Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alpha-2B adrenergic receptor

Gene

adra2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is norepinephrine > epinephrine.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei121 – 1211Implicated in ligand bindingBy similarity
Sitei207 – 2071Implicated in catechol agonist bindingBy similarity
Sitei211 – 2111Implicated in catechol agonist bindingBy similarity

GO - Molecular functioni

  • alpha2-adrenergic receptor activity Source: UniProtKB
  • alpha-adrenergic receptor activity Source: ZFIN

GO - Biological processi

  • adrenergic receptor signaling pathway Source: GOC
  • G-protein coupled receptor signaling pathway Source: ZFIN
  • negative regulation of adenylate cyclase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2B adrenergic receptor
Alternative name(s):
Alpha-2B adrenoreceptor
Short name:
Alpha-2B adrenoceptor
Short name:
Alpha-2BAR
Gene namesi
Name:adra2b
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-021010-2. adra2b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularBy similarityAdd
BLAST
Transmembranei42 – 6726Helical; Name=1By similarityAdd
BLAST
Topological domaini68 – 7811CytoplasmicBy similarityAdd
BLAST
Transmembranei79 – 10426Helical; Name=2By similarityAdd
BLAST
Topological domaini105 – 11410ExtracellularBy similarity
Transmembranei115 – 13723Helical; Name=3By similarityAdd
BLAST
Topological domaini138 – 15922CytoplasmicBy similarityAdd
BLAST
Transmembranei160 – 18425Helical; Name=4By similarityAdd
BLAST
Topological domaini185 – 20016ExtracellularBy similarityAdd
BLAST
Transmembranei201 – 22424Helical; Name=5By similarityAdd
BLAST
Topological domaini225 – 432208CytoplasmicBy similarityAdd
BLAST
Transmembranei433 – 45624Helical; Name=6By similarityAdd
BLAST
Topological domaini457 – 4659ExtracellularBy similarity
Transmembranei466 – 48924Helical; Name=7By similarityAdd
BLAST
Topological domaini490 – 51021CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Alpha-2B adrenergic receptorPRO_0000069102Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence analysis
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence analysis
Disulfide bondi114 ↔ 195PROSITE-ProRule annotation
Lipidationi502 – 5021S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ90WY5.

Expressioni

Gene expression databases

BgeeiQ90WY5.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000110714.

Structurei

3D structure databases

ProteinModelPortaliQ90WY5.
SMRiQ90WY5. Positions 126-157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi326 – 34621Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ90WY5.
KOiK04139.
PhylomeDBiQ90WY5.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90WY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSPCPVAVG LPGHTNGTGG TSSPTCNQSM IKLAPYSPEA TAAFATAITL
60 70 80 90 100
MMLITIVGNI LVIIAVLTSR SLRGPQNLFL VSLAAADILV ATLIIPFSLA
110 120 130 140 150
NELMGYWYFR SVWCEIYLAL DVLFCTSSIV HLCAISLDRY MSISRAVTYG
160 170 180 190 200
PKRTPKRIKC AILVVWLISA VISFPPLLSM NKNKGGGESG ALPQCQLNDE
210 220 230 240 250
RWYILYSTIG SFFAPCLIMI LVYMRIYQIA KQRTRCPPGE PRKEAPANAT
260 270 280 290 300
TPQHKIQNGR GDETPGTLQK KARPPTLAVS QVESVQQAAN TPIANNLLQA
310 320 330 340 350
PSTTLTPTTP CPSPSPSNSS EVAPSKSKEG KKEKKKKKNN KNKNKKEPDN
360 370 380 390 400
NNGESMSSDS DTEQGGRGLE VPCTPTMTPS GIHSPATMQK YRDMIATAKG
410 420 430 440 450
AKLVARKAKQ DGTPNSARRK AMVNREKRFT FVLAVVIGVF VICWFPFFFS
460 470 480 490 500
YSLQAVCPES CALPEPLFKF FFWIGYCNSC LNPVIYTIFN KDFRRAFKKI
510
LCKNTKGTFF
Length:510
Mass (Da):55,971
Last modified:December 1, 2001 - v1
Checksum:i1CB07C0AFC6DE3D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY048970 Genomic DNA. Translation: AAL07509.1.
RefSeqiNP_997521.1. NM_207638.1.
UniGeneiDr.76957.

Genome annotation databases

GeneIDi266751.
KEGGidre:266751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY048970 Genomic DNA. Translation: AAL07509.1.
RefSeqiNP_997521.1. NM_207638.1.
UniGeneiDr.76957.

3D structure databases

ProteinModelPortaliQ90WY5.
SMRiQ90WY5. Positions 126-157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000110714.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ90WY5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi266751.
KEGGidre:266751.

Organism-specific databases

CTDi151.
ZFINiZDB-GENE-021010-2. adra2b.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ90WY5.
KOiK04139.
PhylomeDBiQ90WY5.

Miscellaneous databases

PROiQ90WY5.

Gene expression databases

BgeeiQ90WY5.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of duplicated fourth alpha2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish."
    Ruuskanen J.O., Xhaard H., Marjamaki A., Salaneck E., Salminen T., Yan Y.-L., Postlethwait J.H., Johnson M.S., Larhammar D., Scheinin M.
    Mol. Biol. Evol. 21:14-28(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Conserved structural, pharmacological and functional properties among the three human and five zebrafish alpha2-adrenoceptors."
    Ruuskanen J.O., Laurila J., Xhaard H., Rantanen V.-V., Vuoriluoto K., Wurster S., Marjamaki A., Vainio M., Johnson M.S., Scheinin M.
    Br. J. Pharmacol. 144:165-177(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, 3D-STRUCTURE MODELING.

Entry informationi

Entry nameiADA2B_DANRE
AccessioniPrimary (citable) accession number: Q90WY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.