1, NM_207639.1
UniGeneiDr.90038

Genome annotation databases

EnsembliENSDART00000101562; ENSDARP00000101388; ENSDARG00000069669
GeneIDi266752
KEGGidre:266752

Similar proteinsi

Entry informationi

Entry nameiADA2C_DANRE
AccessioniPrimary (citable) accession number: Q90WY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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