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Protein

Alpha-2C adrenergic receptor

Gene

adra2c

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is dexmedetomidine > norepinephrine > epinephrine.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei115Implicated in ligand bindingBy similarity1
Sitei198Implicated in catechol agonist binding and receptor activationBy similarity1
Sitei202Implicated in catechol agonist binding and receptor activationBy similarity1

GO - Molecular functioni

  • alpha2-adrenergic receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-DRE-390696. Adrenoceptors.
R-DRE-392023. Adrenaline signalling through Alpha-2 adrenergic receptor.
R-DRE-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-DRE-418594. G alpha (i) signalling events.
R-DRE-418597. G alpha (z) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2C adrenergic receptor
Alternative name(s):
Alpha-2C adrenoreceptor
Short name:
Alpha-2C adrenoceptor
Short name:
Alpha-2CAR
Gene namesi
Name:adra2c
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 1

Organism-specific databases

ZFINiZDB-GENE-021010-3. adra2c.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularBy similarityAdd BLAST35
Transmembranei36 – 60Helical; Name=1By similarityAdd BLAST25
Topological domaini61 – 72CytoplasmicBy similarityAdd BLAST12
Transmembranei73 – 98Helical; Name=2By similarityAdd BLAST26
Topological domaini99 – 108ExtracellularBy similarity10
Transmembranei109 – 131Helical; Name=3By similarityAdd BLAST23
Topological domaini132 – 152CytoplasmicBy similarityAdd BLAST21
Transmembranei153 – 175Helical; Name=4By similarityAdd BLAST23
Topological domaini176 – 191ExtracellularBy similarityAdd BLAST16
Transmembranei192 – 215Helical; Name=5By similarityAdd BLAST24
Topological domaini216 – 351CytoplasmicBy similarityAdd BLAST136
Transmembranei352 – 379Helical; Name=6By similarityAdd BLAST28
Topological domaini380 – 392ExtracellularBy similarityAdd BLAST13
Transmembranei393 – 413Helical; Name=7By similarityAdd BLAST21
Topological domaini414 – 432CytoplasmicBy similarityAdd BLAST19

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691081 – 432Alpha-2C adrenergic receptorAdd BLAST432

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Glycosylationi23N-linked (GlcNAc...)Sequence analysis1
Glycosylationi26N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi108 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ90WY6.
PRIDEiQ90WY6.

Expressioni

Gene expression databases

BgeeiENSDARG00000069669.
ExpressionAtlasiQ90WY6. differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000101388.

Structurei

3D structure databases

ProteinModelPortaliQ90WY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi281 – 331Ser-richAdd BLAST51

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ90WY6.
KOiK04140.
OMAiGCTSLRM.
OrthoDBiEOG091G06VI.
PhylomeDBiQ90WY6.
TreeFamiTF316350.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000735. ADRA2C_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF25. PTHR24248:SF25. 2 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00560. ADRENRGCA2CR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90WY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHNLSYASEE DTYTDTDFTP SGNSTNSTSY SPATIIGLAG LVSFLILFTI
60 70 80 90 100
VGNVLVVIAV LTSRALKPPQ NLFLVSLASA DILVATLIIP FSLANELMGY
110 120 130 140 150
WFFGEVWCNI YLALDVLFCT SSIVHLCAIS LDRYWSVTQA VEYNLKRTPR
160 170 180 190 200
RVKGMIVVVW LISAVISFPP LISMDRNTVD ERRPMCQLND HTWYILYSSI
210 220 230 240 250
GSFFAPCVIM ILVYIRIYQV AKTRTRNMSE KRRDPDGGSG TPRLENGLSR
260 270 280 290 300
EDSRRENGHC SSSPGERKPA EDNPDADLED SSSSDEKAKR SQNETAPSKK
310 320 330 340 350
DRRSSRKNSS SSKHSSRKSR ASSKSLDLFS SRRKRRNTIS RKKISQAREK
360 370 380 390 400
RFTFVLAVVM GVFVVCWFPF FFSYSLYGIC REPCAIPDPL FKFFFWIGYC
410 420 430
NSSLNPVIYT IFNQDFRRAF QKILCKSWKR SF
Length:432
Mass (Da):49,137
Last modified:December 1, 2001 - v1
Checksum:i1A52F0283C663DA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY048969 Genomic DNA. Translation: AAL07508.1.
RefSeqiNP_997522.1. NM_207639.1.
UniGeneiDr.90038.

Genome annotation databases

EnsembliENSDART00000101562; ENSDARP00000101388; ENSDARG00000069669.
GeneIDi266752.
KEGGidre:266752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY048969 Genomic DNA. Translation: AAL07508.1.
RefSeqiNP_997522.1. NM_207639.1.
UniGeneiDr.90038.

3D structure databases

ProteinModelPortaliQ90WY6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000101388.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ90WY6.
PRIDEiQ90WY6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000101562; ENSDARP00000101388; ENSDARG00000069669.
GeneIDi266752.
KEGGidre:266752.

Organism-specific databases

CTDi152.
ZFINiZDB-GENE-021010-3. adra2c.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ90WY6.
KOiK04140.
OMAiGCTSLRM.
OrthoDBiEOG091G06VI.
PhylomeDBiQ90WY6.
TreeFamiTF316350.

Enzyme and pathway databases

ReactomeiR-DRE-390696. Adrenoceptors.
R-DRE-392023. Adrenaline signalling through Alpha-2 adrenergic receptor.
R-DRE-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-DRE-418594. G alpha (i) signalling events.
R-DRE-418597. G alpha (z) signalling events.

Miscellaneous databases

PROiQ90WY6.

Gene expression databases

BgeeiENSDARG00000069669.
ExpressionAtlasiQ90WY6. differential.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000735. ADRA2C_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF25. PTHR24248:SF25. 2 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00560. ADRENRGCA2CR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADA2C_DANRE
AccessioniPrimary (citable) accession number: Q90WY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.