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Q90WY6

- ADA2C_DANRE

UniProt

Q90WY6 - ADA2C_DANRE

Protein

Alpha-2C adrenergic receptor

Gene

adra2c

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is dexmedetomidine > norepinephrine > epinephrine.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei115 – 1151Implicated in ligand bindingBy similarity
    Sitei198 – 1981Implicated in catechol agonist binding and receptor activationBy similarity
    Sitei202 – 2021Implicated in catechol agonist binding and receptor activationBy similarity

    GO - Molecular functioni

    1. alpha2-adrenergic receptor activity Source: UniProtKB

    GO - Biological processi

    1. adrenergic receptor signaling pathway Source: GOC
    2. G-protein coupled receptor signaling pathway Source: ZFIN
    3. negative regulation of adenylate cyclase activity Source: UniProtKB
    4. platelet activation Source: InterPro
    5. regulation of smooth muscle contraction Source: InterPro
    6. regulation of vasoconstriction Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_208824. Adrenaline,noradrenaline inhibits insulin secretion.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-2C adrenergic receptor
    Alternative name(s):
    Alpha-2C adrenoreceptor
    Short name:
    Alpha-2C adrenoceptor
    Short name:
    Alpha-2CAR
    Gene namesi
    Name:adra2c
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 1

    Organism-specific databases

    ZFINiZDB-GENE-021010-3. adra2c.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: ZFIN

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 432432Alpha-2C adrenergic receptorPRO_0000069108Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi108 ↔ 186PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ90WY6.

    Expressioni

    Gene expression databases

    BgeeiQ90WY6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ90WY6.
    SMRiQ90WY6. Positions 120-151.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535ExtracellularBy similarityAdd
    BLAST
    Topological domaini61 – 7212CytoplasmicBy similarityAdd
    BLAST
    Topological domaini99 – 10810ExtracellularBy similarity
    Topological domaini132 – 15221CytoplasmicBy similarityAdd
    BLAST
    Topological domaini176 – 19116ExtracellularBy similarityAdd
    BLAST
    Topological domaini216 – 351136CytoplasmicBy similarityAdd
    BLAST
    Topological domaini380 – 39213ExtracellularBy similarityAdd
    BLAST
    Topological domaini414 – 43219CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 6025Helical; Name=1By similarityAdd
    BLAST
    Transmembranei73 – 9826Helical; Name=2By similarityAdd
    BLAST
    Transmembranei109 – 13123Helical; Name=3By similarityAdd
    BLAST
    Transmembranei153 – 17523Helical; Name=4By similarityAdd
    BLAST
    Transmembranei192 – 21524Helical; Name=5By similarityAdd
    BLAST
    Transmembranei352 – 37928Helical; Name=6By similarityAdd
    BLAST
    Transmembranei393 – 41321Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi281 – 33151Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249628.
    GeneTreeiENSGT00750000117640.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    KOiK04140.
    OMAiICREACE.
    OrthoDBiEOG7J9VPT.
    PhylomeDBiQ90WY6.
    TreeFamiTF316350.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR002233. ADR_fam.
    IPR000735. ADRA2C_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24248:SF25. PTHR24248:SF25. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01103. ADRENERGICR.
    PR00560. ADRENRGCA2CR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q90WY6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHNLSYASEE DTYTDTDFTP SGNSTNSTSY SPATIIGLAG LVSFLILFTI    50
    VGNVLVVIAV LTSRALKPPQ NLFLVSLASA DILVATLIIP FSLANELMGY 100
    WFFGEVWCNI YLALDVLFCT SSIVHLCAIS LDRYWSVTQA VEYNLKRTPR 150
    RVKGMIVVVW LISAVISFPP LISMDRNTVD ERRPMCQLND HTWYILYSSI 200
    GSFFAPCVIM ILVYIRIYQV AKTRTRNMSE KRRDPDGGSG TPRLENGLSR 250
    EDSRRENGHC SSSPGERKPA EDNPDADLED SSSSDEKAKR SQNETAPSKK 300
    DRRSSRKNSS SSKHSSRKSR ASSKSLDLFS SRRKRRNTIS RKKISQAREK 350
    RFTFVLAVVM GVFVVCWFPF FFSYSLYGIC REPCAIPDPL FKFFFWIGYC 400
    NSSLNPVIYT IFNQDFRRAF QKILCKSWKR SF 432
    Length:432
    Mass (Da):49,137
    Last modified:December 1, 2001 - v1
    Checksum:i1A52F0283C663DA7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY048969 Genomic DNA. Translation: AAL07508.1.
    RefSeqiNP_997522.1. NM_207639.1.
    UniGeneiDr.90038.

    Genome annotation databases

    EnsembliENSDART00000101562; ENSDARP00000101388; ENSDARG00000069669.
    GeneIDi266752.
    KEGGidre:266752.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY048969 Genomic DNA. Translation: AAL07508.1 .
    RefSeqi NP_997522.1. NM_207639.1.
    UniGenei Dr.90038.

    3D structure databases

    ProteinModelPortali Q90WY6.
    SMRi Q90WY6. Positions 120-151.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi Q90WY6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000101562 ; ENSDARP00000101388 ; ENSDARG00000069669 .
    GeneIDi 266752.
    KEGGi dre:266752.

    Organism-specific databases

    CTDi 152.
    ZFINi ZDB-GENE-021010-3. adra2c.

    Phylogenomic databases

    eggNOGi NOG249628.
    GeneTreei ENSGT00750000117640.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    KOi K04140.
    OMAi ICREACE.
    OrthoDBi EOG7J9VPT.
    PhylomeDBi Q90WY6.
    TreeFami TF316350.

    Enzyme and pathway databases

    Reactomei REACT_208824. Adrenaline,noradrenaline inhibits insulin secretion.

    Miscellaneous databases

    NextBioi 20804824.
    PROi Q90WY6.

    Gene expression databases

    Bgeei Q90WY6.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR002233. ADR_fam.
    IPR000735. ADRA2C_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24248:SF25. PTHR24248:SF25. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01103. ADRENERGICR.
    PR00560. ADRENRGCA2CR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of duplicated fourth alpha2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish."
      Ruuskanen J.O., Xhaard H., Marjamaki A., Salaneck E., Salminen T., Yan Y.-L., Postlethwait J.H., Johnson M.S., Larhammar D., Scheinin M.
      Mol. Biol. Evol. 21:14-28(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Conserved structural, pharmacological and functional properties among the three human and five zebrafish alpha2-adrenoceptors."
      Ruuskanen J.O., Laurila J., Xhaard H., Rantanen V.-V., Vuoriluoto K., Wurster S., Marjamaki A., Vainio M., Johnson M.S., Scheinin M.
      Br. J. Pharmacol. 144:165-177(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, 3D-STRUCTURE MODELING.

    Entry informationi

    Entry nameiADA2C_DANRE
    AccessioniPrimary (citable) accession number: Q90WY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3