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Q90WY6 (ADA2C_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-2C adrenergic receptor
Alternative name(s):
Alpha-2C adrenoreceptor
Short name=Alpha-2C adrenoceptor
Short name=Alpha-2CAR
Gene names
Name:adra2c
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is dexmedetomidine > norepinephrine > epinephrine. Ref.2

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 432432Alpha-2C adrenergic receptor
PRO_0000069108

Regions

Topological domain1 – 3535Extracellular By similarity
Transmembrane36 – 6025Helical; Name=1; By similarity
Topological domain61 – 7212Cytoplasmic By similarity
Transmembrane73 – 9826Helical; Name=2; By similarity
Topological domain99 – 10810Extracellular By similarity
Transmembrane109 – 13123Helical; Name=3; By similarity
Topological domain132 – 15221Cytoplasmic By similarity
Transmembrane153 – 17523Helical; Name=4; By similarity
Topological domain176 – 19116Extracellular By similarity
Transmembrane192 – 21524Helical; Name=5; By similarity
Topological domain216 – 351136Cytoplasmic By similarity
Transmembrane352 – 37928Helical; Name=6; By similarity
Topological domain380 – 39213Extracellular By similarity
Transmembrane393 – 41321Helical; Name=7; By similarity
Topological domain414 – 43219Cytoplasmic By similarity
Compositional bias281 – 33151Ser-rich

Sites

Site1151Implicated in ligand binding By similarity
Site1981Implicated in catechol agonist binding and receptor activation By similarity
Site2021Implicated in catechol agonist binding and receptor activation By similarity

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Glycosylation231N-linked (GlcNAc...) Potential
Glycosylation261N-linked (GlcNAc...) Potential
Disulfide bond108 ↔ 186 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q90WY6 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 1A52F0283C663DA7

FASTA43249,137
        10         20         30         40         50         60 
MHNLSYASEE DTYTDTDFTP SGNSTNSTSY SPATIIGLAG LVSFLILFTI VGNVLVVIAV 

        70         80         90        100        110        120 
LTSRALKPPQ NLFLVSLASA DILVATLIIP FSLANELMGY WFFGEVWCNI YLALDVLFCT 

       130        140        150        160        170        180 
SSIVHLCAIS LDRYWSVTQA VEYNLKRTPR RVKGMIVVVW LISAVISFPP LISMDRNTVD 

       190        200        210        220        230        240 
ERRPMCQLND HTWYILYSSI GSFFAPCVIM ILVYIRIYQV AKTRTRNMSE KRRDPDGGSG 

       250        260        270        280        290        300 
TPRLENGLSR EDSRRENGHC SSSPGERKPA EDNPDADLED SSSSDEKAKR SQNETAPSKK 

       310        320        330        340        350        360 
DRRSSRKNSS SSKHSSRKSR ASSKSLDLFS SRRKRRNTIS RKKISQAREK RFTFVLAVVM 

       370        380        390        400        410        420 
GVFVVCWFPF FFSYSLYGIC REPCAIPDPL FKFFFWIGYC NSSLNPVIYT IFNQDFRRAF 

       430 
QKILCKSWKR SF 

« Hide

References

[1]"Identification of duplicated fourth alpha2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish."
Ruuskanen J.O., Xhaard H., Marjamaki A., Salaneck E., Salminen T., Yan Y.-L., Postlethwait J.H., Johnson M.S., Larhammar D., Scheinin M.
Mol. Biol. Evol. 21:14-28(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Conserved structural, pharmacological and functional properties among the three human and five zebrafish alpha2-adrenoceptors."
Ruuskanen J.O., Laurila J., Xhaard H., Rantanen V.-V., Vuoriluoto K., Wurster S., Marjamaki A., Vainio M., Johnson M.S., Scheinin M.
Br. J. Pharmacol. 144:165-177(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, 3D-STRUCTURE MODELING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY048969 Genomic DNA. Translation: AAL07508.1.
RefSeqNP_997522.1. NM_207639.1.
UniGeneDr.90038.

3D structure databases

ProteinModelPortalQ90WY6.
SMRQ90WY6. Positions 120-151.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEQ90WY6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000101562; ENSDARP00000101388; ENSDARG00000069669.
GeneID266752.
KEGGdre:266752.

Organism-specific databases

CTD152.
ZFINZDB-GENE-021010-3. adra2c.

Phylogenomic databases

eggNOGNOG249628.
GeneTreeENSGT00750000117640.
HOGENOMHOG000239242.
HOVERGENHBG106962.
KOK04140.
OMAICREACE.
OrthoDBEOG7J9VPT.
PhylomeDBQ90WY6.
TreeFamTF316350.

Gene expression databases

BgeeQ90WY6.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR002233. ADR_fam.
IPR000735. ADRA2C_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24248:SF25. PTHR24248:SF25. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01103. ADRENERGICR.
PR00560. ADRENRGCA2CR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20804824.
PROQ90WY6.

Entry information

Entry nameADA2C_DANRE
AccessionPrimary (citable) accession number: Q90WY6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries