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Protein

Alpha-2B adrenergic receptor

Gene

adra2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is norepinephrine > epinephrine.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei121Implicated in ligand bindingBy similarity1
Sitei207Implicated in catechol agonist bindingBy similarity1
Sitei211Implicated in catechol agonist bindingBy similarity1

GO - Molecular functioni

  • alpha2-adrenergic receptor activity Source: UniProtKB
  • alpha-adrenergic receptor activity Source: ZFIN

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2B adrenergic receptor
Alternative name(s):
Alpha-2B adrenoreceptor
Short name:
Alpha-2B adrenoceptor
Short name:
Alpha-2BAR
Gene namesi
Name:adra2b
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-021010-2 adra2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularBy similarityAdd BLAST41
Transmembranei42 – 67Helical; Name=1By similarityAdd BLAST26
Topological domaini68 – 78CytoplasmicBy similarityAdd BLAST11
Transmembranei79 – 104Helical; Name=2By similarityAdd BLAST26
Topological domaini105 – 114ExtracellularBy similarity10
Transmembranei115 – 137Helical; Name=3By similarityAdd BLAST23
Topological domaini138 – 159CytoplasmicBy similarityAdd BLAST22
Transmembranei160 – 184Helical; Name=4By similarityAdd BLAST25
Topological domaini185 – 200ExtracellularBy similarityAdd BLAST16
Transmembranei201 – 224Helical; Name=5By similarityAdd BLAST24
Topological domaini225 – 432CytoplasmicBy similarityAdd BLAST208
Transmembranei433 – 456Helical; Name=6By similarityAdd BLAST24
Topological domaini457 – 465ExtracellularBy similarity9
Transmembranei466 – 489Helical; Name=7By similarityAdd BLAST24
Topological domaini490 – 510CytoplasmicBy similarityAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691021 – 510Alpha-2B adrenergic receptorAdd BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi16N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi114 ↔ 195PROSITE-ProRule annotation
Lipidationi502S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ90WY5
PRIDEiQ90WY5

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000110714

Structurei

3D structure databases

ProteinModelPortaliQ90WY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi326 – 346Lys-richAdd BLAST21

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiQ90WY5
KOiK04139
PhylomeDBiQ90WY5

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q90WY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSPCPVAVG LPGHTNGTGG TSSPTCNQSM IKLAPYSPEA TAAFATAITL
60 70 80 90 100
MMLITIVGNI LVIIAVLTSR SLRGPQNLFL VSLAAADILV ATLIIPFSLA
110 120 130 140 150
NELMGYWYFR SVWCEIYLAL DVLFCTSSIV HLCAISLDRY MSISRAVTYG
160 170 180 190 200
PKRTPKRIKC AILVVWLISA VISFPPLLSM NKNKGGGESG ALPQCQLNDE
210 220 230 240 250
RWYILYSTIG SFFAPCLIMI LVYMRIYQIA KQRTRCPPGE PRKEAPANAT
260 270 280 290 300
TPQHKIQNGR GDETPGTLQK KARPPTLAVS QVESVQQAAN TPIANNLLQA
310 320 330 340 350
PSTTLTPTTP CPSPSPSNSS EVAPSKSKEG KKEKKKKKNN KNKNKKEPDN
360 370 380 390 400
NNGESMSSDS DTEQGGRGLE VPCTPTMTPS GIHSPATMQK YRDMIATAKG
410 420 430 440 450
AKLVARKAKQ DGTPNSARRK AMVNREKRFT FVLAVVIGVF VICWFPFFFS
460 470 480 490 500
YSLQAVCPES CALPEPLFKF FFWIGYCNSC LNPVIYTIFN KDFRRAFKKI
510
LCKNTKGTFF
Length:510
Mass (Da):55,971
Last modified:December 1, 2001 - v1
Checksum:i1CB07C0AFC6DE3D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY048970 Genomic DNA Translation: AAL07509.1
RefSeqiNP_997521.1, NM_207638.1
UniGeneiDr.76957

Genome annotation databases

GeneIDi266751
KEGGidre:266751

Similar proteinsi

Entry informationi

Entry nameiADA2B_DANRE
AccessioniPrimary (citable) accession number: Q90WY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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